ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

643 studies

261–280 of 643 studies

E0 ConsensusReviewPEM unclearReview-Narrative

Long COVID a New Derivative in the Chaos of SARS-CoV-2 Infection: The Emergent Pandemic?

Fernández-Lázaro, Diego, Sánchez-Serrano, Nerea, Mielgo-Ayuso, Juan et al.·Journal of clinical medicine·2021

Long COVID is a condition where symptoms persist for weeks to months after an acute COVID-19 infection. The main symptoms include severe fatigue, difficulty with physical activity that worsens symptoms, brain fog, and reduced ability to do daily activities. This review summarizes what is currently known about Long COVID, including its causes, risk factors, and possible treatments.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

The neurological symptoms of COVID-19: a systematic overview of systematic reviews, comparison with other neurological conditions and implications for healthcare services.

Wildwing, Tamar, Holt, Nicole·Therapeutic advances in chronic disease·2021

This study reviewed 45 existing research papers about neurological symptoms people experience with COVID-19. Researchers found that some COVID-19 patients develop long-lasting symptoms like fatigue and muscle pain that look very similar to ME/CFS and other neurological conditions. The authors suggest that doctors may need better training to recognize and treat these ongoing symptoms, and that healthcare services may need more resources to help patients.

Long COVID Overlap

E0 ConsensusReviewPEM unclearSystematic-Review

Recovery from chronic fatigue syndrome: a systematic review-heterogeneity of definition limits study comparison.

Moore, Yasmin, Serafimova, Teona, Anderson, Nina et al.·Archives of disease in childhood·2021

This study looked at how often children with ME/CFS recover and what 'recovery' actually means. Researchers found that different studies define recovery in very different ways—some focus on returning to school, others on fatigue levels, and others on physical activity. Because of these differences, recovery rates ranged wildly from 4.5% to 83%, making it hard to compare studies fairly.

Diagnostics

E0 ConsensusReviewPEM unclearReview-Narrative

Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome.

Ruiz-Pablos, Manuel, Paiva, Bruno, Montero-Mateo, Rosario et al.·Frontiers in immunology·2021

This review examines whether Epstein-Barr virus (EBV), a common virus that causes mononucleosis, might play a role in causing ME/CFS in some patients. The researchers found that certain people may have genetic traits that make them more vulnerable to EBV, and in these individuals, the virus might hide from the immune system in a way that leads to ME/CFS symptoms. They suggest that antiviral treatments targeting EBV could potentially help some ME/CFS patients.

Immune System

E0 ConsensusReviewPEM unclearReview-Narrative

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection.

Moghimi, Narges, Di Napoli, Mario, Biller, José et al.·Current neurology and neuroscience reports·2021

This review examined what we know about how COVID-19 can affect the nervous system in people who experience long-term symptoms after infection (called PASC or long COVID). The researchers looked at published studies to understand how common these neurological problems are, who is most at risk, why they happen, and how they might be treated. They found that long COVID can range from mild to severely disabling symptoms that last weeks or longer, and that multiple factors—including lingering inflammation, immune system problems, and possible viral effects on the brain—may play a role.

NeuroinflammationImmune System

E0 ConsensusReviewPEM unclearSystematic-Review

Perfectionism, depression and anxiety in chronic fatigue syndrome: A systematic review.

Wright, Amelia, Fisher, Peter L, Baker, Nita et al.·Journal of psychosomatic research·2021

This review looked at seven studies examining whether perfectionism (setting very high standards and worrying about mistakes) is connected to depression in people with ME/CFS. Researchers found strong links between perfectionism and depression, particularly worrying excessively about making mistakes. However, there's much less research on whether perfectionism is linked to anxiety in ME/CFS patients.

E0 ConsensusReviewPEM not requiredMeta-Analysis

Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis.

Lim, Eun-Jin, Son, Chang-Gue·Journal of clinical medicine·2021

This study looked at how common ME/CFS is in Korea and Japan by reviewing eight existing studies. Researchers found that about 0.76-0.77% of people in these countries have ME/CFS—meaning roughly 1 in 130 people. Women were affected about twice as often as men in Korea, though this difference was smaller in Japan.

E0 ConsensusReviewPEM not requiredReview-Narrative

Epidemiology, pathophysiology, and classification of the neurological symptoms of post-COVID-19 syndrome.

Carod-Artal, F J, García-Moncó, J C·Neurology perspectives·2021

This review examines long-term symptoms people experience after COVID-19 infection, particularly neurological (brain and nerve-related) symptoms like brain fog, memory problems, headaches, and sleep issues. The authors found that post-COVID-19 syndrome is complex and variable—affecting different people in different ways—and likely involves multiple causes including immune system changes, nerve dysfunction, and possibly persistent viral effects. Because the definition and criteria for post-COVID-19 syndrome remain unclear, reported rates of occurrence vary dramatically, ranging from 2% to 85% depending on the study.

Cognitive Impairment

E0 ConsensusReviewPEM unclearReview-Narrative

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

Toogood, Peter L, Clauw, Daniel J, Phadke, Sameer et al.·Pharmacological research·2021

ME/CFS is a serious illness causing extreme fatigue that doesn't improve with rest, along with pain, sleep problems, and difficulty thinking clearly. This review looks at what we currently know about ME/CFS, how doctors diagnose it, and what treatments exist today. The authors examined past research to identify promising targets for new medicines that could help treat ME/CFS in the future.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

The Quality of Methodological and Reporting in Network Meta-Analysis of Acupuncture and Moxibustion: A Cross-Sectional Survey.

Yuan, Ting, Xiong, Jun, Wang, Xue et al.·Evidence-based complementary and alternative medicine : eCAM·2021

This study reviewed 29 research papers that used a statistical method called network meta-analysis to compare different acupuncture and moxibustion treatments. The researchers assessed how well these papers were designed and reported their findings. They found that most papers had medium quality, with some having significant gaps in how they explained their methods and results.

E0 ConsensusReviewPEM not requiredMeta-Analysis

Adverse outcomes in trials of graded exercise therapy for adult patients with chronic fatigue syndrome.

White, P D, Etherington, J·Journal of psychosomatic research·2021

This study reviewed 10 previous trials involving 1,279 people to examine whether graded exercise therapy (GET) causes harm in ME/CFS patients. Researchers compared how many people reported feeling much worse, stopped treatment, or dropped out of follow-up appointments between those doing GET and those receiving other treatments. The study found no clear evidence that GET caused more people to report feeling worse than other treatments, though more GET participants did drop out of follow-up appointments.

E0 ConsensusReviewPEM not requiredReview-Narrative

Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments.

Yong, Shin Jie·Infectious diseases (London, England)·2021

This review examines what we know about Long COVID, an illness that affects some people after they recover from COVID-19 infection. The main symptoms are extreme tiredness and breathing difficulties that last for months, along with brain fog, pain, and heart problems. Researchers found that Long COVID may be caused by lasting damage to organs like the lungs and brain, combined with ongoing inflammation in the body.

Immune SystemPost-Exertional Malaise

E0 ConsensusReviewPEM unclearEditorial

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

Ariza, Maria Eugenia·Biomolecules·2021

This review examines whether certain viruses, particularly Epstein-Barr virus (EBV), may play a role in ME/CFS. Earlier research on this topic produced mixed results, leading some scientists to think viruses weren't involved. However, newer research methods have found that specific proteins made by EBV could contribute to immune system and nervous system problems in some ME/CFS patients.

BiomarkersImmune System

E0 ConsensusGuidelinePEM requiredGuideline

ME/CFS: Exercise goals should be set by patients and not driven by treatment plan, says NICE.

Torjesen, Ingrid·BMJ (Clinical research ed.)·2021

The UK's National Institute for Health and Care Excellence (NICE) issued new guidance stating that people with ME/CFS should set their own exercise goals based on their personal circumstances, rather than having exercise targets imposed by healthcare providers as part of a standard treatment plan. This represents an important shift in how ME/CFS care should be approached, emphasizing patient autonomy and individual needs.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

The Safety of Baduanjin Exercise: A Systematic Review.

Fang, Jianqi, Zhang, Liying, Wu, Fangzhen et al.·Evidence-based complementary and alternative medicine : eCAM·2021

Baduanjin is a gentle exercise therapy from traditional Chinese medicine that is becoming more popular around the world. This review looked at 47 studies involving 3,877 people to find out what side effects people experienced when doing Baduanjin. Most studies didn't carefully track side effects, but those that did reported issues like muscle aches, heart palpitations, dizziness, knee pain, and fatigue—though it's unclear if Baduanjin actually caused these problems.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredMeta-Analysis

Cognitive and emotional variables predicting treatment outcome of cognitive behavior therapies for patients with medically unexplained symptoms: A meta-analysis.

Sarter, Lena, Heider, Jens, Kirchner, Lukas et al.·Journal of psychosomatic research·2021

This study looked at 37 research papers about cognitive behavior therapy (CBT)—a type of talk therapy—for people with medically unexplained symptoms. The researchers found that people who worry a lot about their symptoms, have anxiety or mood problems, tend to notice body sensations intensely, or don't believe they can manage their illness tend to get less benefit from CBT. The findings suggest that tailoring CBT to each person's specific concerns might help treatments work better.

Interventions

E0 ConsensusReviewPEM unclearSystematic-Review

Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Shan, Zack Y, Barnden, Leighton R, Kwiatek, Richard A et al.·Journal of translational medicine·2020

This study reviewed 63 brain imaging research papers published over 30 years to identify what brain abnormalities are consistently found in ME/CFS patients. Researchers found that ME/CFS is commonly associated with unusual patterns of brain activity during thinking tasks and problems in the brain stem (the part controlling basic body functions). The findings suggest that the brains of people with ME/CFS may not be delivering oxygen and nutrients to active brain areas as efficiently as they should.

E0 ConsensusReviewPEM unclearSystematic-Review

Gulf war illness, post-HPV vaccination syndrome, and Macrophagic Myofasciitis. Similar disabling conditions possibly linked to vaccine-induced autoimmune dysautonomia.

Martinez-Lavin, Manuel, Tejada-Ruiz, Melina·Autoimmunity reviews·2020

This review looked at three conditions that share similar symptoms—Gulf War illness, post-HPV vaccination syndrome, and Macrophagic Myofasciitis—and found they may have a common cause related to vaccines. All three conditions involve chronic fatigue, widespread pain, and cognitive problems. The authors propose that in some susceptible people, vaccines or multiple vaccines given close together might trigger an autoimmune reaction affecting the nervous system that controls heart rate, blood pressure, and other automatic body functions.

Immune System

E0 ConsensusReviewPEM unclearSystematic-Review

Interventions to treat pain in paediatric CFS/ME: a systematic review.

Ascough, Caitlin, King, Hayley, Serafimova, Teona et al.·BMJ paediatrics open·2020

This review looked at whether treatments for ME/CFS in children help reduce pain, which affects about two-thirds of young patients. Researchers searched medical databases for studies measuring pain before and after treatment. They found that most treatment studies didn't even measure pain, and the few that did weren't specifically designed to treat pain—they focused on overall ME/CFS management. The evidence suggests that children who recover from ME/CFS tend to have less pain than those who don't recover.

Pain and Sensitization

E0 ConsensusReviewPEM not requiredSystematic-Review

A systematic review on the health outcomes associated with non-endocarditis manifestations of chronic Q fever.

Manchal, Naveen, Adegboye, Oyelola A, Eisen, Damon P·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2020

This study looked at chronic Q fever, a bacterial infection that can cause long-term complications beyond heart valve infections. Researchers found that when chronic Q fever affects bones, blood vessels, or causes abscesses (pockets of infection), patients experience significantly more pain than other forms of the disease. Importantly, the study reviewed existing research to understand how pain and fatigue appear in these less common forms of chronic Q fever.

Pain and Sensitization

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Evidence Atlas

Evidence browser

Long COVID a New Derivative in the Chaos of SARS-CoV-2 Infection: The Emergent Pandemic?

The neurological symptoms of COVID-19: a systematic overview of systematic reviews, comparison with other neurological conditions and implications for healthcare services.

Recovery from chronic fatigue syndrome: a systematic review-heterogeneity of definition limits study comparison.

Epstein-Barr Virus and the Origin of Myalgic Encephalomyelitis or Chronic Fatigue Syndrome.

The Neurological Manifestations of Post-Acute Sequelae of SARS-CoV-2 infection.

Perfectionism, depression and anxiety in chronic fatigue syndrome: A systematic review.

Prevalence of Chronic Fatigue Syndrome (CFS) in Korea and Japan: A Meta-Analysis.

Epidemiology, pathophysiology, and classification of the neurological symptoms of post-COVID-19 syndrome.

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Where will the drugs come from?

The Quality of Methodological and Reporting in Network Meta-Analysis of Acupuncture and Moxibustion: A Cross-Sectional Survey.

Adverse outcomes in trials of graded exercise therapy for adult patients with chronic fatigue syndrome.

Long COVID or post-COVID-19 syndrome: putative pathophysiology, risk factors, and treatments.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: The Human Herpesviruses Are Back!

ME/CFS: Exercise goals should be set by patients and not driven by treatment plan, says NICE.

The Safety of Baduanjin Exercise: A Systematic Review.

Cognitive and emotional variables predicting treatment outcome of cognitive behavior therapies for patients with medically unexplained symptoms: A meta-analysis.

Neuroimaging characteristics of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review.

Gulf war illness, post-HPV vaccination syndrome, and Macrophagic Myofasciitis. Similar disabling conditions possibly linked to vaccine-induced autoimmune dysautonomia.

Interventions to treat pain in paediatric CFS/ME: a systematic review.

A systematic review on the health outcomes associated with non-endocarditis manifestations of chronic Q fever.

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