Testai, Lara, Martelli, Alma, Flori, Lorenzo et al. · Nutrients · 2021 · DOI
This review examines how Coenzyme Q10 (CoQ10), a natural substance found in cells that helps produce energy, might help with various conditions including chronic fatigue syndrome. CoQ10 also has anti-inflammatory and antioxidant properties that may protect cells from damage. The researchers looked at studies on CoQ10's effects on migraine, neurological diseases, cancer, and muscle disorders to see if supplementation could improve patient health and quality of life.
ME/CFS is explicitly mentioned as a degenerative muscle disorder where CoQ10 supplementation may be beneficial. Since ME/CFS is characterized by mitochondrial dysfunction and impaired energy metabolism, understanding whether CoQ10 levels are abnormal in patients and whether supplementation improves cellular energy production and reduces inflammation is directly relevant to potential therapeutic approaches.
This review does not establish that CoQ10 supplementation definitively treats ME/CFS or proves causation between low CoQ10 and disease development—only inverse correlations are noted. The evidence quality varies across conditions, and this is a literature review synthesizing existing studies rather than new primary research with control groups. Efficacy claims remain preliminary without large randomized controlled trials in ME/CFS populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Testai, Lara, Martelli, Alma, Flori, Lorenzo, Cicero, Arrigo F G, & Colletti, Alessandro (2021). Coenzyme Q<sub>10</sub>: Clinical Applications beyond Cardiovascular Diseases.. Nutrients. https://doi.org/10.3390/nu13051697
BibTeX
@article{mecfsatlas-testai-2021-coenzyme-sub,
author = {Testai, Lara and Martelli, Alma and Flori, Lorenzo and Cicero, Arrigo F G and Colletti, Alessandro},
title = {Coenzyme Q<sub>10</sub>: Clinical Applications beyond Cardiovascular Diseases.},
journal = {Nutrients},
year = {2021},
doi = {10.3390/nu13051697},
note = {PubMed: 34067632},
url = {https://www.mecfsatlas.com/evidence/testai-2021-coenzyme-sub},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/testai-2021-coenzyme-sub
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