Sáez-Francàs, Naia, Valero, Sergi, Calvo, Natalia et al. · Psychiatry research · 2014 · DOI
This study looked at personality traits in people with ME/CFS compared to healthy people without the condition. Researchers found that people with ME/CFS tend to have lower levels of activity and drive, and higher levels of anxiety and worry. These personality differences were the strongest markers that could distinguish ME/CFS patients from people without the condition.
Understanding personality patterns in ME/CFS may help clinicians better recognize the condition and avoid misattributing symptoms to psychiatric causes. This research clarifies that low activity levels in ME/CFS reflect the disease process itself rather than personality-driven social withdrawal, which has important implications for how the condition is understood and treated.
This study demonstrates association but cannot establish whether these personality traits cause ME/CFS, result from it, or both. The cross-sectional design cannot determine temporal relationships. Additionally, personality questionnaires measure self-reported traits and may be influenced by current symptom burden, so findings do not prove pre-existing personality differences.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Sáez-Francàs, Naia, Valero, Sergi, Calvo, Natalia, Gomà-I-Freixanet, Montserrat, Alegre, José, de Sevilla, Tomás Fernández, et al. (2014). Chronic fatigue syndrome and personality: a case-control study using the Alternative Five Factor Model.. Psychiatry research. https://doi.org/10.1016/j.psychres.2014.02.031
BibTeX
@article{mecfsatlas-sez-francs-2014-chronic-fatigue,
author = {Sáez-Francàs, Naia and Valero, Sergi and Calvo, Natalia and Gomà-I-Freixanet, Montserrat and Alegre, José and de Sevilla, Tomás Fernández and Casas, Miquel},
title = {Chronic fatigue syndrome and personality: a case-control study using the Alternative Five Factor Model.},
journal = {Psychiatry research},
year = {2014},
doi = {10.1016/j.psychres.2014.02.031},
note = {PubMed: 24630915},
url = {https://www.mecfsatlas.com/evidence/sez-francs-2014-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/sez-francs-2014-chronic-fatigue
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