Wang, Jing-Jing, Song, Yu-Jing, Wu, Zhong-Chao et al. · Zhen ci yan jiu = Acupuncture research · 2009
Researchers tested whether acupuncture could help reduce fatigue in 64 people with chronic fatigue syndrome. Half received acupuncture at traditional acupuncture points, while half received needle insertions at non-traditional points nearby. Both groups showed improvement in fatigue scores, but the group receiving acupuncture at traditional points showed slightly better improvement in mental fatigue.
This study addresses the need for non-pharmacological interventions in ME/CFS management. As an RCT with a sham control group, it provides better-quality evidence than observational studies and may inform discussions about complementary treatment options for patients seeking alternatives to or adjuncts to standard care.
This study does not prove acupuncture is an effective treatment for ME/CFS because both groups improved substantially and the between-group differences were not statistically significant. It does not establish long-term benefits, does not address post-exertional malaise or other core ME/CFS symptoms beyond fatigue scales, and does not clarify whether observed improvements reflect specific needling effects or placebo/expectation effects.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wang, Jing-Jing, Song, Yu-Jing, Wu, Zhong-Chao, Chu, Xiao-Ou, Wang, Qiao-Mei, Wang, Xiao-Jie, et al. (2009). [Randomized controlled clinical trials of acupuncture treatment of chronic fatigue syndrome].. Zhen ci yan jiu = Acupuncture research. https://pubmed.ncbi.nlm.nih.gov/19685727/
BibTeX
@article{mecfsatlas-wang-2009-randomized-controlled,
author = {Wang, Jing-Jing and Song, Yu-Jing and Wu, Zhong-Chao and Chu, Xiao-Ou and Wang, Qiao-Mei and Wang, Xiao-Jie and Wei, Li-Na and Meng, Hong and Wang, Xiao-Hong},
title = {[Randomized controlled clinical trials of acupuncture treatment of chronic fatigue syndrome].},
journal = {Zhen ci yan jiu = Acupuncture research},
year = {2009},
note = {PubMed: 19685727},
url = {https://www.mecfsatlas.com/evidence/wang-2009-randomized-controlled},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/wang-2009-randomized-controlled
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