Yamaguti, Kouzi · Nihon rinsho. Japanese journal of clinical medicine · 2007
Researchers tested a new device called acceleration plethysmography to measure fatigue in ME/CFS patients. This device tracks tiny blood vessel changes and nervous system activity in the fingertip. The study found that fatigue levels were connected to specific patterns in these measurements, suggesting this tool might help doctors objectively measure ME/CFS fatigue in the future.
ME/CFS lacks reliable objective biomarkers for fatigue severity, making diagnosis and treatment monitoring challenging. If acceleration plethysmography can objectively quantify autonomic dysfunction and fatigue level, it could improve clinical assessment and potentially serve as an outcome measure in future treatment trials.
This study does not prove that acceleration plethysmography changes *cause* fatigue or that they are specific to ME/CFS rather than other conditions. The abstract does not clarify whether the observed autonomic changes are unique to ME/CFS or reproducible in other patient populations. Correlation between measurements and fatigue does not establish causation or clinical utility in practice.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Yamaguti, Kouzi (2007). [Evaluation of fatigue by using acceleration plethysmography].. Nihon rinsho. Japanese journal of clinical medicine. https://pubmed.ncbi.nlm.nih.gov/17561694/
BibTeX
@article{mecfsatlas-yamaguti-2007-evaluation-fatigue,
author = {Yamaguti, Kouzi},
title = {[Evaluation of fatigue by using acceleration plethysmography].},
journal = {Nihon rinsho. Japanese journal of clinical medicine},
year = {2007},
note = {PubMed: 17561694},
url = {https://www.mecfsatlas.com/evidence/yamaguti-2007-evaluation-fatigue},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-30. https://www.mecfsatlas.com/evidence/yamaguti-2007-evaluation-fatigue
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