Van Houdenhove, Boudewijn, Pae, Chi-Un, Luyten, Patrick · Expert opinion on pharmacotherapy · 2010 · DOI
This review examined whether medications can help ME/CFS patients. Researchers looked at studies from 1988 to 2009 and found that while some drugs (like antivirals and antibiotics) might temporarily help symptoms, they can also cause more harm than good. A few stimulant medications helped some patients, but the long-term safety is unclear. The authors concluded that medications alone are not the best first-line treatment and work best alongside self-management and rehabilitation.
This review is important because ME/CFS patients often seek pharmacological options but have limited evidence-based guidance. By systematically evaluating decades of drug trial data, it clarifies which medications have the most promise, which carry risks, and emphasizes that medication should be combined with self-management strategies—helping both patients and clinicians make informed treatment decisions.
This review does not establish what causes ME/CFS or prove that any single medication is curative. It does not provide evidence that future novel pharmacotherapies targeting immune mechanisms will be effective, nor does it prove that self-management and rehabilitation alone are sufficient for all patients without adjunctive support.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Van Houdenhove, Boudewijn, Pae, Chi-Un, & Luyten, Patrick (2010). Chronic fatigue syndrome: is there a role for non-antidepressant pharmacotherapy?. Expert opinion on pharmacotherapy. https://doi.org/10.1517/14656560903487744
BibTeX
@article{mecfsatlas-van-houdenhove-2010-chronic-fatigue-2,
author = {Van Houdenhove, Boudewijn and Pae, Chi-Un and Luyten, Patrick},
title = {Chronic fatigue syndrome: is there a role for non-antidepressant pharmacotherapy?},
journal = {Expert opinion on pharmacotherapy},
year = {2010},
doi = {10.1517/14656560903487744},
note = {PubMed: 20088743},
url = {https://www.mecfsatlas.com/evidence/van-houdenhove-2010-chronic-fatigue-2},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/van-houdenhove-2010-chronic-fatigue-2
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