ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1361–1380 of 2,807 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome.

Vermeulen, Ruud C W, Vermeulen van Eck, Ineke W G·Journal of translational medicine·2014

This study looked at how well the body uses oxygen during exercise in people with ME/CFS compared to healthy people. Researchers found that people with ME/CFS extract less oxygen from their blood during exercise than healthy people do, suggesting their muscles aren't using oxygen efficiently. Interestingly, their hearts have to pump much harder to deliver oxygen, which argues against the idea that ME/CFS is simply caused by deconditioning (being out of shape).

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Predictors of Post-Infectious Chronic Fatigue Syndrome in Adolescents.

Jason, Leonard A, Katz, Ben Z, Shiraishi, Yukiko et al.·Health psychology and behavioral medicine·2014

This study followed over 300 teenagers who had infectious mononucleosis to see which ones developed ME/CFS afterward. Researchers measured various factors at baseline, including how tired the teens felt, how many days they spent in bed, stress levels, and mood. The key finding was that the severity of the initial mono illness—particularly how long teens stayed in bed—was the strongest predictor of who would develop ME/CFS within 6 months.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

No evidence of XMRV provirus sequences in patients with myalgic encephalomyelitis/chronic fatigue syndrome and individuals with unspecified encephalopathy.

Rasa, Santa, Nora-Krukle, Zaiga, Chapenko, Svetlana et al.·The new microbiologica·2014

Researchers tested blood and brain tissue samples from people with ME/CFS, people with other brain conditions, and healthy people to see if they carried a virus called XMRV. The virus had been suspected as a possible cause of ME/CFS. The study found no evidence of XMRV in any of the samples tested, suggesting this particular virus is not present in ME/CFS patients.

E2 ModerateCohortPEM not requiredLongitudinal

The MAPP research network: design, patient characterization and operations.

Landis, J Richard, Williams, David A, Lucia, M Scott et al.·BMC urology·2014

The MAPP Research Network is a large study designed to understand chronic pelvic pain conditions and related illnesses like fibromyalgia, chronic fatigue syndrome, and irritable bowel syndrome. Researchers followed over 1,000 patients at six sites across the United States, collecting detailed information about their symptoms, blood samples, and brain imaging to identify what causes these conditions and how they connect to each other.

Biomarkers

E2 ModerateCohortPEM unclearObservational

Multivitamin mineral supplementation in patients with chronic fatigue syndrome.

Maric, Daniela, Brkic, Snezana, Tomic, Slavica et al.·Medical science monitor : international medical journal of experimental and clinical research·2014

This study tested whether taking a multivitamin and mineral supplement could help women with ME/CFS feel better. Thirty-eight women took the supplement for 2 months, and researchers measured changes in fatigue, sleep, headaches, and other symptoms. Most symptoms improved notably, including less fatigue and better sleep, though overall quality of life scores did not change.

SleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredLongitudinal

Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study.

Chen, C-S, Lin, W-M, Yang, T-Y et al.·QJM : monthly journal of the Association of Physicians·2014

This study found that people with ME/CFS have a higher risk of breaking bones compared to people without ME/CFS. Researchers followed nearly 4,000 patients with ME/CFS and about 15,000 without the condition over several years and found that fractures occurred more frequently in the ME/CFS group. Interestingly, this increased fracture risk did not appear to be mainly caused by weakened bones (osteoporosis), suggesting a different mechanism may be at play.

E2 ModerateCohortPEM unclearCross-Sectional

Use of an online survey to explore positive and negative outcomes of rehabilitation for people with CFS/ME.

Gladwell, Peter William, Pheby, Derek, Rodriguez, Tristana et al.·Disability and rehabilitation·2014

This study asked 76 people with ME/CFS about their experiences with rehabilitation therapies like graded exercise. Researchers found that people had both positive and negative experiences. Good experiences happened when therapists communicated well, helped patients set realistic goals, and worked at a sustainable pace. Bad experiences occurred when therapists pushed patients too hard, didn't listen to their concerns, or blamed patients when symptoms got worse.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

High flow variant postural orthostatic tachycardia syndrome amplifies the cardiac output response to exercise in adolescents.

Pianosi, Paolo T, Goodloe, Adele H, Soma, David et al.·Physiological reports·2014

This study found that about 40% of adolescents with POTS (a condition causing dizziness, fatigue, and rapid heartbeat when standing) have an unusual heart response to exercise: their hearts pump out more blood than expected to keep blood pressure normal. Instead of blood vessels tightening during exercise as they normally do, these patients' blood vessels stay too relaxed, forcing the heart to work harder by pumping more blood to maintain adequate pressure.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredLongitudinal

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Tsai, S-Y, Yang, T-Y, Chen, H-J et al.·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014

This study found that people who had shingles (herpes zoster) had a higher risk of developing ME/CFS compared to people who didn't have shingles. Researchers followed thousands of people over several years and found that those with a history of shingles were about 29% more likely to develop chronic fatigue syndrome, suggesting that viral infections like shingles may trigger ME/CFS in some people.

E2 ModerateCohortPEM unclearObservational

Attenuation of autoimmune responses to oxidative specific epitopes, but not nitroso-adducts, is associated with a better clinical outcome in Myalgic Encephalomyelitis/chronic fatigue syndrome.

Maes, Michael, Leunis, Jean-Claude·Neuro endocrinology letters·2014

This study looked at whether certain harmful substances in the blood of ME/CFS patients were linked to how sick they felt. Researchers gave 76 patients with ME/CFS supplements designed to reduce inflammation and oxidative stress, and found that patients whose levels of these harmful substances decreased the most—particularly those related to fat oxidation—reported feeling better. However, another type of harmful substance (related to nitrosative stress) didn't show this same connection to improvement.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Attention processes in chronic fatigue syndrome: attentional bias for health-related threat and the role of attentional control.

Hou, Ruihua, Moss-Morris, Rona, Risdale, Anna et al.·Behaviour research and therapy·2014

This study looked at whether people with ME/CFS pay more attention to health-related words and images, and whether difficulty controlling attention might be connected to this pattern. Researchers found that people with ME/CFS do tend to focus more on health-threat words, and many also have trouble with executive attention (the mental control needed to stay focused). Importantly, people with ME/CFS who had weaker attention control showed the strongest focus on health threats.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures.

Cockshell, Susan J, Mathias, Jane L·Neuropsychology·2014

This study looked at whether people with ME/CFS who report memory and concentration problems actually perform worse on cognitive tests. Fifty people with ME/CFS and 50 healthy controls completed questionnaires about their cognitive difficulties and took standardized memory and attention tests. Surprisingly, while people with ME/CFS reported significantly more cognitive problems in daily life, both groups performed similarly on the objective tests, and reported problems didn't match test results in either group.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Use of single-nucleotide polymorphisms (SNPs) to distinguish gene expression subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Shimosako, Nana, Kerr, Jonathan R·Journal of clinical pathology·2014

This study looked at small variations in DNA (called SNPs) from people with ME/CFS to see if these genetic differences could help identify different subtypes of the condition. Researchers compared DNA from 108 ME/CFS patients with 17 people with depression and 68 healthy people. They found that certain genetic variations were more common in ME/CFS patients and that different combinations of these variations appeared to match different subtypes of the illness.

Biomarkers

E2 ModerateCohortPEM not requiredObservational

Effect of high dose vitamin C on Epstein-Barr viral infection.

Mikirova, Nina, Hunninghake, Ronald·Medical science monitor : international medical journal of experimental and clinical research·2014

This study looked at whether high-dose vitamin C given through an IV might help people with Epstein-Barr virus (EBV) infection, including those with ME/CFS. Researchers reviewed medical records of 178 patients who received vitamin C infusions and had elevated EBV antibodies. They found that patients who received these treatments showed lower levels of EBV antibodies over time, and that higher vitamin C levels in the blood were associated with lower viral markers.

E2 ModerateCohortPEM not requiredObservational

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Lebedeva, A V, Shchukin, I A, Soldatov, M A et al.·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·2014

This study looked at 35 people with multiple sclerosis (MS) who experienced severe fatigue and mood problems. Researchers gave them a supplement called idebenon for 6 months and found it reduced their fatigue, tiredness, and depression. While this is interesting, it's important to note this study focused on MS patients, not ME/CFS patients, though both conditions involve fatigue.

E2 ModerateBehavioralPEM unclearCross-Sectional

Psychosocial factors involved in memory and cognitive failures in people with myalgic encephalomyelitis/chronic fatigue syndrome.

Attree, Elizabeth A, Arroll, Megan A, Dancey, Christine P et al.·Psychology research and behavior management·2014

This study looked at how memory and concentration problems in ME/CFS are connected to emotional and physical factors. Researchers asked 87 people with ME/CFS about their fatigue, mood, anxiety, and support systems, then measured their memory and cognitive problems. They found that fatigue, depression, and a person's sense of personal capability were linked to memory difficulties and thinking problems.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Impaired range of motion of limbs and spine in chronic fatigue syndrome.

Rowe, Peter C, Marden, Colleen L, Flaherty, Marissa A K et al.·The Journal of pediatrics·2014

This study compared how freely teenagers and young adults with ME/CFS could move their limbs and spine compared to healthy peers. Researchers found that people with ME/CFS had much more restricted movement and were more likely to experience pain or other symptoms when their nerves and muscles were gently stretched during testing. The findings suggest that movement limitations are a real physical feature of ME/CFS, not just in the mind.

E2 ModerateCohortPEM not requiredCross-Sectional

Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces.

Zhang, L, Xu, M-M, Zeng, L et al.·European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·2014

Researchers tested whether a virus called Borna disease virus (BDV) is found more often in people with ME/CFS and other brain-related illnesses compared to healthy people. They analyzed blood samples from nearly 1,700 people across three regions in western China and found that people with ME/CFS had higher rates of BDV infection (12.7%) compared to healthy controls. This suggests BDV might be involved in causing ME/CFS in some patients, though more research is needed to understand the connection.

E2 ModerateBehavioralPEM not requiredLongitudinal

Influence of graded exercise therapy on anxiety levels and health-related quality of life in chronic fatigue syndrome.

Klasnja, A, Grujic, N, Popadic Gacesa, J et al.·The Journal of sports medicine and physical fitness·2014

This study tested whether graded exercise therapy (GET)—a program of gradually increasing physical activity—could help 26 ME/CFS patients feel better and worry less. After 12 weeks of GET, patients reported improved energy levels and reduced anxiety, particularly trait anxiety (how anxious people generally feel). The study also found that anxiety and quality of life are closely connected: patients with higher anxiety had lower quality of life, and vice versa.

E2 ModerateCohortPEM not requiredLongitudinal

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: a population-based matched-cohort study.

Chung, Shiu-Dong, Lin, Ching-Chun, Liu, Shih-Ping et al.·Neurourology and urodynamics·2014

This study found that people with obstructive sleep apnea (OSA)—a condition where breathing stops repeatedly during sleep—are nearly 4 times more likely to develop bladder pain syndrome/interstitial cystitis (BPS/IC) compared to people without OSA. Researchers followed over 32,000 people in Taiwan for 3 years and tracked who developed BPS/IC. The findings suggest that sleep problems and bladder pain may be connected, and doctors should ask patients with sleep apnea about urinary symptoms.

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Decreased oxygen extraction during cardiopulmonary exercise test in patients with chronic fatigue syndrome.

Predictors of Post-Infectious Chronic Fatigue Syndrome in Adolescents.

No evidence of XMRV provirus sequences in patients with myalgic encephalomyelitis/chronic fatigue syndrome and individuals with unspecified encephalopathy.

The MAPP research network: design, patient characterization and operations.

Multivitamin mineral supplementation in patients with chronic fatigue syndrome.

Chronic fatigue syndrome is associated with the risk of fracture: a nationwide cohort study.

Use of an online survey to explore positive and negative outcomes of rehabilitation for people with CFS/ME.

High flow variant postural orthostatic tachycardia syndrome amplifies the cardiac output response to exercise in adolescents.

Increased risk of chronic fatigue syndrome following herpes zoster: a population-based study.

Attenuation of autoimmune responses to oxidative specific epitopes, but not nitroso-adducts, is associated with a better clinical outcome in Myalgic Encephalomyelitis/chronic fatigue syndrome.

Attention processes in chronic fatigue syndrome: attentional bias for health-related threat and the role of attentional control.

Cognitive functioning in people with chronic fatigue syndrome: a comparison between subjective and objective measures.

Use of single-nucleotide polymorphisms (SNPs) to distinguish gene expression subtypes of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Effect of high dose vitamin C on Epstein-Barr viral infection.

[Asthenia, emotional disorders and quality of life of patients with multiple sclerosis].

Psychosocial factors involved in memory and cognitive failures in people with myalgic encephalomyelitis/chronic fatigue syndrome.

Impaired range of motion of limbs and spine in chronic fatigue syndrome.

Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces.

Influence of graded exercise therapy on anxiety levels and health-related quality of life in chronic fatigue syndrome.

Obstructive sleep apnea increases the risk of bladder pain syndrome/interstitial cystitis: a population-based matched-cohort study.

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