Wang, Jingyang, Wang, Xin, Xiu, Weiye et al. · Food & function · 2025 · DOI
Researchers created tiny particles made from selenium and sweet corn cob material and tested whether they could help reduce fatigue symptoms in mice with chronic fatigue syndrome. The particles appeared to improve energy production in cells and reduce harmful oxidative stress, while also making positive changes to the bacteria in the digestive system.
This research addresses two key ME/CFS mechanisms—impaired cellular energy production and oxidative stress—by testing a novel therapeutic compound. If these findings translate to human studies, selenium-polysaccharide nanoparticles could represent a new approach to managing core ME/CFS pathology alongside recognized gut dysbiosis.
This study does not establish that U-SCPSeNPs would be effective or safe in humans with ME/CFS; animal models do not always translate to clinical benefit. The research cannot prove causation of fatigue symptom improvement, only that the particles altered certain biochemical markers in mice. The study does not identify which component (selenium, polysaccharide, or nanoparticle form) drives the observed effects.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
The first block is for the primary paper and is the citation you should use in research work. The atlas-snapshot line only applies if you are specifically referring to this atlas’s reading of the paper on the date shown.
Primary citation
Wang, Jingyang, Wang, Xin, Xiu, Weiye, Li, Chenchen, Yu, Shiyou, Zhu, Haobin, et al. (2025). Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome.. Food & function. https://doi.org/10.1039/d4fo04195j
BibTeX
@article{mecfsatlas-wang-2025-ultrasound-assisted,
author = {Wang, Jingyang and Wang, Xin and Xiu, Weiye and Li, Chenchen and Yu, Shiyou and Zhu, Haobin and Yang, Chenxi and Zhou, Kechi and Ma, Yongqiang},
title = {Ultrasound-assisted preparation of sweet corn cob polysaccharide selenium nanoparticles alleviates symptoms of chronic fatigue syndrome.},
journal = {Food & function},
year = {2025},
doi = {10.1039/d4fo04195j},
note = {PubMed: 39635725},
url = {https://www.mecfsatlas.com/evidence/wang-2025-ultrasound-assisted},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-29. https://www.mecfsatlas.com/evidence/wang-2025-ultrasound-assisted
Contribute
Private, reviewed by a human. Not a public comment thread.