ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2021–2040 of 2,807 studies

E2 ModerateBehavioralPEM not requiredObservational

[Clinical observation on electroacupuncture for treatment of chronic fatigue syndrome].

Wang, Qian, Xiong, Jia-Xuan·Zhongguo zhen jiu = Chinese acupuncture & moxibustion·2005

This small study looked at whether acupuncture with electrical stimulation could help people with chronic fatigue syndrome (ME/CFS). Forty patients received electroacupuncture treatments targeting specific points on the back. After treatment, patients reported that their fatigue improved, their mood lifted, and anxiety decreased based on questionnaire scores.

E2 ModerateMechanismPEM requiredMechanistic

Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjects.

Whistler, Toni, Jones, James F, Unger, Elizabeth R et al.·BMC physiology·2005

Researchers studied women with ME/CFS and compared them to healthy women to look for biological markers of post-exertional malaise (when activity makes symptoms worse). They measured how genes 'turn on and off' in blood cells before and after exercise. The study found that genes related to ion transport and cellular functions behave differently in ME/CFS patients after exercise compared to healthy people.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome of childhood. Comparative study with emotional disorders.

Garralda, M Elena, Rangel, Luiza·European child & adolescent psychiatry·2005

This study compared children diagnosed with ME/CFS to children with emotional disorders like anxiety and depression to see how these conditions differ. While both groups of children experienced some similar emotional challenges, children with ME/CFS reported more severe tiredness and physical symptoms, and were more likely to have had infections or medical problems before getting sick. The results show that ME/CFS and emotional disorders can look similar in some ways but have important differences.

Diagnostics

E2 ModerateBehavioralPEM not requiredLongitudinal

A 12-month follow-up study of self-management training for people with chronic disease: are changes maintained over time?

Barlow, J H, Wright, C C, Turner, A P et al.·British journal of health psychology·2005

This study followed 171 people with chronic illnesses (including ME/CFS) for 12 months after they completed a self-management training course. The improvements they experienced at 4 months—such as better fatigue management, increased confidence in managing their health, and improved mood—stayed the same at 12 months. People continued using the techniques they learned on the course.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

[Cognitive function and psychological characteristics of patients with chronic fatigue syndrome].

Li, Yong-jie, Gao, Xu-guang, Wang, De-Xin et al.·Zhonghua yi xue za zhi·2005

This study looked at how ME/CFS affects thinking and memory in 91 Chinese patients compared to 30 healthy people. Researchers found that 90% of ME/CFS patients had problems with memory and attention, and most also experienced depression, anxiety, and obsessive thoughts. The results show that ME/CFS causes real cognitive problems that are different from those seen in psychiatric illnesses alone.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome.

Jones, Mark G, Goodwin, C Stewart, Amjad, Saira et al.·Clinica chimica acta; international journal of clinical chemistry·2005

Researchers tested whether people with ME/CFS have low levels of carnitine, a substance that helps muscles produce energy. They compared blood and urine samples from 31 ME/CFS patients with samples from healthy people and patients with other conditions. The study found no significant differences in carnitine levels between the groups, suggesting that low carnitine is not responsible for the fatigue experienced by ME/CFS patients.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic fatigue in a population sample: definitions and heterogeneity.

Sullivan, Patrick F, Pedersen, Nancy L, Jacks, Andreas et al.·Psychological medicine·2005

This study looked at how doctors define ME/CFS by surveying over 31,000 Swedish adults about their fatigue symptoms. The researchers found that the current official checklist for diagnosing ME/CFS (requiring 4 out of 8 specific symptoms) doesn't match how fatigue actually varies in real populations. Using statistical analysis, they identified a recognizable ME/CFS-like illness pattern, but concluded that a simpler definition focusing on severe, disabling fatigue might work better.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The prevalence of self-reported chronic fatigue in a U.S. twin registry.

Furberg, Helena, Olarte, Megan, Afari, Niloo et al.·Journal of psychosomatic research·2005

This study looked at how common fatigue-related illnesses are among twins in the United States and found that fatigue symptoms are quite common, affecting over one-third of people at some point in their lives. Women were 2-3 times more likely to report fatigue than men, and women typically experienced it at younger ages. People with chronic fatigue had significantly worse quality of life and more additional symptoms than those without fatigue.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue in adult coeliac disease.

Siniscalchi, M, Iovino, P, Tortora, R et al.·Alimentary pharmacology & therapeutics·2005

This study looked at fatigue in people with coeliac disease (an immune condition triggered by gluten). Researchers compared 130 coeliac disease patients—some following a gluten-free diet and some not—with 80 healthy people. They found that people with coeliac disease experienced significantly more fatigue and depression symptoms than healthy controls, though fatigue improved somewhat in those following a strict gluten-free diet.

E2 ModerateBehavioralPEM not requiredCross-Sectional

[A preliminary epidemiological study and discussion on traditional Chinese medicine pathogenesis of chronic fatigue syndrome in Hong Kong].

Yiu, Yan-Mun, Qiu, Ming-Yi·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·2005

This study surveyed over 1,000 adults in Hong Kong to see how common ME/CFS is and how it appears according to traditional Chinese medicine (TCM) principles. Researchers found that about 6.4% of adults aged 20-50 met ME/CFS diagnostic criteria. According to TCM assessment, most patients showed patterns related to low energy reserves and poor circulation, with symptoms including fatigue, weak knees, poor sleep, and memory problems.

E2 ModerateCohortPEM not requiredCross-Sectional

Spinal fluid abnormalities in patients with chronic fatigue syndrome.

Natelson, Benjamin H, Weaver, Shelley A, Tseng, Chin-Lin et al.·Clinical and diagnostic laboratory immunology·2005

Researchers performed spinal taps on 44 ME/CFS patients and 13 healthy people to look for signs of brain inflammation. They found that 30% of ME/CFS patients had abnormal levels of white blood cells or proteins in their spinal fluid, compared to none in the healthy group. They also found that certain immune molecules were different in ME/CFS patients, particularly in those with sudden flu-like symptom onset. These results suggest that ME/CFS may involve real physical changes in the nervous system, not just psychological factors.

NeuroinflammationImmune System

E2 ModerateCohortPEM not requiredObservational

Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome.

Vernon, Suzanne D, Reeves, William C·Journal of autoimmune diseases·2005

Researchers tested blood samples from people with ME/CFS and healthy controls to look for autoantibodies—proteins the immune system makes that can attack the body's own cells. They found that some people with ME/CFS had higher levels of antibodies against two specific targets: a brain protein called MAP2 and a component of DNA. However, most common autoantibodies were not elevated in ME/CFS patients.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

Primary healthcare provision and Chronic Fatigue Syndrome: a survey of patients' and General Practitioners' beliefs.

Thomas, Marie A, Smith, Andrew P·BMC family practice·2005

This study asked both ME/CFS patients and general practitioners (GPs) in Wales what they knew about ME/CFS. Researchers found that many GPs had very little specialist knowledge about the condition, and concerningly, only about half of the GPs surveyed actually believed ME/CFS was a real illness. The study suggested that creating better educational materials for both GPs and patients could help improve understanding and care.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

The epidemiology of chronic fatigue in the Swedish Twin Registry.

Evengård, Birgitta, Jacks, Andreas, Pedersen, Nancy L et al.·Psychological medicine·2005

This Swedish study contacted over 31,000 people and found that about 2.4% had symptoms matching chronic fatigue syndrome. Women were nearly four times more likely to have these symptoms than men. The researchers were surprised to find that ME/CFS may be more common than doctors previously thought.

E2 ModerateCohortPEM not requiredCross-Sectional

[Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases].

Li, Yong-Jie, Wang, De-Xin, Bai, Xiao-Li et al.·Zhonghua yi xue za zhi·2005

This study examined 82 Chinese patients with ME/CFS to understand what symptoms they experience and what might be causing their illness. Researchers found that most patients had memory and attention problems alongside fatigue, many showed signs of anxiety or depression, and some had low levels of a substance called L-carnitine (which helps produce energy) or evidence of a viral infection. When patients took L-carnitine supplements, their levels improved and symptoms got better.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Diurnal patterns of salivary cortisol and cortisone output in chronic fatigue syndrome.

Jerjes, W K, Cleare, A J, Wessely, S et al.·Journal of affective disorders·2005

This study measured stress hormone levels (cortisol and cortisone) in saliva samples from ME/CFS patients and healthy people throughout the day. Researchers found that ME/CFS patients had lower levels of both hormones compared to healthy controls, but the daily pattern of these hormones remained similar between the two groups. This suggests that the body's stress response system may not be working at full capacity in some ME/CFS patients.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635.

Cleare, Anthony J, Messa, Cristina, Rabiner, Eugenii A et al.·Biological psychiatry·2005

This study used brain imaging to measure a specific receptor (5-HT1A) that helps regulate serotonin, a chemical messenger in the brain. Researchers compared 10 ME/CFS patients with 10 healthy people and found that ME/CFS patients had significantly fewer of these receptors, especially in a brain region called the hippocampus (involved in memory and emotion). This suggests that serotonin regulation in the brain may work differently in ME/CFS.

E2 ModerateCohortPEM not requiredObservational

Prospective observational study of treatments for unexplained chronic fatigue.

Bentler, Suzanne E, Hartz, Arthur J, Kuhn, Evelyn M·The Journal of clinical psychiatry·2005

This study followed 155 people with chronic fatigue over 2 years to see which treatments they found helpful. Researchers asked participants about medications, supplements, exercise, yoga, and support groups they tried. While some treatments like yoga and vitamins were associated with feeling better, other treatments like magnesium and support groups were linked to feeling worse—though it's unclear why.

Interventions

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.

Gottschalk, Michaela, Kümpfel, Tania, Flachenecker, Peter et al.·Archives of neurology·2005

This study looked at fatigue in multiple sclerosis (MS) patients and examined whether their stress hormone system (HPA axis) might be involved. Researchers tested 31 MS patients using three different fatigue questionnaires and a special hormone test. They found that MS patients with severe fatigue had higher levels of a stress hormone called ACTH compared to MS patients without fatigue.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Cardiovascular reactivity in fibromyalgia: evidence for pathogenic heterogeneity.

Naschitz, Jochanan E, Rozenbaum, Michael, Fields, Madeline C et al.·The Journal of rheumatology·2005

This study looked at how the hearts of fibromyalgia patients respond to position changes (lying down versus standing up) compared to people with other conditions including ME/CFS. Researchers used a specialized test that measures heart rate patterns during a tilt test and analyzed the data with advanced mathematical methods. They found no single heart response pattern that was unique to fibromyalgia, suggesting that fibromyalgia patients have different types of heart responses rather than one shared pattern.

Autonomic Nervous System

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Evidence browser

[Clinical observation on electroacupuncture for treatment of chronic fatigue syndrome].

Exercise responsive genes measured in peripheral blood of women with chronic fatigue syndrome and matched control subjects.

Chronic fatigue syndrome of childhood. Comparative study with emotional disorders.

A 12-month follow-up study of self-management training for people with chronic disease: are changes maintained over time?

[Cognitive function and psychological characteristics of patients with chronic fatigue syndrome].

Plasma and urinary carnitine and acylcarnitines in chronic fatigue syndrome.

Chronic fatigue in a population sample: definitions and heterogeneity.

The prevalence of self-reported chronic fatigue in a U.S. twin registry.

Fatigue in adult coeliac disease.

[A preliminary epidemiological study and discussion on traditional Chinese medicine pathogenesis of chronic fatigue syndrome in Hong Kong].

Spinal fluid abnormalities in patients with chronic fatigue syndrome.

Evaluation of autoantibodies to common and neuronal cell antigens in Chronic Fatigue Syndrome.

Primary healthcare provision and Chronic Fatigue Syndrome: a survey of patients' and General Practitioners' beliefs.

The epidemiology of chronic fatigue in the Swedish Twin Registry.

[Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases].

Diurnal patterns of salivary cortisol and cortisone output in chronic fatigue syndrome.

Brain 5-HT1A receptor binding in chronic fatigue syndrome measured using positron emission tomography and [11C]WAY-100635.

Prospective observational study of treatments for unexplained chronic fatigue.

Fatigue and regulation of the hypothalamo-pituitary-adrenal axis in multiple sclerosis.

Cardiovascular reactivity in fibromyalgia: evidence for pathogenic heterogeneity.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research