Scott, L V, Salahuddin, F, Cooney, J et al. · Journal of affective disorders · 1999 · DOI
This study measured several hormones related to stress in people with ME/CFS, depression, and healthy individuals. Researchers found that people with ME/CFS had significantly lower levels of DHEA and DHEA-S (hormones produced by the adrenal glands) compared to healthy people, while cortisol levels were similar across all groups. This suggests ME/CFS may involve a different hormone pattern than depression, and DHEA could potentially help diagnose or treat ME/CFS.
This research identifies a potential biochemical signature of ME/CFS—specifically low DHEA and DHEA-S—that distinguishes it from major depression and healthy controls. Understanding these hormone abnormalities could lead to diagnostic biomarkers and new treatment approaches targeting adrenal function in ME/CFS.
This study does not prove that low DHEA causes ME/CFS or that DHEA replacement will treat the condition. The cross-sectional design cannot establish causality. The small sample size (15 CFS patients) limits generalizability, and the findings need replication in larger, longitudinal studies before clinical use is recommended.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Scott, L V, Salahuddin, F, Cooney, J, Svec, F, & Dinan, T G (1999). Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.. Journal of affective disorders. https://doi.org/10.1016/s0165-0327(98)00169-4
BibTeX
@article{mecfsatlas-scott-1999-differences-adrenal,
author = {Scott, L V and Salahuddin, F and Cooney, J and Svec, F and Dinan, T G},
title = {Differences in adrenal steroid profile in chronic fatigue syndrome, in depression and in health.},
journal = {Journal of affective disorders},
year = {1999},
doi = {10.1016/s0165-0327(98)00169-4},
note = {PubMed: 10403156},
url = {https://www.mecfsatlas.com/evidence/scott-1999-differences-adrenal},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/scott-1999-differences-adrenal
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