ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1561–1580 of 2,807 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Adolescent chronic fatigue syndrome: prevalence, incidence, and morbidity.

Nijhof, Sanne L, Maijer, Kimberley, Bleijenberg, Gijs et al.·Pediatrics·2011

This Dutch study looked at how many teenagers have ME/CFS and how many develop it each year. Researchers found that about 111 out of every 100,000 teenagers have ME/CFS, and about 12 per 100,000 develop it annually. Most teens with ME/CFS experience severe fatigue and physical impairment, and nearly half miss more than half their school days.

E2 ModerateCohortPEM not requiredCross-Sectional

Length of illness does not predict cognitive dysfunction in chronic fatigue syndrome.

Santamarina-Perez, Pilar, Eiroa-Orosa, Francisco Jose, Freniche, Verónica et al.·Applied neuropsychology·2011

This study examined whether cognitive problems (like memory and concentration difficulties) in ME/CFS get worse the longer someone has the illness. Researchers tested 56 women with ME/CFS and divided them into groups based on how long they'd been sick. They found that cognitive problems were similar across all groups, regardless of illness duration. This suggests that cognitive difficulties in ME/CFS don't progressively worsen over time.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Toxicokinetics of mercury after long-term repeated exposure to thimerosal-containing vaccine.

Barregard, Lars, Rekić, Dinko, Horvat, Milena et al.·Toxicological sciences : an official journal of the Society of Toxicology·2011

This study looked at whether mercury from a vaccine preservative (thimerosal) builds up in the blood of adults receiving repeated vaccine injections over weeks. Researchers found that while mercury levels briefly increased 1 day after each injection, they returned to normal within a few weeks and did not accumulate over time. The mercury was cleared from the body relatively quickly, similar to how the body handles other forms of mercury.

E2 ModerateCohortPEM not requiredCross-Sectional

Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals.

Lintas, Carla, Guidi, Francesco, Manzi, Barbara et al.·PloS one·2011

Researchers wanted to know if a virus called XMRV or related viruses might cause autism. They tested blood, brain tissue, and semen samples from people with autism, their fathers, and control groups. They found no evidence that XMRV or similar viruses were present in autism patients, suggesting these viruses are unlikely to play a role in causing autism.

E2 ModerateCohortPEM unclearCross-Sectional

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Brenu, Ekua W, van Driel, Mieke L, Staines, Don R et al.·Journal of translational medicine·2011

This study examined immune system markers in 95 ME/CFS patients compared to 50 healthy people to see if certain blood tests could help diagnose the condition. Researchers found that ME/CFS patients had imbalanced immune responses, including higher levels of certain inflammatory proteins and lower activity of immune cells that normally fight infections. These immune differences might one day be used as reliable diagnostic markers to help doctors identify ME/CFS.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCase-Control

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.

Moldofsky, Harvey, Patcai, John·BMC neurology·2011

This study looked at people who had severe SARS infection and were unable to return to work for over a year afterward. These patients experienced long-lasting fatigue, widespread muscle pain, weakness, depression, and poor sleep quality. Researchers found that their sleep patterns and symptoms were very similar to those seen in fibromyalgia and chronic fatigue syndrome.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredLongitudinal

Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort.

Clark, Charlotte, Goodwin, Laura, Stansfeld, Stephen A et al.·The British journal of psychiatry : the journal of mental science·2011

This study followed over 11,000 British children from birth until age 42 to identify early warning signs of ME/CFS. Researchers found that people who experienced physical abuse from parents, had frequent stomach problems as children, or caught many colds were more likely to develop ME/CFS later in life. The study also confirmed that mood and mental health problems occurring before ME/CFS developed played an important role in the condition's development.

E2 ModerateCohortPEM not requiredCross-Sectional

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome.

Smits, Bart, van den Heuvel, Lambert, Knoop, Hans et al.·Mitochondrion·2011

This study looked at whether measurements of mitochondria (the energy-producing parts of cells) can help distinguish ME/CFS from true mitochondrial diseases. The researchers found that while people with ME/CFS have fewer mitochondria overall, the mitochondria that are present work normally. In contrast, people with actual mitochondrial disorders have mitochondria that don't function well, even when mitochondrial numbers are considered.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

[The role of depression in cognitive impairment in patients with chronic fatigue syndrome].

Santamarina-Pérez, Pilar, Freniche, Verónica, Eiroa-Orosa, Francisco Jose et al.·Medicina clinica·2011

This study tested whether depression explains the thinking and memory problems that people with ME/CFS experience. Researchers gave 57 women with ME/CFS a variety of cognitive tests measuring attention, memory, and processing speed, then compared results between those with and without depression. The findings showed that cognitive problems were present in ME/CFS patients regardless of whether they had depression, suggesting that the brain fog and thinking difficulties are part of ME/CFS itself, not caused by depression.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome.

Jerome, Keith R, Diem, Kurt, Huang, Meei-Li et al.·Diagnostic microbiology and infectious disease·2011

Researchers tested whether a virus called XMRV was present in people with ME/CFS by comparing identical twins where one had the illness and one didn't. They looked for the virus in blood samples using multiple sensitive tests. They found no evidence of XMRV in any of the people with ME/CFS, suggesting this virus is not likely a cause of the disease.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome.

Eglinton, Rebekah, Chung, Man Cheung·Psychiatry research·2011

This study looked at whether people with ME/CFS have higher rates of PTSD (post-traumatic stress disorder) and whether trauma-related stress affects fatigue levels. Researchers found that ME/CFS patients did experience more PTSD symptoms and traumatic life events than healthy controls, but surprisingly, the severity of PTSD symptoms did not directly predict how severe their fatigue was. Instead, a sense of helplessness was more strongly linked to both fatigue and mental health problems.

E2 ModerateCohortPEM not requiredCase-Control

Cognitive impairment in fatigue and sleepiness associated conditions.

Neu, Daniel, Kajosch, Hendrik, Peigneux, Philippe et al.·Psychiatry research·2011

This study compared how fatigue and sleepiness affect thinking and memory. Researchers tested 15 people with ME/CFS, 15 people with sleep apnea, and 16 healthy controls using memory tests, attention tasks, and brain wave measurements. Both patient groups showed cognitive problems, though people with sleep apnea had slightly more difficulty with certain thinking tasks and movement speed.

SleepCognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

Investigation into the presence of and serological response to XMRV in CFS patients.

Erlwein, Otto, Robinson, Mark J, Kaye, Steve et al.·PloS one·2011

This study tested whether a virus called XMRV could be found in people with ME/CFS. Researchers used the same methods from earlier studies that had suggested a link between this virus and ME/CFS. They checked patient blood samples for the virus itself and for antibodies (immune response markers) to the virus. Their results found no evidence that XMRV is associated with ME/CFS in UK patients.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

Williams, Allison M, Kitchen, Peter, Eby, Jeanette·BMC complementary and alternative medicine·2011

This study looked at how many people in Ontario, Canada visited alternative health care providers like massage therapists, acupuncturists, and naturopaths in 2005. Researchers found that about 13% of adults (over 1.2 million people) used these services. People with chronic conditions, including chronic fatigue syndrome, were more likely to visit alternative providers, especially if they felt their regular doctors weren't meeting their health needs.

E2 ModerateCohortPEM not requiredObservational

The effect of exercise cessation on non-articular tenderness measures and quality of life in well-trained athletes.

Zeller, Lior, Abu-Shakra, Mahmoud, Weitzman, Dahlia et al.·The Israel Medical Association journal : IMAJ·2011

This study looked at what happens to healthy athletes when they stop exercising for just one week. Researchers found that after 7 days without exercise, athletes developed increased body tenderness (similar to fibromyalgia pain) and reported lower quality of life. The findings suggest that lack of exercise might trigger symptoms similar to those seen in chronic fatigue syndrome and fibromyalgia.

E2 ModerateBehavioralPEM not requiredObservational

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Cella, Matteo, Stahl, Daniel, Reme, Silje Endresen et al.·Psychotherapy research : journal of the Society for Psychotherapy Research·2011

This study looked at whether it matters which therapist treats patients with ME/CFS when they receive cognitive behavioral therapy (CBT). Researchers tracked 374 ME/CFS patients treated by 12 different therapists in a specialized clinic and measured changes in fatigue and disability. They found that while patients improved overall, the individual therapist made almost no difference in outcomes—the patients' improvements were similar regardless of which qualified therapist treated them.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Physical activity intensity but not sedentary activity is reduced in chronic fatigue syndrome and is associated with autonomic regulation.

Newton, J L, Pairman, J, Hallsworth, K et al.·QJM : monthly journal of the Association of Physicians·2011

This study looked at how much people with ME/CFS move around during the day compared to healthy people. Researchers found that people with ME/CFS do less intense physical activity (like brisk walking or exercise) than healthy controls, even though they spend similar amounts of time sitting. The study also found that reduced physical activity was linked to problems with heart rate regulation in ME/CFS patients.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Selected Health Conditions Among Overweight, Obese, and Non-Obese Veterans of the 1991 Gulf War: Results from a Survey Conducted in 2003-2005.

Coughlin, Steven S, Kang, Han K, Mahan, Clare M·The open epidemiology journal·2011

This study looked at nearly 10,000 Gulf War veterans and veterans from the same era to see if weight and obesity were connected to health problems like chronic fatigue syndrome (CFS), post-traumatic stress disorder (PTSD), and multi-symptom illness. The researchers found that obese veterans were more likely to have PTSD, but obesity did not explain why Gulf War veterans had more CFS-like illness or multi-symptom illness compared to other veterans.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue syndrome: labels, meanings and consequences.

Wojcik, Wojtek, Armstrong, David, Kanaan, Richard·Journal of psychosomatic research·2011

This study surveyed British neurologists to understand how they view ME/CFS and whether they consider it a neurological condition. The results revealed that 84% of neurologists did not view ME/CFS as a neurological disorder, even though it is officially classified as one in the ICD-10 medical coding system. The researchers discuss how the way we label and classify ME/CFS affects how doctors treat patients and how patients understand their own illness.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients.

Delviks-Frankenberry, Krista A, Chaipan, Chawaree, Bagni, Rachel et al.·Advances in virology·2011

Researchers tested whether a virus called XMRV, which had been proposed as a possible cause of ME/CFS, was present in HIV-positive patients who developed lymphoma (a type of cancer). They checked blood samples from 26 patients using three different detection methods, but did not find any evidence of XMRV. This suggests that XMRV is not associated with lymphomas that develop in people with HIV.

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Evidence browser

Adolescent chronic fatigue syndrome: prevalence, incidence, and morbidity.

Length of illness does not predict cognitive dysfunction in chronic fatigue syndrome.

Toxicokinetics of mercury after long-term repeated exposure to thimerosal-containing vaccine.

Lack of infection with XMRV or other MLV-related viruses in blood, post-mortem brains and paternal gametes of autistic individuals.

Immunological abnormalities as potential biomarkers in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis.

Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post-SARS syndrome; a case-controlled study.

Premorbid risk markers for chronic fatigue syndrome in the 1958 British birth cohort.

Mitochondrial enzymes discriminate between mitochondrial disorders and chronic fatigue syndrome.

[The role of depression in cognitive impairment in patients with chronic fatigue syndrome].

Xenotropic murine leukemia virus-related virus in monozygotic twins discordant for chronic fatigue syndrome.

The relationship between posttraumatic stress disorder, illness cognitions, defence styles, fatigue severity and psychological well-being in chronic fatigue syndrome.

Cognitive impairment in fatigue and sleepiness associated conditions.

Investigation into the presence of and serological response to XMRV in CFS patients.

Alternative health care consultations in Ontario, Canada: A geographic and socio-demographic analysis.

The effect of exercise cessation on non-articular tenderness measures and quality of life in well-trained athletes.

Therapist effects in routine psychotherapy practice: an account from chronic fatigue syndrome.

Physical activity intensity but not sedentary activity is reduced in chronic fatigue syndrome and is associated with autonomic regulation.

Selected Health Conditions Among Overweight, Obese, and Non-Obese Veterans of the 1991 Gulf War: Results from a Survey Conducted in 2003-2005.

Chronic fatigue syndrome: labels, meanings and consequences.

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients.

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