Tangirala, Sivateja, Patel, Chirag J · Scientific reports · 2018 · DOI
Researchers compared gene activity in identical twins where one twin had ME/CFS and the other didn't, along with studying six other conditions. They wanted to understand how environment (rather than genes) influences disease by looking at which genes were turned on or off differently between affected and unaffected twins. The study found that while different diseases may share some similar changes in gene activity, each condition has its own unique pattern of gene changes.
ME/CFS etiology remains poorly understood, with both genetic and environmental factors implicated. This study uses twins to help isolate environmental contributions to gene expression in ME/CFS, which is critical for identifying modifiable factors and potential therapeutic targets. The creation of a public database enables researchers to explore how environmental factors shape gene activity in ME/CFS compared to other conditions.
This study does not prove what specific environmental exposures caused the gene expression differences observed, nor does it establish causality between the measured gene changes and ME/CFS symptoms. The identification of small-effect common signatures across diseases does not establish that these conditions share underlying environmental etiologies. Cross-sectional gene expression data cannot determine whether observed differences are causes or consequences of disease.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Tangirala, Sivateja & Patel, Chirag J (2018). Integrated Analysis of Gene Expression Differences in Twins Discordant for Disease and Binary Phenotypes.. Scientific reports. https://doi.org/10.1038/s41598-017-18585-3
BibTeX
@article{mecfsatlas-tangirala-2018-integrated-analysis,
author = {Tangirala, Sivateja and Patel, Chirag J},
title = {Integrated Analysis of Gene Expression Differences in Twins Discordant for Disease and Binary Phenotypes.},
journal = {Scientific reports},
year = {2018},
doi = {10.1038/s41598-017-18585-3},
note = {PubMed: 29311748},
url = {https://www.mecfsatlas.com/evidence/tangirala-2018-integrated-analysis},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/tangirala-2018-integrated-analysis
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