ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1421–1440 of 2,807 studies

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.

Mørch, Kristine, Hanevik, Kurt, Rivenes, Ann C et al.·BMC gastroenterology·2013

After a water contamination outbreak in Norway, researchers followed people who developed severe tiredness following a Giardia intestinal infection. Five years after infection, they found that about 41% of patients still had chronic fatigue syndrome, while about 21% had recovered completely. The study also identified other conditions like sleep problems and depression that sometimes occur alongside post-infectious fatigue.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Views on the nature of chronic fatigue syndrome: content analysis.

Hossenbaccus, Zahra, White, Peter D·JRSM short reports·2013

This study looked at how ME/CFS is described in newspapers, patient websites, and medical textbooks in the UK. Researchers found that patient organizations typically view ME/CFS as a physical illness, while doctors' resources were more likely to describe it as both physical and psychological. This disagreement may explain why some patients and doctors struggle to understand each other.

E2 ModerateCohortPEM not requiredObservational

Fatigue heralding multiple sclerosis.

Berger, Joseph R, Pocoski, Jennifer, Preblick, Ronald et al.·Multiple sclerosis (Houndmills, Basingstoke, England)·2013

This study looked at medical records to see how often fatigue appears before someone is diagnosed with multiple sclerosis (MS). Researchers found that about 29% of newly diagnosed MS patients had been labeled with fatigue in the 3 years before their MS diagnosis, often 1–2 years earlier. The findings suggest that persistent fatigue might be an early warning sign of MS, and doctors should carefully evaluate people with unexplained fatigue for possible neurological causes.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Patterns of abnormal visual attention in myalgic encephalomyelitis.

Hutchinson, Claire V, Badham, Stephen P·Optometry and vision science : official publication of the American Academy of Optometry·2013

This study tested whether people with ME/CFS have difficulty with visual attention—the ability to focus on and track things they see. Researchers compared 29 patients with ME/CFS to 29 healthy people using eye-tracking tests. The results showed that ME/CFS patients did struggle more with certain types of visual attention tasks, particularly when they had to focus on specific things or search for objects, supporting what many patients report experiencing.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients.

Frémont, Marc, Coomans, Danny, Massart, Sebastien et al.·Anaerobe·2013

This study examined bacteria in the gut of ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients have different types and amounts of gut bacteria than healthy controls, particularly an overgrowth of certain bacteria and a decrease in others. These differences suggest that gut bacteria imbalance may be linked to ME/CFS, and testing for these specific bacteria changes might help diagnose the condition or guide new treatments like probiotics.

E2 ModerateCohortPEM not requiredCross-Sectional

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

Schüttrumpf, Jörg, Hourfar, M Kai, Alesci, Sonja et al.·Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie·2013

Researchers tested whether XMRV, a virus that had been suggested as a possible cause of ME/CFS, was present in the blood of people with hemophilia who received frequent blood products. Using sensitive testing methods, they found no trace of XMRV in any of the 127 people tested, even in those who had received many blood transfusions and factor treatments over time.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Bossuyt, Xavier, Cooreman, Sarah, De Baere, Heidi et al.·Clinica chimica acta; international journal of clinical chemistry·2013

This study tested an automated machine to detect antinuclear antibodies (ANA)—proteins the immune system sometimes makes that can be seen in blood tests. Researchers compared how well this automated system worked compared to traditional methods, using blood samples from people with autoimmune diseases, healthy donors, people with chronic fatigue syndrome, and other patient groups. The machine was good at collecting images but had difficulty identifying the specific patterns of these antibodies accurately.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Neblett, Randy, Cohen, Howard, Choi, YunHee et al.·The journal of pain·2013

This study tested a questionnaire called the Central Sensitization Inventory (CSI) to see if it could help doctors identify patients with conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers believe these conditions may share a common cause: the nervous system becoming overly sensitive to pain and other stimuli. The study found that a CSI score of 40 or higher was a good way to identify patients with these central sensitivity syndromes.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Chan, Winnie, Bosch, Jos A, Jones, David et al.·Transplantation·2013

This study looked at tiredness in people who have received kidney transplants and are doing well medically. Researchers found that nearly 6 out of 10 kidney transplant patients experience significant fatigue that affects their daily life and quality of life, yet most doctors weren't documenting this problem in their medical records. The fatigue levels were similar to those seen in chronic fatigue syndrome, and it was linked to factors like inflammation, kidney function decline, poor sleep, anxiety, and depression.

Sleep

E2 ModerateCohortPEM not requiredCross-Sectional

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Mariman, An, Delesie, Liesbeth, Tobback, Els et al.·Journal of psychosomatic research·2013

Researchers studied nearly 280 patients who came to a specialized clinic thinking they had ME/CFS, and gave them thorough medical, sleep, and mental health assessments. They found that only about 23% actually had clear-cut ME/CFS; most others had sleep problems like sleep apnea, depression or anxiety, or a combination of these conditions. This suggests that when people feel persistently exhausted, many different medical and mental health issues could be the real cause.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

Gotts, Zoe M, Deary, Vincent, Newton, Julia et al.·BMJ open·2013

This study looked at sleep patterns in 343 people with chronic fatigue syndrome using overnight sleep monitoring machines. Researchers found that about 30% of patients had a separate sleep disorder, and the remaining patients fell into four different groups based on their sleep problems—some had trouble falling asleep, some had frequent sleep interruptions, some slept longer than average, and some had very short sleep with lots of waking. The findings suggest that people with ME/CFS have different types of sleep problems and may benefit from different sleep treatments based on their specific pattern.

Sleep

E2 ModerateCohortPEM unclearObservational

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Rezaei, Simin D, Hearps, Anna C, Mills, John et al.·Virology journal·2013

Researchers tested tissue samples from 35 Australian prostate cancer patients to see if they contained XMRV or related viruses, which had been claimed to cause both prostate cancer and ME/CFS. Using sensitive laboratory tests, they found no evidence of these viruses in any of the samples. This study adds to growing evidence that XMRV is not actually involved in prostate cancer and was likely a laboratory contamination rather than a real virus.

E2 ModerateBehavioralPEM not requiredLongitudinal

Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up.

Nijhof, Sanne L, Priesterbach, Loudy P, Uiterwaal, Cuno S P M et al.·Pediatrics·2013

This study followed adolescents with ME/CFS for nearly 3 years after they completed an internet-based cognitive behavioral therapy program called FITNET. About 59% of teenagers had recovered from their illness by the end of the follow-up period, and most of those who improved right after treatment stayed better. Interestingly, teens who received standard care also recovered at similar rates over time, though it took longer.

E2 ModerateBehavioralPEM not requiredCase-Control

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Kempke, Stefan, Van Den Eede, Filip, Schotte, Chris et al.·International journal of behavioral medicine·2013

This study tested whether people with ME/CFS have more personality disorders than the general population. Researchers gave 92 women with ME/CFS and two comparison groups (92 community members and 92 psychiatric patients) a questionnaire about personality traits. The results showed that ME/CFS patients had personality disorder rates similar to healthy people, not higher rates, though they did show some depressive and obsessive-compulsive traits.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive performance is of clinical importance, but is unrelated to pain severity in women with chronic fatigue syndrome.

Ickmans, Kelly, Meeus, Mira, Kos, Daphne et al.·Clinical rheumatology·2013

This study looked at whether cognitive problems (thinking, memory, attention) in women with ME/CFS are related to pain severity. Researchers gave cognitive tests and questionnaires to 29 women with ME/CFS and 17 healthy women. They found that cognitive problems were NOT linked to pain levels, but were connected to fatigue and mental health, suggesting that cognitive difficulties in ME/CFS may work differently than in other chronic pain conditions.

Pain and SensitizationCognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring.

Dixit, Ronak, Popescu, Alexandra, Bagić, Anto et al.·Epilepsy & behavior : E&B·2013

This study looked at 280 patients seen at a hospital epilepsy unit to understand what health conditions are more common in people with psychogenic nonepileptic spells (PNES)—seizure-like episodes that aren't caused by epilepsy—compared to those with actual epilepsy. They found that patients with PNES were more likely to be female, have a history of trauma, and experience conditions like fibromyalgia, chronic fatigue syndrome, chronic pain, and irritable bowel syndrome. The researchers suggest these patterns might help doctors identify PNES earlier and order the right tests sooner.

Diagnostics

E2 ModerateBehavioralPEM not requiredLongitudinal

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Kempke, S, Luyten, P, Claes, S et al.·Psychological medicine·2013

This study looked at whether a personality trait called self-critical perfectionism—the tendency to be harshly self-critical and set unrealistic standards—might be linked to daily fatigue and pain in ME/CFS patients. Over 14 days, 90 patients recorded their fatigue and pain levels each day. The researchers found that patients who scored higher on self-critical perfectionism did experience more fatigue and pain during the study period, even after accounting for mood differences.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome.

Curriu, Marta, Carrillo, Jorge, Massanella, Marta et al.·Journal of translational medicine·2013

This study examined the immune cells in the blood of 22 people with ME/CFS and 30 healthy controls using a technique called flow cytometry. Researchers found that people with ME/CFS had some notable differences in their T cells and NK cells—types of white blood cells that help fight infections—while B cells appeared largely normal. These immune cell differences may help doctors identify ME/CFS and might explain why people with the condition get frequent viral infections.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome.

Cella, M, White, P D, Sharpe, M et al.·Psychological medicine·2013

This study looked at how often certain thought patterns and behaviors occur in ME/CFS patients, and whether these patterns differ when patients also have depression or anxiety. Researchers surveyed 640 ME/CFS patients and found that more than half had ME/CFS alone, while the rest also had depression and/or anxiety. Different thinking patterns appeared in patients with different mental health combinations—for example, patients with anxiety were more likely to focus heavily on their symptoms, while those with depression were more likely to avoid activities.

Cognitive Impairment

E2 ModerateBehavioralPEM unclearLongitudinal

Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort.

Goodwin, Laura, White, Peter D, Hotopf, Matthew et al.·Psychosomatic medicine·2013

This study followed thousands of people born in 1958 in the UK to see who developed irritable bowel syndrome (IBS) by age 42. Researchers found that women were twice as likely to develop IBS, and people who had psychological distress in their 20s and 30s were more likely to later develop IBS. Surprisingly, difficult childhood experiences were not associated with later IBS development.

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Chronic fatigue syndrome 5 years after giardiasis: differential diagnoses, characteristics and natural course.

Views on the nature of chronic fatigue syndrome: content analysis.

Fatigue heralding multiple sclerosis.

Patterns of abnormal visual attention in myalgic encephalomyelitis.

High-throughput 16S rRNA gene sequencing reveals alterations of intestinal microbiota in myalgic encephalomyelitis/chronic fatigue syndrome patients.

No detection of the retrovirus xenotropic murine leukemia virus-related virus in individuals with hemophilia.

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Predictors and consequences of fatigue in prevalent kidney transplant recipients.

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Are there sleep-specific phenotypes in patients with chronic fatigue syndrome? A cross-sectional polysomnography analysis.

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up.

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Cognitive performance is of clinical importance, but is unrelated to pain severity in women with chronic fatigue syndrome.

Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring.

Self-critical perfectionism and its relationship to fatigue and pain in the daily flow of life in patients with chronic fatigue syndrome.

Screening NK-, B- and T-cell phenotype and function in patients suffering from Chronic Fatigue Syndrome.

Cognitions, behaviours and co-morbid psychiatric diagnoses in patients with chronic fatigue syndrome.

Life course study of the etiology of self-reported irritable bowel syndrome in the 1958 British birth cohort.

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