Schultz, Katlin R, Katz, Ben Z, Bockian, Neil R et al. · Clinical therapeutics · 2019 · DOI
This study looked at whether what young people with ME/CFS report feeling about dizziness and heart symptoms matches what doctors measure during physical exams. Researchers compared answers from questionnaires with actual measurements of blood pressure and heart rate changes. They found that while patients reported these symptoms, the physical measurements didn't always show the same problems, suggesting current testing methods may miss real autonomic problems in young ME/CFS patients.
This study highlights an important diagnostic gap in ME/CFS care: young patients clearly experience autonomic symptoms like orthostatic intolerance, but standard clinical measurements often fail to detect these problems. Understanding this mismatch is crucial for developing better diagnostic tools and helping physicians recognize autonomic dysfunction that current assessments may miss.
This study does not prove that autonomic dysfunction is absent in youth with ME/CFS; rather, it suggests current measurement methods are inadequate for detection. It does not establish causation or determine which measurement approach (self-report vs. physician assessment) is more accurate. The cross-sectional design cannot explain why correlations between subjective and objective measures are weak.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Schultz, Katlin R, Katz, Ben Z, Bockian, Neil R, & Jason, Leonard A (2019). Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth.. Clinical therapeutics. https://doi.org/10.1016/j.clinthera.2019.02.010
BibTeX
@article{mecfsatlas-schultz-2019-associations-between,
author = {Schultz, Katlin R and Katz, Ben Z and Bockian, Neil R and Jason, Leonard A},
title = {Associations Between Autonomic and Orthostatic Self-report and Physician Ratings of Orthostatic Intolerance in Youth.},
journal = {Clinical therapeutics},
year = {2019},
doi = {10.1016/j.clinthera.2019.02.010},
note = {PubMed: 30876666},
url = {https://www.mecfsatlas.com/evidence/schultz-2019-associations-between},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/schultz-2019-associations-between
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