ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1421–1440 of 2,768 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Gotts, Zoe M, Deary, Vincent, Newton, Julia et al.·BMJ open·2013

This study looked at sleep patterns in 343 people with chronic fatigue syndrome using overnight sleep monitoring machines. Researchers found that about 30% of patients had a separate sleep disorder, and the remaining patients fell into four different groups based on their sleep problems—some had trouble falling asleep, some had frequent sleep interruptions, some slept longer than average, and some had very short sleep with lots of waking. The findings suggest that people with ME/CFS have different types of sleep problems and may benefit from different sleep treatments based on their specific pattern.

Sleep

E2 ModerateCohortPEM unclearLongitudinal

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

Crawley, E, Collin, S M, White, P D et al.·QJM : monthly journal of the Association of Physicians·2013

This study tracked over 800 people with ME/CFS who received care at NHS specialist services in England for 8-20 months. Patients showed meaningful improvements in fatigue, physical function, anxiety, depression, and pain. The study found that patients who started with more severe fatigue, disability, or pain tended to have less improvement, suggesting baseline severity is an important predictor of how well someone will improve with specialist care.

Pain and Sensitization

E2 ModerateBehavioralPEM unclearCross-Sectional

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Lattie, Emily G, Antoni, Michael H, Fletcher, Mary Ann et al.·Fatigue : biomedicine, health & behavior·2013

This study examined whether learning to manage stress could help people with ME/CFS feel less burdened by their illness, even if their symptoms don't improve. Researchers found that people who felt they had better stress management skills reported lower emotional distress and felt less limited in their daily activities and social life. Importantly, this benefit existed independently of how severe their ME/CFS symptoms were.

E2 ModerateBehavioralPEM not requiredLongitudinal

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Kempke, S, Luyten, P, Claes, S et al.·Psychological medicine·2013

This study looked at whether a personality trait called self-critical perfectionism—the tendency to be harshly self-critical and set unrealistic standards—might be linked to daily fatigue and pain in ME/CFS patients. Over 14 days, 90 patients recorded their fatigue and pain levels each day. The researchers found that patients who scored higher on self-critical perfectionism did experience more fatigue and pain during the study period, even after accounting for mood differences.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women.

He, Xiaotong, Walker, Thomas D J, Maranga, Innocent O et al.·PloS one·2012

This study tested whether a virus called XMRV could be found in cervical samples from 224 Kenyan women, some with HIV and some without. Using sensitive lab techniques, the researchers found no trace of XMRV in any of the samples. This supports the idea that XMRV, once linked to ME/CFS, is likely a lab contamination rather than a real human infection.

E2 ModerateCohortPEM not requiredLongitudinal

Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Katz, Ben Z, Stewart, Julian M, Shiraishi, Yukiko et al.·Clinical pediatrics·2012

This study looked at whether teenagers with ME/CFS have trouble standing up for long periods (a condition called orthostatic intolerance). Researchers tested 36 teens with ME/CFS and 43 recovered teens, all about 6 months after having infectious mononucleosis. Surprisingly, they found that similar numbers of both groups had difficulty with standing tolerance, suggesting this may not be a key difference between those who recover and those who develop ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Contrasting case definitions for chronic fatigue syndrome, Myalgic Encephalomyelitis/chronic fatigue syndrome and myalgic encephalomyelitis.

Jason, Leonard A, Brown, Abigail, Clyne, Erin et al.·Evaluation & the health professions·2012

This study looked at patients diagnosed with chronic fatigue syndrome (CFS) using an older definition and compared how many of them would also meet two newer, stricter definitions: ME/CFS and ME. Researchers found that patients meeting the newer, stricter definitions had more severe symptoms and greater disability than those who only met the older CFS definition. This suggests that the newer definitions may help doctors identify the most severely affected patients.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome.

Paolucci, Stefania, Piralla, Antonio, Zanello, Cinzia et al.·The new microbiologica·2012

This study looked for two viruses (XMRV and MLV-related viruses) that had been suggested as possible causes of ME/CFS. Researchers tested 12 ME/CFS patients and 40 healthy control subjects. They found these viruses in only 2 of the 12 patients, while all controls tested negative. The results suggest these viruses are not common in ME/CFS patients, and previous reports of finding them may have been due to laboratory contamination with mouse DNA.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Confidence judgment in depression and dysphoria: the depressive realism vs. negativity hypotheses.

Szu-Ting Fu, Tiffany, Koutstaal, Wilma, Poon, Lucia et al.·Journal of behavior therapy and experimental psychiatry·2012

This study looked at how accurately people judge their own knowledge and abilities. Researchers compared three groups: healthy people, those with clinical depression, and people with chronic fatigue syndrome who felt sad or low. They found that people with depression were overly critical of themselves, while people with chronic fatigue syndrome were more realistic about their abilities—similar to healthy controls.

Cognitive Impairment

E2 ModerateCohortPEM unclearObservational

[Epidemiology, diagnostics, and treatment of complications after neuroinfections: chronic fatigue syndrome].

Verner, O M, Murashko, N K·Likars'ka sprava·2012

This study looked at how often ME/CFS occurs in people who have had brain infections, finding that more than 20% of patients who recover from certain infections develop ME/CFS afterward. The condition was more common in people aged 40-59, and women were affected about 4 times more often than men. While the exact cause remains unknown, researchers think it may be related to genetics, immune system problems, or lingering effects from infections like Epstein-Barr virus.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome and impaired peripheral pulse characteristics on orthostasis--a new potential diagnostic biomarker.

Allen, John, Murray, Alan, Di Maria, Costanzo et al.·Physiological measurement·2012

This study tested a new way to measure how the heart and blood vessels respond when people stand up, using a painless light-based sensor on the ears, fingers, and toes. Researchers found that people with ME/CFS had a weaker blood vessel response to standing compared to healthy controls, which could potentially be used as an objective test to help diagnose ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Antinuclear antibody detection by automated multiplex immunoassay in untreated patients at the time of diagnosis.

Op De Beéck, Katrijn, Vermeersch, Pieter, Verschueren, Patrick et al.·Autoimmunity reviews·2012

This study compared two different blood tests for detecting autoantibodies (proteins the immune system makes that attack the body's own cells) in patients with various autoimmune diseases and in people with ME/CFS. The researchers found that one newer automated test missed some antibodies that an older, more traditional test detected, and that having multiple antibodies together was much more common in autoimmune disease patients than in ME/CFS patients.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Lyme disease in a British referral clinic.

Cottle, L E, Mekonnen, E, Beadsworth, M B J et al.·QJM : monthly journal of the Association of Physicians·2012

This UK study looked at 115 patients who were referred to a specialist clinic because doctors suspected they had Lyme disease. The researchers found that only 23% actually had Lyme disease, while about one-third had ME/CFS instead. Importantly, some ME/CFS patients had been incorrectly told they had Lyme disease by non-specialist doctors, leading them to take unnecessary antibiotics.

E2 ModerateDiagnosticPEM unclearMethods-Paper

Data mining: comparing the empiric CFS to the Canadian ME/CFS case definition.

Jason, Leonard A, Skendrovic, Beth, Furst, Jacob et al.·Journal of clinical psychology·2012

This study compared two different sets of diagnostic criteria used to identify ME/CFS patients. Researchers used a computer-based analysis technique to test which questions from patient surveys were most helpful in accurately diagnosing the illness. They found that the Canadian criteria correctly identified 87% of ME/CFS patients, while the older empiric criteria identified about 79%, suggesting the Canadian approach may be more effective for diagnosis.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

[Effects of tuina on the mechanical properties of skeletal muscles of four limbs in patients with chronic fatigue syndrome].

Liu, Kun-Peng, Fang, Min, Jiang, Shu-Yun·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2012

This study tested whether tuina (a traditional Chinese massage therapy) could help ME/CFS patients regain muscle strength and reduce fatigue. Sixty people participated—30 with ME/CFS and 30 healthy controls. After 10 sessions of tuina therapy, ME/CFS patients showed improvements in muscle strength measurements and reported feeling less fatigued, though their muscles remained weaker than those of healthy people.

E2 ModerateCohortPEM not requiredCase-Control

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.

Hanevik, Kurt, Kristoffersen, Einar K, Sørnes, Steinar et al.·BMC infectious diseases·2012

This study looked at immune system changes in people who developed chronic fatigue and gut problems after a Giardia infection. Researchers found that people with post-infectious chronic fatigue had lower levels of natural killer (NK) cells, which are important for fighting infections. The more severe someone's fatigue and stomach symptoms were, the lower their NK cells tended to be.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile.

Cockshell, Susan J, Mathias, Jane L·Journal of clinical and experimental neuropsychology·2012

This study tested whether people with ME/CFS perform poorly on thinking tests because they aren't trying hard enough, or because of the illness itself. Researchers gave 54 people with ME/CFS and 54 healthy people a special test designed to measure effort and intention during testing. The results showed that most people in both groups were trying their best, and very few showed signs of not putting in effort—suggesting that low effort is not the reason people with ME/CFS struggle with cognitive tasks.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care.

Wiborg, Jan F, Knoop, Hans, Wensing, Michel et al.·Behaviour research and therapy·2012

This study looked at how well cognitive behavior therapy (CBT) for ME/CFS works when delivered by different therapists in regular mental health clinics rather than specialized centers. Researchers found that the individual therapist made a big difference in patient outcomes—accounting for 21% of the improvement variation. The therapist's beliefs about using treatment manuals and the specific clinic where treatment happened both influenced how well patients did.

E2 ModerateCohortPEM not requiredCross-Sectional

Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes.

Okamoto, Luis E, Raj, Satish R, Peltier, Amanda et al.·Clinical science (London, England : 1979)·2012

This study looked at patients with POTS (a condition where heart rate increases too much when standing) to see how many also have ME/CFS and whether they are different from POTS patients without ME/CFS. The researchers found that most POTS patients experience severe fatigue, and about two-thirds also meet ME/CFS criteria. Those with both conditions had stronger heart rate increases when standing and signs of greater stress hormone activity.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Fibromyalgia and chronic fatigue syndrome in children.

Itoh, Yasuhiko, Shigemori, Tomoko, Igarashi, Tohru et al.·Pediatrics international : official journal of the Japan Pediatric Society·2012

This study looked at two conditions that cause long-term pain and exhaustion in children: fibromyalgia and chronic fatigue syndrome. Researchers tested blood samples from children with each condition to see if they had similar immune system patterns. They found that while these conditions share some symptoms, they appear to have different immune system signatures, suggesting they may be separate diseases—though some children can have both.

Immune System

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Treatment outcome in adults with chronic fatigue syndrome: a prospective study in England based on the CFS/ME National Outcomes Database.

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Symptom Severity: Stress Management Skills are Related to Lower Illness Burden.

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

No biological evidence of XMRV infection in cervical smears from HIV/ HPV positive and negative Kenyan women.

Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Contrasting case definitions for chronic fatigue syndrome, Myalgic Encephalomyelitis/chronic fatigue syndrome and myalgic encephalomyelitis.

Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome.

Confidence judgment in depression and dysphoria: the depressive realism vs. negativity hypotheses.

[Epidemiology, diagnostics, and treatment of complications after neuroinfections: chronic fatigue syndrome].

Chronic fatigue syndrome and impaired peripheral pulse characteristics on orthostasis--a new potential diagnostic biomarker.

Antinuclear antibody detection by automated multiplex immunoassay in untreated patients at the time of diagnosis.

Lyme disease in a British referral clinic.

Data mining: comparing the empiric CFS to the Canadian ME/CFS case definition.

[Effects of tuina on the mechanical properties of skeletal muscles of four limbs in patients with chronic fatigue syndrome].

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.

Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile.

Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care.

Neurohumoral and haemodynamic profile in postural tachycardia and chronic fatigue syndromes.

Fibromyalgia and chronic fatigue syndrome in children.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research