Tomic, Slavica, Brkic, Snezana, Maric, Daniela et al. · Archives of medical science : AMS · 2012 · DOI
This study looked for signs of oxidative stress—damage caused by harmful molecules in the body—in women with ME/CFS compared to healthy women. Researchers found that women with ME/CFS had higher levels of markers showing damage to fats and proteins in their blood, along with an unhealthy cholesterol pattern. These findings suggest that oxidative stress may be occurring in ME/CFS and could potentially increase heart disease risk over time.
Oxidative stress may be a measurable biological mechanism contributing to ME/CFS pathology. If oxidative damage is confirmed as a feature of the disease, it could support both basic research into disease mechanisms and potential therapeutic approaches using antioxidants or lifestyle interventions. This work also highlights cardiovascular risk as an understudied complication in ME/CFS populations.
This study does not prove that oxidative stress causes ME/CFS—it only shows an association in a small sample. The cross-sectional design cannot establish temporal relationship or causality. It also does not demonstrate that antioxidant treatment would improve ME/CFS symptoms or reduce cardiovascular risk, nor does it show whether oxidative stress markers predict disease progression or outcomes.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Tomic, Slavica, Brkic, Snezana, Maric, Daniela, & Mikic, Aleksandra Novakov (2012). Lipid and protein oxidation in female patients with chronic fatigue syndrome.. Archives of medical science : AMS. https://doi.org/10.5114/aoms.2012.31620
BibTeX
@article{mecfsatlas-tomic-2012-lipid-protein,
author = {Tomic, Slavica and Brkic, Snezana and Maric, Daniela and Mikic, Aleksandra Novakov},
title = {Lipid and protein oxidation in female patients with chronic fatigue syndrome.},
journal = {Archives of medical science : AMS},
year = {2012},
doi = {10.5114/aoms.2012.31620},
note = {PubMed: 23185200},
url = {https://www.mecfsatlas.com/evidence/tomic-2012-lipid-protein},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/tomic-2012-lipid-protein
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