ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

637 studies

381–400 of 637 studies

E0 ConsensusReviewPEM not requiredReview-Narrative

Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

Mahjoub, Fatemeh, Salari, Roshanak, Noras, Mohammad Reza et al.·Journal of evidence-based complementary & alternative medicine·2017

This study looked at how traditional Persian medicine approaches fibromyalgia and ME/CFS, which are conditions that cause widespread pain and extreme tiredness. The researchers compared ancient Persian medical texts, particularly writings by the physician Avicenna, with modern understanding of these diseases. They found that traditional medicine recognized fatigue as a complex condition with different types, each with distinct symptoms.

Pain and Sensitization

E0 ConsensusReviewPEM not requiredMeta-Analysis

[Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses].

Pinquart, Martin·Praxis der Kinderpsychologie und Kinderpsychiatrie·2017

This study reviewed research on how children with long-term illnesses and their parents cope emotionally. The researchers found that children with ME/CFS and chronic headaches showed the highest levels of depression and anxiety. Interestingly, parents were often more distressed than their sick children, particularly parents of children with HIV/AIDS or cerebral palsy.

E0 ConsensusReviewPEM not requiredSystematic-Review

What treatments work for anxiety in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)? Systematic review.

Stoll, Sarah Victoria Ellen, Crawley, Esther, Richards, Victoria et al.·BMJ open·2017

Many children with ME/CFS experience anxiety alongside their fatigue symptoms. This review looked at nine studies to find out which treatments help reduce anxiety in children with ME/CFS. While a few treatments showed some promise—particularly therapy approaches like cognitive behavioural therapy and one immune treatment—the evidence is limited and no treatment was specifically designed to target anxiety in this group.

E0 ConsensusGuidelinePEM not requiredGuideline

Chronic Pelvic Pain in Women.

Speer, Linda M, Mushkbar, Saudia, Erbele, Tara·American family physician·2016

Chronic pelvic pain in women is long-lasting pain in the pelvic area that lasts more than six months and often has no clear cause. This guideline explains that pelvic pain is frequently linked to other pain conditions and mental health issues like depression, and recommends a whole-person approach to treatment that combines medical care, physical therapy, and behavioral support.

Pain and Sensitization

E0 ConsensusReviewPEM not requiredSystematic-Review

A systematic review of the comorbidity between Temporomandibular Disorders and Chronic Fatigue Syndrome.

Robinson, L J, Durham, J, Newton, J L·Journal of oral rehabilitation·2016

This review looked at studies examining how often jaw and facial pain disorders (TMD) occur together with ME/CFS. Researchers found that between 21-32% of people with ME/CFS also reported jaw pain problems, and when ME/CFS was combined with fibromyalgia, this number rose to 50%. However, the quality of existing research on this topic is limited, and better studies with consistent diagnostic methods are needed to understand this connection.

E0 ConsensusReviewPEM not requiredSystematic-Review

Attentional and interpretive bias towards illness-related information in chronic fatigue syndrome: A systematic review.

Hughes, Alicia, Hirsch, Colette, Chalder, Trudie et al.·British journal of health psychology·2016

This review looked at research studies examining how people with ME/CFS pay attention to and interpret information about illness and symptoms. The studies found that some people with ME/CFS tend to notice health-related threats more quickly and interpret their body sensations as signs of illness more readily than healthy people do. These thinking patterns may help keep the fatigue and illness beliefs going, even when other factors aren't actively causing symptoms.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredSystematic-Review

The differential diagnosis of tiredness: a systematic review.

Stadje, Rebekka, Dornieden, Katharina, Baum, Erika et al.·BMC family practice·2016

This study reviewed 26 previous research studies about why people feel tired when they visit their doctor. The researchers found that serious physical diseases are actually quite rare in tired patients—only about 4% have a serious organic condition. Depression was much more common, affecting about 18% of people who complain of tiredness. The main message is that doctors should focus on checking for depression and emotional stress rather than ordering extensive tests for serious diseases in most cases.

Diagnostics

E0 ConsensusReviewPEM requiredSystematic-Review

A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Collatz, Ansel, Johnston, Samantha C, Staines, Donald R et al.·Clinical therapeutics·2016

Researchers searched for studies testing medications for ME/CFS and found 26 high-quality trials. While 10 medications showed some benefit in their respective studies, no single medication worked well for everyone with ME/CFS. This suggests that different patients may need different treatments, and more research is needed to find which medications help which patients.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

Yoga intervention and functional pain syndromes: a selective review.

Sutar, Roshan, Yadav, Suresh, Desai, Geetha·International review of psychiatry (Abingdon, England)·2016

This review looked at studies examining whether yoga might help people with chronic pain conditions that are hard to diagnose, including ME/CFS. The researchers found that several studies suggested yoga may provide modest benefits for these types of pain conditions. However, more large-scale research is needed to confirm how helpful yoga really is.

Pain and Sensitization

E0 ConsensusReviewPEM unclearSystematic-Review

An abridged version of the Cochrane review of exercise therapy for chronic fatigue syndrome.

Larun, Lillebeth, Odgaard-Jensen, Jan, Price, Jonathan R et al.·European journal of physical and rehabilitation medicine·2016

This review looked at 8 studies involving over 1,500 people with ME/CFS to see if exercise therapy helps. The findings suggest that graded exercise (like walking, swimming, or cycling done gradually) may reduce fatigue and improve daily functioning and sleep better than doing nothing or standard care. The therapy did not appear to make symptoms worse, though researchers need more information about its effects on pain and mood.

E0 ConsensusReviewPEM not requiredSystematic-Review

The association between borderline personality disorder, fibromyalgia and chronic fatigue syndrome: systematic review.

Penfold, Sarah, St Denis, Emily, Mazhar, Mir Nadeem·BJPsych open·2016

This review examined whether borderline personality disorder (BPD)—a mental health condition affecting emotions and relationships—occurs more often in people with ME/CFS or fibromyalgia than in the general population. The researchers found that BPD appeared in roughly 2-17% of ME/CFS patients and 1-17% of fibromyalgia patients across different studies, but the numbers varied widely. The authors concluded that more research is needed to understand whether these conditions are truly connected.

E0 ConsensusReviewPEM not requiredReview-Narrative

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature.

Walitt, Brian, Ceko, Marta, Gracely, John L et al.·Current rheumatology reviews·2016

This review examined brain imaging studies of ME/CFS and similar conditions to understand what happens in the nervous system. Researchers found that people with these conditions show increased sensitivity to pain and other sensations, suggesting these are real physical conditions—not imaginary or feigned. However, brain imaging hasn't yet revealed a single clear pattern or 'fingerprint' that all these conditions share, and we still don't know if this sensory sensitivity causes the disease or is a result of it.

Pain and Sensitization

E0 ConsensusReviewPEM unclearReview-Narrative

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

Navaneetharaja, Navena, Griffiths, Verity, Wileman, Tom et al.·Journal of clinical medicine·2016

This review examines whether infections—particularly viruses in the gut—might trigger ME/CFS. The authors suggest that an imbalance in the gut's microbial and viral communities could be a key factor in developing the disease. They propose that understanding these gut infections could help identify better treatments and ways to prevent ME/CFS.

Immune System

E0 ConsensusReviewPEM not requiredSystematic-Review

Exercise therapy for chronic fatigue syndrome.

Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan et al.·The Cochrane database of systematic reviews·2016

This review looked at eight studies testing whether exercise therapy helps people with ME/CFS feel less fatigued. Overall, exercise therapy reduced fatigue more than doing nothing or standard care, and patients also reported improvements in sleep, physical function, and general health. The review found no evidence that exercise made things worse, though more research is needed to determine the best type and intensity of exercise for each person.

Sleep

E0 ConsensusReviewPEM requiredMeta-Analysis

Effect of Acute Exercise on Fatigue in People with ME/CFS/SEID: A Meta-analysis.

Loy, Bryan D, O'Connor, Patrick J, Dishman, Rodney K·Medicine and science in sports and exercise·2016

This review of seven studies looked at how a single exercise session affects fatigue in people with ME/CFS. The combined results showed that exercise increased fatigue more in people with ME/CFS compared to healthy controls. Importantly, fatigue got worse over time—it was most noticeable 4 or more hours after exercise ended, rather than immediately during or right after the activity stopped.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredSystematic-Review

Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review.

Loades, Maria E, Sheils, Elizabeth A, Crawley, Esther·BMJ open·2016

This review looked at studies treating depression in children and teens with ME/CFS, since about one-third of young people with ME/CFS also experience depression. The researchers found that while some treatments like cognitive-behavioural therapy and specialized hospital programmes showed some promise in helping with depression symptoms, there are no studies specifically designed to test what works best for depression in young people with ME/CFS. This means we still don't have clear answers about the best way to help these young people.

E0 ConsensusReviewPEM unclearSystematic-Review

Chronic fatigue syndrome - an update.

Rimbaut, Steven, Van Gutte, Céline, Van Brabander, Lina et al.·Acta clinica Belgica·2016

This review examined research on ME/CFS published over 25 years and found that despite extensive scientific study, no single cause of the condition has been definitively proven. Currently, the best-supported treatments are cognitive behavioral therapy (a talk therapy) and graded exercise therapy (gradually increasing activity), though these show only moderate benefits. The study highlights how common ME/CFS is and how significantly it affects people's ability to work and participate in daily life.

E0 ConsensusReviewPEM not requiredSystematic-Review

Exercise therapy for chronic fatigue syndrome.

Larun, Lillebeth, Brurberg, Kjetil G, Odgaard-Jensen, Jan et al.·The Cochrane database of systematic reviews·2016

This review looked at eight studies involving 1,518 people with ME/CFS to see if exercise therapy helps. Most studies showed that exercise reduced fatigue and improved sleep and physical function compared to no treatment or relaxation. Exercise therapy seemed to work about as well as cognitive-behavioral therapy, though the quality of evidence varied.

Sleep

E0 ConsensusReviewPEM not requiredReview-Narrative

Cognitive Dysfunction in Chronic Fatigue Syndrome: a Review of Recent Evidence.

Cvejic, Erin, Birch, Rachael C, Vollmer-Conna, Uté·Current rheumatology reports·2016

People with ME/CFS commonly experience 'brain fog'—problems with memory, attention, and concentration. While these cognitive problems are real and significantly impact daily life, the exact biological causes remain unclear. This review suggests that problems with blood flow to the brain and nervous system dysfunction may be involved, and calls for standardized testing methods to better understand what's happening.

Autonomic Nervous System

E0 ConsensusReviewPEM unclearSystematic-Review

Distress in significant others of patients with chronic fatigue syndrome: A systematic review of the literature.

Harris, Kamelia, Band, Rebecca J, Cooper, Hazel et al.·British journal of health psychology·2016

This review looked at six studies examining how ME/CFS affects the emotional health of family members and partners of patients. Most studies found that loved ones experience significant stress and worry. The review discovered that supporters feel more distressed when they blame the patient for their symptoms, when they are female, or when the patient is struggling with mental health issues. However, one study suggested that accepting the illness could help reduce this stress.

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Are Traditional Remedies Useful in Management of Fibromyalgia and Chronic Fatigue Syndrome? A Review Study.

[Psychological Health of Children with Chronic Physical Illness and their Parents - Results from Meta-Analyses].

What treatments work for anxiety in children with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME)? Systematic review.

Chronic Pelvic Pain in Women.

A systematic review of the comorbidity between Temporomandibular Disorders and Chronic Fatigue Syndrome.

Attentional and interpretive bias towards illness-related information in chronic fatigue syndrome: A systematic review.

The differential diagnosis of tiredness: a systematic review.

A Systematic Review of Drug Therapies for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Yoga intervention and functional pain syndromes: a selective review.

An abridged version of the Cochrane review of exercise therapy for chronic fatigue syndrome.

The association between borderline personality disorder, fibromyalgia and chronic fatigue syndrome: systematic review.

Neuroimaging of Central Sensitivity Syndromes: Key Insights from the Scientific Literature.

A Role for the Intestinal Microbiota and Virome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)?

Exercise therapy for chronic fatigue syndrome.

Effect of Acute Exercise on Fatigue in People with ME/CFS/SEID: A Meta-analysis.

Treatment for paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) and comorbid depression: a systematic review.

Chronic fatigue syndrome - an update.

Exercise therapy for chronic fatigue syndrome.

Cognitive Dysfunction in Chronic Fatigue Syndrome: a Review of Recent Evidence.

Distress in significant others of patients with chronic fatigue syndrome: A systematic review of the literature.

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