ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

320 studies

121–140 of 320 studies

Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial.

Castro-Marrero, Jesus, Sáez-Francàs, Naia, Segundo, María Jose et al.·Clinical nutrition (Edinburgh, Scotland)·2016

This study tested whether two supplements called CoQ10 and NADH could help people with ME/CFS feel less fatigued and improve their exercise capacity. Eighty patients took either the supplements or placebo for 8 weeks. The results showed modest improvements: the supplement group had lower maximum heart rates during exercise testing and reported less fatigue, but pain and sleep didn't improve.

E1 ReplicatedTrialPEM not requiredRCT

Treatment expectations influence the outcome of multidisciplinary rehabilitation treatment in patients with CFS.

Vos-Vromans, D C W M, Huijnen, I P J, Rijnders, L J M et al.·Journal of psychosomatic research·2016

This study tested whether patients' expectations about treatment affect how well they recover from ME/CFS. Researchers gave 122 patients either cognitive behavioral therapy (CBT) or multidisciplinary rehabilitation treatment (MRT) and measured their expectations before starting. They found that for patients receiving MRT, having positive expectations was linked to better outcomes in fatigue and physical quality of life—but this connection was not found in the CBT group.

Interventions

E1 ReplicatedTrialPEM not requiredRCT

Human Placental Extract as a Subcutaneous Injection Is Effective in Chronic Fatigue Syndrome: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study.

Park, Sat Byul, Kim, Kyu-Nam, Sung, Eunju et al.·Biological & pharmaceutical bulletin·2016

Researchers tested whether injections of human placental extract (a substance derived from placentas) could help people with ME/CFS feel less fatigued. Seventy-eight people with chronic fatigue received either the placental extract or a placebo (dummy injection) three times per week for 6 weeks. Those who received the real extract reported greater improvements in fatigue levels compared to the placebo group, though the benefit was only seen in people with ME/CFS, not in those with other types of chronic fatigue.

E1 ReplicatedTrialPEM not requiredRCT

Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.

Fukuda, Sanae, Nojima, Junzo, Kajimoto, Osami et al.·BioFactors (Oxford, England)·2016

This study tested whether taking a supplement called ubiquinol-10 (a form of coenzyme Q10) could help people with ME/CFS feel better. Researchers first gave 20 patients ubiquinol-10 for 8 weeks and saw improvements, then tested it more rigorously in 43 patients who either received ubiquinol-10 or a placebo for 12 weeks. The results suggested that ubiquinol-10 may help improve some CFS symptoms, particularly problems with nerve function and thinking ability.

Autonomic Nervous System

E1 ReplicatedTrialPEM not requiredRCT

Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome.

Ostojic, Sergej M, Stojanovic, Marko, Drid, Patrik et al.·Nutrients·2016

Researchers tested whether a supplement called guanidinoacetic acid (GAA) could help women with ME/CFS. Twenty-one women took either GAA or a placebo for three months. While GAA increased muscle creatine levels and improved some measures of strength and aerobic power, it did not reduce fatigue or muscle pain—the main symptoms patients care about most.

Energy Metabolism

E1 ReplicatedTrialPEM not requiredRCT

Acupuncture and Moxibustion have Different Effects on Fatigue by Regulating the Autonomic Nervous System: A Pilot Controlled Clinical Trial.

Shu, Qing, Wang, Hua, Litscher, Daniela et al.·Scientific reports·2016

This study tested whether two traditional Chinese medicine treatments—acupuncture and moxibustion (warming therapy)—could help reduce fatigue in ME/CFS patients. Forty-five people were divided into three groups: two received acupuncture and one received moxibustion. Both treatments reduced fatigue, but moxibustion appeared to work better, especially over the long term, possibly by calming the nervous system.

Autonomic Nervous System

E1 ReplicatedTrialPEM not requiredCross-Sectional

Participant attributions for global change ratings in unexplained chronic fatigue and chronic fatigue syndrome.

Friedberg, Fred, Coronel, Janna, Seva, Viktoria et al.·Journal of health psychology·2016

Researchers asked 67 people with chronic fatigue who were trying a behavioral treatment program why they felt better, worse, or unchanged after 3 months. Those who improved pointed to specific changes in their daily activities and habits. Those who didn't improve mentioned that their lifestyle hadn't really changed. Those who felt worse blamed stress or major life events. Understanding what patients think helped or hurt them could help doctors develop better treatment strategies.

E1 ReplicatedTrialPEM requiredRCT

Fatigue Exacerbation by Interval or Continuous Exercise in Chronic Fatigue Syndrome.

Sandler, Carolina X, Lloyd, Andrew R, Barry, Benjamin K·Medicine and science in sports and exercise·2016

This study compared how people with ME/CFS feel after two types of exercise: high-intensity interval training (short bursts of harder exercise) and steady, continuous moderate exercise. Both types of exercise caused fatigue to worsen slightly afterward, but there was no meaningful difference between them. The findings suggest that high-intensity exercise might be safe to study further as part of graded exercise therapy programs.

Post-Exertional Malaise

E1 ReplicatedTrialPEM not requiredProtocol

Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial.

van Der Schaaf, Marieke E, Schmits, Iris C, Roerink, Megan et al.·BMC psychiatry·2015

This study investigated how cognitive behavioral therapy (CBT) works for ME/CFS by examining brain imaging and blood markers before and after treatment. Researchers compared 60 ME/CFS patients receiving CBT with 30 on a waiting list and 30 healthy controls to see how their brains changed and whether hormone and immune markers were involved in recovery.

Immune System

E1 ReplicatedTrialPEM not requiredRCT

Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial.

Kim, Jung-Eun, Seo, Byung-Kwan, Choi, Jin-Bong et al.·Trials·2015

This study tested whether acupuncture—a traditional practice involving thin needles inserted into the skin—could help people with chronic fatigue syndrome (CFS) and related fatigue conditions. Researchers divided 150 patients into three groups: two received different types of acupuncture for 4 weeks along with their usual care, while one group continued usual care alone. The acupuncture groups showed some improvements in fatigue, stress, and pain compared to the usual care group.

Pain and Sensitization

E1 ReplicatedTrialPEM not requiredRCT

From Body to Mind and Spirit: Qigong Exercise for Bereaved Persons with Chronic Fatigue Syndrome-Like Illness.

Li, Jie, Chan, Jessie S M, Chow, Amy Y M et al.·Evidence-based complementary and alternative medicine : eCAM·2015

This study looked at how grief affects people with ME/CFS-like illness and tested whether a traditional Chinese exercise called Qigong could help. People who were grieving had more mental fatigue and lower physical quality of life than those not grieving. After 5 weeks of Qigong classes plus home practice, grieving participants who did Qigong improved more in fatigue, mood, spiritual well-being, and quality of life compared to those who didn't do Qigong.

E1 ReplicatedTrialPEM not requiredRCT

Therapist Effects and the Impact of Early Therapeutic Alliance on Symptomatic Outcome in Chronic Fatigue Syndrome.

Goldsmith, Lucy P, Dunn, Graham, Bentall, Richard P et al.·PloS one·2015

This study looked at whether the quality of the relationship between therapist and patient affects how well two different talking therapies work for ME/CFS. Researchers tracked 296 patients who received either a home-based rehabilitation program, counselling support, or standard care, and measured how well patients improved. They found that the therapist you saw did not make a difference in treatment outcomes, and the strength of the relationship between therapist and patient did not predict who got better.

E1 ReplicatedTrialPEM not requiredRCT

A randomized, placebo-controlled, double-blinded trial of duloxetine in the treatment of general fatigue in patients with chronic fatigue syndrome.

Arnold, Lesley M, Blom, Thomas J, Welge, Jeffrey A et al.·Psychosomatics·2015

This study tested whether duloxetine, a medication that affects mood and pain, could help reduce fatigue in people with ME/CFS. Over 12 weeks, 60 patients either took duloxetine or a placebo (dummy pill). While the medication did not significantly improve general fatigue compared to placebo, it did help some people with mental fatigue, pain, and overall symptom severity.

Interventions

E1 ReplicatedTrialPEM not requiredRCT

Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial.

Chalder, Trudie, Goldsmith, Kimberley A, White, Peter D et al.·The lancet. Psychiatry·2015

This study examined how cognitive behaviour therapy (CBT) and graded exercise therapy (GET) help reduce fatigue and improve physical function in ME/CFS patients. The researchers found that both treatments work partly by changing how afraid patients are of activity and what they believe about their illness, and that GET also works by gradually building exercise tolerance. The study suggests that changing unhelpful thoughts and gradually increasing activity are important parts of recovery for some patients.

E1 ReplicatedTrialPEM not requiredRCT

Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial.

Fagermoen, Even, Sulheim, Dag, Winger, Anette et al.·BMC pediatrics·2015

This study tested whether a low-dose blood pressure medication called clonidine could help adolescents with ME/CFS, particularly those experiencing dizziness when standing up. Researchers found that clonidine did reduce certain stress hormones in the blood and improved some measurements of heart rhythm control while lying down, but it did not relieve the actual symptoms of dizziness or improve heart function during positional changes.

Autonomic Nervous System

E1 ReplicatedBehavioralPEM not requiredLongitudinal

Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial.

Sharpe, Michael, Goldsmith, Kimberley A, Johnson, Anthony L et al.·The lancet. Psychiatry·2015

This study followed up with people who participated in the PACE trial 2-3 years after it ended to see how they were doing long-term. People who received cognitive behavioral therapy (CBT) or graded exercise therapy (GET) maintained their improvements in fatigue and physical function. Interestingly, people who initially received standard medical care or adaptive pacing therapy also improved over time, though many had sought additional treatment on their own after the trial ended.

E1 ReplicatedTrialPEM not requiredRCT

Activity Pacing Self-Management in Chronic Fatigue Syndrome: A Randomized Controlled Trial.

Kos, Daphne, van Eupen, Inge, Meirte, Jill et al.·The American journal of occupational therapy : official publication of the American Occupational Therapy Association·2015

This study tested whether learning to pace activities (doing things gradually and breaking them into manageable chunks) helped women with ME/CFS feel more satisfied with their daily lives. Thirty-three women were split into two groups: one learned activity pacing strategies while the other received relaxation training. Women who learned pacing reported greater satisfaction with their activities and experienced improvements in fatigue levels, suggesting this approach may help people with ME/CFS do more of what matters to them.

E1 ReplicatedTrialPEM not requiredRCT

Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?

Castro-Marrero, Jesús, Cordero, Mario D, Segundo, María José et al.·Antioxidants & redox signaling·2015

This 8-week study tested whether taking two supplements—coenzyme Q10 and NADH—could reduce fatigue in people with ME/CFS. Seventy-three Spanish patients received either the supplements or a placebo. The group taking the supplements reported less fatigue and showed improvements in blood markers related to energy production and oxidative stress compared to the placebo group.

Energy Metabolism

E1 ReplicatedTrialPEM not requiredRCT

Randomised controlled trial of cognitive behaviour therapy delivered in groups of patients with chronic fatigue syndrome.

Wiborg, Jan F, van Bussel, Jose, van Dijk, Agaat et al.·Psychotherapy and psychosomatics·2015

This study tested whether cognitive behaviour therapy (CBT)—a type of talking therapy that helps people change thought patterns and behaviours—could help people with ME/CFS when delivered in group settings. 204 patients were randomly assigned to either receive group CBT or join a waiting list. Those who received CBT showed significant improvements in fatigue severity, physical functioning, and overall quality of life compared to those who waited.

E1 ReplicatedTrialPEM not requiredRCT

Effect of Lixujieyu recipe in combination with Five Elements music therapy on chronic fatigue syndrome.

Zhang, Zhenxian, Cai, Zhixing, Yu, Yonghui et al.·Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan·2015

This study tested whether a traditional Chinese herbal medicine (Lixujieyu recipe) combined with specific types of music therapy could help reduce fatigue, depression, and anxiety in people with chronic fatigue syndrome. Researchers assigned 90 patients to different groups: five groups received the herbal medicine plus different types of music therapy, and one group received the herbal medicine alone. After 4 weeks of treatment, patients who received the herbal medicine combined with certain music types (Gong-Tune or Jiao-Tune) showed better improvement in fatigue, depression, and anxiety compared to the herbal medicine alone.

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Effect of coenzyme Q10 plus nicotinamide adenine dinucleotide supplementation on maximum heart rate after exercise testing in chronic fatigue syndrome - A randomized, controlled, double-blind trial.

Treatment expectations influence the outcome of multidisciplinary rehabilitation treatment in patients with CFS.

Human Placental Extract as a Subcutaneous Injection Is Effective in Chronic Fatigue Syndrome: A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study.

Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome.

Supplementation with Guanidinoacetic Acid in Women with Chronic Fatigue Syndrome.

Acupuncture and Moxibustion have Different Effects on Fatigue by Regulating the Autonomic Nervous System: A Pilot Controlled Clinical Trial.

Participant attributions for global change ratings in unexplained chronic fatigue and chronic fatigue syndrome.

Fatigue Exacerbation by Interval or Continuous Exercise in Chronic Fatigue Syndrome.

Investigating neural mechanisms of change of cognitive behavioural therapy for chronic fatigue syndrome: a randomized controlled trial.

Acupuncture for chronic fatigue syndrome and idiopathic chronic fatigue: a multicenter, nonblinded, randomized controlled trial.

From Body to Mind and Spirit: Qigong Exercise for Bereaved Persons with Chronic Fatigue Syndrome-Like Illness.

Therapist Effects and the Impact of Early Therapeutic Alliance on Symptomatic Outcome in Chronic Fatigue Syndrome.

A randomized, placebo-controlled, double-blinded trial of duloxetine in the treatment of general fatigue in patients with chronic fatigue syndrome.

Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial.

Effects of low-dose clonidine on cardiovascular and autonomic variables in adolescents with chronic fatigue: a randomized controlled trial.

Rehabilitative treatments for chronic fatigue syndrome: long-term follow-up from the PACE trial.

Activity Pacing Self-Management in Chronic Fatigue Syndrome: A Randomized Controlled Trial.

Does oral coenzyme Q10 plus NADH supplementation improve fatigue and biochemical parameters in chronic fatigue syndrome?

Randomised controlled trial of cognitive behaviour therapy delivered in groups of patients with chronic fatigue syndrome.

Effect of Lixujieyu recipe in combination with Five Elements music therapy on chronic fatigue syndrome.

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