van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C · Journal of clinical medicine · 2024 · DOI
This study looked at how the bodies of ME/CFS patients with POTS (a condition causing rapid heart rate when standing) respond to positional changes differently than healthy people. Researchers found that ME/CFS patients with POTS fall into two groups: those with a smaller heart rate increase appear to have blood pooling in their legs, while those with a larger heart rate increase seem to have an overactive stress response system. These two different patterns might benefit from different treatments.
Understanding that POTS in ME/CFS patients has multiple underlying mechanisms rather than a single cause is crucial for developing targeted treatments. If some patients primarily have blood pooling while others have hyperadrenergic responses, they may benefit from fundamentally different therapeutic approaches, potentially improving outcomes and reducing treatment failures.
This study does not prove that these two hemodynamic profiles are the only subtypes of POTS in ME/CFS or that they are stable across time in individual patients. It also does not establish which treatments are most effective for each profile—that would require prospective intervention studies. The observational design means we cannot determine causation, only correlations between HR changes and stroke volume patterns.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
van Campen, C Linda M C, Rowe, Peter C, & Visser, Frans C (2024). Two Different Hemodynamic Responses in ME/CFS Patients with Postural Orthostatic Tachycardia Syndrome During Head-Up Tilt Testing.. Journal of clinical medicine. https://doi.org/10.3390/jcm13247726
BibTeX
@article{mecfsatlas-van-campen-2024-two-different,
author = {van Campen, C Linda M C and Rowe, Peter C and Visser, Frans C},
title = {Two Different Hemodynamic Responses in ME/CFS Patients with Postural Orthostatic Tachycardia Syndrome During Head-Up Tilt Testing.},
journal = {Journal of clinical medicine},
year = {2024},
doi = {10.3390/jcm13247726},
note = {PubMed: 39768649},
url = {https://www.mecfsatlas.com/evidence/van-campen-2024-two-different},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-26. https://www.mecfsatlas.com/evidence/van-campen-2024-two-different
Contribute
Private, reviewed by a human. Not a public comment thread.