ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

1281–1300 of 2,784 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Comorbid personality disorders in chronic fatigue syndrome patients: a marker of psychopathological severity.

Calvo, Natalia, Sáez-Francàs, Naia, Valero, Sergi et al.·Actas espanolas de psiquiatria·2015

This study looked at whether people with ME/CFS are more likely to have personality disorders—long-standing patterns of thinking and behavior that can affect how someone relates to others. Researchers assessed 132 ME/CFS patients and found that about half had traits associated with personality disorders, particularly obsessive-compulsive and avoidant patterns. Patients with these personality traits also reported more depression, irritability, and guilt.

E2 ModerateCohortPEM not requiredCross-Sectional

Altered resting brain connectivity in persistent cancer related fatigue.

Hampson, Johnson P, Zick, Suzanna M, Khabir, Tohfa et al.·NeuroImage. Clinical·2015

This study used brain imaging to compare how the brains of breast cancer survivors with fatigue differ from those without fatigue. Researchers found that people experiencing persistent cancer-related fatigue showed different patterns of communication between brain regions, particularly involving areas linked to thinking about oneself and regulating sleep. These brain connectivity differences were associated with worse physical fatigue and poor sleep quality.

Sleep

E2 ModeratePEM not requiredRegistry-Resource

Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.

Belcaro, G, Cornelli, U, Luzzi, R et al.·Journal of neurosurgical sciences·2015

This study tested whether a natural plant extract called Robuvit (made from oak wood) might help people with ME/CFS who had signs of increased oxidative stress—a type of cellular damage. Thirty-eight people with ME/CFS took Robuvit supplements for 6 months while also following a structured lifestyle plan (better sleep, exercise, diet, and relaxation), and they were compared to 42 similar people who followed the plan without the supplement. The group taking Robuvit reported more improvement in fatigue symptoms and had lower markers of oxidative stress in their blood.

E2 ModerateBehavioralPEM not requiredLongitudinal

The Process of Change in Pain During Cognitive-Behavior Therapy for Chronic Fatigue Syndrome.

Bloot, Lotte, Heins, Marianne J, Donders, Rogier et al.·The Clinical journal of pain·2015

This study looked at how cognitive-behavioral therapy (CBT)—a talk therapy that helps change thoughts and behaviors—reduces pain in ME/CFS patients. Researchers followed 142 patients over the course of their treatment and found that pain and fatigue tend to improve together. The improvement in pain appeared to be partly explained by patients doing more physical activity and thinking less about their symptoms, though other factors also played a role.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Reduced gait automaticity in female patients with chronic fatigue syndrome: Case-control study.

Eyskens, Jan B, Nijs, Jo, Wouters, Kristien et al.·Journal of rehabilitation research and development·2015

This study tested how automatically women with ME/CFS can walk while doing other things at the same time. Researchers asked women with ME/CFS and healthy women to walk, close their eyes, and solve a math problem. Most women with ME/CFS stopped walking when they had to do the math problem with their eyes closed, while most healthy women kept walking. This suggests that walking requires more conscious effort and attention in ME/CFS patients than in healthy people.

E2 ModerateCohortPEM not requiredCross-Sectional

Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana.

Bauer, Amy E, Olivas, Sonora, Cooper, Maria et al.·BMC veterinary research·2015

Researchers tested milk samples from 316 dairy farms in Indiana to see how common a bacterium called Coxiella burnetii is in cattle herds. This bacterium causes Q fever, which can lead to chronic fatigue in people. They found that over 61% of Indiana dairy herds had evidence of this bacterium in their milk, suggesting it is widespread among cattle.

E2 ModerateCohortPEM unclearCross-Sectional

Characteristics of women with endometriosis from the USA and Puerto Rico.

Fourquet, Jessica, Sinaii, Ninet, Stratton, Pamela et al.·Journal of endometriosis and pelvic pain disorders·2015

This study compared women with endometriosis in the USA and Puerto Rico to see if their symptoms and health conditions differed. Researchers found that while both groups experienced similar types of pain and fertility problems, women in the USA reported more severe pain and more often had other chronic conditions like chronic fatigue syndrome and fibromyalgia. Women in Puerto Rico more frequently reported miscarriages.

E2 ModerateCohortPEM not requiredCross-Sectional

Timed loaded standing in female chronic fatigue syndrome compared with other populations.

Eyskens, Jan B, Nijs, Jo, D'Août, Kristiaan et al.·Journal of rehabilitation research and development·2015

Researchers tested how long women with ME/CFS could hold small weights with their arms extended straight out—a test that measures muscle endurance in the arms and trunk. Women with ME/CFS performed significantly worse than healthy women and even worse than older women with osteoporosis, suggesting a specific weakness pattern in ME/CFS. This finding could help guide rehabilitation programs that focus on movement quality rather than just building strength.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

[Mapping of function in chronic fatigue syndrome].

Nyland, Harald, Næss, Halvor, Nyland, Morten·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2015

This study examined how different body functions are affected in people with ME/CFS by mapping their characteristics across a group of patients. The research looked at various functional areas to better understand the pattern of symptoms and impairments experienced by those with the condition. This type of mapping helps clinicians and researchers see which functions are most commonly affected and how they relate to each other.

E2 ModerateCohortPEM requiredObservational

Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Shukla, Sanjay K, Cook, Dane, Meyer, Jacob et al.·PloS one·2015

This study examined whether the bacteria living in the gut of ME/CFS patients behave differently after exercise compared to healthy people. Researchers collected stool and blood samples from 10 ME/CFS patients and 10 healthy controls before and after an intense exercise test. They found that after exercise, ME/CFS patients showed unusual changes in their gut bacteria and had more bacterial DNA circulating in their blood 72 hours later—something that didn't happen in healthy people.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Frequency of Migraine Headaches in Patients With Fibromyalgia.

Vij, Brinder, Whipple, Mary O, Tepper, Stewart J et al.·Headache·2015

This study examined how often people with fibromyalgia experience migraine headaches. Researchers surveyed over 1,700 fibromyalgia patients and found that about 56% met the criteria for migraines. People with both conditions were more likely to also have depression, anxiety, IBS, and chronic fatigue syndrome, suggesting these overlapping conditions increase overall burden on patients.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

A Cross Cultural Comparison of Disability and Symptomatology Associated with CFS.

Zdunek, Maria, Jason, Leonard A, Evans, Meredyth et al.·International journal of psychology and behavioral sciences·2015

This study compared ME/CFS symptoms and disability between patients in the United States and the United Kingdom to see if the illness looks different depending on where people live. Researchers found that UK patients reported more mental health problems, pain, memory/concentration issues, and immune symptoms, while US patients more often experienced sudden illness onset and attributed their illness to physical causes. The study suggests that ME/CFS may present somewhat differently across these two countries.

Pain and SensitizationSleepCognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Lau, Chi-ieong, Lin, Che-Chen, Chen, Wei-Hung et al.·Journal of psychosomatic research·2015

This study found that people with migraine headaches are 1.5 times more likely to develop ME/CFS than people without migraine. The risk was even higher in older adults (age 65+), who were more than twice as likely to develop ME/CFS if they had migraines. The more frequently someone had migraines, the higher their risk of developing ME/CFS appeared to be.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the LifeLines Cohort Study.

Janssens, Karin A M, Zijlema, Wilma L, Joustra, Monica L et al.·Psychosomatic medicine·2015

This study looked at how often mood and anxiety disorders occur in people with ME/CFS, fibromyalgia, and irritable bowel syndrome compared to people without these conditions. Researchers found that people with these syndromes do experience depression and anxiety more often than the general population, but most people with these conditions do not have a psychiatric disorder. ME/CFS patients had the highest rates of mood and anxiety problems among the three conditions studied.

E2 ModerateCohortPEM not requiredCross-Sectional

Functional level of patients with chronic fatigue syndrome reporting use of alternative vs. traditional treatments.

Wise, Shelby, Jantke, Rachel, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2015

This study looked at 97 ME/CFS patients to compare how well they were functioning based on the treatments they used. Patients were divided into three groups: those using only complementary/alternative medicine (CAM), those using only traditional medicine, and those using both. The study found that patients using CAM alone had better social functioning and fewer psychiatric diagnoses compared to the other groups.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology.

Sáez-Francàs, Naia, Calvo, Natalia, Alegre, José et al.·Comprehensive psychiatry·2015

This study looked at whether ME/CFS patients who experienced childhood trauma are more likely to have personality disorders and mental health challenges like depression. Researchers surveyed 166 ME/CFS patients using questionnaires about their childhood experiences and current mental health. They found that about one-third had experienced childhood trauma, and nearly half had signs of a personality disorder. Importantly, emotional trauma (like neglect or abuse) was more strongly connected to personality disorders than physical trauma.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report.

Coplan, Jeremy, Singh, Deepan, Gopinath, Srinath et al.·The Journal of neuropsychiatry and clinical neurosciences·2015

Researchers found that people with anxiety disorders often experience multiple related physical and mental health conditions together—including joint looseness, chronic pain, immune problems, and mood disorders. They studied 76 patients and discovered that over 80% had panic attacks, fibromyalgia, and depression at the same time. This suggests these conditions may be connected as part of a larger syndrome rather than separate illnesses.

Immune System

E2 ModerateBehavioralPEM not requiredLongitudinal

The impact of significant other expressed emotion on patient outcomes in chronic fatigue syndrome.

Band, Rebecca, Barrowclough, Christine, Wearden, Alison·Health psychology : official journal of the Division of Health Psychology, American Psychological Association·2014

This study looked at how the emotional responses of family members or partners affect ME/CFS patients' health outcomes. Researchers found that when significant others were overly critical or overly involved, patients tended to have worse fatigue, more disability, and more depression 6 months later. The emotional support you receive from those close to you appears to matter for how your ME/CFS progresses.

E2 ModeratePEM unclearRegistry-Resource

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012.

Bakken, Inger Johanne, Tveito, Kari, Gunnes, Nina et al.·BMC medicine·2014

This study tracked how often ME/CFS is diagnosed in Norway between 2008 and 2012. Researchers found that about 26 people per 100,000 develop ME/CFS each year, and women are diagnosed about three times more often than men. Interestingly, the disease peaks twice: once in teenagers and again in people in their 30s, which suggests that different life stages or age-related factors may influence who gets ME/CFS.

E2 ModerateCohortPEM not requiredObservational

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Lebedeva, A V, Shchukin, I A, Soldatov, M A et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2014

This study looked at 35 people with multiple sclerosis (MS) who experienced severe fatigue and mood problems. Researchers gave them a supplement called idebenon for 6 months and found it reduced their fatigue, tiredness, and depression. While this is interesting, it's important to note this study focused on MS patients, not ME/CFS patients, though both conditions involve fatigue.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Comorbid personality disorders in chronic fatigue syndrome patients: a marker of psychopathological severity.

Altered resting brain connectivity in persistent cancer related fatigue.

Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.

The Process of Change in Pain During Cognitive-Behavior Therapy for Chronic Fatigue Syndrome.

Reduced gait automaticity in female patients with chronic fatigue syndrome: Case-control study.

Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana.

Characteristics of women with endometriosis from the USA and Puerto Rico.

Timed loaded standing in female chronic fatigue syndrome compared with other populations.

[Mapping of function in chronic fatigue syndrome].

Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Frequency of Migraine Headaches in Patients With Fibromyalgia.

A Cross Cultural Comparison of Disability and Symptomatology Associated with CFS.

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Mood and Anxiety Disorders in Chronic Fatigue Syndrome, Fibromyalgia, and Irritable Bowel Syndrome: Results From the LifeLines Cohort Study.

Functional level of patients with chronic fatigue syndrome reporting use of alternative vs. traditional treatments.

Childhood trauma in Chronic Fatigue Syndrome: focus on personality disorders and psychopathology.

A Novel Anxiety and Affective Spectrum Disorder of Mind and Body-The ALPIM (Anxiety-Laxity-Pain-Immune-Mood) Syndrome: A Preliminary Report.

The impact of significant other expressed emotion on patient outcomes in chronic fatigue syndrome.

Two age peaks in the incidence of chronic fatigue syndrome/myalgic encephalomyelitis: a population-based registry study from Norway 2008-2012.

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research