Sáez-Francàs, Naia, Calvo, Natalia, Alegre, José et al. · Comprehensive psychiatry · 2015 · DOI
This study looked at whether ME/CFS patients who experienced childhood trauma are more likely to have personality disorders and mental health challenges like depression. Researchers surveyed 166 ME/CFS patients using questionnaires about their childhood experiences and current mental health. They found that about one-third had experienced childhood trauma, and nearly half had signs of a personality disorder. Importantly, emotional trauma (like neglect or abuse) was more strongly connected to personality disorders than physical trauma.
Understanding how childhood trauma and personality factors contribute to ME/CFS psychopathology can improve clinical assessment and psychological support strategies for this population. This study provides evidence that emotional trauma history may be particularly relevant to mental health outcomes in ME/CFS, informing targeted intervention development and clinician awareness of psychological comorbidities.
This study cannot establish causality or temporal sequence—it does not prove that childhood trauma causes personality disorders or ME/CFS, only that they are associated. The cross-sectional design means we cannot determine whether trauma preceded CFS onset or whether other unmeasured factors explain the associations. Additionally, findings in this specific CFS cohort may not generalize to all ME/CFS populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Sáez-Francàs, Naia, Calvo, Natalia, Alegre, José, Castro-Marrero, Jesús, Ramírez, Nicolás, Hernández-Vara, Jorge, et al. (2015). Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology.. Comprehensive psychiatry. https://doi.org/10.1016/j.comppsych.2015.06.010
BibTeX
@article{mecfsatlas-sez-francs-2015-childhood-trauma,
author = {Sáez-Francàs, Naia and Calvo, Natalia and Alegre, José and Castro-Marrero, Jesús and Ramírez, Nicolás and Hernández-Vara, Jorge and Casas, Miguel},
title = {Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology.},
journal = {Comprehensive psychiatry},
year = {2015},
doi = {10.1016/j.comppsych.2015.06.010},
note = {PubMed: 26343462},
url = {https://www.mecfsatlas.com/evidence/sez-francs-2015-childhood-trauma},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/sez-francs-2015-childhood-trauma
Contribute
Private, reviewed by a human. Not a public comment thread.