ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2101–2120 of 2,807 studies

E2 ModerateBehavioralPEM not requiredLongitudinal

Predictors of outcome in fatigued employees on sick leave: results from a randomised trial.

Huibers, Marcus J H, Bleijenberg, Gijs, van Amelsvoort, Ludovic G P M et al.·Journal of psychosomatic research·2004

This study followed 151 tired employees on sick leave for one year to see who recovered and who returned to work. The researchers found that about 43% of people stopped having persistent fatigue, and 62% went back to work. Interestingly, getting better from fatigue and returning to work were driven by different factors—people who recovered from fatigue tended to view their condition differently psychologically, while those who returned to work tended to be younger, male, and have fewer thinking/memory problems.

Cognitive Impairment

E2 ModerateCohortPEM not requiredObservational

The economic impact of chronic fatigue syndrome.

Reynolds, Kenneth J, Vernon, Suzanne D, Bouchery, Ellen et al.·Cost effectiveness and resource allocation : C/E·2004

This study looked at how much money people with ME/CFS lose because they cannot work or be as productive at home. Researchers found that people with ME/CFS lose about $20,000 per year in productivity on average, and the total cost to the United States economy is around $9.1 billion annually. This financial burden is similar to what other serious diseases like digestive disorders or nervous system conditions cost the country.

E2 ModerateCohortPEM not requiredObservational

Elevated levels of some neuroactive progesterone metabolites, particularly isopregnanolone, in women with chronic fatigue syndrome.

Murphy, B E Pearson, Abbott, F V, Allison, C M et al.·Psychoneuroendocrinology·2004

Researchers measured hormone breakdown products in the blood of women with ME/CFS and compared them to healthy women. They found that women with ME/CFS had significantly higher levels of a specific progesterone metabolite called isopregnanolone—more than twice as high as controls. This suggests that abnormal hormone metabolism may be involved in ME/CFS, and that depression alone cannot explain these chemical differences.

Biomarkers

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue and indicators of long-term employment disability in psychosomatic inpatients.

Tritt, Karin, Nickel, Marius, Mitterlehner, Ferdinand et al.·Wiener klinische Wochenschrift·2004

This study looked at 1,000 patients at a hospital clinic to understand why some people with severe, persistent exhaustion become unable to work. The researchers found that patients who couldn't work had stronger focus on physical symptoms, difficulty recognizing their own feelings, and trouble getting along with coworkers—not necessarily because they were sicker, but because of how they coped with their condition.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Post-traumatic stress disorder among patients with chronic pain and chronic fatigue.

Roy-Byrne, P, Smith, W R, Goldberg, J et al.·Psychological medicine·2004

This study examined whether trauma and PTSD are more common in people with fibromyalgia and chronic fatigue syndrome. Researchers found that among 571 patients, about 20% had experienced PTSD and 42% had depression. The link between fibromyalgia symptoms (pain and tender points) and PTSD was strongest in patients who also had depression, suggesting that depression may play an important role in how trauma and chronic pain conditions are connected.

E2 ModerateBehavioralPEM not requiredObservational

Regional prevalence of fatiguing illnesses in the United States before and after the terrorist attacks of September 11, 2001.

Heim, Christine, Bierl, Cynthia, Nisenbaum, Rosane et al.·Psychosomatic medicine·2004

This study examined whether severe fatigue and ME/CFS-like illness were more or less common in different U.S. regions before and after the September 11 terrorist attacks. Researchers interviewed over 7,000 people about fatigue symptoms and found that reported cases of prolonged fatigue and chronic fatigue actually decreased after the attacks, which was unexpected. The authors suggest that the extreme stress of the attacks may have temporarily changed how people experienced or reported fatigue symptoms.

E2 ModerateCohortPEM unclearCross-Sectional

Working memory deficits in chronic fatigue syndrome: differentiating between speed and accuracy of information processing.

Deluca, John, Christodoulou, Christopher, Diamond, Bruce J et al.·Journal of the International Neuropsychological Society : JINS·2004

This study tested how quickly people with ME/CFS can process information (like reading or hearing something fast) and how well they can hold information in their working memory (like remembering a phone number while writing it down). The researchers found that people with ME/CFS without mental health conditions had slower information processing speeds, but their memory ability was normal. Interestingly, people with ME/CFS who also had depression or anxiety showed similar results to healthy people.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Cellular and humoral immune abnormalities in Gulf War veterans.

Vojdani, Aristo, Thrasher, Jack D·Environmental health perspectives·2004

Researchers compared immune system markers in 100 Gulf War veterans with symptoms to 100 healthy controls. They found that Gulf War veterans had lower natural killer cell activity, higher B cells, more immune complexes, and stronger antibody responses to multiple viruses—changes that persisted 2–8 years after the war. These findings suggest that Gulf War syndrome involves multiple immune system abnormalities similar to those seen in chronic fatigue syndrome.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Prevalence of chronic fatigue syndrome-like caseness in the working population: results from the Maastricht cohort study.

Huibers, M J H, Kant, I J, Swaen, G M H et al.·Occupational and environmental medicine·2004

This study looked at how common ME/CFS-like illness is among working people in the Netherlands. Researchers followed nearly 5,500 employees over about 3 years and 8 months and found that 3.6% met the medical criteria for ME/CFS, even though only 0.36% had actually been diagnosed by a doctor. This suggests that ME/CFS may be going unrecognized and undiagnosed in many working people.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic disabling fatigue in children and adolescents.

Farmer, Anne, Fowler, Tom, Scourfield, Jane et al.·The British journal of psychiatry : the journal of mental science·2004

This study looked at how common disabling fatigue is in children and teenagers aged 8-17 years old. Researchers asked parents whether their children had ever experienced periods of extreme tiredness lasting more than a few days, and then followed up with phone interviews. They found that about 2-3% of young people experienced disabling fatigue lasting at least 3 months, while about 1% met criteria similar to adult ME/CFS.

E2 ModerateCohortPEM not requiredLongitudinal

Illness and disability in Danish Chronic Fatigue Syndrome patients at diagnosis and 5-year follow-up.

Andersen, M M, Permin, H, Albrecht, F·Journal of psychosomatic research·2004

This study followed 33 people with ME/CFS for 5 years to see how their illness affected their daily lives. Researchers found that most people remained severely disabled, with very few experiencing meaningful recovery. While emotional well-being sometimes improved over time, problems like difficulty reading and allergies often got worse.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Patterns of cardiovascular reactivity in disease diagnosis.

Naschitz, J E, Rosner, I, Rozenbaum, M et al.·QJM : monthly journal of the Association of Physicians·2004

This study looked at how the heart and blood vessels respond to changes in body position (lying down versus standing up) in people with ME/CFS compared to healthy people and those with other conditions. Researchers used a simple test where patients lie down and then tilt upright while measuring heart rate and blood vessel changes. They found that people with ME/CFS have a distinctive pattern of heart and blood vessel responses that could help doctors identify the condition.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Neuropsychological deficits in patients with chronic fatigue syndrome.

Busichio, Kim, Tiersky, Lana A, Deluca, John et al.·Journal of the International Neuropsychological Society : JINS·2004

This study tested how thinking and memory work in people with ME/CFS compared to healthy people. Researchers gave 141 ME/CFS patients and 76 healthy volunteers a series of brain function tests. They found that ME/CFS patients performed noticeably worse on tests measuring attention, processing speed, and motor skills, with some showing significant difficulties across multiple areas.

Cognitive Impairment

E2 ModerateCohortPEM unclearCase-Control

Hypothalamic-pituitary-gonadal axis hormones and cortisol in both menstrual phases of women with chronic fatigue syndrome and effect of depressive mood on these hormones.

Cevik, Remzi, Gur, Ali, Acar, Suat et al.·BMC musculoskeletal disorders·2004

This study examined hormone levels in women with ME/CFS, focusing on hormones that control the menstrual cycle and stress response. Researchers found that women with ME/CFS had lower stress hormone (cortisol) levels than healthy women, while menstrual cycle hormones were normal. Depression symptoms did not change these hormone patterns.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredCross-Sectional

Impairment and coping in children and adolescents with chronic fatigue syndrome: a comparative study with other paediatric disorders.

Garralda, M Elena, Rangel, Luiza·Journal of child psychology and psychiatry, and allied disciplines·2004

This study compared how much ME/CFS affects children's daily lives compared to other conditions like arthritis and emotional disorders. Children with ME/CFS had more severe problems with school attendance and were more worried about their illness than the other groups. The study found that children with ME/CFS used different coping strategies—they were less likely to solve problems actively and more likely to give up or regulate their emotions when dealing with illness.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome and sexual dysfunction.

Vermeulen, Ruud C W, Scholte, Hans R·Journal of psychosomatic research·2004

This study examined whether women with ME/CFS experience more sexual problems than healthy women. Researchers surveyed 35 women with ME/CFS and 36 healthy women using questionnaires about fatigue and sexual function. Interestingly, the women with ME/CFS reported similar levels of sexual satisfaction as healthy women, even though they had significantly higher fatigue levels.

E2 ModerateBehavioralPEM not requiredObservational

Kinesiophobia in chronic fatigue syndrome: assessment and associations with disability.

Nijs, Jo, De Meirleir, Kenny, Duquet, William·Archives of physical medicine and rehabilitation·2004

This study looked at whether ME/CFS patients who fear movement (kinesiophobia) have more activity limitations than others. Researchers used a questionnaire to measure fear of movement and found that patients with higher fear of movement reported more difficulty with daily activities, but this fear did not actually relate to how much exercise capacity they had when tested on a bike.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population-based study.

Jones, James F, Nisenbaum, Rosane, Solomon, Laura et al.·The Journal of adolescent health : official publication of the Society for Adolescent Medicine·2004

Researchers surveyed families in Kansas to see how many adolescents (ages 12-17) had chronic fatigue syndrome (CFS) or other long-term fatigue illnesses. They found that CFS is much less common in teenagers than in adults. When both teens and their parents were carefully evaluated by doctors, none of the participating teenagers actually met the full definition of CFS, though some had prolonged fatigue from other causes.

Diagnostics

E2 ModerateCohortPEM not requiredLongitudinal

Chronic fatigue syndrome in adolescents: a follow-up study.

Gill, Anna C, Dosen, Ana, Ziegler, John B·Archives of pediatrics & adolescent medicine·2004

This study followed teenagers with severe fatigue for up to 8 years to see how many got better. Teenagers who had been fatigued for less than 6 months all recovered completely. Those diagnosed with ME/CFS had worse outcomes, with less than a quarter showing near-complete improvement, though some did get partially better. Being admitted to the hospital did not change whether teenagers recovered or not.

E2 ModerateCohortPEM not requiredCross-Sectional

The feeling of fatigue--fatigue severity by unidimensional versus composite questionnaires.

Naschitz, Jochanan E, Rozenbaum, Michael, Shaviv, Nomi et al.·Behavioral medicine (Washington, D.C.)·2004

This study compared two different questionnaires used to measure fatigue in ME/CFS patients and other groups with fatigue. Researchers found that a simple one-question fatigue scale and a more detailed multi-part fatigue scale gave very similar results, suggesting the simpler tool works just as well for tracking how severe someone's fatigue is.

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Predictors of outcome in fatigued employees on sick leave: results from a randomised trial.

The economic impact of chronic fatigue syndrome.

Elevated levels of some neuroactive progesterone metabolites, particularly isopregnanolone, in women with chronic fatigue syndrome.

Chronic fatigue and indicators of long-term employment disability in psychosomatic inpatients.

Post-traumatic stress disorder among patients with chronic pain and chronic fatigue.

Regional prevalence of fatiguing illnesses in the United States before and after the terrorist attacks of September 11, 2001.

Working memory deficits in chronic fatigue syndrome: differentiating between speed and accuracy of information processing.

Cellular and humoral immune abnormalities in Gulf War veterans.

Prevalence of chronic fatigue syndrome-like caseness in the working population: results from the Maastricht cohort study.

Prevalence of chronic disabling fatigue in children and adolescents.

Illness and disability in Danish Chronic Fatigue Syndrome patients at diagnosis and 5-year follow-up.

Patterns of cardiovascular reactivity in disease diagnosis.

Neuropsychological deficits in patients with chronic fatigue syndrome.

Hypothalamic-pituitary-gonadal axis hormones and cortisol in both menstrual phases of women with chronic fatigue syndrome and effect of depressive mood on these hormones.

Impairment and coping in children and adolescents with chronic fatigue syndrome: a comparative study with other paediatric disorders.

Chronic fatigue syndrome and sexual dysfunction.

Kinesiophobia in chronic fatigue syndrome: assessment and associations with disability.

Chronic fatigue syndrome and other fatiguing illnesses in adolescents: a population-based study.

Chronic fatigue syndrome in adolescents: a follow-up study.

The feeling of fatigue--fatigue severity by unidimensional versus composite questionnaires.

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