ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1441–1460 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Long-term parental unemployment in childhood and subsequent chronic fatigue syndrome.

Fuller-Thomson, Esme, Mehta, Rukshan, Sulman, Joanne·ISRN family medicine·2013

This study looked at whether having a parent who was unemployed for a long time during childhood is connected to developing ME/CFS later in life. Researchers surveyed over 7,000 Canadian women and found that those who experienced parental unemployment in childhood were about 3 times more likely to have ME/CFS as adults, even after accounting for other life challenges and health factors.

E2 ModerateCohortPEM not requiredCross-Sectional

Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children.

Kawabata, Minako, Ueno, Taro, Tomita, Jun et al.·BMC psychiatry·2013

This study looked at sleep and rest patterns in healthy children and children with chronic fatigue syndrome (CFS) using wristband activity trackers. The researchers found that when they looked at the patterns of rest and sleep separately—distinguishing between time spent out of bed versus in bed—children with CFS had different patterns compared to healthy children. This suggests that how the body organizes rest and activity may be disrupted in CFS.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Contrasting Chronic Fatigue Syndrome versus Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Jason, Leonard A, Brown, Abigail, Evans, Meredyth et al.·Fatigue : biomedicine, health & behavior·2013

This study compared two different sets of diagnostic criteria used to identify ME/CFS patients. Researchers found that the Canadian criteria are stricter and identify patients who tend to be more severely affected, while the older Fukuda criteria cast a wider net. This suggests that the criteria used to diagnose someone with ME/CFS can significantly affect who gets identified as having the condition.

Diagnostics

E2 ModerateBehavioralPEM not requiredLongitudinal

Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up.

Nijhof, Sanne L, Priesterbach, Loudy P, Uiterwaal, Cuno S P M et al.·Pediatrics·2013

This study followed adolescents with ME/CFS for nearly 3 years after they completed an internet-based cognitive behavioral therapy program called FITNET. About 59% of teenagers had recovered from their illness by the end of the follow-up period, and most of those who improved right after treatment stayed better. Interestingly, teens who received standard care also recovered at similar rates over time, though it took longer.

E2 ModeratePEM not requiredRegistry-Resource

Cholecystectomy and clinical presentations of gastroparesis.

Parkman, Henry P, Yates, Katherine, Hasler, William L et al.·Digestive diseases and sciences·2013

This study looked at 391 patients with gastroparesis (a condition where the stomach empties food slowly) to see if those who had their gallbladder removed had different symptoms than those who hadn't. They found that patients who had gallbladder surgery experienced more severe upper abdominal pain and retching, but less constipation. Interestingly, patients with prior gallbladder removal also had more other health conditions, including chronic fatigue syndrome and fibromyalgia.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring.

Dixit, Ronak, Popescu, Alexandra, Bagić, Anto et al.·Epilepsy & behavior : E&B·2013

This study looked at 280 patients seen at a hospital epilepsy unit to understand what health conditions are more common in people with psychogenic nonepileptic spells (PNES)—seizure-like episodes that aren't caused by epilepsy—compared to those with actual epilepsy. They found that patients with PNES were more likely to be female, have a history of trauma, and experience conditions like fibromyalgia, chronic fatigue syndrome, chronic pain, and irritable bowel syndrome. The researchers suggest these patterns might help doctors identify PNES earlier and order the right tests sooner.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

Neblett, Randy, Cohen, Howard, Choi, YunHee et al.·The journal of pain·2013

This study tested a questionnaire called the Central Sensitization Inventory (CSI) to see if it could help doctors identify patients with conditions like ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers believe these conditions may share a common cause: the nervous system becoming overly sensitive to pain and other stimuli. The study found that a CSI score of 40 or higher was a good way to identify patients with these central sensitivity syndromes.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria.

Baraniuk, James N, Adewuyi, Oluwatoyin, Merck, Samantha Jean et al.·American journal of translational research·2013

This study created a scoring system to help doctors better identify and measure ME/CFS severity by combining eight common symptoms (fatigue, pain, cognitive problems, sleep issues, and post-exertion exhaustion). Researchers found that a total symptom score of 14 or higher, combined with moderate-to-severe fatigue, accurately distinguished ME/CFS patients from healthy people. This scoring system was highly consistent and may help match patients to specific disease subtypes.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Mariman, An, Delesie, Liesbeth, Tobback, Els et al.·Journal of psychosomatic research·2013

Researchers studied nearly 280 patients who came to a specialized clinic thinking they had ME/CFS, and gave them thorough medical, sleep, and mental health assessments. They found that only about 23% actually had clear-cut ME/CFS; most others had sleep problems like sleep apnea, depression or anxiety, or a combination of these conditions. This suggests that when people feel persistently exhausted, many different medical and mental health issues could be the real cause.

Diagnostics

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Bossuyt, Xavier, Cooreman, Sarah, De Baere, Heidi et al.·Clinica chimica acta; international journal of clinical chemistry·2013

This study tested an automated machine to detect antinuclear antibodies (ANA)—proteins the immune system sometimes makes that can be seen in blood tests. Researchers compared how well this automated system worked compared to traditional methods, using blood samples from people with autoimmune diseases, healthy donors, people with chronic fatigue syndrome, and other patient groups. The machine was good at collecting images but had difficulty identifying the specific patterns of these antibodies accurately.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

Association of bladder pain syndrome/interstitial cystitis with urinary calculus: a nationwide population-based study.

Keller, Joseph, Chen, Yi-Kuang, Lin, Herng-Ching·International urogynecology journal·2013

This study looked at whether people with bladder pain syndrome/interstitial cystitis (BPS/IC) are more likely to have had kidney stones or other urinary stones. Researchers compared about 9,000 people newly diagnosed with BPS/IC to over 46,000 similar people without BPS/IC and found that those with BPS/IC were significantly more likely to have a history of urinary stones, particularly bladder stones.

Pain and Sensitization

E2 ModerateCohortPEM not requiredObservational

Fatigue heralding multiple sclerosis.

Berger, Joseph R, Pocoski, Jennifer, Preblick, Ronald et al.·Multiple sclerosis (Houndmills, Basingstoke, England)·2013

This study looked at medical records to see how often fatigue appears before someone is diagnosed with multiple sclerosis (MS). Researchers found that about 29% of newly diagnosed MS patients had been labeled with fatigue in the 3 years before their MS diagnosis, often 1–2 years earlier. The findings suggest that persistent fatigue might be an early warning sign of MS, and doctors should carefully evaluate people with unexplained fatigue for possible neurological causes.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome.

Lewis, I, Pairman, J, Spickett, G et al.·Journal of internal medicine·2013

Some ME/CFS patients also have POTS (a condition where the heart rate and blood pressure don't adjust properly when standing up). This study found that ME/CFS patients with POTS are younger, experience less severe fatigue and depression, and have different patterns of daytime sleepiness compared to ME/CFS patients without POTS. A simple combination of two questionnaires can accurately identify which ME/CFS patients have POTS, potentially helping doctors decide who needs additional testing and treatment.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCase-Control

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

Kempke, Stefan, Van Den Eede, Filip, Schotte, Chris et al.·International journal of behavioral medicine·2013

This study tested whether people with ME/CFS have more personality disorders than the general population. Researchers gave 92 women with ME/CFS and two comparison groups (92 community members and 92 psychiatric patients) a questionnaire about personality traits. The results showed that ME/CFS patients had personality disorder rates similar to healthy people, not higher rates, though they did show some depressive and obsessive-compulsive traits.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Marques, M, De Gucht, V, Leal, I et al.·International journal of behavioral medicine·2013

This study compared ME/CFS patients from Portugal and the Netherlands to see how their experiences with fatigue, physical symptoms, and quality of life were similar or different. Researchers found that while both groups experienced worse quality of life when fatigue was more severe, the psychological and behavioral factors that made fatigue worse were somewhat different between the two countries.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Smorgick, Noam, Marsh, Courtney A, As-Sanie, Sawsan et al.·Journal of pediatric and adolescent gynecology·2013

This study looked at young women (under age 24) with endometriosis to see how often they also experienced other pain conditions, mood problems, and asthma. Researchers found that more than half had multiple pain syndromes (like chronic fatigue syndrome, fibromyalgia, or irritable bowel syndrome), about half had depression or anxiety, and about a quarter had asthma. The study suggests these conditions often occur together in young women with endometriosis.

E2 ModerateCohortPEM not requiredObservational

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

Donegan, Katherine, Beau-Lejdstrom, Raphaelle, King, Bridget et al.·Vaccine·2013

This study examined whether the cervical cancer vaccine (Cervarix) given to girls in the UK was linked to chronic fatigue syndrome or other fatigue conditions. Researchers compared how often fatigue-related conditions were reported after the vaccine was introduced in 2008 to how often they were expected to occur naturally. They found no evidence that the vaccine increased the risk of developing these fatigue syndromes.

E2 ModerateCohortPEM unclearObservational

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Rezaei, Simin D, Hearps, Anna C, Mills, John et al.·Virology journal·2013

Researchers tested tissue samples from 35 Australian prostate cancer patients to see if they contained XMRV or related viruses, which had been claimed to cause both prostate cancer and ME/CFS. Using sensitive laboratory tests, they found no evidence of these viruses in any of the samples. This study adds to growing evidence that XMRV is not actually involved in prostate cancer and was likely a laboratory contamination rather than a real virus.

E2 ModerateCohortPEM not requiredCross-Sectional

Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation.

Rayhan, Rakib U, Ravindran, Murugan K, Baraniuk, James N·Frontiers in physiology·2013

This study found that migraines are very common in people with ME/CFS and Gulf War Illness—occurring in about 8 out of 10 ME/CFS patients and 6 out of 10 Gulf War Illness patients, compared to only 1 out of 8 healthy people. The researchers suggest that both conditions may affect how the brain and nervous system process pain, and that doctors should routinely check for and treat migraines in patients with these illnesses.

Pain and Sensitization

E2 ModerateBehavioralPEM unclearObservational

Cognitive behavior therapy in patients with chronic fatigue syndrome: the role of illness acceptance and neuroticism.

Poppe, Carine, Petrovic, Mirko, Vogelaers, Dirk et al.·Journal of psychosomatic research·2013

This study tested whether cognitive behavior therapy (CBT)—a talking treatment that helps change thought patterns and behaviors—improves quality of life in ME/CFS patients. Eighty patients received CBT and reported on their mental health, physical wellbeing, fatigue, and personality traits before and after treatment. While patients did improve, the gains were modest, and the study found that personality traits like neuroticism and how much patients accept their illness affected who benefited most.

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Long-term parental unemployment in childhood and subsequent chronic fatigue syndrome.

Temporal organization of rest defined by actigraphy data in healthy and childhood chronic fatigue syndrome children.

Contrasting Chronic Fatigue Syndrome versus Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Internet-based therapy for adolescents with chronic fatigue syndrome: long-term follow-up.

Cholecystectomy and clinical presentations of gastroparesis.

Medical comorbidities in patients with psychogenic nonepileptic spells (PNES) referred for video-EEG monitoring.

The Central Sensitization Inventory (CSI): establishing clinically significant values for identifying central sensitivity syndromes in an outpatient chronic pain sample.

A Chronic Fatigue Syndrome (CFS) severity score based on case designation criteria.

Undiagnosed and comorbid disorders in patients with presumed chronic fatigue syndrome.

Detection of antinuclear antibodies by automated indirect immunofluorescence analysis.

Association of bladder pain syndrome/interstitial cystitis with urinary calculus: a nationwide population-based study.

Fatigue heralding multiple sclerosis.

Clinical characteristics of a novel subgroup of chronic fatigue syndrome patients with postural orthostatic tachycardia syndrome.

Prevalence of DSM-IV personality disorders in patients with chronic fatigue syndrome: a controlled study.

A cross-cultural perspective on psychological determinants of chronic fatigue syndrome: a comparison between a Portuguese and a Dutch patient sample.

Prevalence of pain syndromes, mood conditions, and asthma in adolescents and young women with endometriosis.

Bivalent human papillomavirus vaccine and the risk of fatigue syndromes in girls in the UK.

No association between XMRV or related gammaretroviruses in Australian prostate cancer patients.

Migraine in gulf war illness and chronic fatigue syndrome: prevalence, potential mechanisms, and evaluation.

Cognitive behavior therapy in patients with chronic fatigue syndrome: the role of illness acceptance and neuroticism.

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