Volodin, V V, Sidorova, Iu S, Mazo, V K · Voprosy pitaniia · 2013
This review discusses 20-hydroxyecdysone, a compound found in plants that may help the body become more resistant to stress. The authors suggest it could reduce fatigue and improve memory and attention, and propose it as a possible supplement for athletes and people with chronic fatigue.
ME/CFS patients experience persistent, debilitating fatigue and cognitive dysfunction resistant to conventional treatments. If phytoecdysteroids could reduce stress mediator overactivation and improve energy metabolism, they might represent a novel therapeutic approach; however, rigorous human clinical trials would be needed to establish safety and efficacy in this population.
This review does not establish clinical efficacy of 20-hydroxyecdysone in ME/CFS patients—it presents only anecdotal references to potential applications without controlled human trials. The mechanism of action proposed (stress mediator normalization) is largely hypothetical and has not been validated in the ME/CFS population. Animal studies of anabolic effects do not necessarily translate to therapeutic benefit in human disease.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Volodin, V V, Sidorova, Iu S, & Mazo, V K (2013). [20-Hydroxyecdysone--plant adaptogen: an anabolic effect, possible use in sports nutrition].. Voprosy pitaniia. https://pubmed.ncbi.nlm.nih.gov/24741953/
BibTeX
@article{mecfsatlas-volodin-2013-hydroxyecdysone-plant,
author = {Volodin, V V and Sidorova, Iu S and Mazo, V K},
title = {[20-Hydroxyecdysone--plant adaptogen: an anabolic effect, possible use in sports nutrition].},
journal = {Voprosy pitaniia},
year = {2013},
note = {PubMed: 24741953},
url = {https://www.mecfsatlas.com/evidence/volodin-2013-hydroxyecdysone-plant},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/volodin-2013-hydroxyecdysone-plant
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