ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

1901–1920 of 2,768 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Feeling bad in more ways than one: comorbidity patterns of medically unexplained and psychiatric conditions.

Schur, Ellen A, Afari, Niloofar, Furberg, Helena et al.·Journal of general internal medicine·2007

This study looked at how often nine conditions—including ME/CFS, fibromyalgia, depression, and others—occur together in the same people. Researchers found that these conditions overlap far more than would happen by chance, suggesting they may share common underlying causes. The study identified four different groups of people based on their condition patterns, with one small group having nearly all nine conditions and experiencing the worst health outcomes.

E2 ModerateCohortPEM not requiredCross-Sectional

Complementary and alternative medical therapy utilization by people with chronic fatiguing illnesses in the United States.

Jones, James F, Maloney, Elizabeth M, Boneva, Roumiana S et al.·BMC complementary and alternative medicine·2007

This study looked at how many people with ME/CFS and similar fatiguing illnesses use complementary and alternative medicine (CAM) therapies like massage, chiropractic care, prayer, and other non-conventional treatments. Researchers surveyed over 880 people across the United States and found that people with ME/CFS-like illness were more likely to use body-based therapies (like massage and chiropractic) and mind-body therapies than people without fatigue.

Interventions

E2 ModerateCohortPEM unclearObservational

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Yoshiuchi, Kazuhiro, Cook, Dane B, Ohashi, Kyoko et al.·Physiology & behavior·2007

This study looked at what happens to people with ME/CFS after they exercise, tracking their symptoms in real-time using a watch-like computer for a week before and two weeks after exercise. The main finding was that physical symptoms like pain and fatigue got worse in ME/CFS patients, but this didn't happen right away—it took about five days to appear. Interestingly, mental symptoms and thinking abilities didn't show the same delayed worsening pattern that physical symptoms did.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Sherlin, Leslie, Budzynski, Thomas, Kogan Budzynski, Helen et al.·NeuroImage·2007

Researchers used a special brain scanning technique called LORETA to measure electrical activity in the brains of identical twins—one with ME/CFS and one without. They found that twins with ME/CFS had different patterns of brain activity in specific regions, particularly in areas related to mood, energy management, and the nervous system's stress response. This suggests that ME/CFS may involve measurable differences in how certain parts of the brain function.

E2 ModerateCohortPEM unclearCross-Sectional

Functioning in individuals with chronic fatigue syndrome: increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia.

Brown, Molly M, Jason, Leonard A·Dynamic medicine : DM·2007

This study looked at 114 people with ME/CFS to see how often they also had fibromyalgia or multiple chemical sensitivity, and whether having more than one condition made their symptoms worse. The researchers found that about 44% had ME/CFS alone, while others had it combined with one or both of the other conditions. People with all three conditions were the most disabled and had the hardest time with daily activities compared to those with ME/CFS alone.

E2 ModerateCohortPEM not requiredCross-Sectional

Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome.

Natelson, Benjamin H, Intriligator, Roxann, Cherniack, Neil S et al.·Dynamic medicine : DM·2007

This study compared how ME/CFS patients and healthy volunteers responded to standing up for 8 minutes. Researchers measured blood pressure, heart rate, breathing rate, and carbon dioxide levels in the blood. ME/CFS patients were more likely than healthy people to have abnormal responses, particularly low carbon dioxide levels (hypocapnia), which was linked to feeling more ill and short of breath.

Biomarkers

E2 ModerateCohortPEM unclearCross-Sectional

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability.

Maes, Michael, Mihaylova, Ivana, Leunis, Jean-Claude·Journal of affective disorders·2007

This study found that people with ME/CFS have higher levels of immune antibodies (IgA and IgM) that react against bacteria normally found in the gut. The researchers suggest this indicates the gut barrier may be more permeable (leaky), allowing bacterial products to enter the bloodstream and trigger an immune response. The study suggests testing for these antibodies might help identify and treat this potential gut problem in ME/CFS patients.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Publication trends in chronic fatigue syndrome: comparisons with fibromyalgia and fatigue: 1995-2004.

Friedberg, Fred, Sohl, Stephanie, Schmeizer, Brett·Journal of psychosomatic research·2007

This study looked at how many scientific articles about ME/CFS were published between 1995 and 2004, and compared this to articles about fibromyalgia and fatigue. The researchers found that while articles about fibromyalgia and general fatigue increased significantly during this decade, the number of ME/CFS articles stayed relatively flat. This suggests that ME/CFS was not receiving growing research attention compared to similar conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

[Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis].

Tajima, Seiki, Kuratsune, Hirohiko, Yamaguti, Kouzi et al.·Nihon rinsho. Japanese journal of clinical medicine·2007

This study measured activity levels and sleep patterns in people with ME/CFS using wearable devices and heart rate analysis. Researchers found that ME/CFS patients had lower activity during waking hours, slept longer, experienced more frequent sleep disruptions, and showed abnormal nervous system activity during sleep compared to healthy people.

SleepAutonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome.

Rajeevan, M S, Smith, A K, Dimulescu, I et al.·Genes, brain, and behavior·2007

This study looked at whether differences in a specific gene (the glucocorticoid receptor gene) might affect who develops ME/CFS. Researchers compared 40 people with ME/CFS to people without the illness and found that certain genetic variations were more common in those with ME/CFS. This gene is involved in how the body manages stress through a system called the HPA axis, which may be disrupted in ME/CFS.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredLongitudinal

[Course, consequences and treatment of prolonged fatigue among workers: an overview of findings from the Maastricht Cohort Study].

Kant, Ij, Jansen, N W H, van Amelsvoort, L G P M et al.·Tijdschrift voor psychiatrie·2007

This study followed over 12,000 workers for 4 years to understand how prolonged fatigue develops and affects people's lives. Researchers found that fatigue often lasts a long time and can lead to serious problems like missed work, job loss, and weakened immunity. When doctors tried treating fatigue with brief talk therapy, it did not help.

E2 ModerateCohortPEM not requiredCross-Sectional

beta-Alanine and gamma-aminobutyric acid in chronic fatigue syndrome.

Hannestad, Ulf, Theodorsson, Elvar, Evengård, Birgitta·Clinica chimica acta; international journal of clinical chemistry·2007

Researchers measured two brain chemicals (GABA and beta-alanine) in the urine of ME/CFS patients and healthy people to see if abnormal levels might explain fatigue and sleep problems. They found no overall difference between patients and controls, but a small subgroup of ME/CFS patients (4 out of 33) had unusually high beta-alanine levels, suggesting this chemical imbalance might affect some—but not all—people with ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

[Multiple chemical sensitivity: study of 52 cases].

Nogué, Santiago, Fernández-Solá, Joaquim, Rovira, Elisabet et al.·Medicina clinica·2007

This study looked at 52 patients with multiple chemical sensitivity (MCS)—a condition where people react badly to everyday chemicals like pesticides and cleaning products. Most patients were middle-aged women, and about 60% developed MCS after a workplace chemical exposure. The researchers found that people with MCS often have very similar symptoms to chronic fatigue syndrome, and while their condition stayed stable over time, it significantly reduced their quality of life.

E2 ModerateCohortPEM not required

Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

Boiko, A N, Batysheva, T T, Matvievskaya, O V et al.·Neuroscience and behavioral physiology·2007

This study looked at why people with brain injuries (from multiple sclerosis, stroke, infection, or trauma) develop severe fatigue. Researchers tested 50 patients and gave half of them a medication called Fezam to see if it would help. The medication reduced fatigue symptoms, especially in MS patients, with few side effects.

Interventions

E2 ModerateBehavioralPEM not requiredCross-Sectional

The impact of informational interventions about cognitive behavioral therapy for chronic fatigue syndrome on GPs referral behavior.

Scheeres, Korine, Wensing, Michel, Mes, Carola et al.·Patient education and counseling·2007

This study looked at whether giving doctors written information about cognitive behavioral therapy (CBT) as a treatment for ME/CFS would encourage them to refer their patients to try it. Researchers surveyed over 300 general practitioners and found that most who received the information remembered it and had better understanding of ME/CFS. About 22% of the doctors ended up referring at least one patient for CBT treatment during the study period.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of clinically significant functional fatigue or weakness in specialty outpatient clinics of Pune, India.

Paralikar, Vasudeo, Agashe, Mohan, Oke, Meera et al.·Journal of the Indian Medical Association·2007

This study looked at how common significant fatigue and weakness are in hospital outpatient clinics in Pune, India. Researchers surveyed nearly 1,900 patients across four different specialty clinics and found that about 5% experienced clinically significant fatigue or weakness. Women were more likely to have this condition than men, and it was more common in dermatology and traditional medicine clinics than in psychiatry or general medicine clinics.

E2 ModerateCohortPEM not requiredCross-Sectional

Endometriosis is associated with prevalence of comorbid conditions in migraine.

Tietjen, Gretchen E, Bushnell, Cheryl D, Herial, Nabeel A et al.·Headache·2007

This study found that women with migraines who also have endometriosis (a painful condition affecting the uterus) experience more frequent and severe headaches than women with migraines alone. Women with both conditions were also more likely to have other related conditions like chronic fatigue syndrome, anxiety, and bladder pain. The findings suggest these conditions may share common underlying factors, possibly related to hormones.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Health status and health care utilization of multiple sclerosis in Canada.

Pohar, Sheri L, Jones, C Allyson, Warren, Sharon et al.·The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2007

This Canadian study compared people living with multiple sclerosis (MS) to people without MS to understand how the disease affects their daily lives and health care needs. People with MS reported much worse overall health, were far more likely to experience fatigue and urinary problems, and had greater health care utilization. The study found that MS significantly burdens patients' quality of life and that their health care needs were often not being met.

E2 ModerateCohortPEM not requiredCase-Control

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Niblett, Suzanne H, King, Katrina E, Dunstan, R Hugh et al.·Experimental biology and medicine (Maywood, N.J.)·2007

Researchers compared blood and urine samples from 100 people with ME/CFS and 82 healthy controls to look for abnormalities. While standard blood tests appeared normal, closer examination found subtle differences in blood cell counts and patterns in how patients' bodies were processing and excreting amino acids (building blocks of protein) and other compounds in their urine.

Energy MetabolismImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow.

Yoshiuchi, Kazuhiro, Farkas, Jeffrey, Natelson, Benjamin H·Clinical physiology and functional imaging·2006

This study used advanced brain imaging to measure blood flow in the brains of 25 ME/CFS patients and 7 healthy people. Researchers found that ME/CFS patients had less blood flowing to parts of their brain compared to healthy controls, especially those without concurrent psychiatric conditions. This reduced blood flow might help explain some of the cognitive and physical symptoms ME/CFS patients experience.

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Feeling bad in more ways than one: comorbidity patterns of medically unexplained and psychiatric conditions.

Complementary and alternative medical therapy utilization by people with chronic fatiguing illnesses in the United States.

A real-time assessment of the effect of exercise in chronic fatigue syndrome.

Low-resolution electromagnetic brain tomography (LORETA) of monozygotic twins discordant for chronic fatigue syndrome.

Functioning in individuals with chronic fatigue syndrome: increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia.

Hypocapnia is a biological marker for orthostatic intolerance in some patients with chronic fatigue syndrome.

Increased serum IgA and IgM against LPS of enterobacteria in chronic fatigue syndrome (CFS): indication for the involvement of gram-negative enterobacteria in the etiology of CFS and for the presence of an increased gut-intestinal permeability.

Publication trends in chronic fatigue syndrome: comparisons with fibromyalgia and fatigue: 1995-2004.

[Estimation of fatigue state in patient with CFS using actigraph and R-R interval power spectrum analysis].

Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome.

[Course, consequences and treatment of prolonged fatigue among workers: an overview of findings from the Maastricht Cohort Study].

beta-Alanine and gamma-aminobutyric acid in chronic fatigue syndrome.

[Multiple chemical sensitivity: study of 52 cases].

Characteristics of the formation of chronic fatigue syndrome and approaches to its treatment in young patients with focal brain damage.

The impact of informational interventions about cognitive behavioral therapy for chronic fatigue syndrome on GPs referral behavior.

Prevalence of clinically significant functional fatigue or weakness in specialty outpatient clinics of Pune, India.

Endometriosis is associated with prevalence of comorbid conditions in migraine.

Health status and health care utilization of multiple sclerosis in Canada.

Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome.

Patients with chronic fatigue syndrome have reduced absolute cortical blood flow.

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