Roma, Maria, Marden, Colleen L, Flaherty, Marissa A K et al. · Frontiers in pediatrics · 2019 · DOI
This study looked at how ME/CFS affects the daily lives and well-being of teenagers and young adults compared to healthy peers. Young people with ME/CFS reported much worse quality of life across all areas tested, and the study found that post-exertional malaise (feeling much worse after activity) was the strongest predictor of this reduced quality of life. The findings confirm that ME/CFS in young people is as serious as or more serious than other chronic childhood illnesses like asthma, diabetes, and cystic fibrosis.
This research provides robust evidence that ME/CFS causes substantial disability in youth comparable to or exceeding that of other serious chronic pediatric illnesses, challenging potential underestimation of disease severity. By identifying post-exertional malaise as the core symptom most strongly linked to quality-of-life impairment, the study reinforces the importance of activity pacing interventions and validates its inclusion in diagnostic criteria.
This study demonstrates association between post-exertional malaise and quality-of-life impairment but cannot establish causation or directionality due to its cross-sectional design. The single North American tertiary care center sample may not represent all ME/CFS presentations, particularly milder or more severe cases, limiting generalizability. The study does not evaluate whether treating or managing specific symptoms would improve quality of life.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Roma, Maria, Marden, Colleen L, Flaherty, Marissa A K, Jasion, Samantha E, Cranston, Erica M, & Rowe, Peter C (2019). Impaired Health-Related Quality of Life in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Impact of Core Symptoms.. Frontiers in pediatrics. https://doi.org/10.3389/fped.2019.00026
BibTeX
@article{mecfsatlas-roma-2019-impaired-health,
author = {Roma, Maria and Marden, Colleen L and Flaherty, Marissa A K and Jasion, Samantha E and Cranston, Erica M and Rowe, Peter C},
title = {Impaired Health-Related Quality of Life in Adolescent Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Impact of Core Symptoms.},
journal = {Frontiers in pediatrics},
year = {2019},
doi = {10.3389/fped.2019.00026},
note = {PubMed: 30828572},
url = {https://www.mecfsatlas.com/evidence/roma-2019-impaired-health},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/roma-2019-impaired-health
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