ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1341–1360 of 2,807 studies

E2 ModerateCohortPEM not requiredCase-Control

A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study.

Norheim, Katrine Brække, Le Hellard, Stephanie, Nordmark, Gunnel et al.·Rheumatology international·2014

This study looked at whether specific genetic differences might explain why some people with Sjögren's syndrome experience severe fatigue while others don't. Researchers compared the genes of 193 Sjögren's patients with high and low fatigue levels to 376 healthy people. They found hints that variations in two genes (SLC25A40 and PKN1) might be linked to fatigue, particularly severe fatigue, but the findings were preliminary and need to be confirmed in larger studies.

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue and depression in sick-listed chronic low back pain patients.

Snekkevik, Hildegun, Eriksen, Hege R, Tangen, Tone et al.·Pain medicine (Malden, Mass.)·2014

This study looked at 569 people with chronic lower back pain who were off work, and found that about 70% of them experienced severe fatigue. People with more fatigue also reported more pain, depression, and disability. Importantly, fatigue was able to predict who would have more difficulty functioning 6 to 12 months later, even after accounting for pain and depression.

E2 ModerateCohortPEM unclearCross-Sectional

Traditional Chinese medicine and new concepts of predictive, preventive and personalized medicine in diagnosis and treatment of suboptimal health.

Wang, Wei, Russell, Alyce, Yan, Yuxiang et al.·The EPMA journal·2014

This study looked at how to identify people in the early stages of health problems before they develop into serious diseases. The researchers created a simple 25-question survey to measure 'suboptimal health'—a state where people feel unwell with fatigue and other complaints but don't have a clear diagnosis. They tested this survey with over 3,400 people in China and found that answers to the survey were connected to blood pressure, blood sugar, and cholesterol levels.

Diagnostics

E2 ModerateBehavioralPEM not requiredLongitudinal

Construct validity and temporal stability of the abridged 31-item Illness Behaviour Questionnaire.

Prior, Kirsty N, Bond, Malcolm J·Psychology & health·2014

This study tested a questionnaire that measures how people think about their illness, including how much they believe they are ill, how worried they are about their health, and their overall mood. Researchers gave this questionnaire to 675 people—some healthy and some with chronic conditions like asthma, diabetes, chronic pain, or ME/CFS—and checked it again after 3 and 12 months. The questionnaire performed reasonably well and remained fairly stable over time.

E2 ModerateCohortPEM unclearCase-Control

Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia.

Ickmans, Kelly, Meeus, Mira, De Kooning, Margot et al.·European journal of clinical investigation·2014

This study looked at how quickly upper arm muscles recover after exercise in people with ME/CFS. Researchers compared three groups: people with ME/CFS alone, people with ME/CFS plus fibromyalgia, and healthy controls. They found that people with both ME/CFS and fibromyalgia had slower muscle recovery than healthy people, but those with ME/CFS alone did not show this difference. This suggests ME/CFS may affect people differently depending on whether they also have fibromyalgia.

Post-Exertional Malaise

E2 ModeratePEM not requiredRegistry-Resource

Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.

Belcaro, G, Cornelli, U, Luzzi, R et al.·Panminerva medica·2014

This small study tested whether a supplement made from French oak wood extract (Robuvit®) could help people with chronic fatigue syndrome (CFS) when combined with a structured management plan. About half of the 91 participants received the supplement for 6 months while the other half followed the management plan alone. The supplement group showed greater improvements in fatigue symptoms and mood compared to the management-only group, and no side effects were reported.

Interventions

E2 ModerateBehavioralPEM not requiredLongitudinal

Influence of graded exercise therapy on anxiety levels and health-related quality of life in chronic fatigue syndrome.

Klasnja, A, Grujic, N, Popadic Gacesa, J et al.·The Journal of sports medicine and physical fitness·2014

This study tested whether graded exercise therapy (GET)—a program of gradually increasing physical activity—could help 26 ME/CFS patients feel better and worry less. After 12 weeks of GET, patients reported improved energy levels and reduced anxiety, particularly trait anxiety (how anxious people generally feel). The study also found that anxiety and quality of life are closely connected: patients with higher anxiety had lower quality of life, and vice versa.

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort.

Reynolds, G K, Lewis, D P, Richardson, A M et al.·Journal of internal medicine·2014

This study looked at patients with ME/CFS to see how many also have POTS (a condition where heart rate increases too much when standing). The researchers found that about 1 in 9 ME/CFS patients also had POTS, and these patients were younger, got sick more recently, and found it much harder to stand for long periods compared to ME/CFS patients without POTS.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCase-Control

Dimensions of pure chronic fatigue: psychophysical, cognitive and biological correlates in the chronic fatigue syndrome.

Neu, Daniel, Mairesse, Olivier, Montana, Xavier et al.·European journal of applied physiology·2014

This study compared 16 people with ME/CFS to 14 healthy controls to understand fatigue better. Researchers measured attention, reaction time, muscle strength, sleep patterns, and immune markers (cytokines). They found that people with ME/CFS had cognitive problems, slower reactions, weaker grip strength, and higher levels of certain inflammatory markers—but their sleep time was actually similar to controls.

Immune System

E2 ModeratePEM unclearBiobank-Resource

No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank.

Irlbeck, David M, Vernon, Suzanne D, McCleary, K Kimberly et al.·BMC research notes·2014

Researchers investigated whether two viruses (XMRV and pMLV) were present in people with ME/CFS, as had been suggested by earlier studies. They collected blood samples from people with ME/CFS and healthy people across five different U.S. locations and used sensitive testing methods to look for these viruses. They found no meaningful difference in virus detection between the two groups, and the virus sequences they did find appeared to be contamination from lab materials rather than real infections.

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Tsai, S-Y, Yang, T-Y, Chen, H-J et al.·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014

This study found that people who had shingles (herpes zoster) had a higher risk of developing ME/CFS compared to people who didn't have shingles. Researchers followed thousands of people over several years and found that those with a history of shingles were about 29% more likely to develop chronic fatigue syndrome, suggesting that viral infections like shingles may trigger ME/CFS in some people.

E2 ModerateMechanismPEM unclearMechanistic

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

Yasuhito Nakatomi, Kei Mizuno, Akira Ishii et al.·Brain, Behavior, and Immunity·2014·n=9

Japanese researchers used PET imaging with a neuroinflammation tracer (PK11195) in 9 ME/CFS patients and healthy controls. They found significantly elevated neuroinflammation signals across multiple brain regions in ME/CFS patients, particularly in the cingulate cortex, thalamus, and brainstem — areas regulating fatigue and cognition.

Neuroinflammation

E2 ModerateReviewPEM unclearReview-Narrative

The neuroinflammatory hypothesis of chronic fatigue syndrome/myalgic encephalomyelitis: an update

Jarred W. Younger, Linda Yan, Sean Mackey·Journal of Neuroinflammation·2014·n=18

Using thermography and brain temperature imaging at Stanford, this study found evidence consistent with neuroinflammation — specifically elevated brain temperature — in ME/CFS patients compared to healthy controls. Brain regions associated with pain and fatigue showed the strongest signal.

Neuroinflammation

E2 ModerateCohortPEM not requiredObservational

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Lebedeva, A V, Shchukin, I A, Soldatov, M A et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2014

This study looked at 35 people with multiple sclerosis (MS) who experienced severe fatigue and mood problems. Researchers gave them a supplement called idebenon for 6 months and found it reduced their fatigue, tiredness, and depression. While this is interesting, it's important to note this study focused on MS patients, not ME/CFS patients, though both conditions involve fatigue.

E2 ModerateCohortPEM not requiredObservational

Effect of high dose vitamin C on Epstein-Barr viral infection.

Mikirova, Nina, Hunninghake, Ronald·Medical science monitor : international medical journal of experimental and clinical research·2014

This study looked at whether high-dose vitamin C given through an IV might help people with Epstein-Barr virus (EBV) infection, including those with ME/CFS. Researchers reviewed medical records of 178 patients who received vitamin C infusions and had elevated EBV antibodies. They found that patients who received these treatments showed lower levels of EBV antibodies over time, and that higher vitamin C levels in the blood were associated with lower viral markers.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures.

Cockshell, Susan J, Mathias, Jane L·Neuropsychology·2014

This study looked at whether people with ME/CFS who report memory and concentration problems actually perform worse on cognitive tests. Fifty people with ME/CFS and 50 healthy controls completed questionnaires about their cognitive difficulties and took standardized memory and attention tests. Surprisingly, while people with ME/CFS reported significantly more cognitive problems in daily life, both groups performed similarly on the objective tests, and reported problems didn't match test results in either group.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Cortisol output in adolescents with chronic fatigue syndrome: pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment.

Rimes, Katharine A, Papadopoulos, Andrew S, Cleare, Anthony J et al.·Journal of psychosomatic research·2014

This study measured stress hormone (cortisol) levels in teenagers with ME/CFS compared to healthy teenagers. Teenagers with ME/CFS had lower cortisol levels throughout the day than healthy peers. After cognitive behavioural treatment, cortisol levels in the ME/CFS group returned to normal, suggesting the hormonal difference may be reversible.

Endocrine Disruption

E2 ModerateCohortPEM not requiredLongitudinal

The role of hypocortisolism in chronic fatigue syndrome.

Nijhof, Sanne L, Rutten, Juliette M T M, Uiterwaal, Cuno S P M et al.·Psychoneuroendocrinology·2014

This study looked at stress hormone levels (cortisol) in adolescents with ME/CFS by measuring saliva samples. Teenagers with ME/CFS had lower cortisol levels than healthy peers, and those who improved with treatment showed their cortisol levels normalize, while those who didn't recover showed little change. The findings suggest that restoration of normal cortisol production during treatment may be linked to better outcomes.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

How is paediatric chronic fatigue syndrome/myalgic encephalomyelitis diagnosed and managed by paediatricians? An Australian Paediatric Research Network Study.

Knight, Sarah, Harvey, Adrienne, Towns, Susan et al.·Journal of paediatrics and child health·2014

This study asked Australian pediatricians how they diagnose and treat children with ME/CFS. Only 39% of the doctors who responded said they actually diagnose and manage this condition, and they used very different approaches from each other. The doctors found that children with ME/CFS often also have anxiety, depression, and other conditions, and most used a team approach involving teachers, physiotherapists, and psychologists.

Diagnostics

E2 ModerateCohortPEM requiredCross-Sectional

Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis.

Jason, Leonard A, Sunnquist, Madison, Brown, Abigail et al.·Fatigue : biomedicine, health & behavior·2014

This study looked at different ways doctors define ME/CFS by comparing symptoms in 236 patients and 86 healthy people. The researchers found that simply looking for the presence of symptoms isn't enough—the frequency and severity matter greatly. Three key symptoms stood out as the best way to identify ME/CFS patients: extreme fatigue, difficulty focusing on multiple things at once, and feeling heavy or exhausted after exercise.

Post-Exertional Malaise

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A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study.

Fatigue and depression in sick-listed chronic low back pain patients.

Traditional Chinese medicine and new concepts of predictive, preventive and personalized medicine in diagnosis and treatment of suboptimal health.

Construct validity and temporal stability of the abridged 31-item Illness Behaviour Questionnaire.

Recovery of upper limb muscle function in chronic fatigue syndrome with and without fibromyalgia.

Improved management of primary chronic fatigue syndrome with the supplement French oak wood extract (Robuvit®): a pilot, registry evaluation.

Influence of graded exercise therapy on anxiety levels and health-related quality of life in chronic fatigue syndrome.

Comorbidity of postural orthostatic tachycardia syndrome and chronic fatigue syndrome in an Australian cohort.

Dimensions of pure chronic fatigue: psychophysical, cognitive and biological correlates in the chronic fatigue syndrome.

No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank.

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis

The neuroinflammatory hypothesis of chronic fatigue syndrome/myalgic encephalomyelitis: an update

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Effect of high dose vitamin C on Epstein-Barr viral infection.

Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures.

Cortisol output in adolescents with chronic fatigue syndrome: pilot study on the comparison with healthy adolescents and change after cognitive behavioural guided self-help treatment.

The role of hypocortisolism in chronic fatigue syndrome.

How is paediatric chronic fatigue syndrome/myalgic encephalomyelitis diagnosed and managed by paediatricians? An Australian Paediatric Research Network Study.

Examining case definition criteria for chronic fatigue syndrome and myalgic encephalomyelitis.

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