Wang, Taiwu, Yu, Lei, Xu, Cong et al. · PloS one · 2018 · DOI
Researchers studied the bacteria living in the mouths of ME/CFS patients and compared them to healthy people. They found that ME/CFS patients have a different balance of oral bacteria, with some types being more common and others less common. These bacterial differences appear to affect how the body processes energy and amino acids, which could be relevant to understanding ME/CFS.
This study provides evidence that ME/CFS involves alterations in the oral microbiome beyond the gut, suggesting host-microbe interactions may be broadly relevant to disease pathogenesis. Understanding these microbial changes could eventually lead to new diagnostic markers or microbiome-targeted treatments, and the focus on metabolic pathways (energy, amino acids) aligns with known ME/CFS cellular dysfunction.
This study does not prove that oral microbiome changes cause ME/CFS—it only shows association. The cross-sectional design cannot establish whether bacterial alterations are a cause, consequence, or bystander phenomenon in ME/CFS. Results are limited to a Chinese Han population and may not generalize to other ethnic groups.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wang, Taiwu, Yu, Lei, Xu, Cong, Pan, Keli, Mo, Minglu, Duan, Mingxiang, et al. (2018). Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function.. PloS one. https://doi.org/10.1371/journal.pone.0203503
BibTeX
@article{mecfsatlas-wang-2018-chronic-fatigue,
author = {Wang, Taiwu and Yu, Lei and Xu, Cong and Pan, Keli and Mo, Minglu and Duan, Mingxiang and Zhang, Yao and Xiong, Hongyan},
title = {Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function.},
journal = {PloS one},
year = {2018},
doi = {10.1371/journal.pone.0203503},
note = {PubMed: 30204780},
url = {https://www.mecfsatlas.com/evidence/wang-2018-chronic-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/wang-2018-chronic-fatigue
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