Saggini, R, Pizzigallo, E, Vecchiet, J et al. · Journal of the neurological sciences · 1998 · DOI
This study looked at how people with ME/CFS walk compared to healthy people. Researchers used specialized movement analysis tools to measure walking patterns in 12 patients and found clear differences in how smoothly and symmetrically they walked. Interestingly, these walking problems appeared right from the start of walking, not after fatigue set in, suggesting the issue may be related to how the brain controls movement rather than muscle tiredness.
This study provides objective, measurable evidence that ME/CFS affects how the nervous system controls movement, not just muscle function or fatigue. Finding early-onset gait abnormalities supports the hypothesis that ME/CFS involves central nervous system dysfunction, which could help validate the neurological basis of the disease and guide future diagnostic and treatment approaches.
This study does not prove that CNS involvement causes ME/CFS, only that gait abnormalities correlate with the condition. The small sample size and lack of longitudinal follow-up mean results may not represent all ME/CFS patients. The study does not determine whether gait abnormalities improve with treatment or how they relate to disease severity or patient outcomes.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Saggini, R, Pizzigallo, E, Vecchiet, J, Macellari, V, & Giacomozzi, C (1998). Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.. Journal of the neurological sciences. https://doi.org/10.1016/s0022-510x(97)00200-1
BibTeX
@article{mecfsatlas-saggini-1998-alteration-spatial,
author = {Saggini, R and Pizzigallo, E and Vecchiet, J and Macellari, V and Giacomozzi, C},
title = {Alteration of spatial-temporal parameters of gait in Chronic Fatigue Syndrome patients.},
journal = {Journal of the neurological sciences},
year = {1998},
doi = {10.1016/s0022-510x(97)00200-1},
note = {PubMed: 9543318},
url = {https://www.mecfsatlas.com/evidence/saggini-1998-alteration-spatial},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/saggini-1998-alteration-spatial
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