ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

644 studies

581–600 of 644 studies

E0 ConsensusReviewPEM not requiredMeta-Analysis

Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review.

Henningsen, Peter, Zimmermann, Thomas, Sattel, Heribert·Psychosomatic medicine·2003

This large review of 244 studies examined whether people with ME/CFS, fibromyalgia, IBS, and similar conditions experience more anxiety and depression than healthy people or those with other illnesses. The researchers found moderate but consistent links between these conditions and depression/anxiety, but importantly, the conditions cannot be fully explained by mental health alone. This suggests these syndromes are distinct medical conditions rather than simply psychiatric problems.

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2003

This systematic review summarizes what is known about chronic fatigue syndrome (ME/CFS) by examining existing research. The authors looked at the best available evidence about how the condition develops, how it affects people, and what treatments might help. This type of review helps doctors and patients understand the current state of knowledge about ME/CFS.

Interventions

E0 ConsensusReviewPEM not requiredReview-Narrative

The neuroendocrinology of chronic fatigue syndrome.

Cleare, Anthony J·Endocrine reviews·2003

This review examined how hormones—particularly the stress hormone cortisol and others made by the brain and glands—may be altered in ME/CFS patients. The researchers found that some patients have lower cortisol levels than expected, and their bodies may respond differently to stress, but these changes vary significantly from person to person. The review suggests that many factors like inactivity, poor sleep, and ongoing stress likely contribute to these hormone changes rather than a single cause.

Endocrine Disruption

E0 ConsensusReviewPEM unclearReview-Narrative

Chronic fatigue syndrome.

Reid, Steven, Chalder, Trudie, Cleare, Anthony et al.·Clinical evidence·2002

This systematic review examined all available evidence about chronic fatigue syndrome (ME/CFS) to understand what treatments work best. The authors looked at multiple studies together to see what the overall evidence shows about managing this condition. This type of review helps doctors and patients understand which approaches have the strongest scientific support.

E0 ConsensusGuidelinePEM unclearGuideline

Chronic fatigue syndrome. Clinical practice guidelines--2002.

Working Group of the Royal Australasian College of Physicians·The Medical journal of Australia·2002

These guidelines were created by Australian medical experts in 2002 to help doctors recognize, diagnose, and treat ME/CFS (a condition also called chronic fatigue syndrome). The guidelines set standards for how patients should be evaluated and managed, based on the best medical knowledge available at that time. They aim to improve the quality of care patients receive and reduce confusion about how to properly approach this illness.

Diagnostics

E0 ConsensusReviewPEM not requiredEditorial

Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex illness?

Gerrity, Timothy R, Bates, Janet, Bell, David S et al.·Neuroimmunomodulation·2002

This paper brings together expert opinions about how the autonomic nervous system (the part of your nervous system that controls automatic functions like heart rate and breathing) may be involved in ME/CFS. The authors reviewed what was known in 2000 about connections between autonomic nervous system problems and other system dysfunctions seen in ME/CFS, including immune and hormone abnormalities.

Autonomic Nervous System

E0 ConsensusGuidelinePEM unclearGuideline

Chronic fatigue syndrome: a step towards agreement.

Clark, Christopher, Buchwald, Dedra, MacIntyre, Anne et al.·Lancet (London, England)·2002

This 2002 guideline paper from leading ME/CFS researchers brought together different international perspectives on how to define and diagnose chronic fatigue syndrome, aiming to reduce confusion among doctors. The authors reviewed existing diagnostic criteria and clinical approaches to help create more consistent standards for identifying the condition. This work was an important step toward getting doctors and researchers to agree on what ME/CFS actually is.

Diagnostics

E0 ConsensusReviewPEM not requiredSystematic-Review

Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?

Whitehead, William E, Palsson, Olafur, Jones, Kenneth R·Gastroenterology·2002

This review examined how irritable bowel syndrome (IBS) often occurs together with other conditions like fibromyalgia, chronic fatigue syndrome, anxiety, and depression. Researchers found that patients with IBS frequently have multiple other health problems at the same time, suggesting these conditions may share common underlying mechanisms rather than being completely separate disorders.

E0 ConsensusReviewPEM not requiredReview-Narrative

Annotation: Chronic Fatigue Syndrome in children and adolescents.

Garralda, M Elena, Rangel, Luiza·Journal of child psychology and psychiatry, and allied disciplines·2002

This review looked at studies of ME/CFS (chronic fatigue syndrome) in children and teenagers over 20 years. The main symptom is severe tiredness along with other physical symptoms that stop children from doing normal activities. Most cases seem to start after an infection, and many children also have mood problems like depression. Treatment involving family support, gradual increases in activity, and help with mood disorders showed promise, with over two-thirds of children improving.

E0 ConsensusReviewPEM unclearSystematic-Review

Systematic review of the current literature related to disability and chronic fatigue syndrome.

Ross, S D, Levine, C, Ganz, N et al.·Evidence report/technology assessment (Summary)·2002

This study reviewed all existing research about how ME/CFS affects a person's ability to work and function in daily life. The researchers looked at what scientists had already discovered about disability in ME/CFS to understand the bigger picture of how this illness impacts people. This type of comprehensive review helps identify what we know and what gaps still exist in our understanding.

E0 ConsensusReviewPEM unclearSystematic-Review

Interventions for the treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis.

Bagnall, A M, Whiting, P, Richardson, R et al.·Quality & safety in health care·2002

This review looked at all the available research studies about treatments for ME/CFS to understand which approaches actually work. The authors examined evidence from previously published studies to summarize what we know about managing this condition. This type of review helps doctors and patients understand the current state of treatment options based on the best available evidence.

E0 ConsensusReviewPEM not requiredSystematic-Review

Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?

Raine, Rosalind, Haines, Andy, Sensky, Tom et al.·BMJ (Clinical research ed.)·2002

Researchers reviewed 61 studies testing mental health treatments for ME/CFS, irritable bowel syndrome, and chronic back pain. They found that cognitive behavioural therapy and behaviour therapy helped with ME/CFS and back pain, while antidepressants helped with irritable bowel syndrome. Treatments worked better when delivered in hospital settings than in GP surgeries, possibly because hospital patients had more severe illness or received closer supervision.

E0 ConsensusReviewPEM unclearReview-Narrative

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

Mehendale, Anand W, Goldman, Mark P·Pain practice : the official journal of World Institute of Pain·2002

This review summarizes what scientists and doctors know about fibromyalgia and ME/CFS by examining research from the past 25 years. The authors looked at studies on symptoms, causes, blood test findings, brain imaging, and what patients reported about their experiences. They propose that these conditions may need to be understood in an entirely new way.

Pain and Sensitization

E0 ConsensusReviewPEM unclearEditorial

A status report on chronic fatigue syndrome.

Natelson, Benjamin H, Lange, Gudrun·Environmental health perspectives·2002

This review examines why people develop ME/CFS, a condition marked by extreme tiredness and other symptoms that doctors struggle to explain. The authors suggest that ME/CFS likely isn't caused by a single thing, but rather by several different problems—including brain issues, difficulty handling stress, and concerns about making symptoms worse through activity. They note that while severe infections can trigger ME/CFS, the condition seems to persist through different biological mechanisms than the original infection itself.

Post-Exertional Malaise

E0 ConsensusReviewPEM not requiredReview-Narrative

Dysautonomias: clinical disorders of the autonomic nervous system.

Goldstein, David S, Robertson, David, Esler, Murray et al.·Annals of internal medicine·2002

This review examines dysautonomias—conditions where the autonomic nervous system (the part of your body that controls heart rate, blood pressure, and other automatic functions) stops working properly. The authors discuss how these problems can range from occasional fainting spells to serious nerve damage. Importantly, they note that ME/CFS patients often show signs of orthostatic intolerance (difficulty maintaining blood pressure when standing), but a common treatment that works for other autonomic conditions does not appear to help ME/CFS patients.

Autonomic Nervous System

E0 ConsensusReviewPEM not requiredReview-Narrative

Behavioral medicine approaches to somatoform disorders.

Looper, Karl J, Kirmayer, Laurence J·Journal of consulting and clinical psychology·2002

This review looked at research studies testing whether cognitive-behavioral therapy (CBT)—a type of talk therapy that helps people change unhelpful thinking patterns—works for conditions where people have physical symptoms that doctors cannot fully explain. The review found that CBT appears helpful for several conditions including chronic fatigue syndrome, though the quality and amount of evidence varies.

E0 ConsensusReviewPEM not requiredReview-Narrative

The neuroendocrinology of chronic fatigue syndrome and fibromyalgia.

Parker, A J, Wessely, S, Cleare, A J·Psychological medicine·2001

This review examined how hormones and brain chemicals differ in ME/CFS patients. Researchers found that some patients have lower stress hormone (cortisol) levels, and their bodies show unusual patterns in serotonin and other brain chemical systems when tested. However, the findings were inconsistent across studies, and it's still unclear whether these changes cause ME/CFS symptoms or result from living with the illness.

Endocrine Disruption

E0 ConsensusReviewPEM not requiredSystematic-Review

[What happens to the fibromyalgia syndrome?].

Maquet, D, Croisier, J L, Crielaard, J M·Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique·2001

This review examined fibromyalgia, a condition causing widespread muscle and joint pain that lasts at least three months. The researchers found that fibromyalgia involves multiple problems working together: abnormal pain processing in the nervous system, poor sleep quality, muscle weakness, and hormonal imbalances. They concluded that treating fibromyalgia effectively requires a team approach addressing all these different issues, not just pain alone.

Pain and Sensitization

E0 ConsensusReviewPEM not requiredReview-Narrative

Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment.

Friedberg, F, Jason, L A·Journal of clinical psychology·2001

This review examines how ME/CFS and fibromyalgia are similar conditions that doctors don't fully understand yet. The authors looked at research on what causes these illnesses, how to diagnose them (including checking for depression and anxiety), and what treatments work—including medications, alternative therapies, and talking with a therapist. The study suggests that mental health professionals can play an important role in helping patients manage their symptoms.

Diagnostics

E0 ConsensusReviewPEM not requiredReview-Narrative

Controlled exposures to volatile organic compounds in sensitive groups.

Fiedler, N, Kipen, H M·Annals of the New York Academy of Sciences·2001

This review looked at studies where people with chemical sensitivities were exposed to different odors and chemical mixtures in controlled lab settings. Researchers found that people with chemical sensitivities did have real symptoms when exposed to certain chemicals, even at low levels, but these symptoms weren't always linked to measurable changes in heart rate, breathing, or other body functions that usually indicate stress.

Autonomic Nervous System

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Evidence browser

Medically unexplained physical symptoms, anxiety, and depression: a meta-analytic review.

Chronic fatigue syndrome.

The neuroendocrinology of chronic fatigue syndrome.

Chronic fatigue syndrome.

Chronic fatigue syndrome. Clinical practice guidelines--2002.

Chronic fatigue syndrome: what role does the autonomic nervous system play in the pathophysiology of this complex illness?

Chronic fatigue syndrome: a step towards agreement.

Systematic review of the comorbidity of irritable bowel syndrome with other disorders: what are the causes and implications?

Annotation: Chronic Fatigue Syndrome in children and adolescents.

Systematic review of the current literature related to disability and chronic fatigue syndrome.

Interventions for the treatment and management of chronic fatigue syndrome/myalgic encephalomyelitis.

Systematic review of mental health interventions for patients with common somatic symptoms: can research evidence from secondary care be extrapolated to primary care?

Fibromyalgia syndrome, idiopathic widespread persistent pain or syndrome of myalgic encephalomyelopathy (SME): what is its nature?

A status report on chronic fatigue syndrome.

Dysautonomias: clinical disorders of the autonomic nervous system.

Behavioral medicine approaches to somatoform disorders.

The neuroendocrinology of chronic fatigue syndrome and fibromyalgia.

[What happens to the fibromyalgia syndrome?].

Chronic fatigue syndrome and fibromyalgia: clinical assessment and treatment.

Controlled exposures to volatile organic compounds in sensitive groups.

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