Wang, Lei, Xu, Yujia, Zhong, Xiang et al. · Frontiers in molecular biosciences · 2025 · DOI
This review examines tiny packages called exosomes that cells release into the body, which contain special molecules called long noncoding RNAs (lncRNAs). These molecules may help cells communicate with each other and could be involved in ME/CFS. The researchers explored whether these lncRNAs could potentially be used as biological markers to help doctors identify and diagnose ME/CFS earlier.
ME/CFS currently lacks reliable diagnostic biomarkers and disease-modifying treatments, creating significant diagnostic and clinical challenges. This review identifies exosomal lncRNAs as a novel research avenue that could lead to better understanding of disease mechanisms and development of diagnostic tools and targeted therapies for patients.
This is a review article that does not present primary research data or clinical evidence. It does not prove that exosomal lncRNAs cause ME/CFS or that they can serve as practical diagnostic biomarkers—only that they warrant further investigation. The study presents theoretical mechanisms and potential associations rather than established causal relationships.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Wang, Lei, Xu, Yujia, Zhong, Xiang, Wang, Guiping, Shi, Zijun, Mei, Can, et al. (2025). The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers.. Frontiers in molecular biosciences. https://doi.org/10.3389/fmolb.2025.1653627
BibTeX
@article{mecfsatlas-wang-2025-emerging-role,
author = {Wang, Lei and Xu, Yujia and Zhong, Xiang and Wang, Guiping and Shi, Zijun and Mei, Can and Chen, Linwanyue and Zhan, Jianbo and Cheng, Jing},
title = {The emerging role of exosomal LncRNAs in chronic fatigue syndrome: from intercellular communication to disease biomarkers.},
journal = {Frontiers in molecular biosciences},
year = {2025},
doi = {10.3389/fmolb.2025.1653627},
note = {PubMed: 40950577},
url = {https://www.mecfsatlas.com/evidence/wang-2025-emerging-role},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/wang-2025-emerging-role
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