ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1281–1300 of 2,795 studies

E2 ModerateCohortPEM requiredCross-Sectional

Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome.

Asprusten, Tarjei Tørre, Fagermoen, Even, Sulheim, Dag et al.·Acta paediatrica (Oslo, Norway : 1992)·2015

Researchers tested whether the Canadian Consensus Criteria—a set of guidelines used to diagnose ME/CFS in teenagers—actually identify meaningful differences between patients. They compared 120 adolescents with ME/CFS, grouping them by whether they met these criteria or not. The study found that the two groups were nearly identical in most disease markers and how they recovered over time, suggesting the criteria may not be capturing important real-world differences between patients.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Frequent IgG subclass and mannose binding lectin deficiency in patients with chronic fatigue syndrome.

Guenther, Sabrina, Loebel, Madlen, Mooslechner, Agnes A et al.·Human immunology·2015

This study looked at immune system proteins called antibodies and a molecule called mannose binding lectin (MBL) in 300 people with ME/CFS. The researchers found that about 25% of patients had lower-than-normal levels of certain antibodies, while another 25% had higher-than-normal levels. Additionally, 15% had low MBL levels, compared to only 6% in healthy people. These immune defects were connected to frequent respiratory infections in ME/CFS patients.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

[Mapping of function in chronic fatigue syndrome].

Nyland, Harald, Næss, Halvor, Nyland, Morten·Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·2015

This study examined how different body functions are affected in people with ME/CFS by mapping their characteristics across a group of patients. The research looked at various functional areas to better understand the pattern of symptoms and impairments experienced by those with the condition. This type of mapping helps clinicians and researchers see which functions are most commonly affected and how they relate to each other.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Comorbid personality disorders in chronic fatigue syndrome patients: a marker of psychopathological severity.

Calvo, Natalia, Sáez-Francàs, Naia, Valero, Sergi et al.·Actas espanolas de psiquiatria·2015

This study looked at whether people with ME/CFS are more likely to have personality disorders—long-standing patterns of thinking and behavior that can affect how someone relates to others. Researchers assessed 132 ME/CFS patients and found that about half had traits associated with personality disorders, particularly obsessive-compulsive and avoidant patterns. Patients with these personality traits also reported more depression, irritability, and guilt.

E2 ModerateCohortPEM not requiredCross-Sectional

Painful Bladder Filling and Painful Urgency are Distinct Characteristics in Men and Women with Urological Chronic Pelvic Pain Syndromes: A MAPP Research Network Study.

Lai, H Henry, Krieger, John N, Pontari, Michel A et al.·The Journal of urology·2015

This study looked at bladder pain patterns in people with chronic pelvic pain conditions. Researchers found that most patients experienced either pain when their bladder filled up or pain/pressure sensations when feeling the urge to urinate. People with these bladder symptoms also reported more severe pain, more frequent urges to urinate, depression, fatigue, and poorer quality of life compared to those without these specific bladder symptoms.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Altered resting brain connectivity in persistent cancer related fatigue.

Hampson, Johnson P, Zick, Suzanna M, Khabir, Tohfa et al.·NeuroImage. Clinical·2015

This study used brain imaging to compare how the brains of breast cancer survivors with fatigue differ from those without fatigue. Researchers found that people experiencing persistent cancer-related fatigue showed different patterns of communication between brain regions, particularly involving areas linked to thinking about oneself and regulating sleep. These brain connectivity differences were associated with worse physical fatigue and poor sleep quality.

Sleep

E2 ModerateCohortPEM requiredCross-Sectional

Chronic Fatigue Syndrome and Myalgic Encephalomyelitis: Toward An Empirical Case Definition.

Jason, Leonard A, Kot, Bobby, Sunnquist, Madison et al.·Health psychology and behavioral medicine·2015

Researchers studied which symptoms are most important for diagnosing ME/CFS by comparing patients with the condition to people without it. They found that four main symptoms stood out: extreme fatigue, symptom worsening after activity (called post-exertional malaise), thinking or memory problems, and sleep that doesn't feel refreshing. Using these core symptoms could help doctors diagnose ME/CFS more reliably.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Frequency of Migraine Headaches in Patients With Fibromyalgia.

Vij, Brinder, Whipple, Mary O, Tepper, Stewart J et al.·Headache·2015

This study examined how often people with fibromyalgia experience migraine headaches. Researchers surveyed over 1,700 fibromyalgia patients and found that about 56% met the criteria for migraines. People with both conditions were more likely to also have depression, anxiety, IBS, and chronic fatigue syndrome, suggesting these overlapping conditions increase overall burden on patients.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Slow wave sleep in the chronically fatigued: Power spectra distribution patterns in chronic fatigue syndrome and primary insomnia.

Neu, Daniel, Mairesse, Olivier, Verbanck, Paul et al.·Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2015

This study looked at the deepest, most restorative type of sleep in people with ME/CFS and primary insomnia to understand why both groups feel tired and don't feel rested despite sleeping. Researchers used special brain wave measurements during sleep and found that both groups had unusual patterns of very slow brain waves during deep sleep, even though they were getting normal or sometimes even extra amounts of deep sleep. The findings suggest that the problem may not be getting enough deep sleep, but rather that the quality or type of brain activity during that sleep is different.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic multisymptom illness among female Veterans deployed to Iraq and Afghanistan.

Mohanty, April F, Muthukutty, Anusha, Carter, Marjorie E et al.·Medical care·2015

This study looked at how common chronic multisymptom illnesses—including chronic fatigue syndrome, fibromyalgia, and irritable bowel syndrome—are among female veterans who deployed to Iraq and Afghanistan. Researchers found that these conditions were more than twice as common in this group compared to other female veterans. The study suggests that deployment experiences may play a role in developing these illnesses.

E2 ModeratePEM not requiredRegistry-Resource

Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.

Belcaro, G, Cornelli, U, Luzzi, R et al.·Journal of neurosurgical sciences·2015

This study tested whether a natural plant extract called Robuvit (made from oak wood) might help people with ME/CFS who had signs of increased oxidative stress—a type of cellular damage. Thirty-eight people with ME/CFS took Robuvit supplements for 6 months while also following a structured lifestyle plan (better sleep, exercise, diet, and relaxation), and they were compared to 42 similar people who followed the plan without the supplement. The group taking Robuvit reported more improvement in fatigue symptoms and had lower markers of oxidative stress in their blood.

E2 ModerateCohortPEM not requiredObservational

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.

Vangeel, Elise, Van Den Eede, Filip, Hompes, Titia et al.·Psychosomatic medicine·2015

This study looked at a chemical marker called DNA methylation on a gene (NR3C1) that controls how the body responds to stress. Researchers found that people with ME/CFS had lower levels of this methylation compared to healthy people, which may explain why their bodies don't handle stress hormones properly. Interestingly, childhood trauma did not appear to create additional changes in this marker among ME/CFS patients.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana.

Bauer, Amy E, Olivas, Sonora, Cooper, Maria et al.·BMC veterinary research·2015

Researchers tested milk samples from 316 dairy farms in Indiana to see how common a bacterium called Coxiella burnetii is in cattle herds. This bacterium causes Q fever, which can lead to chronic fatigue in people. They found that over 61% of Indiana dairy herds had evidence of this bacterium in their milk, suggesting it is widespread among cattle.

E2 ModerateBehavioralPEM not requiredLongitudinal

The Process of Change in Pain During Cognitive-Behavior Therapy for Chronic Fatigue Syndrome.

Bloot, Lotte, Heins, Marianne J, Donders, Rogier et al.·The Clinical journal of pain·2015

This study looked at how cognitive-behavioral therapy (CBT)—a talk therapy that helps change thoughts and behaviors—reduces pain in ME/CFS patients. Researchers followed 142 patients over the course of their treatment and found that pain and fatigue tend to improve together. The improvement in pain appeared to be partly explained by patients doing more physical activity and thinking less about their symptoms, though other factors also played a role.

Pain and Sensitization

E2 ModerateBehavioralPEM not requiredCross-Sectional

The Preinterventional Psychiatric History as a Major Predictor for a Reduced Quality of Life After Treatment of Unruptured Intracranial Aneurysms.

Fontana, Johann, Wenz, Ralf, Groden, Christoph et al.·World neurosurgery·2015

This study looked at patients who had surgery for unruptured brain aneurysms (weak blood vessel spots in the brain that hadn't bled yet) and compared them to patients who had surgery for brain tumors. The researchers found that patients with a history of psychiatric conditions before surgery reported worse quality of life and more chronic fatigue symptoms after surgery, but when they removed those patients from the analysis, the differences went away. This suggests that pre-existing mental health conditions, not the aneurysm or surgery itself, may explain poor outcomes.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Reduced gait automaticity in female patients with chronic fatigue syndrome: Case-control study.

Eyskens, Jan B, Nijs, Jo, Wouters, Kristien et al.·Journal of rehabilitation research and development·2015

This study tested how automatically women with ME/CFS can walk while doing other things at the same time. Researchers asked women with ME/CFS and healthy women to walk, close their eyes, and solve a math problem. Most women with ME/CFS stopped walking when they had to do the math problem with their eyes closed, while most healthy women kept walking. This suggests that walking requires more conscious effort and attention in ME/CFS patients than in healthy people.

E2 ModerateCohortPEM not requiredCross-Sectional

Timed loaded standing in female chronic fatigue syndrome compared with other populations.

Eyskens, Jan B, Nijs, Jo, D'Août, Kristiaan et al.·Journal of rehabilitation research and development·2015

Researchers tested how long women with ME/CFS could hold small weights with their arms extended straight out—a test that measures muscle endurance in the arms and trunk. Women with ME/CFS performed significantly worse than healthy women and even worse than older women with osteoporosis, suggesting a specific weakness pattern in ME/CFS. This finding could help guide rehabilitation programs that focus on movement quality rather than just building strength.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredObservational

Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Shukla, Sanjay K, Cook, Dane, Meyer, Jacob et al.·PloS one·2015

This study examined whether the bacteria living in the gut of ME/CFS patients behave differently after exercise compared to healthy people. Researchers collected stool and blood samples from 10 ME/CFS patients and 10 healthy controls before and after an intense exercise test. They found that after exercise, ME/CFS patients showed unusual changes in their gut bacteria and had more bacterial DNA circulating in their blood 72 hours later—something that didn't happen in healthy people.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

Lau, Chi-ieong, Lin, Che-Chen, Chen, Wei-Hung et al.·Journal of psychosomatic research·2015

This study found that people with migraine headaches are 1.5 times more likely to develop ME/CFS than people without migraine. The risk was even higher in older adults (age 65+), who were more than twice as likely to develop ME/CFS if they had migraines. The more frequently someone had migraines, the higher their risk of developing ME/CFS appeared to be.

E2 ModerateCohortPEM not requiredCross-Sectional

A Cross Cultural Comparison of Disability and Symptomatology Associated with CFS.

Zdunek, Maria, Jason, Leonard A, Evans, Meredyth et al.·International journal of psychology and behavioral sciences·2015

This study compared ME/CFS symptoms and disability between patients in the United States and the United Kingdom to see if the illness looks different depending on where people live. Researchers found that UK patients reported more mental health problems, pain, memory/concentration issues, and immune symptoms, while US patients more often experienced sudden illness onset and attributed their illness to physical causes. The study suggests that ME/CFS may present somewhat differently across these two countries.

Pain and SensitizationSleepCognitive Impairment

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Study findings challenge the content validity of the Canadian Consensus Criteria for adolescent chronic fatigue syndrome.

Frequent IgG subclass and mannose binding lectin deficiency in patients with chronic fatigue syndrome.

[Mapping of function in chronic fatigue syndrome].

Comorbid personality disorders in chronic fatigue syndrome patients: a marker of psychopathological severity.

Painful Bladder Filling and Painful Urgency are Distinct Characteristics in Men and Women with Urological Chronic Pelvic Pain Syndromes: A MAPP Research Network Study.

Altered resting brain connectivity in persistent cancer related fatigue.

Chronic Fatigue Syndrome and Myalgic Encephalomyelitis: Toward An Empirical Case Definition.

Frequency of Migraine Headaches in Patients With Fibromyalgia.

Slow wave sleep in the chronically fatigued: Power spectra distribution patterns in chronic fatigue syndrome and primary insomnia.

Chronic multisymptom illness among female Veterans deployed to Iraq and Afghanistan.

Robuvit® (Quercus robur extract) supplementation in subjects with chronic fatigue syndrome and increased oxidative stress. A pilot registry study.

Chronic Fatigue Syndrome and DNA Hypomethylation of the Glucocorticoid Receptor Gene Promoter 1F Region: Associations With HPA Axis Hypofunction and Childhood Trauma.

Estimated herd prevalence and sequence types of Coxiella burnetii in bulk tank milk samples from commercial dairies in Indiana.

The Process of Change in Pain During Cognitive-Behavior Therapy for Chronic Fatigue Syndrome.

The Preinterventional Psychiatric History as a Major Predictor for a Reduced Quality of Life After Treatment of Unruptured Intracranial Aneurysms.

Reduced gait automaticity in female patients with chronic fatigue syndrome: Case-control study.

Timed loaded standing in female chronic fatigue syndrome compared with other populations.

Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Increased risk of chronic fatigue syndrome in patients with migraine: A retrospective cohort study.

A Cross Cultural Comparison of Disability and Symptomatology Associated with CFS.

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