ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1441–1460 of 2,768 studies

E2 ModerateCohortPEM not requiredCross-Sectional

A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.

Loew, Stephen J, Watson, Kenneth·Perceptual and motor skills·2012

This study looked at whether a specific gene called APOB might be linked to Meares-Irlen syndrome, a condition that affects how the eyes process visual information and can make reading difficult. The researchers found that certain variations of this gene were more common in people with Meares-Irlen syndrome than in people without it. This is interesting because the same gene has been connected to problems with fat and cholesterol metabolism, which have also been found in ME/CFS and other conditions.

Pain and Sensitization

E2 ModerateCohortPEM not requiredLongitudinal

Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Katz, Ben Z, Stewart, Julian M, Shiraishi, Yukiko et al.·Clinical pediatrics·2012

This study looked at whether teenagers with ME/CFS have trouble standing up for long periods (a condition called orthostatic intolerance). Researchers tested 36 teens with ME/CFS and 43 recovered teens, all about 6 months after having infectious mononucleosis. Surprisingly, they found that similar numbers of both groups had difficulty with standing tolerance, suggesting this may not be a key difference between those who recover and those who develop ME/CFS.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies.

Ravindran, Murugan, Adewuyi, Oluwatoyin, Zheng, Yin et al.·Global journal of health science·2012

Many people with ME/CFS experience shortness of breath, but this study found that their lungs work normally—the problem isn't with how well air moves in and out. Instead, people with ME/CFS seem to be overly sensitive to physical sensations like rapid heartbeat, chest pain, and dizziness during exertion, which makes them feel breathless. This suggests the shortness of breath in ME/CFS comes from how the nervous system processes these sensations rather than from damaged lungs.

Pain and Sensitization

E2 ModerateCohortPEM unclearCase-Control

IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.

Maes, Michael, Mihaylova, Ivana, Kubera, Marta et al.·Metabolic brain disease·2012

This study examined immune system markers in people with ME/CFS, depression, and healthy controls. Researchers found that people with ME/CFS had higher levels of specific immune antibodies (IgM) attacking certain body molecules compared to people with depression. These antibodies were especially high against fatty acid anchors and oxidatively damaged proteins, suggesting ME/CFS may involve distinct immune processes that differ from depression.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls.

White, Andrea T, Light, Alan R, Hughen, Ronald W et al.·Psychosomatic medicine·2012

This study compared how the bodies of ME/CFS patients, multiple sclerosis (MS) patients, and healthy people respond to moderate exercise by measuring changes in specific genes in blood cells. ME/CFS patients experienced much larger increases in fatigue and pain after exercise, and showed distinctive patterns of gene activity related to pain sensing and stress hormones that were different from MS patients and healthy controls.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

[Effects of tuina on the mechanical properties of skeletal muscles of four limbs in patients with chronic fatigue syndrome].

Liu, Kun-Peng, Fang, Min, Jiang, Shu-Yun·Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine·2012

This study tested whether tuina (a traditional Chinese massage therapy) could help ME/CFS patients regain muscle strength and reduce fatigue. Sixty people participated—30 with ME/CFS and 30 healthy controls. After 10 sessions of tuina therapy, ME/CFS patients showed improvements in muscle strength measurements and reported feeling less fatigued, though their muscles remained weaker than those of healthy people.

E2 ModerateCohortPEM unclearCross-Sectional

No evidence for xenotropic murine leukemia-related virus infection in Sweden using internally controlled multiepitope suspension array serology.

Blomberg, Jonas, Blomberg, Fredrik, Sjösten, Anna et al.·Clinical and vaccine immunology : CVI·2012

Researchers tested blood samples from ME/CFS patients and healthy blood donors to see if they had been infected with a mouse virus called XMRV, which had been proposed as a possible cause of ME/CFS. Using a sensitive new testing method that looked for multiple signs of XMRV infection, they found no difference in viral markers between the two groups, suggesting XMRV is not associated with ME/CFS.

E2 ModerateCohortPEM unclearObservational

A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus.

Alter, Harvey J, Mikovits, Judy A, Switzer, William M et al.·mBio·2012

Earlier studies suggested that two viruses (XMRV and pMLV) might cause ME/CFS, but this finding was controversial. In this study, the same scientists who originally reported finding these viruses carefully re-examined blood samples from 147 ME/CFS patients and 146 healthy people without knowing which samples came from which group. They found no evidence that either virus was present in any of the samples, meaning the original finding could not be confirmed.

E2 ModerateCohortPEM not requiredObservational

Comparison of chronic fatigue syndrome/myalgic encephalopathy with other disorders: an observational study.

Knudsen, Ak, Lervik, Lv, Harvey, Sb et al.·JRSM short reports·2012

Researchers looked at how many people were using online discussion forums for different health conditions in Norway in 2009. They found that ME/CFS forums were far more active than forums for other illnesses—with more users and more messages posted relative to how many people have the condition. This high activity might mean that people with ME/CFS are seeking answers and support online, especially since the condition is poorly understood and sometimes stigmatized.

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care.

Wiborg, Jan F, Knoop, Hans, Wensing, Michel et al.·Behaviour research and therapy·2012

This study looked at how well cognitive behavior therapy (CBT) for ME/CFS works when delivered by different therapists in regular mental health clinics rather than specialized centers. Researchers found that the individual therapist made a big difference in patient outcomes—accounting for 21% of the improvement variation. The therapist's beliefs about using treatment manuals and the specific clinic where treatment happened both influenced how well patients did.

E2 ModerateCohortPEM not requiredObservational

Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project.

Vincent, Ann, Brimmer, Dana J, Whipple, Mary O et al.·Mayo Clinic proceedings·2012

This study looked at how many people in one county had ME/CFS by reviewing medical records from 1998-2002. Researchers found that about 71 out of every 100,000 people had ME/CFS, and about 13 out of every 100,000 per year were newly diagnosed. Importantly, they discovered that 70% of people initially suspected of having ME/CFS actually had other medical conditions that explained their fatigue instead.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.

Hanevik, Kurt, Kristoffersen, Einar K, Sørnes, Steinar et al.·BMC infectious diseases·2012

This study looked at immune system changes in people who developed chronic fatigue and gut problems after a Giardia infection. Researchers found that people with post-infectious chronic fatigue had lower levels of natural killer (NK) cells, which are important for fighting infections. The more severe someone's fatigue and stomach symptoms were, the lower their NK cells tended to be.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis.

Warren, John W, Clauw, Daniel J·Psychosomatic medicine·2012

This study found that when doctors ask patients "Have you been diagnosed with ME/CFS or fibromyalgia?" they miss many people who actually have these conditions based on their symptoms. For example, doctors missed 90% of people who truly had ME/CFS by symptom criteria, and 77% of those with fibromyalgia. The researchers showed that asking about symptoms directly, rather than relying on patients to report a doctor's diagnosis, is much more accurate for identifying these conditions.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Attention-deficit hyperactivity disorder in chronic fatigue syndrome patients.

Sáez-Francàs, Naia, Alegre, José, Calvo, Natalia et al.·Psychiatry research·2012

This study looked at whether people with ME/CFS also have ADHD (attention-deficit hyperactivity disorder), a condition that affects focus and attention. Researchers found that about 30% of ME/CFS patients had ADHD as children, and about 21% still had it as adults. People with ME/CFS who also had ADHD experienced worse depression and anxiety, more severe fatigue, and higher suicide risk than those without ADHD.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile.

Cockshell, Susan J, Mathias, Jane L·Journal of clinical and experimental neuropsychology·2012

This study tested whether people with ME/CFS perform poorly on thinking tests because they aren't trying hard enough, or because of the illness itself. Researchers gave 54 people with ME/CFS and 54 healthy people a special test designed to measure effort and intention during testing. The results showed that most people in both groups were trying their best, and very few showed signs of not putting in effort—suggesting that low effort is not the reason people with ME/CFS struggle with cognitive tasks.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control study.

Jones, David E J, Hollingsworth, Kieren G, Jakovljevic, Djordje G et al.·European journal of clinical investigation·2012

This study looked at how muscles produce and use energy during exercise in ME/CFS patients compared to healthy people. Researchers found that ME/CFS patients' muscles became more acidic (like buildup of lactic acid) during exercise and took much longer to recover back to normal levels, even after repeated exercise sessions. This abnormal response to exercise may explain why some ME/CFS patients feel worse after exertion rather than better.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Responses to exercise differ for chronic fatigue syndrome patients with fibromyalgia.

Cook, Dane B, Stegner, Aaron J, Nagelkirk, Paul R et al.·Medicine and science in sports and exercise·2012

This study compared how the bodies of ME/CFS patients respond to moderate exercise on a stationary bike. Researchers found that patients who have both ME/CFS and fibromyalgia (a condition causing widespread pain) showed different heart and breathing responses during exercise compared to healthy people, including higher perceived effort and different blood pressure patterns.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Booth, Norman E, Myhill, Sarah, McLaren-Howard, John·International journal of clinical and experimental medicine·2012

This study tested whether ME/CFS fatigue is caused by problems with how cells produce energy. Researchers measured energy production in immune cells from 138 ME/CFS patients and compared them to healthy controls, finding that all patients had measurable problems with their cellular energy factories (mitochondria) that matched how sick they felt. The study also found signs of tissue damage in the blood, suggesting these energy problems affect many cells throughout the body.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

Factor analysis of the Beck Depression Inventory-II with patients with chronic fatigue syndrome.

Brown, Molly, Kaplan, Carly, Jason, Leonard·Journal of health psychology·2012

This study looked at how well a depression screening tool (the Beck Depression Inventory-II) works for people with ME/CFS. The researchers found that the tool picks up on physical and emotional symptoms separately, and that people with ME/CFS tend to score high on the physical symptom questions because many overlap with ME/CFS symptoms like fatigue. A simpler version of the tool designed for primary care settings worked better for this group.

E2 ModerateCohortPEM not requiredCross-Sectional

Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome.

Paolucci, Stefania, Piralla, Antonio, Zanello, Cinzia et al.·The new microbiologica·2012

This study looked for two viruses (XMRV and MLV-related viruses) that had been suggested as possible causes of ME/CFS. Researchers tested 12 ME/CFS patients and 40 healthy control subjects. They found these viruses in only 2 of the 12 patients, while all controls tested negative. The results suggest these viruses are not common in ME/CFS patients, and previous reports of finding them may have been due to laboratory contamination with mouse DNA.

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A prospective genetic marker of the visual-perception disorder Meares-Irlen syndrome.

Orthostatic tolerance testing in a prospective cohort of adolescents with chronic fatigue syndrome and recovered controls following infectious mononucleosis.

Dyspnea in Chronic Fatigue Syndrome (CFS): comparison of two prospective cross-sectional studies.

IgM-mediated autoimmune responses directed against anchorage epitopes are greater in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) than in major depression.

Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls.

[Effects of tuina on the mechanical properties of skeletal muscles of four limbs in patients with chronic fatigue syndrome].

No evidence for xenotropic murine leukemia-related virus infection in Sweden using internally controlled multiepitope suspension array serology.

A multicenter blinded analysis indicates no association between chronic fatigue syndrome/myalgic encephalomyelitis and either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus.

Comparison of chronic fatigue syndrome/myalgic encephalopathy with other disorders: an observational study.

Therapist effects and the dissemination of cognitive behavior therapy for chronic fatigue syndrome in community-based mental health care.

Prevalence, incidence, and classification of chronic fatigue syndrome in Olmsted County, Minnesota, as estimated using the Rochester Epidemiology Project.

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome.

Functional somatic syndromes: sensitivities and specificities of self-reports of physician diagnosis.

Attention-deficit hyperactivity disorder in chronic fatigue syndrome patients.

Test effort in persons with Chronic Fatigue Syndrome when assessed using the Validity Indicator Profile.

Loss of capacity to recover from acidosis on repeat exercise in chronic fatigue syndrome: a case-control study.

Responses to exercise differ for chronic fatigue syndrome patients with fibromyalgia.

Mitochondrial dysfunction and the pathophysiology of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Factor analysis of the Beck Depression Inventory-II with patients with chronic fatigue syndrome.

Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome.

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