ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1021–1040 of 2,795 studies

E2 ModerateCohortPEM unclearCross-Sectional

Blood Volume Status in ME/CFS Correlates With the Presence or Absence of Orthostatic Symptoms: Preliminary Results.

van Campen, C Linda M C, Rowe, Peter C, Visser, Frans C·Frontiers in pediatrics·2018

This study measured the amount of blood circulating in the bodies of 20 adults with ME/CFS and found that those with symptoms of dizziness or lightheadedness when standing up had significantly less blood volume than those without these symptoms. On average, all ME/CFS patients had about 11 milliliters less blood per kilogram of body weight than expected, but the drop was much more pronounced in patients with orthostatic symptoms. This finding suggests that reduced blood volume may be connected to specific symptoms some ME/CFS patients experience.

Autonomic Nervous System

E2 ModerateBehavioralPEM unclearCross-Sectional

Symptoms of chronic fatigue syndrome/myalgic encephalopathy are not determined by activity pacing when measured by the chronic pain coping inventory.

Thompson, D P, Antcliff, D, Woby, S R·Physiotherapy·2018

This study looked at whether activity pacing—a common strategy where people with ME/CFS carefully manage their activity levels to avoid worsening symptoms—actually helps reduce pain, fatigue, or disability. Researchers surveyed 114 ME/CFS patients and tracked 35 others through a symptom management program. They found no clear link between how much patients used pacing and their symptom levels, suggesting that pacing alone may not be the key factor in controlling ME/CFS symptoms.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

School Functioning in Adolescents With Chronic Fatigue Syndrome.

Knight, Sarah Jenette, Politis, Jennifer, Garnham, Christine et al.·Frontiers in pediatrics·2018

This study looked at how ME/CFS affects teenagers' school lives by comparing 39 adolescents with ME/CFS to 28 healthy peers. Researchers found that teens with ME/CFS missed more school, felt less connected to school, participated less in school activities, and had lower academic performance. The severity of fatigue and emotional symptoms were linked to these school difficulties.

E2 ModerateCohortPEM requiredCross-Sectional

Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Rivas, Jose Luis, Palencia, Teresa, Fernández, Guerau et al.·Frontiers in immunology·2018

This study compared immune system cells in the blood of people with ME/CFS to healthy people. Researchers found that ME/CFS patients had different levels of certain immune cells, particularly lower regulatory T cells and higher NKT-like cells, along with changes in natural killer (NK) cells. Using these immune cell differences, researchers could correctly identify about 70% of ME/CFS patients versus healthy controls, suggesting these immune markers might someday help doctors diagnose the condition.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cross-Cultural Study of Information Processing Biases in Chronic Fatigue Syndrome: Comparison of Dutch and UK Chronic Fatigue Patients.

Hughes, Alicia M, Hirsch, Colette R, Nikolaus, Stephanie et al.·International journal of behavioral medicine·2018

This study looked at how people with ME/CFS pay attention to and interpret information related to illness and symptoms. Researchers in the Netherlands and UK tested whether people with ME/CFS tend to notice illness-related words more quickly and interpret unclear situations in ways related to their symptoms. They found that people with ME/CFS did show these patterns, and importantly, these patterns were similar in both countries, suggesting this is a consistent feature of the condition rather than a cultural difference.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

The X-Y factor: Females and males with urological chronic pelvic pain syndrome present distinct clinical phenotypes.

Hosier, Gregory W, Doiron, R Christopher, Tolls, Victoria et al.·Canadian Urological Association journal = Journal de l'Association des urologues du Canada·2018

This study compared how chronic pelvic pain affects men and women differently. Researchers found that women with pelvic pain had more bladder symptoms, nerve-related symptoms, and were more likely to have other conditions like chronic fatigue syndrome, fibromyalgia, and depression. Men and women with the same diagnosis actually experience quite different patterns of pain and related health problems.

E2 ModerateCohortPEM not requiredCase-Control

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients.

Vangeel, Elise Beau, Kempke, Stefan, Bakusic, Jelena et al.·Journal of psychosomatic research·2018

This study looked at chemical changes (called methylation) on genes that control how the body handles stress in people with ME/CFS compared to healthy controls. The researchers found small but consistent differences in a stress-response gene, particularly in patients who had experienced childhood trauma. While the differences were tiny (about 1-2%), they suggest that ME/CFS may involve changes in how the body's stress system works.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Physical Activity and Sleep in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort LifeLines.

Joustra, Monica L, Zijlema, Wilma L, Rosmalen, Judith G M et al.·Pain research & management·2018

This study looked at how physical activity and sleep relate to symptom severity in ME/CFS and fibromyalgia by comparing nearly 91,000 people from a large population study. Patients with ME/CFS and fibromyalgia were less active and slept longer than healthy controls. Interestingly, both too little and too much physical activity or sleep were linked to worse symptoms, suggesting that finding the right balance is important for managing these conditions.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Patients with chronic fatigue syndrome do not score higher on the autism-spectrum quotient than healthy controls: Comparison with autism spectrum disorder.

Bileviciute-Ljungar, Indre, Maroti, Daniel, Bejerot, Susanne·Scandinavian journal of psychology·2018

This study compared autistic traits in people with ME/CFS, people with autism spectrum disorder (ASD), and healthy people. Although ME/CFS and autism share some overlapping symptoms like fatigue, brain fog, and sensitivity to sound and light, the study found that people with ME/CFS did not show more autistic traits than healthy controls. People with autism did score higher on the autism assessment, showing the test can distinguish between the conditions.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

Reciprocal associations between daily need-based experiences, energy, and sleep in chronic fatigue syndrome.

Campbell, Rachel, Vansteenkiste, Maarten, Delesie, Liesbeth et al.·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2018

This study tracked 120 ME/CFS patients for 14 days to understand how their daily psychological needs, energy levels, and sleep quality relate to each other. Researchers found that on days when patients felt their needs were met (feeling in control, capable, and connected to others), they had more energy and better sleep. On days when patients felt frustrated in meeting these needs, they experienced more fatigue and worse sleep quality.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls.

Kingdon, Caroline C, Bowman, Erinna W, Curran, Hayley et al.·PharmacoEconomics - open·2018

This study compared how much ME/CFS affects people's daily lives compared to people with multiple sclerosis and healthy people. Researchers found that people with ME/CFS reported significantly worse physical function, ability to work, and social activities than the other two groups. People with ME/CFS also worked fewer hours and earned less money, showing the real-world impact of the illness on their lives.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model.

Milrad, Sara F, Hall, Daniel L, Jutagir, Devika R et al.·International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2018

This study examined how depression, stress hormone levels, and inflammation connect in ME/CFS patients. Researchers found that people with ME/CFS who had higher evening cortisol (a stress hormone) levels also had more depression and higher levels of inflammatory markers in their blood. The results suggest that depression, hormones, and the immune system may be interconnected in ME/CFS, though more research is needed to understand which causes which.

Immune System

E2 ModerateCohortPEM requiredCase-Control

Autonomic Nervous System Functioning Related to Nocturnal Sleep in Patients With Chronic Fatigue Syndrome Compared to Tired Controls.

Orjatsalo, Maija, Alakuijala, Anniina, Partinen, Markku·Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2018

This study examined how the nervous system controls heart rate and blood pressure during sleep in ME/CFS patients compared to people without the condition. Researchers found that ME/CFS patients showed unusual patterns during sleep: their sympathetic nervous system (the 'fight or flight' system) was more active than normal, while their parasympathetic nervous system (the 'rest and digest' system) was less active, especially during deep sleep. This abnormal nervous system activity during sleep may help explain why ME/CFS patients often wake up feeling unrefreshed.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

A content analysis of chronic fatigue syndrome and myalgic encephalomyelitis in the news from 1987 to 2013.

Siegel, Zachary A, Brown, Abigail, Devendorf, Andrew et al.·Chronic illness·2018

Researchers examined 214 newspaper articles about ME/CFS published between 1987 and 2013 to see how the illness was described to the public. They found that newspapers often got the facts wrong or incomplete—nearly 1 in 5 headlines used the wrong name for the illness, most articles didn't explain how to diagnose it, and half didn't mention any treatments. This study shows that people reading the news may have received confusing or incomplete information about ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Illness beliefs of adolescents with CFS and their parents: the perceived causes of illness and beliefs about recovery.

Loades, Maria E, Rimes, Katharine A, Lievesley, Kate et al.·International journal of adolescent medicine and health·2018

This study asked teenagers with ME/CFS and their parents what they thought caused the illness. Most believed it was triggered by a virus or stressful life events. Interestingly, teenagers and parents largely agreed with each other about the causes. Many teenagers weren't sure how long it would take them to recover, suggesting doctors should better inform young patients about what to expect.

E2 ModerateCohortPEM unclearCross-Sectional

Operationalizing Substantial Reduction in Functioning Among Young Adults with Chronic Fatigue Syndrome.

Gleason, Kristen D, Stoothoff, Jamie, McClellan, Damani et al.·International journal of behavioral medicine·2018

This study looked for the best way to measure the 'substantial reduction in functioning' that is required for ME/CFS diagnosis. Researchers used a standard health survey (SF-36) with young adults (ages 18-29) who had ME/CFS and compared them to people without the condition. They found that specific cutoff scores on four areas of the survey—physical functioning, general health, role physical (ability to work), and social functioning—could accurately identify who has ME/CFS.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort.

Collin, Simon M, Norris, Tom, Deere, Kevin C et al.·Archives of disease in childhood·2018

This study followed children in England from age 11 to 16 years to see if being physically active at age 11 was connected to developing long-lasting, disabling fatigue later on. Children who were more physically active at age 11 had lower chances of developing chronic disabling fatigue by age 13, while those who spent more time sitting had higher chances. However, this connection weakened by age 16, suggesting the relationship may be more complicated than a simple cause-and-effect.

E2 ModerateCohortPEM requiredCase-Control

The Role of Autonomic Function in Exercise-induced Endogenous Analgesia: A Case-control Study in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Healthy People.

Oosterwijck, Jessica Van, Marusic, Uros, De Wandele, Inge et al.·Pain physician·2017

This study looked at why exercise doesn't reduce pain in people with ME/CFS the way it normally does in healthy people. Researchers measured how the nervous system recovered after exercise and tracked pain levels in 20 women with ME/CFS and 20 healthy women. They found that people with ME/CFS had problems with their nervous system's ability to 'turn off' after exercise, and this was connected to their pain not improving like it should.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity.

Natelson, Benjamin H, Mao, Xiangling, Stegner, Aaron J et al.·Journal of the neurological sciences·2017

This study compared brain and spinal fluid measurements in people with ME/CFS and healthy controls to understand what physical changes occur in the condition. Researchers found that ME/CFS patients had lower levels of a protective brain chemical (glutathione), reduced blood flow to the brain, higher levels of lactate (a sign of energy problems), and more abnormalities in spinal fluid compared to healthy people. Importantly, these differences were the same whether or not ME/CFS patients also had depression or anxiety, suggesting psychiatric conditions are not making the disease worse.

Biomarkers

E2 ModerateCohortPEM requiredObservational

Incidence rates of Guillain Barré (GBS), chronic fatigue/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS) prior to introduction of human papilloma virus (HPV) vaccination among adolescent girls in Finland, 2002-2012.

Skufca, J, Ollgren, J, Ruokokoski, E et al.·Papillomavirus research (Amsterdam, Netherlands)·2017

This Finnish study looked at how often three conditions—ME/CFS, Guillain-Barré syndrome (GBS), and POTS—were diagnosed in teenage girls between 2002 and 2012, before the HPV vaccine program started. Researchers wanted to establish baseline numbers to help evaluate vaccine safety in the future. They found these conditions were relatively rare, though ME/CFS and POTS diagnoses increased over the decade studied.

Diagnostics

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Blood Volume Status in ME/CFS Correlates With the Presence or Absence of Orthostatic Symptoms: Preliminary Results.

Symptoms of chronic fatigue syndrome/myalgic encephalopathy are not determined by activity pacing when measured by the chronic pain coping inventory.

School Functioning in Adolescents With Chronic Fatigue Syndrome.

Association of T and NK Cell Phenotype With the Diagnosis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Cross-Cultural Study of Information Processing Biases in Chronic Fatigue Syndrome: Comparison of Dutch and UK Chronic Fatigue Patients.

The X-Y factor: Females and males with urological chronic pelvic pain syndrome present distinct clinical phenotypes.

Glucocorticoid receptor DNA methylation and childhood trauma in chronic fatigue syndrome patients.

Physical Activity and Sleep in Chronic Fatigue Syndrome and Fibromyalgia Syndrome: Associations with Symptom Severity in the General Population Cohort LifeLines.

Patients with chronic fatigue syndrome do not score higher on the autism-spectrum quotient than healthy controls: Comparison with autism spectrum disorder.

Reciprocal associations between daily need-based experiences, energy, and sleep in chronic fatigue syndrome.

Functional Status and Well-Being in People with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Compared with People with Multiple Sclerosis and Healthy Controls.

Depression, evening salivary cortisol and inflammation in chronic fatigue syndrome: A psychoneuroendocrinological structural regression model.

Autonomic Nervous System Functioning Related to Nocturnal Sleep in Patients With Chronic Fatigue Syndrome Compared to Tired Controls.

A content analysis of chronic fatigue syndrome and myalgic encephalomyelitis in the news from 1987 to 2013.

Illness beliefs of adolescents with CFS and their parents: the perceived causes of illness and beliefs about recovery.

Operationalizing Substantial Reduction in Functioning Among Young Adults with Chronic Fatigue Syndrome.

Physical activity at age 11 years and chronic disabling fatigue at ages 13 and 16 years in a UK birth cohort.

The Role of Autonomic Function in Exercise-induced Endogenous Analgesia: A Case-control Study in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Healthy People.

Multimodal and simultaneous assessments of brain and spinal fluid abnormalities in chronic fatigue syndrome and the effects of psychiatric comorbidity.

Incidence rates of Guillain Barré (GBS), chronic fatigue/systemic exertion intolerance disease (CFS/SEID) and postural orthostatic tachycardia syndrome (POTS) prior to introduction of human papilloma virus (HPV) vaccination among adolescent girls in Finland, 2002-2012.

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