ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2784 studies

1421–1440 of 2,784 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

The role of neuroticism, perfectionism and depression in chronic fatigue syndrome. A structural equation modeling approach.

Valero, Sergi, Sáez-Francàs, Naia, Calvo, Natalia et al.·Comprehensive psychiatry·2013

This study examined whether personality traits and depression influence how severe ME/CFS symptoms are in patients. Researchers looked at 229 ME/CFS patients and tested whether neuroticism (a tendency toward negative emotions) and perfectionism affect fatigue severity, and whether depression acts as a connecting link between these traits and fatigue. They found that neuroticism appears to influence fatigue severity primarily through depression—meaning people with high neuroticism tend to develop depression, which then worsens fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Gotts, Zoe M, Deary, Vincent, Newton, Julia et al.·BMJ open·2013

This study looked at sleep patterns in 343 people with chronic fatigue syndrome using overnight sleep monitoring machines. Researchers found that about 30% of patients had a separate sleep disorder, and the remaining patients fell into four different groups based on their sleep problems—some had trouble falling asleep, some had frequent sleep interruptions, some slept longer than average, and some had very short sleep with lots of waking. The findings suggest that people with ME/CFS have different types of sleep problems and may benefit from different sleep treatments based on their specific pattern.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Mental illness in metropolitan, urban and rural Georgia populations.

Reeves, William C, Lin, Jin-Mann S, Nater, Urs M·BMC public health·2013

This study looked at how common mental health conditions like anxiety and depression are in people living in different areas of Georgia (cities, towns, and rural areas). Researchers found that people with ME/CFS-like illness had higher rates of anxiety and depression than people without the condition. Women, people with less education, and those living in rural areas were more likely to experience these mental health conditions.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Influence of symptom expectancies on stair-climbing performance in chronic fatigue syndrome: effect of study context.

Heins, Marianne, Knoop, Hans, Nijs, Jo et al.·International journal of behavioral medicine·2013

This study looked at how ME/CFS patients' expectations about getting worse after physical activity affect how they actually perform during that activity. Researchers had 49 patients climb stairs while measuring how long it took and how their heart rate changed. They found that patients who expected to feel more fatigued after climbing took longer to complete the task, even after accounting for their initial fatigue level. Worry about symptoms and catastrophic thinking about their condition appeared to play a role in these expectations.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

CFS in Children and Adolescent: Ten Years of Retrospective Clinical Evaluation.

Elgen, Irene, Hikmat, Omar, Aspevik, Tora N et al.·International journal of pediatrics·2013

This study looked at 27 children and adolescents diagnosed with ME/CFS over a 10-year period in one clinic. Almost all of them developed fatigue after an infection and showed evidence of past viral infections. About 44% were underweight. The researchers concluded that diagnosing ME/CFS in young people requires careful evaluation by multiple specialists and attention to nutrition and mental health.

E2 ModerateCohortPEM not requiredObservational

Fatigue heralding multiple sclerosis.

Berger, Joseph R, Pocoski, Jennifer, Preblick, Ronald et al.·Multiple sclerosis (Houndmills, Basingstoke, England)·2013

This study looked at medical records to see how often fatigue appears before someone is diagnosed with multiple sclerosis (MS). Researchers found that about 29% of newly diagnosed MS patients had been labeled with fatigue in the 3 years before their MS diagnosis, often 1–2 years earlier. The findings suggest that persistent fatigue might be an early warning sign of MS, and doctors should carefully evaluate people with unexplained fatigue for possible neurological causes.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Examining the impact of obesity on individuals with chronic fatigue syndrome.

Flores, Samantha, Brown, Abigail, Adeoye, Samuel et al.·Workplace health & safety·2013

This study looked at how weight affects people with ME/CFS compared to healthy people of similar weight. Researchers found that people with ME/CFS who were overweight or obese had worse health and functioning than healthy people carrying the same amount of weight. The findings suggest that having ME/CFS makes weight-related health challenges even more difficult.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning.

Cockshell, Susan J, Mathias, Jane L·Neuropsychology·2013

Researchers compared thinking and memory skills between 50 people with ME/CFS and 50 healthy people. They found that people with ME/CFS were slower at processing information (like reaction time), but performed normally on other thinking tasks like memory and attention. Interestingly, this slowness was not explained by depression, anxiety, fatigue, or sleep problems.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome.

Heins, Marianne J, Knoop, Hans, Bleijenberg, Gijs·Behaviour research and therapy·2013

This study looked at whether the quality of the relationship between patients and their CBT therapist affects how much CBT helps reduce fatigue in ME/CFS. Researchers followed 217 patients through CBT treatment and measured both the therapeutic relationship (like whether patients felt heard and had confidence in treatment) and changes in fatigue-related thoughts and behaviors. They found that when patients started therapy with positive expectations and felt they understood what the therapy aimed to do, they experienced better improvements in fatigue by the end of treatment.

Interventions

E2 ModerateCohortPEM not requiredObservational

Treatment of 741 Italian patients with chronic fatigue syndrome.

Tirelli, U, Lleshi, A, Berretta, M et al.·European review for medical and pharmacological sciences·2013

This study looked at 741 ME/CFS patients treated at an Italian hospital between 2000 and 2005 to see which treatments helped the most. Antiviral and immunoglobulin drugs (which boost the immune system) showed the best results, with about 15% of patients improving. The study also found that patients who received 4 or more different treatments had better outcomes than those who received fewer treatments.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Smorgick, Noam, Marsh, Courtney A, As-Sanie, Sawsan et al.·Journal of pediatric and adolescent gynecology·2013

This study looked at young women (under age 24) with endometriosis to see how often they also experienced other pain conditions, mood problems, and asthma. Researchers found that more than half had multiple pain syndromes (like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome), about half had depression or anxiety, and about a quarter had asthma. The study suggests these conditions often occur together in young women with endometriosis.

E2 ModerateCohortPEM not requiredCross-Sectional

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

Schüttrumpf, Jörg, Hourfar, M Kai, Alesci, Sonja et al.·Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2013

Researchers tested whether XMRV, a virus that had been suggested as a possible cause of ME/CFS, was present in the blood of people with hemophilia who received frequent blood products. Using sensitive testing methods, they found no trace of XMRV in any of the 127 people tested, even in those who had received many blood transfusions and factor treatments over time.

E2 ModerateBehavioralPEM not requiredCase-Control

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Warren, John W, Langenberg, Patricia, Clauw, Daniel J·Journal of psychosomatic research·2013

This study found that people who have multiple overlapping illnesses like fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and others are more likely to develop additional new conditions over time. The more conditions someone already had, the higher their risk of developing a new one. This suggests these conditions may share common underlying causes rather than being completely separate diseases.

E2 ModerateCohortPEM not requiredCross-Sectional

Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls.

Bradley, A S, Ford, B, Bansal, A S·Clinical and experimental immunology·2013

This study looked at different types of B cells (immune cells that help fight infection) in people with ME/CFS compared to healthy people. Researchers found that ME/CFS patients had more immature B cells and fewer fully developed B cells than healthy controls, suggesting their immune system might not be developing B cells normally. This finding is interesting because a drug that removes B cells helped some ME/CFS patients improve.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome.

Warren, John W, Clauw, Daniel J, Langenberg, Patricia·BJU international·2013

This study followed 304 women with interstitial cystitis/painful bladder syndrome (IC/PBS)—a condition causing bladder pain, urgency, and frequent urination—for about 3 years after their symptoms started. Researchers found that women who had mild symptoms at the beginning were more likely to stay mild, while women who also had chronic fatigue syndrome (ME/CFS) tended to develop more severe bladder symptoms over time.

E2 ModerateCohortPEM unclearObservational

Lack of evidence for retroviral infections formerly related to chronic fatigue in Spanish fibromyalgia patients.

Oltra, Elisa, García-Escudero, María, Mena-Durán, Armando Vicente et al.·Virology journal·2013

Researchers tested whether two viruses previously thought to be linked to ME/CFS and fibromyalgia were actually present in Spanish patients with these conditions. They found no reliable evidence that either virus was present in patient samples, and concluded that earlier positive results were likely due to contamination in the laboratory rather than genuine infections.

E2 ModerateCohortPEM unclearCross-Sectional

Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?

Castro-Marrero, Jesús, Cordero, Mario D, Sáez-Francas, Naia et al.·Antioxidants & redox signaling·2013

This study looked at whether problems in the energy-producing parts of cells (mitochondria) might be different between ME/CFS and fibromyalgia, two conditions that cause fatigue and are often confused with each other. Researchers tested blood cells from people with ME/CFS, fibromyalgia, and healthy people, measuring energy-related markers and signs of cellular damage. They found that both conditions showed some mitochondrial problems, but the patterns were different—suggesting mitochondrial dysfunction might help doctors tell these two conditions apart.

Diagnostics

E2 ModerateBehavioralPEM not requiredLongitudinal

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Kempke, S, Luyten, P, Claes, S et al.·Psychological medicine·2013

This study looked at whether a personality trait called self-critical perfectionism—the tendency to be harshly self-critical and set unrealistic standards—might be linked to daily fatigue and pain in ME/CFS patients. Over 14 days, 90 patients recorded their fatigue and pain levels each day. The researchers found that patients who scored higher on self-critical perfectionism did experience more fatigue and pain during the study period, even after accounting for mood differences.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Chan, Winnie, Bosch, Jos A, Jones, David et al.·Transplantation·2013

This study looked at tiredness in people who have received kidney transplants and are doing well medically. Researchers found that nearly 6 out of 10 kidney transplant patients experience significant fatigue that affects their daily life and quality of life, yet most doctors weren't documenting this problem in their medical records. The fatigue levels were similar to those seen in chronic fatigue syndrome, and it was linked to factors like inflammation, kidney function decline, poor sleep, anxiety, and depression.

Sleep

E2 ModerateCohortPEM not requiredCase-Control

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Chung, Shiu-Dong, Liu, Shih-Ping, Lin, Ching-Chun et al.·PloS one·2013

This study found that women with bladder pain syndrome/interstitial cystitis (BPS/IC) are more than twice as likely to have had hyperthyroidism (an overactive thyroid) compared to women without bladder pain. The researchers reviewed medical records from Taiwan and suggest that doctors treating women with thyroid problems should ask about urinary symptoms.

Autonomic Nervous System

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The role of neuroticism, perfectionism and depression in chronic fatigue syndrome. A structural equation modeling approach.

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Mental illness in metropolitan, urban and rural Georgia populations.

Influence of symptom expectancies on stair-climbing performance in chronic fatigue syndrome: effect of study context.

CFS in Children and Adolescent: Ten Years of Retrospective Clinical Evaluation.

Fatigue heralding multiple sclerosis.

Examining the impact of obesity on individuals with chronic fatigue syndrome.

Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning.

The role of the therapeutic relationship in cognitive behaviour therapy for chronic fatigue syndrome.

Treatment of 741 Italian patients with chronic fatigue syndrome.

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Altered functional B cell subset populations in patients with chronic fatigue syndrome compared to healthy controls.

Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome.

Lack of evidence for retroviral infections formerly related to chronic fatigue in Spanish fibromyalgia patients.

Could mitochondrial dysfunction be a differentiating marker between chronic fatigue syndrome and fibromyalgia?

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

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