ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

2241–2260 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Possible influence of defenses and negative life events on patients with chronic fatigue syndrome: a pilot study.

Sundbom, Elisabet, Henningsson, Mikael, Holm, Ulla et al.·Psychological reports·2002

This small study explored whether people with ME/CFS use different psychological defense mechanisms (unconscious ways the mind protects itself from difficult emotions) compared to healthy people and those with conversion disorder. The researchers also asked patients whether they had experienced traumatic events before getting sick. They found that ME/CFS patients showed different patterns of handling aggressive feelings and reported more negative life events in their past, including physical or sexual assault, compared to healthy controls.

E2 ModerateCohortPEM unclearCase-Control

Chronic fatigue syndrome and immune dysfunction: cause or effect?

Pollack, Shimon·The Israel Medical Association journal : IMAJ·2002

This study examined whether immune system problems in ME/CFS patients are a cause of the illness or a result of having the illness. Researchers compared immune markers between people with ME/CFS and healthy controls to understand this relationship better. The study helps clarify an important question: does a faulty immune system trigger ME/CFS, or does having ME/CFS damage the immune system over time?

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Long-term follow-up of patients from the 1989 Q fever outbreak: no evidence of excess cardiac disease in those with fatigue.

Ayres, J G, Wildman, M, Groves, J et al.·QJM : monthly journal of the Association of Physicians·2002

This study followed people who had Q fever (a bacterial infection) during an outbreak in 1989 to see if persistent fatigue afterward was caused by heart damage. Researchers tested their hearts using ECGs, ultrasounds, and exercise tests over many years. They found that people with ongoing fatigue after Q fever did not have hidden heart problems, though a few people did develop serious heart infections from the original infection.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Underlying self-esteem in chronic fatigue syndrome.

Creswell, Cathy, Chalder, Trudie·Journal of psychosomatic research·2002

This study looked at whether people with ME/CFS have low self-esteem, using two different types of tests. When asked directly, people with ME/CFS reported lower self-esteem than healthy people and those with other chronic illnesses. However, a special test that measures unconscious reactions suggested their true underlying self-esteem was even lower than what they reported, possibly because they use mental defense mechanisms to protect themselves.

E2 ModerateCohortPEM unclearCase-Control

Comparative examination of complaints of patients with breast-cancer with and without silicone implants.

Berner, Imke, Gaubitz, Markus, Jackisch, Christian et al.·European journal of obstetrics, gynecology, and reproductive biology·2002

This study compared 96 women with breast cancer—some with silicone implants and some without—to see if silicone implants cause chronic fatigue, joint pain, muscle pain, or other symptoms. The researchers found that most symptoms were equally common in both groups, and there was no link between silicone implants and chronic fatigue syndrome symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Dry eyes and mouth syndrome--a subgroup of patients presenting with sicca symptoms.

Price, E J, Venables, P J W·Rheumatology (Oxford, England)·2002

This study looked at 34 patients who had dry eyes and dry mouth symptoms but did not meet the standard criteria for Sjögren's syndrome. These patients had many symptoms on questionnaires but few objective physical findings, and most of them also had features more typical of fibromyalgia or chronic fatigue syndrome rather than Sjögren's.

Diagnostics

E2 ModerateCohortPEM requiredLongitudinal

Prognosis of chronic fatigue in a community-based sample.

Taylor, Renee R, Jason, Leonard A, Curie, Carrie J·Psychosomatic medicine·2002

Researchers followed up with people from a large community study to see which factors predict whether chronic fatigue gets better or worse over time. They found that how severe fatigue was at the start, and especially whether exercise made symptoms worse for 24 hours or more (a symptom called postexertional malaise), were the strongest predictors of whether someone would still have chronic fatigue years later.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

Health and functional status of twins with chronic regional and widespread pain.

Aaron, Leslie A, Arguelles, Lester M, Ashton, Suzanne et al.·The Journal of rheumatology·2002

This study looked at twins where one had chronic pain (either in one area or widespread) and the other did not, to understand how pain affects health and function independent of ME/CFS. Researchers found that chronic pain significantly worsens general health perception, physical functioning, and sleep quality, effects that remain even after accounting for ME/CFS. However, the mental health impact of pain appears closely linked to having ME/CFS symptoms together.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relations among body consciousness, somatic symptom report, and information processing speed in chronic fatigue syndrome.

van der Werf, Sieberen P, de Vree, Berna, van Der Meer, Jos W M et al.·Neuropsychiatry, neuropsychology, and behavioral neurology·2002

This study looked at whether paying too much attention to bodily sensations and reporting many physical symptoms might slow down how quickly people with ME/CFS can process information and react to tasks. Researchers measured how fast patients could respond to simple tests and found that people who were highly aware of their body sensations reported more symptoms and performed more slowly on reaction time tests. The study suggests that increased attention to the body may be partly responsible for the cognitive slowing that people with ME/CFS experience.

Cognitive Impairment

E2 ModeratePEM unclearRegistry-Resource

The Swedish Twin Registry in the third millennium.

Pedersen, Nancy L, Lichtenstein, Paul, Svedberg, Pia·Twin research : the official journal of the International Society for Twin Studies·2002

The Swedish Twin Registry is a long-running database that tracks pairs of twins in Sweden to understand how genetics and environment affect disease. This paper describes the registry's history since the 1950s and mentions plans to study chronic fatigue syndrome (ME/CFS) along with other diseases by collecting blood samples and genetic information from twins.

E2 ModerateBehavioralPEM not requiredLongitudinal

Natural course and predicting self-reported improvement in patients with chronic fatigue syndrome with a relatively short illness duration.

van der Werf, Sieberen P, de Vree, Berna, Alberts, Maurice et al.·Journal of psychosomatic research·2002

This study followed 79 people with ME/CFS who had been ill for less than 2 years to see what happened over the next year without treatment. About 46% of these patients reported feeling better after one year, which is much higher than the 20% improvement rate seen in people who had been ill for longer. The study found that people who didn't improve tended to have worse concentration problems, fewer social supports, and didn't believe their illness had a physical cause.

E2 ModerateBehavioralPEM not requiredObservational

Chronic fatigue syndrome: successful outcome of an intensive inpatient programme.

Lim, A, Lubitz, L·Journal of paediatrics and child health·2002

This study looked at teenagers with ME/CFS who participated in an intensive inpatient rehabilitation program at an Australian hospital. Most participants improved significantly, with the majority returning to full-time or nearly full-time school and increasing their physical activity and social involvement. These improvements lasted for up to 5 years after the program ended.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Patients' strategies for coping with psoriasis.

Fortune, D G, Richards, H L, Main, C J et al.·Clinical and experimental dermatology·2002

This study looked at how people with psoriasis (a skin condition) cope with their illness by comparing their coping strategies to healthy people and those with other diseases. Researchers found that psoriasis patients most often use acceptance and planning to manage their condition, while least often turning to alcohol, drugs, or denial. Interestingly, people with psoriasis used fewer active coping strategies than healthy controls, but used similar coping approaches to patients with other conditions like chronic fatigue syndrome and cancer.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale).

Zachrisson, Olof, Regland, Björn, Jahreskog, Marianne et al.·Journal of psychosomatic research·2002

Researchers created a simple checklist called the FibroFatigue scale to help doctors measure how severe fibromyalgia and ME/CFS symptoms are and track whether treatments are working. The scale includes 12 questions about common symptoms like pain, tiredness, sleep problems, and concentration difficulties. The new tool was tested on 100 women with both conditions and was found to be reliable and accurate.

E2 ModerateCohortPEM not requiredCase-Control

Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome.

Sabath, Daniel E, Barcy, Serge, Koelle, David M et al.·The Journal of infectious diseases·2002

This study looked at immune system differences in identical twins where one twin had ME/CFS and the other didn't. By comparing identical twins, researchers could focus on immune changes related to the illness rather than genetic differences. The study found that certain immune cells were more variable in twins with ME/CFS, suggesting the immune system may be less stable in this condition.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

[Relationship between chronic fatigue and subjective symptoms of fatigue with performance status (P.S.) and subjective fatigue scale for young adults (SFS-Y)].

Kobayashi, Hidetsugu, Demura, Shinichi·[Nihon koshu eisei zasshi] Japanese journal of public health·2002

This study looked at whether a new questionnaire (the SFS-Y) could help identify young people experiencing chronic fatigue by measuring different types of tiredness symptoms. Researchers gave the questionnaire to over 1,100 teenagers and found that the tool was quite good at spotting chronic fatigue, especially when it measured difficulty concentrating. The results suggest this questionnaire might be useful for screening young people who could develop ME/CFS-like conditions.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

The prognosis after multidisciplinary treatment for patients with postinfectious chronic fatigue syndrome and noninfectious chronic fatigue syndrome.

Masuda, Akinori, Nakayama, Takashi, Yamanaka, Takao et al.·Journal of behavioral medicine·2002

This study compared two types of ME/CFS patients: those whose illness started after an infection and those whose didn't. After multidisciplinary treatment, patients who developed ME/CFS after infection showed better improvement in symptoms and were more likely to return to work. Importantly, a marker of immune function called NK cell activity also showed more improvement in the post-infectious group, suggesting their bodies may respond differently to treatment.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Fractal analysis and recurrence quantification analysis of heart rate and pulse transit time for diagnosing chronic fatigue syndrome.

Naschitz, Jochanan E, Sabo, Edmond, Naschitz, Shaul et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2002

This study tested a new way to diagnose ME/CFS by measuring how the heart and blood vessels respond to a simple tilt test (lying down then standing up). Researchers used mathematical analysis of heart rate patterns and blood flow timing to create a scoring system that could correctly identify ME/CFS patients 70% of the time. The test was safe and well-tolerated by participants.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

A six-month trial of valacyclovir in the Epstein-Barr virus subset of chronic fatigue syndrome: improvement in left ventricular function.

Lerner, A Martin, Beqaj, Safedin H, Deeter, Robert G et al.·Drugs of today (Barcelona, Spain : 1998)·2002

This small study tested whether an antiviral medication called valacyclovir could help ME/CFS patients who had persistent Epstein-Barr virus (EBV) infection. Researchers gave 25 patients valacyclovir for 6 months and found that those with only EBV infection showed improvement in heart function and energy levels, but those with both EBV and cytomegalovirus infections did not improve.

E2 ModerateCohortPEM not requiredCross-Sectional

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Sargent, Charli, Scroop, Garry C, Nemeth, Peter M et al.·Medicine and science in sports and exercise·2002

This study tested whether people with ME/CFS have reduced oxygen processing ability compared to healthy people. Researchers had 33 ME/CFS patients and 33 matched healthy controls perform exercise tests on stationary bikes while measuring heart rate and oxygen use. The results showed that ME/CFS patients had normal oxygen uptake capacity similar to sedentary healthy people of the same age and gender, contrary to what some earlier studies had reported.

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Possible influence of defenses and negative life events on patients with chronic fatigue syndrome: a pilot study.

Chronic fatigue syndrome and immune dysfunction: cause or effect?

Long-term follow-up of patients from the 1989 Q fever outbreak: no evidence of excess cardiac disease in those with fatigue.

Underlying self-esteem in chronic fatigue syndrome.

Comparative examination of complaints of patients with breast-cancer with and without silicone implants.

Dry eyes and mouth syndrome--a subgroup of patients presenting with sicca symptoms.

Prognosis of chronic fatigue in a community-based sample.

Health and functional status of twins with chronic regional and widespread pain.

The relations among body consciousness, somatic symptom report, and information processing speed in chronic fatigue syndrome.

The Swedish Twin Registry in the third millennium.

Natural course and predicting self-reported improvement in patients with chronic fatigue syndrome with a relatively short illness duration.

Chronic fatigue syndrome: successful outcome of an intensive inpatient programme.

Patients' strategies for coping with psoriasis.

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale).

Cellular immunity in monozygotic twins discordant for chronic fatigue syndrome.

[Relationship between chronic fatigue and subjective symptoms of fatigue with performance status (P.S.) and subjective fatigue scale for young adults (SFS-Y)].

The prognosis after multidisciplinary treatment for patients with postinfectious chronic fatigue syndrome and noninfectious chronic fatigue syndrome.

Fractal analysis and recurrence quantification analysis of heart rate and pulse transit time for diagnosing chronic fatigue syndrome.

A six-month trial of valacyclovir in the Epstein-Barr virus subset of chronic fatigue syndrome: improvement in left ventricular function.

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

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