Seeley, Marie-Claire, Gallagher, Celine, Ong, Eric et al. · Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023 · DOI
This study compared quality of life in people with POTS (a condition causing rapid heartbeat when standing) to people without POTS. Researchers found that people with POTS reported significantly worse quality of life across all areas tested, including mobility, self-care, daily activities, pain, and mood. The impact was consistent across all age groups, and was worse in people with severe symptoms, women, those with fatigue, and those who also had ME/CFS.
This study is important because it quantifies the significant functional burden of POTS, a condition that commonly co-occurs with ME/CFS. The finding that ME/CFS comorbidity independently worsens quality of life in POTS suggests these conditions have compounding effects on daily functioning. Understanding the magnitude of HrQoL impairment helps validate patient experiences and may inform clinical prioritization and treatment strategies.
This cross-sectional study cannot establish causation or whether POTS causes reduced quality of life or vice versa. It does not prove that treating POTS symptoms will improve quality of life, only that the conditions are associated with worse outcomes. The predominantly female sample (90.6%) limits generalizability to male POTS patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Seeley, Marie-Claire, Gallagher, Celine, Ong, Eric, Langdon, Amy, Chieng, Jonathan, Bailey, Danielle, et al. (2023). Poor health-related quality of life in postural orthostatic tachycardia syndrome in comparison with a sex- and age-matched normative population.. Clinical autonomic research : official journal of the Clinical Autonomic Research Society. https://doi.org/10.1007/s10286-023-00955-9
BibTeX
@article{mecfsatlas-seeley-2023-poor-health,
author = {Seeley, Marie-Claire and Gallagher, Celine and Ong, Eric and Langdon, Amy and Chieng, Jonathan and Bailey, Danielle and Dennis, Annabelle and McCaffrey, Nikki and Lau, Dennis H},
title = {Poor health-related quality of life in postural orthostatic tachycardia syndrome in comparison with a sex- and age-matched normative population.},
journal = {Clinical autonomic research : official journal of the Clinical Autonomic Research Society},
year = {2023},
doi = {10.1007/s10286-023-00955-9},
note = {PubMed: 37338634},
url = {https://www.mecfsatlas.com/evidence/seeley-2023-poor-health},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-25. https://www.mecfsatlas.com/evidence/seeley-2023-poor-health
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