Puri, Basant K · International review of psychiatry (Abingdon, England) · 2006 · DOI
This study describes advanced brain imaging techniques that can measure specific chemicals in the brain without surgery. These techniques help researchers understand how the brain uses fats and other building blocks to maintain healthy cell membranes. The authors explain how these imaging methods could be applied to study brain chemistry in ME/CFS and other conditions.
This study is significant because it outlines non-invasive neuroimaging methods that could reveal underlying brain chemistry abnormalities in ME/CFS. Understanding abnormal membrane phospholipid metabolism could provide biological markers for the disease and guide development of targeted treatments, particularly fatty acid interventions. These techniques offer potential for objectively studying brain-based mechanisms in ME/CFS.
This review article does not provide empirical evidence that membrane phospholipid abnormalities actually exist in ME/CFS patients—it only proposes that the imaging techniques could detect such abnormalities if present. It does not demonstrate causation between any biochemical changes and ME/CFS symptoms. The study does not compare ME/CFS patients to healthy controls or show that fatty acid interventions improve outcomes.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Puri, Basant K (2006). Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.. International review of psychiatry (Abingdon, England). https://doi.org/10.1080/09540260600581852
BibTeX
@article{mecfsatlas-puri-2006-proton-phosphorus,
author = {Puri, Basant K},
title = {Proton and 31-phosphorus neurospectroscopy in the study of membrane phospholipids and fatty acid intervention in schizophrenia, depression, chronic fatigue syndrome (myalgic encephalomyelitis) and dyslexia.},
journal = {International review of psychiatry (Abingdon, England)},
year = {2006},
doi = {10.1080/09540260600581852},
note = {PubMed: 16777668},
url = {https://www.mecfsatlas.com/evidence/puri-2006-proton-phosphorus},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/puri-2006-proton-phosphorus
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