Wang, Yu-Yi, Li, Xin-Xue, Liu, Jian-Ping et al. · Complementary therapies in medicine · 2014 · DOI
This review examined 23 studies testing traditional Chinese medicine (TCM) treatments for chronic fatigue syndrome, involving 1,776 patients. The treatments included herbal medicines, acupuncture, qigong, and other TCM approaches. Most studies found that TCM helped reduce fatigue symptoms, though the quality of these studies was often poor, and it's unclear if TCM improves overall quality of life for patients.
This systematic review synthesizes the largest body of evidence on TCM for CFS, which represents a commonly used treatment approach globally, particularly in Asian healthcare systems. Understanding both the potential benefits and significant research limitations helps patients and clinicians make informed decisions about TCM use while highlighting the need for higher-quality evidence.
This review does not establish that TCM definitively treats CFS, as the included studies had high methodological bias and used varying interventions, making it impossible to determine which, if any, TCM approaches are truly effective. The lack of data on quality of life means symptomatic fatigue reduction may not translate to meaningful functional improvement for patients. The review cannot identify which specific TCM modalities work best or for which patient populations.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wang, Yu-Yi, Li, Xin-Xue, Liu, Jian-Ping, Luo, Hui, Ma, Li-Xin, & Alraek, Terje (2014). Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials.. Complementary therapies in medicine. https://doi.org/10.1016/j.ctim.2014.06.004
BibTeX
@article{mecfsatlas-wang-2014-traditional-chinese-2,
author = {Wang, Yu-Yi and Li, Xin-Xue and Liu, Jian-Ping and Luo, Hui and Ma, Li-Xin and Alraek, Terje},
title = {Traditional Chinese medicine for chronic fatigue syndrome: a systematic review of randomized clinical trials.},
journal = {Complementary therapies in medicine},
year = {2014},
doi = {10.1016/j.ctim.2014.06.004},
note = {PubMed: 25146086},
url = {https://www.mecfsatlas.com/evidence/wang-2014-traditional-chinese-2},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/wang-2014-traditional-chinese-2
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