ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1341–1360 of 2,795 studies

E2 ModerateBehavioralPEM not requiredCase-Control

Dimensions of pure chronic fatigue: psychophysical, cognitive and biological correlates in the chronic fatigue syndrome.

Neu, Daniel, Mairesse, Olivier, Montana, Xavier et al.·European journal of applied physiology·2014

This study compared 16 people with ME/CFS to 14 healthy controls to understand fatigue better. Researchers measured attention, reaction time, muscle strength, sleep patterns, and immune markers (cytokines). They found that people with ME/CFS had cognitive problems, slower reactions, weaker grip strength, and higher levels of certain inflammatory markers—but their sleep time was actually similar to controls.

Immune System

E2 ModeratePEM not requiredRegistry-Resource

Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.

Belcaro, G, Cornelli, U, Luzzi, R et al.·Panminerva medica·2014

This small study tested whether a supplement made from French oak wood extract (Robuvit®) could help people with chronic fatigue syndrome (CFS) when combined with a structured management plan. About half of the 91 participants received the supplement for 6 months while the other half followed the management plan alone. The supplement group showed greater improvements in fatigue symptoms and mood compared to the management-only group, and no side effects were reported.

Interventions

E2 ModeratePEM unclearBiobank-Resource

No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank.

Irlbeck, David M, Vernon, Suzanne D, McCleary, K Kimberly et al.·BMC research notes·2014

Researchers investigated whether two viruses (XMRV and pMLV) were present in people with ME/CFS, as had been suggested by earlier studies. They collected blood samples from people with ME/CFS and healthy people across five different U.S. locations and used sensitive testing methods to look for these viruses. They found no meaningful difference in virus detection between the two groups, and the virus sequences they did find appeared to be contamination from lab materials rather than real infections.

E2 ModerateMechanismPEM unclearMechanistic

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Yasuhito Nakatomi, Kei Mizuno, Akira Ishii et al.·Brain, Behavior, and Immunity·2014·n=9

Japanese researchers used PET imaging with a neuroinflammation tracer (PK11195) in 9 ME/CFS patients and healthy controls. They found significantly elevated neuroinflammation signals across multiple brain regions in ME/CFS patients, particularly in the cingulate cortex, thalamus, and brainstem — areas regulating fatigue and cognition.

Neuroinflammation

E2 ModerateReviewPEM unclearReview-Narrative

The neuroinflammatory hypothesis of chronic fatigue syndrome/myalgic encephalomyelitis: an update

Jarred W. Younger, Linda Yan, Sean Mackey·Journal of Neuroinflammation·2014·n=18

Using thermography and brain temperature imaging at Stanford, this study found evidence consistent with neuroinflammation — specifically elevated brain temperature — in ME/CFS patients compared to healthy controls. Brain regions associated with pain and fatigue showed the strongest signal.

Neuroinflammation

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Tsai, S-Y, Yang, T-Y, Chen, H-J et al.·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014

This study found that people who had shingles (herpes zoster) had a higher risk of developing ME/CFS compared to people who didn't have shingles. Researchers followed thousands of people over several years and found that those with a history of shingles were about 29% more likely to develop chronic fatigue syndrome, suggesting that viral infections like shingles may trigger ME/CFS in some people.

E2 ModerateCohortPEM unclearCross-Sectional

Use of an online survey to explore positive and negative outcomes of rehabilitation for people with CFS/ME.

Gladwell, Peter William, Pheby, Derek, Rodriguez, Tristana et al.·Disability and rehabilitation·2014

This study asked 76 people with ME/CFS about their experiences with rehabilitation therapies like graded exercise. Researchers found that people had both positive and negative experiences. Good experiences happened when therapists communicated well, helped patients set realistic goals, and worked at a sustainable pace. Bad experiences occurred when therapists pushed patients too hard, didn't listen to their concerns, or blamed patients when symptoms got worse.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures.

Cockshell, Susan J, Mathias, Jane L·Neuropsychology·2014

This study looked at whether people with ME/CFS who report memory and concentration problems actually perform worse on cognitive tests. Fifty people with ME/CFS and 50 healthy controls completed questionnaires about their cognitive difficulties and took standardized memory and attention tests. Surprisingly, while people with ME/CFS reported significantly more cognitive problems in daily life, both groups performed similarly on the objective tests, and reported problems didn't match test results in either group.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Cortisol output in adolescents with chronic fatigue syndrome: pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment.

Rimes, Katharine A, Papadopoulos, Andrew S, Cleare, Anthony J et al.·Journal of psychosomatic research·2014

This study measured stress hormone (cortisol) levels in teenagers with ME/CFS compared to healthy teenagers. Teenagers with ME/CFS had lower cortisol levels throughout the day than healthy peers. After cognitive behavioural treatment, cortisol levels in the ME/CFS group returned to normal, suggesting the hormonal difference may be reversible.

Endocrine Disruption

E2 ModerateCohortPEM not requiredLongitudinal

The role of hypocortisolism in chronic fatigue syndrome.

Nijhof, Sanne L, Rutten, Juliette M T M, Uiterwaal, Cuno S P M et al.·Psychoneuroendocrinology·2014

This study looked at stress hormone levels (cortisol) in adolescents with ME/CFS by measuring saliva samples. Teenagers with ME/CFS had lower cortisol levels than healthy peers, and those who improved with treatment showed their cortisol levels normalize, while those who didn't recover showed little change. The findings suggest that restoration of normal cortisol production during treatment may be linked to better outcomes.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study.

Norheim, Katrine Brække, Le Hellard, Stephanie, Nordmark, Gunnel et al.·Rheumatology international·2014

This study looked at whether specific genetic differences might explain why some people with Sjögren's syndrome experience severe fatigue while others don't. Researchers compared the genes of 193 Sjögren's patients with high and low fatigue levels to 376 healthy people. They found hints that variations in two genes (SLC25A40 and PKN1) might be linked to fatigue, particularly severe fatigue, but the findings were preliminary and need to be confirmed in larger studies.

E2 ModerateCohortPEM not requiredLongitudinal

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: a population-based matched-cohort study.

Chung, Shiu-Dong, Lin, Ching-Chun, Liu, Shih-Ping et al.·Neurourology and urodynamics·2014

This study found that people with obstructive sleep apnea (OSA)—a condition where breathing stops repeatedly during sleep—are nearly 4 times more likely to develop bladder pain syndrome/interstitial cystitis (BPS/IC) compared to people without OSA. Researchers followed over 32,000 people in Taiwan for 3 years and tracked who developed BPS/IC. The findings suggest that sleep problems and bladder pain may be connected, and doctors should ask patients with sleep apnea about urinary symptoms.

Sleep

E2 ModerateCohortPEM not requiredObservational

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Lebedeva, A V, Shchukin, I A, Soldatov, M A et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2014

This study looked at 35 people with multiple sclerosis (MS) who experienced severe fatigue and mood problems. Researchers gave them a supplement called idebenon for 6 months and found it reduced their fatigue, tiredness, and depression. While this is interesting, it's important to note this study focused on MS patients, not ME/CFS patients, though both conditions involve fatigue.

E2 ModerateCohortPEM not requiredObservational

Effect of high dose vitamin C on Epstein-Barr viral infection.

Mikirova, Nina, Hunninghake, Ronald·Medical science monitor : international medical journal of experimental and clinical research·2014

This study looked at whether high-dose vitamin C given through an IV might help people with Epstein-Barr virus (EBV) infection, including those with ME/CFS. Researchers reviewed medical records of 178 patients who received vitamin C infusions and had elevated EBV antibodies. They found that patients who received these treatments showed lower levels of EBV antibodies over time, and that higher vitamin C levels in the blood were associated with lower viral markers.

E2 ModerateCohortPEM requiredCross-Sectional

Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis.

Jason, Leonard A, Sunnquist, Madison, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2014

This study looked at different ways doctors define ME/CFS by comparing symptoms in 236 patients and 86 healthy people. The researchers found that simply looking for the presence of symptoms isn't enough—the frequency and severity matter greatly. Three key symptoms stood out as the best way to identify ME/CFS patients: extreme fatigue, difficulty focusing on multiple things at once, and feeling heavy or exhausted after exercise.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Predictors of Post-Infectious Chronic Fatigue Syndrome in Adolescents.

Jason, Leonard A, Katz, Ben Z, Shiraishi, Yukiko et al.·Health psychology and behavioral medicine·2014

This study followed over 300 teenagers who had infectious mononucleosis to see which ones developed ME/CFS afterward. Researchers measured various factors at baseline, including how tired the teens felt, how many days they spent in bed, stress levels, and mood. The key finding was that the severity of the initial mono illness—particularly how long teens stayed in bed—was the strongest predictor of who would develop ME/CFS within 6 months.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

No evidence of XMRV provirus sequences in patients with myalgic encephalomyelitis/chronic fatigue syndrome and individuals with unspecified encephalopathy.

Rasa, Santa, Nora-Krukle, Zaiga, Chapenko, Svetlana et al.·The new microbiologica·2014

Researchers tested blood and brain tissue samples from people with ME/CFS, people with other brain conditions, and healthy people to see if they carried a virus called XMRV. The virus had been suspected as a possible cause of ME/CFS. The study found no evidence of XMRV in any of the samples tested, suggesting this particular virus is not present in ME/CFS patients.

E2 ModerateCohortPEM unclearCross-Sectional

[Impact of the fibromyalgia in the chronic fatigue syndrome].

Faro, Mónica, Sáez-Francàs, Naia, Castro-Marrero, Jesús et al.·Medicina clinica·2014

This study looked at nearly 1,000 ME/CFS patients to see how many also had fibromyalgia (a condition causing widespread pain and fatigue), and whether having both conditions made symptoms worse. They found that about half of the ME/CFS patients also had fibromyalgia, and those patients experienced higher levels of fatigue, pain, sleep problems, and cognitive difficulties. People with both conditions reported a much greater impact on their quality of life compared to those with ME/CFS alone.

SleepAutonomic Nervous SystemCognitive Impairment

E2 ModerateCohortPEM not requiredLongitudinal

Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study.

Chen, C-S, Lin, W-M, Yang, T-Y et al.·QJM : monthly journal of the Association of Physicians·2014

This study found that people with ME/CFS have a higher risk of breaking bones compared to people without ME/CFS. Researchers followed nearly 4,000 patients with ME/CFS and about 15,000 without the condition over several years and found that fractures occurred more frequently in the ME/CFS group. Interestingly, this increased fracture risk did not appear to be mainly caused by weakened bones (osteoporosis), suggesting a different mechanism may be at play.

E2 ModerateCohortPEM not requiredLongitudinal

The MAPP research network: design, patient characterization and operations.

Landis, J Richard, Williams, David A, Lucia, M Scott et al.·BMC urology·2014

The MAPP Research Network is a large study designed to understand chronic pelvic pain conditions and related illnesses like fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. Researchers followed over 1,000 patients at six sites across the United States, collecting detailed information about their symptoms, blood samples, and brain imaging to identify what causes these conditions and how they connect to each other.

Biomarkers

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Dimensions of pure chronic fatigue: psychophysical, cognitive and biological correlates in the chronic fatigue syndrome.

Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.

No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

The neuroinflammatory hypothesis of chronic fatigue syndrome/myalgic encephalomyelitis: an update

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Use of an online survey to explore positive and negative outcomes of rehabilitation for people with CFS/ME.

Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures.

Cortisol output in adolescents with chronic fatigue syndrome: pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment.

The role of hypocortisolism in chronic fatigue syndrome.

A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study.

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: a population-based matched-cohort study.

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Effect of high dose vitamin C on Epstein-Barr viral infection.

Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis.

Predictors of Post-Infectious Chronic Fatigue Syndrome in Adolescents.

No evidence of XMRV provirus sequences in patients with myalgic encephalomyelitis/chronic fatigue syndrome and individuals with unspecified encephalopathy.

[Impact of the fibromyalgia in the chronic fatigue syndrome].

Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study.

The MAPP research network: design, patient characterization and operations.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research