Yamano, Emi, Kataoka, Yosky · Brain and nerve = Shinkei kenkyu no shinpo · 2018 · DOI
This study looked at the chemicals and compounds in the blood of people with ME/CFS compared to healthy people to find objective markers that could help doctors diagnose the condition. Researchers used advanced testing methods to examine how the body's metabolism, immune system, and hormones differ in people with ME/CFS. The goal was to develop a simple blood test that could definitively identify ME/CFS, since there is currently no reliable diagnostic test.
Developing objective blood-based biomarkers for ME/CFS is crucial because currently diagnosis relies on clinical criteria and exclusion of other diseases. An objective diagnostic test could reduce diagnostic delays, improve access to appropriate care, and enable more rigorous patient stratification in future treatment trials.
This study does not prove that any identified metabolic markers are causally responsible for ME/CFS symptoms, nor does it establish that metabolomic findings alone can reliably replace clinical diagnosis in routine practice. The study does not demonstrate whether these biomarkers distinguish ME/CFS from other post-viral or fatiguing illnesses.
About the PEM badge: “PEM required” means post-exertional malaise was an explicit required diagnostic criterion for participant inclusion in this study — not that PEM was studied, observed, or discussed. Studies using criteria that do not require PEM (e.g. Fukuda, Oxford) are tagged “PEM not required”. How the atlas works →
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Primary citation
Yamano, Emi & Kataoka, Yosky (2018). [New Diagnostic Biomarkers for Chronic Fatigue Syndrome].. Brain and nerve = Shinkei kenkyu no shinpo. https://doi.org/10.11477/mf.1416200946
BibTeX
@article{mecfsatlas-yamano-2018-new-diagnostic,
author = {Yamano, Emi and Kataoka, Yosky},
title = {[New Diagnostic Biomarkers for Chronic Fatigue Syndrome].},
journal = {Brain and nerve = Shinkei kenkyu no shinpo},
year = {2018},
doi = {10.11477/mf.1416200946},
note = {PubMed: 29348372},
url = {https://www.mecfsatlas.com/evidence/yamano-2018-new-diagnostic},
}Atlas snapshot reference
ME/CFS Atlas. Generator v1 / Scanner v1.4 / policy v0.1. Accessed 2026-05-28. https://www.mecfsatlas.com/evidence/yamano-2018-new-diagnostic
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