ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2795 studies

1441–1460 of 2,795 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Smorgick, Noam, Marsh, Courtney A, As-Sanie, Sawsan et al.·Journal of pediatric and adolescent gynecology·2013

This study looked at young women (under age 24) with endometriosis to see how often they also experienced other pain conditions, mood problems, and asthma. Researchers found that more than half had multiple pain syndromes (like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome), about half had depression or anxiety, and about a quarter had asthma. The study suggests these conditions often occur together in young women with endometriosis.

E2 ModerateCohortPEM not requiredCase-Control

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Chung, Shiu-Dong, Liu, Shih-Ping, Lin, Ching-Chun et al.·PloS one·2013

This study found that women with bladder pain syndrome/interstitial cystitis (BPS/IC) are more than twice as likely to have had hyperthyroidism (an overactive thyroid) compared to women without bladder pain. The researchers reviewed medical records from Taiwan and suggest that doctors treating women with thyroid problems should ask about urinary symptoms.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive performance is of clinical importance, but is unrelated to pain severity in women with chronic fatigue syndrome.

Ickmans, Kelly, Meeus, Mira, Kos, Daphne et al.·Clinical rheumatology·2013

This study looked at whether cognitive problems (thinking, memory, attention) in women with ME/CFS are related to pain severity. Researchers gave cognitive tests and questionnaires to 29 women with ME/CFS and 17 healthy women. They found that cognitive problems were NOT linked to pain levels, but were connected to fatigue and mental health, suggesting that cognitive difficulties in ME/CFS may work differently than in other chronic pain conditions.

Pain and SensitizationCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Mariman, An, Delesie, Liesbeth, Tobback, Els et al.·Journal of psychosomatic research·2013

Researchers studied nearly 280 patients who came to a specialized clinic thinking they had ME/CFS, and gave them thorough medical, sleep, and mental health assessments. They found that only about 23% actually had clear-cut ME/CFS; most others had sleep problems like sleep apnea, depression or anxiety, or a combination of these conditions. This suggests that when people feel persistently exhausted, many different medical and mental health issues could be the real cause.

Diagnostics

E2 ModerateBehavioralPEM not requiredCase-Control

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Kempke, Stefan, Van Den Eede, Filip, Schotte, Chris et al.·International journal of behavioral medicine·2013

This study tested whether people with ME/CFS have more personality disorders than the general population. Researchers gave 92 women with ME/CFS and two comparison groups (92 community members and 92 psychiatric patients) a questionnaire about personality traits. The results showed that ME/CFS patients had personality disorder rates similar to healthy people, not higher rates, though they did show some depressive and obsessive-compulsive traits.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Bossuyt, Xavier, Cooreman, Sarah, De Baere, Heidi et al.·Clinica chimica acta; international journal of clinical chemistry·2013

This study tested an automated machine to detect antinuclear antibodies (ANA)—proteins the immune system sometimes makes that can be seen in blood tests. Researchers compared how well this automated system worked compared to traditional methods, using blood samples from people with autoimmune diseases, healthy donors, people with chronic fatigue syndrome, and other patient groups. The machine was good at collecting images but had difficulty identifying the specific patterns of these antibodies accurately.

Immune System

E2 ModerateBehavioralPEM not requiredCase-Control

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Warren, John W, Langenberg, Patricia, Clauw, Daniel J·Journal of psychosomatic research·2013

This study found that people who have multiple overlapping illnesses like fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and others are more likely to develop additional new conditions over time. The more conditions someone already had, the higher their risk of developing a new one. This suggests these conditions may share common underlying causes rather than being completely separate diseases.

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning.

Cockshell, Susan J, Mathias, Jane L·Neuropsychology·2013

Researchers compared thinking and memory skills between 50 people with ME/CFS and 50 healthy people. They found that people with ME/CFS were slower at processing information (like reaction time), but performed normally on other thinking tasks like memory and attention. Interestingly, this slowness was not explained by depression, anxiety, fatigue, or sleep problems.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.

Elfaitouri, Amal, Herrmann, Björn, Bölin-Wiener, Agnes et al.·PloS one·2013

This study looked at whether ME/CFS patients have different immune responses to heat shock protein 60 (HSP60), a protein found in both human cells and bacteria. Researchers tested blood samples from ME/CFS patients and healthy people, finding that some ME/CFS patients had specific antibodies against a bacterial version of this protein. This suggests that a past infection might trigger the immune system to attack proteins in the body, which could contribute to ME/CFS.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome.

Warren, John W, Clauw, Daniel J, Langenberg, Patricia·BJU international·2013

This study followed 304 women with interstitial cystitis/painful bladder syndrome (IC/PBS)—a condition causing bladder pain, urgency, and frequent urination—for about 3 years after their symptoms started. Researchers found that women who had mild symptoms at the beginning were more likely to stay mild, while women who also had chronic fatigue syndrome (ME/CFS) tended to develop more severe bladder symptoms over time.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Marques, M, De Gucht, V, Leal, I et al.·International journal of behavioral medicine·2013

This study compared ME/CFS patients from Portugal and the Netherlands to see how their experiences with fatigue, physical symptoms, and quality of life were similar or different. Researchers found that while both groups experienced worse quality of life when fatigue was more severe, the psychological and behavioral factors that made fatigue worse were somewhat different between the two countries.

E2 ModerateBehavioralPEM not requiredLongitudinal

Role of psychological aspects in both chronic pain and in daily functioning in chronic fatigue syndrome: a prospective longitudinal study.

Meeus, Mira, Nijs, Jo, Van Mol, Evelyne et al.·Clinical rheumatology·2012

This study looked at 103 people with ME/CFS who also experience widespread muscle pain, and examined how psychological factors like catastrophizing (expecting the worst), depression, and fear of movement affect their pain levels and daily activities. Over 6-12 months, the researchers found that catastrophizing and depression were the strongest predictors of both pain intensity and difficulty with daily functioning. The findings suggest that addressing these psychological factors alongside physical symptoms may be important for managing pain in ME/CFS.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Prevalence of xenotropic murine leukemia virus-related virus infection in different risk populations in Spain.

Arredondo, Miguel, Hackett, John, de Bethencourt, Fermín R et al.·AIDS research and human retroviruses·2012

Researchers tested blood samples from over 1,100 people in Spain, including those with ME/CFS and fibromyalgia, to look for a virus called XMRV that had been suggested as a possible cause of these conditions. They found no reliable evidence that XMRV was present in any of the groups they studied, including people with ME/CFS, cancer, other viral infections, or healthy blood donors.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Are fatigue symptoms and chronic fatigue syndrome following Q fever infection related to psychosocial variables?

Strauss, Bernhard, Löschau, Maria, Seidel, Thomas et al.·Journal of psychosomatic research·2012

This study looked at fatigue in people who had been infected with Q fever (a bacterial infection) compared to people who hadn't had it. Researchers found that Q fever survivors reported much more fatigue than the control group, but very few met the strict criteria for chronic fatigue syndrome (CFS). People with Q fever who had fatigue also reported more health worries, physical symptoms, and emotional stress than those without fatigue.

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins.

Jammes, Y, Steinberg, J G, Delliaux, S·Journal of internal medicine·2012

This study examined whether a history of intense exercise or serious infections in ME/CFS patients affects how their bodies handle oxidative stress (cellular damage) and produce protective heat shock proteins. Researchers compared 43 ME/CFS patients with different backgrounds to 23 healthy controls, measuring stress markers and protective proteins both at rest and after exercise. They found that ME/CFS patients with a history of high-level sports or infections showed signs of greater cellular damage and weaker protective responses to exercise.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Conditions comorbid with chronic fatigue in a population-based sample.

Dansie, Elizabeth J, Furberg, Helena, Afari, Niloofar et al.·Psychosomatics·2012

This study looked at how often ME/CFS occurs together with other conditions like chronic widespread pain, irritable bowel syndrome, and depression in a general population sample. Researchers found that people with ME/CFS-like illness were about 14 times more likely to have at least one of these three conditions compared to those without them. The study suggests that these conditions frequently occur together with ME/CFS, but it did not find that having these additional conditions made the ME/CFS itself fundamentally different.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The comorbidity of self-reported chronic fatigue syndrome, post-traumatic stress disorder, and traumatic symptoms.

Dansie, Elizabeth J, Heppner, Pia, Furberg, Helena et al.·Psychosomatics·2012

This study found that people with ME/CFS are much more likely to have experienced trauma or PTSD than the general population. Researchers surveyed over 8,500 twins and discovered that those with a history of PTSD were 8 times more likely to report ME/CFS, and those with high trauma symptom scores were 4 times more likely to report ME/CFS. The connection remained strong even after accounting for shared family factors.

E2 ModerateCohortPEM unclearCross-Sectional

Seroprevalence of xenotropic murine leukemia virus-related virus in normal and retrovirus-infected blood donors.

Qiu, Xiaoxing, Swanson, Priscilla, Tang, Ning et al.·Transfusion·2012

Researchers tested blood samples from over 2,000 donors worldwide to see if they carried XMRV, a virus that had been suggested as a possible cause of ME/CFS. They found very little evidence that XMRV was present in most people's blood. The small amount of positive results they found were likely false positives caused by confusion with a different virus (HTLV-I) that shares similar genetic sequences.

E2 ModerateCohortPEM not requiredCase-Control

The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission.

Mikirova, Nina, Casciari, Joseph, Hunninghake, Ronald·Alternative therapies in health and medicine·2012

This study tested whether measuring a specific molecule in the blood called NAD(P)H could help diagnose and monitor ME/CFS. The researchers found that people with ME/CFS had lower levels of this energy-related molecule compared to healthy people, and this difference might be useful as a blood test marker for the disease.

Energy Metabolism

E2 ModerateCohortPEM unclearCross-Sectional

Short communication: RNASEL alleles and susceptibility to infection by human retroviruses and hepatitis viruses.

Arredondo, Miguel, de Bethencourt, Fermín, Treviño, Ana et al.·AIDS research and human retroviruses·2012

This study looked at whether a specific gene variant called RNASEL affects how likely people are to get infected with certain viruses. Researchers compared the gene variant in people with different viral infections, including chronic fatigue syndrome (ME/CFS), HIV, hepatitis, and others. They found that the gene variant did not seem to influence susceptibility to most common viral infections studied, though there were some interesting patterns with two less common viruses.

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Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Bladder pain syndrome/interstitial cystitis is associated with hyperthyroidism.

Cognitive performance is of clinical importance, but is unrelated to pain severity in women with chronic fatigue syndrome.

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

The number of existing functional somatic syndromes (FSSs) is an important risk factor for new, different FSSs.

Cognitive deficits in chronic fatigue syndrome and their relationship to psychological status, symptomatology, and everyday functioning.

Epitopes of microbial and human heat shock protein 60 and their recognition in myalgic encephalomyelitis.

Prognostic factors for recent-onset interstitial cystitis/painful bladder syndrome.

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Role of psychological aspects in both chronic pain and in daily functioning in chronic fatigue syndrome: a prospective longitudinal study.

Prevalence of xenotropic murine leukemia virus-related virus infection in different risk populations in Spain.

Are fatigue symptoms and chronic fatigue syndrome following Q fever infection related to psychosocial variables?

Chronic fatigue syndrome: acute infection and history of physical activity affect resting levels and response to exercise of plasma oxidant/antioxidant status and heat shock proteins.

Conditions comorbid with chronic fatigue in a population-based sample.

The comorbidity of self-reported chronic fatigue syndrome, post-traumatic stress disorder, and traumatic symptoms.

Seroprevalence of xenotropic murine leukemia virus-related virus in normal and retrovirus-infected blood donors.

The assessment of the energy metabolism in patients with chronic fatigue syndrome by serum fluorescence emission.

Short communication: RNASEL alleles and susceptibility to infection by human retroviruses and hepatitis viruses.

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