ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

654 studies

581–600 of 654 studies

E0 ConsensusReviewPEM not requiredReview-Narrative

The management of fibromyalgia.

Rao, Srinivas G, Clauw, Daniel J·Drugs of today (Barcelona, Spain : 1998)·2004

This guideline reviews how fibromyalgia is managed and notes that it shares similarities with other conditions like ME/CFS, irritable bowel syndrome, and chronic headaches. These conditions cause pain that comes from the central nervous system rather than from injured tissue, which means common pain medications like NSAIDs and opioids don't work well. Instead, certain antidepressants, anti-seizure drugs, exercise, and talk therapy tend to be more helpful.

E0 ConsensusReviewPEM not requiredEditorial

Medically unexplained symptoms and neuropsychological assessment.

Binder, Laurence M, Campbell, Keith A·Journal of clinical and experimental neuropsychology·2004

This review examines several long-term illnesses—including ME/CFS—where patients experience real symptoms but standard medical tests don't show an obvious cause. The authors found that some patients do have measurable thinking and memory problems, but these may result from a combination of stress, past trauma, and how the body responds to illness rather than from traditional brain disease alone.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredSystematic-Review

Disability and chronic fatigue syndrome: a focus on function.

Ross, Susan D, Estok, Rhonda P, Frame, Diana et al.·Archives of internal medicine·2004

Researchers reviewed 37 studies about how ME/CFS affects people's ability to work. They found that most people with ME/CFS in these studies were unemployed. Surprisingly, depression was the only factor clearly linked to job loss, while other symptoms didn't consistently predict employment problems. Only three types of treatment—cognitive behavior therapy, rehabilitation, and exercise—showed promise in helping people return to work.

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2004

This review examined what we know about treating chronic fatigue syndrome (ME/CFS) by looking at multiple existing studies together. The authors searched medical literature to find which treatments have evidence supporting their use. This systematic review helps doctors and patients understand what treatments have been studied and what the research shows about their effectiveness.

E0 ConsensusReviewPEM unclearSystematic-Review

Exercise therapy for chronic fatigue syndrome.

Edmonds, M, McGuire, H, Price, J·The Cochrane database of systematic reviews·2004

This review looked at five studies testing whether graded exercise helps people with ME/CFS. At 12 weeks, patients who did exercise therapy felt less tired and had better physical function than those who didn't exercise. However, more people dropped out of the exercise groups, suggesting the treatment may be difficult for some patients to continue.

E0 ConsensusReviewPEM unclearSystematic-Review

Psycho-educational interventions for children with chronic disease, parents and siblings: an overview of the research evidence base.

Barlow, J H, Ellard, D R·Child: care, health and development·2004

This review looked at studies testing whether educational and psychological programs help children and teenagers with chronic diseases—including ME/CFS—and their families cope better. The researchers found that programs using cognitive-behavioral techniques (which help people change unhelpful thinking patterns) showed promise for improving things like confidence in managing illness, quality of life, and reducing symptoms like fatigue in ME/CFS patients. However, the review found that most studies were small and didn't always explain their programs clearly.

E0 ConsensusReviewPEM requiredEditorial

Safety of immunisation and adverse events following vaccination against hepatitis B.

Duclos, Philippe·Expert opinion on drug safety·2003

This review examined whether the hepatitis B vaccine is safe, particularly looking at claims that it might cause chronic fatigue syndrome, multiple sclerosis, diabetes, and other serious conditions. After reviewing scientific evidence from multiple independent health organizations including the WHO and US Institute of Medicine, researchers found no proof that the vaccine causes these conditions. The vaccine has a strong safety record, and the theoretical risks are far outweighed by its proven benefits in preventing liver disease and cancer.

E0 ConsensusReviewPEM not requiredReview-Narrative

The neuroendocrinology of chronic fatigue syndrome.

Cleare, Anthony J·Endocrine reviews·2003

This review examined how hormones—particularly the stress hormone cortisol and others made by the brain and glands—may be altered in ME/CFS patients. The researchers found that some patients have lower cortisol levels than expected, and their bodies may respond differently to stress, but these changes vary significantly from person to person. The review suggests that many factors like inactivity, poor sleep, and ongoing stress likely contribute to these hormone changes rather than a single cause.

Endocrine Disruption

E0 ConsensusReviewPEM not requiredSystematic-Review

A systematic review and critical evaluation of the immunology of chronic fatigue syndrome.

Lyall, Marc, Peakman, Mark, Wessely, Simon·Journal of psychosomatic research·2003

Researchers reviewed all the studies looking at immune system problems in ME/CFS patients to see what patterns emerged. They found that results were mixed and often contradictory—some studies showed low natural killer cells, while others didn't, especially when looking at higher-quality research. The review suggests that how studies are designed and conducted can affect whether certain immune changes are found.

Immune System

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome: a review.

Afari, Niloofar, Buchwald, Dedra·The American journal of psychiatry·2003

ME/CFS is a serious illness marked by extreme tiredness lasting at least 6 months, along with other symptoms that significantly limit daily activities. This review brings together current scientific knowledge about how ME/CFS is diagnosed, how common it is, what causes it, and how it can be treated. The evidence suggests ME/CFS is complex, likely caused by multiple factors working together, and treatment works best when tailored to each person's specific needs.

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2003

This systematic review summarizes what is known about chronic fatigue syndrome (ME/CFS) by examining existing research. The authors looked at the best available evidence about how the condition develops, how it affects people, and what treatments might help. This type of review helps doctors and patients understand the current state of knowledge about ME/CFS.

Interventions

E0 ConsensusReviewPEM not requiredSystematic-Review

Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash.

van Hout, Moniek S E, Wekking, Ellie M, Berg, Ina J et al.·Psychotherapy and psychosomatics·2003

This review looked at studies on psychological treatments for chronic toxic encephalopathy (a condition from long-term solvent exposure) and compared them with research on chronic fatigue syndrome and whiplash injuries. The reviewers found that cognitive-behavioral therapy (CBT)—a type of talk therapy that helps change unhelpful thinking patterns—and gradually increasing activity levels showed promise in helping people with fatigue and thinking problems. They suggest these same approaches might help people with toxic encephalopathy, though more research is needed.

Cognitive Impairment

E0 ConsensusReviewPEM not requiredMeta-Analysis

Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review.

Henningsen, Peter, Zimmermann, Thomas, Sattel, Heribert·Psychosomatic medicine·2003

This large review of 244 studies examined whether people with ME/CFS, fibromyalgia, IBS, and similar conditions experience more anxiety and depression than healthy people or those with other illnesses. The researchers found moderate but consistent links between these conditions and depression/anxiety, but importantly, the conditions cannot be fully explained by mental health alone. This suggests these syndromes are distinct medical conditions rather than simply psychiatric problems.

E0 ConsensusReviewPEM not requiredReview-Narrative

Behavioral medicine approaches to somatoform disorders.

Looper, Karl J, Kirmayer, Laurence J·Journal of consulting and clinical psychology·2002

This review looked at research studies testing whether cognitive-behavioral therapy (CBT)—a type of talk therapy that helps people change unhelpful thinking patterns—works for conditions where people have physical symptoms that doctors cannot fully explain. The review found that CBT appears helpful for several conditions including chronic fatigue syndrome, though the quality and amount of evidence varies.

E0 ConsensusReviewPEM unclearReview-Narrative

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

Mehendale, Anand W, Goldman, Mark P·Pain practice : the official journal of World Institute of Pain·2002

This review summarizes what scientists and doctors know about fibromyalgia and ME/CFS by examining research from the past 25 years. The authors looked at studies on symptoms, causes, blood test findings, brain imaging, and what patients reported about their experiences. They propose that these conditions may need to be understood in an entirely new way.

Pain and Sensitization

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2002

This systematic review examined all available evidence about chronic fatigue syndrome (ME/CFS) to understand what treatments work best. The authors looked at multiple studies together to see what the overall evidence shows about managing this condition. This type of review helps doctors and patients understand which approaches have the strongest scientific support.

E0 ConsensusGuidelinePEM unclearGuideline

Chronic fatigue syndrome. Clinical practice guidelines--2002.

Working Group of the Royal Australasian College of Physicians·The Medical journal of Australia·2002

These guidelines were created by Australian medical experts in 2002 to help doctors recognize, diagnose, and treat ME/CFS (a condition also called chronic fatigue syndrome). The guidelines set standards for how patients should be evaluated and managed, based on the best medical knowledge available at that time. They aim to improve the quality of care patients receive and reduce confusion about how to properly approach this illness.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Dysautonomias: clinical disorders of the autonomic nervous system.

Goldstein, David S, Robertson, David, Esler, Murray et al.·Annals of internal medicine·2002

This review examines dysautonomias—conditions where the autonomic nervous system (the part of your body that controls heart rate, blood pressure, and other automatic functions) stops working properly. The authors discuss how these problems can range from occasional fainting spells to serious nerve damage. Importantly, they note that ME/CFS patients often show signs of orthostatic intolerance (difficulty maintaining blood pressure when standing), but a common treatment that works for other autonomic conditions does not appear to help ME/CFS patients.

Autonomic Nervous System

E0 ConsensusGuidelinePEM unclearGuideline

Chronic fatigue syndrome: a step towards agreement.

Clark, Christopher, Buchwald, Dedra, MacIntyre, Anne et al.·Lancet (London, England)·2002

This 2002 guideline paper from leading ME/CFS researchers brought together different international perspectives on how to define and diagnose chronic fatigue syndrome, aiming to reduce confusion among doctors. The authors reviewed existing diagnostic criteria and clinical approaches to help create more consistent standards for identifying the condition. This work was an important step toward getting doctors and researchers to agree on what ME/CFS actually is.

Diagnostics

E0 ConsensusReviewPEM not requiredEditorial

Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex illness?

Gerrity, Timothy R, Bates, Janet, Bell, David S et al.·Neuroimmunomodulation·2002

This paper brings together expert opinions about how the autonomic nervous system (the part of your nervous system that controls automatic functions like heart rate and breathing) may be involved in ME/CFS. The authors reviewed what was known in 2000 about connections between autonomic nervous system problems and other system dysfunctions seen in ME/CFS, including immune and hormone abnormalities.

Autonomic Nervous System

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Evidence browser

The management of fibromyalgia.

Medically unexplained symptoms and neuropsychological assessment.

Disability and chronic fatigue syndrome: a focus on function.

Chronic fatigue syndrome.

Exercise therapy for chronic fatigue syndrome.

Psycho-educational interventions for children with chronic disease, parents and siblings: an overview of the research evidence base.

Safety of immunisation and adverse events following vaccination against hepatitis B.

The neuroendocrinology of chronic fatigue syndrome.

A systematic review and critical evaluation of the immunology of chronic fatigue syndrome.

Chronic fatigue syndrome: a review.

Chronic fatigue syndrome.

Psychological treatment of patients with chronic toxic encephalopathy: lessons from studies of chronic fatigue and whiplash.

Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review.

Behavioral medicine approaches to somatoform disorders.

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

Chronic fatigue syndrome.

Chronic fatigue syndrome. Clinical practice guidelines--2002.

Dysautonomias: clinical disorders of the autonomic nervous system.

Chronic fatigue syndrome: a step towards agreement.

Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex illness?

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