ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

1741–1760 of 2,807 studies

E2 ModerateCohortPEM not requiredObservational

[Multiple chemical sensitivity: epidemiological, clinical and prognostic differences between occupational and non-occupational cases].

Nogué Xarau, Santiago, Alarcón Romay, María, Martínez Martínez, José-Miguel et al.·Medicina clinica·2010

This study looked at 165 people with multiple chemical sensitivity (MCS)—a condition where people react badly to everyday chemicals—to see if it made a difference whether their condition started from workplace exposure or other sources. People whose MCS began at work had fewer related conditions like chronic fatigue and fibromyalgia, and were less likely to become permanently disabled, compared to those whose MCS developed from non-work exposures.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality features and personality disorders in chronic fatigue syndrome: a population-based study.

Nater, Urs M, Jones, James F, Lin, Jin-Mann S et al.·Psychotherapy and psychosomatics·2010

This study looked at whether certain personality traits are more common in people with ME/CFS. Researchers compared 113 people with ME/CFS to people without it and found that those with ME/CFS had higher rates of certain personality patterns (like being more anxious or withdrawn) and personality disorders. However, these personality differences were not unique to ME/CFS—they also appeared in other chronically ill groups.

E2 ModerateCohortPEM unclearCross-Sectional

No evidence for XMRV association in pediatric idiopathic diseases in France.

Jeziorski, Eric, Foulongne, Vincent, Ludwig, Catherine et al.·Retrovirology·2010

Researchers tested whether a virus called XMRV might be causing various childhood illnesses and respiratory diseases. They checked samples from 151 children and adults with different conditions, but found no evidence that XMRV was present in any of them. This suggests that XMRV is likely not responsible for these particular diseases.

E2 ModerateCohortPEM unclearCase-Control

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.

Meeus, Mira, Nijs, Jo, Huybrechts, Sven et al.·Clinical rheumatology·2010

This study tested whether people with ME/CFS feel pain more intensely than healthy people, even in areas where they don't typically experience pain. Researchers measured how much pressure patients and healthy volunteers could tolerate before feeling pain. They found that ME/CFS patients with chronic pain had significantly lower pain thresholds everywhere on their body, suggesting their nervous system may be in a heightened state of sensitivity.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue and chronic fatigue syndrome-like complaints in the general population.

van't Leven, Marjolein, Zielhuis, Gerhard A, van der Meer, Jos W et al.·European journal of public health·2010

This study surveyed over 9,000 Dutch adults to understand how common fatigue is in the general population and what factors might be associated with it. Researchers found that about 1% of adults experience fatigue meeting CFS-like criteria, and 30% experience longer-lasting fatigue. People with CFS-like fatigue were more likely to be female, less physically active, obese, and taking painkillers regularly.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders.

Fink, Per, Schröder, Andreas·Journal of psychosomatic research·2010

This study looked at whether a new diagnosis called 'bodily distress syndrome' could capture several different conditions that cause physical symptoms not explained by standard medical tests—including ME/CFS, fibromyalgia, and irritable bowel syndrome. Researchers tested nearly 1,000 patients and found that bodily distress syndrome successfully identified 95% of patients across all these different diagnoses, suggesting these conditions might be better understood as variations of one underlying problem rather than completely separate diseases.

Diagnostics

E2 ModerateBehavioralPEM not requiredObservational

Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

Roberts, A D L, Charler, M-L, Papadopoulos, A et al.·Psychological medicine·2010

This study looked at whether a hormone called cortisol, which helps regulate stress and energy, affects how well cognitive behavioural therapy (CBT) works for ME/CFS patients. The researchers measured cortisol levels in 84 ME/CFS patients and tracked how many improved after receiving CBT. They found that patients with lower cortisol levels were less likely to respond well to CBT, suggesting that abnormal cortisol may be one reason why ME/CFS persists in some people.

Interventions

E2 ModerateCohortPEM not requiredCase-Control

A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome.

Fukuda, Sanae, Hashimoto, Ryota, Ohi, Kazutaka et al.·Life sciences·2010

This study looked at a genetic variant (a small difference in DNA) in a gene called DISC1 to see if it might be linked to ME/CFS. Researchers compared blood samples from people with ME/CFS and healthy controls, and found that people carrying a particular version of this genetic variant (called Cys704) had a higher risk of developing ME/CFS. This suggests that DISC1 might play a role in how ME/CFS develops, though more research is needed to understand exactly how.

E2 ModerateBehavioralPEM not requiredObservational

Predictors of outcome in a multi-component treatment program for chronic fatigue syndrome.

Kempke, Stefan, Goossens, Lutgarde, Luyten, Patrick et al.·Journal of affective disorders·2010

This study followed 178 ME/CFS patients through a multi-component treatment program to identify which patient characteristics predicted who would improve. The researchers found that only depression severity before treatment started was associated with how fatigued patients remained after treatment—patients with higher depression were more likely to stay fatigued afterward. This suggests that addressing depression alongside other ME/CFS treatments may be important.

Interventions

E2 ModerateCohortPEM not requiredLongitudinal

Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome.

Miwa, Kunihisa, Fujita, Masatoshi·Heart and vessels·2010

This study examined whether people with ME/CFS have lower levels of vitamin E, an important antioxidant that protects cells from damage. Researchers found that ME/CFS patients had significantly lower vitamin E levels than healthy controls, and these levels improved when patients went into remission, suggesting that oxidative stress (cellular damage from chemical imbalances) may play a role in ME/CFS.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease.

Maes, Michael, Mihaylova, Ivanka, Kubera, Marta et al.·Journal of affective disorders·2010

This study found that people with depression have higher levels of harmful molecules called peroxides and antibodies to oxidized cholesterol in their blood compared to healthy people. These markers suggest that depression involves increased oxidative stress—a type of cellular damage. Because these same markers are linked to heart disease and brain degeneration, the findings suggest depression may increase risk for these serious conditions through shared biological pathways.

E2 ModerateCohortPEM not requiredCross-Sectional

Methods for objective measure, quantification and analysis of sedentary behaviour and inactivity.

Chastin, S F M, Granat, M H·Gait & posture·2010

This study looked at how people spend their time sitting versus moving around by using objective tracking devices. The researchers compared four groups: healthy people with active jobs, healthy people with desk jobs, people with chronic back pain, and people with ME/CFS. Interestingly, all groups spent similar total amounts of time sitting, but the way they accumulated that sitting time was very different—people with ME/CFS and those with sedentary jobs tended to sit in longer stretches, while active people took more frequent breaks.

E2 ModerateCohortPEM not requiredCross-Sectional

Co-occurrence and associations of pain and fatigue in a community sample of Dutch adults.

Creavin, Samuel T, Dunn, Kate M, Mallen, Christian D et al.·European journal of pain (London, England)·2010

This study looked at how often pain and fatigue occur together in everyday people. Researchers found that when someone has chronic widespread pain, they are much more likely to also experience persistent fatigue, and vice versa. People who had both symptoms were more likely to also experience anxiety or depression, and certain factors like being overweight, having other chronic diseases, or low activity levels made having both symptoms more common.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCase-Control

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome.

Jones, D E J, Hollingsworth, K G, Taylor, R et al.·Journal of internal medicine·2010

This study looked at how muscles clear acid buildup after exercise in people with ME/CFS compared to healthy people. Researchers used a special MRI technique to measure this process and also checked the nervous system's ability to regulate heart rate. People with ME/CFS had much slower acid clearance from their muscles after exercise, and this slowness was linked to problems with their autonomic nervous system (the part that controls automatic body functions).

Post-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Use of adaptol in the treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia.

Mokina, T V, Antipenko, E A, Gustov, A V·Neuroscience and behavioral physiology·2010

This study looked at whether a medication called adaptol could help people with ME/CFS who also had reduced blood flow to the brain. Researchers observed patients taking adaptol and tracked whether it helped with their fatigue and other symptoms. This was an early-stage observation study designed to see if adaptol might be worth studying more carefully in the future.

E2 ModerateCohortPEM not requiredObservational

[Effectiveness of medical rehabilitation in patients with chronic fatigue syndrome at a health resort].

Tovbushenko, M P, Merkulova, G A, Anashkin, V V et al.·Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury·2010

Researchers tested whether a spa resort program combined with specific treatments—including electrophoresis with succinic acid, mud therapy, and immune-boosting injections—could help ME/CFS patients feel better. The study found that this combination approach appeared to be effective at improving symptoms in the patients who participated.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Clinical assessment of the physical activity pattern of chronic fatigue syndrome patients: a validation of three methods.

Scheeres, Korine, Knoop, Hans, Meer, van der Jos et al.·Health and quality of life outcomes·2009

This study tested three different ways to measure physical activity patterns in ME/CFS patients to see which method works best. Researchers compared a clinical interview, two questionnaires, and an objective activity monitor (actometer) in 226 patients. All three methods were reasonably accurate but had significant errors, and the questionnaire called IPAQ was best at identifying patients with low activity levels, which is important for treatment planning.

E2 ModerateMechanismPEM not requiredMechanistic

Transcription profile analysis of vastus lateralis muscle from patients with chronic fatigue syndrome.

Pietrangelo, T, Mancinelli, R, Toniolo, L et al.·International journal of immunopathology and pharmacology·2009

Researchers examined muscle tissue from ME/CFS patients and found abnormalities in how genes are expressed—essentially, certain genetic instructions were turned up or down compared to healthy people. The biggest changes involved genes related to energy production in cells, muscle structure, and communication between nerves and muscles. These findings suggest that problems at the cellular level may explain why ME/CFS patients experience muscle weakness and fatigue.

Energy Metabolism

E2 ModerateCohortPEM not requiredLongitudinal

Neuropsychological functioning, illness perception, mood and quality of life in chronic fatigue syndrome, autoimmune thyroid disease and healthy participants.

Dickson, A, Toft, A, O'Carroll, R E·Psychological medicine·2009

This study compared thinking and memory skills, mood, and quality of life in people with ME/CFS, people with thyroid disease, and healthy people. People with ME/CFS showed more problems with memory, attention, and concentration, plus higher levels of anxiety and depression. Importantly, the attention problems stayed even after researchers accounted for mood issues, suggesting cognitive problems are a core feature of ME/CFS rather than just a result of feeling depressed or anxious.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Barriers to healthcare utilization in fatiguing illness: a population-based study in Georgia.

Lin, Jin-Mann S, Brimmer, Dana J, Boneva, Roumiana S et al.·BMC health services research·2009

This study looked at why people with ME/CFS and other fatiguing illnesses skip or delay needed medical care. Researchers surveyed 780 people, including 112 with CFS, and found that 55% of those with CFS faced barriers to getting healthcare. The main barriers fell into three categories: trouble accessing care (like travel or scheduling), healthcare providers' attitudes and knowledge gaps, and problems with how the healthcare system itself works.

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[Multiple chemical sensitivity: epidemiological, clinical and prognostic differences between occupational and non-occupational cases].

Personality features and personality disorders in chronic fatigue syndrome: a population-based study.

No evidence for XMRV association in pediatric idiopathic diseases in France.

Evidence for generalized hyperalgesia in chronic fatigue syndrome: a case control study.

Fatigue and chronic fatigue syndrome-like complaints in the general population.

One single diagnosis, bodily distress syndrome, succeeded to capture 10 diagnostic categories of functional somatic syndromes and somatoform disorders.

Does hypocortisolism predict a poor response to cognitive behavioural therapy in chronic fatigue syndrome?

A functional polymorphism in the disrupted-in schizophrenia 1 gene is associated with chronic fatigue syndrome.

Predictors of outcome in a multi-component treatment program for chronic fatigue syndrome.

Fluctuation of serum vitamin E (alpha-tocopherol) concentrations during exacerbation and remission phases in patients with chronic fatigue syndrome.

Increased plasma peroxides and serum oxidized low density lipoprotein antibodies in major depression: markers that further explain the higher incidence of neurodegeneration and coronary artery disease.

Methods for objective measure, quantification and analysis of sedentary behaviour and inactivity.

Co-occurrence and associations of pain and fatigue in a community sample of Dutch adults.

Abnormalities in pH handling by peripheral muscle and potential regulation by the autonomic nervous system in chronic fatigue syndrome.

Use of adaptol in the treatment of chronic fatigue syndrome in patients with chronic cerebral ischemia.

[Effectiveness of medical rehabilitation in patients with chronic fatigue syndrome at a health resort].

Clinical assessment of the physical activity pattern of chronic fatigue syndrome patients: a validation of three methods.

Transcription profile analysis of vastus lateralis muscle from patients with chronic fatigue syndrome.

Neuropsychological functioning, illness perception, mood and quality of life in chronic fatigue syndrome, autoimmune thyroid disease and healthy participants.

Barriers to healthcare utilization in fatiguing illness: a population-based study in Georgia.

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