Titova, N V, Bezdolny, Yu N, Katunina, E A · Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova · 2023 · DOI
This article discusses asthenia, which is a condition characterized by extreme tiredness that affects daily functioning and productivity. The authors explain that it's important to distinguish between simple chronic tiredness and chronic fatigue syndrome (CFS), and that fatigue can affect both the body and the mind. The article reviews how the brain may be involved in causing fatigue and cognitive problems, and suggests that a combination treatment using specific medications may help patients with fatigue and thinking difficulties.
Understanding the distinction between different types of fatigue and their neurobiological mechanisms is crucial for ME/CFS patients, as it may help clinicians identify the underlying causes of symptoms and select appropriate treatments. This review connects fatigue, cognitive impairment, and mental stress, which many ME/CFS patients experience simultaneously, offering a framework for understanding how these symptoms relate to each other.
As an editorial review rather than a clinical trial, this article does not provide empirical evidence that the proposed combination therapy is effective in ME/CFS patients. The article presents theoretical rationale and existing knowledge rather than new data, so it does not establish the efficacy, safety, or appropriate dosing of the suggested treatment. The review does not prove that the proposed mechanisms are the primary drivers of fatigue in all CFS patients.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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