Vishnu, Prakash, Aboulafia, David M · Clinics in laboratory medicine · 2025 · DOI
This review examines blood clotting problems that have been reported in people with COVID-19, those who received COVID-19 vaccines, and people with Long-COVID (including ME/CFS-like symptoms). The authors summarize what we know about these clotting issues, ranging from minor platelet problems to serious blood clots, and discuss areas where doctors and researchers disagree about what's happening and why.
Many ME/CFS patients report having or suspecting hemostatic (blood clotting) abnormalities, and some ME/CFS cases emerge or worsen after COVID-19 infection or vaccination. This comprehensive review of clotting complications helps clarify what is currently known and where evidence gaps exist, potentially informing clinical investigation and management of hemostasis in Long-COVID and ME/CFS populations.
As an evidence map and review article, this study does not prove causation between COVID-19 or vaccination and specific hemostatic disorders in any individual patient—it summarizes existing evidence and acknowledges controversies rather than establishing definitive causal mechanisms. The abstract does not clarify whether hemostatic abnormalities are directly responsible for Long-COVID symptoms like fatigue and post-exertional malaise, nor does it establish prevalence or incidence rates across populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Vishnu, Prakash & Aboulafia, David M (2025). Hemostatic Disorders Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection, COVID-19 Vaccination, and Long-COVID Syndrome: Current Evidence and Controversies in Clinical Practice.. Clinics in laboratory medicine. https://doi.org/10.1016/j.cll.2025.07.008
BibTeX
@article{mecfsatlas-vishnu-2025-hemostatic-disorders,
author = {Vishnu, Prakash and Aboulafia, David M},
title = {Hemostatic Disorders Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection, COVID-19 Vaccination, and Long-COVID Syndrome: Current Evidence and Controversies in Clinical Practice.},
journal = {Clinics in laboratory medicine},
year = {2025},
doi = {10.1016/j.cll.2025.07.008},
note = {PubMed: 41161981},
url = {https://www.mecfsatlas.com/evidence/vishnu-2025-hemostatic-disorders},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/vishnu-2025-hemostatic-disorders
Contribute
Private, reviewed by a human. Not a public comment thread.