ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2241–2260 of 2,768 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Illness perceptions and mood in chronic fatigue syndrome.

Edwards, R, Suresh, R, Lynch, S et al.·Journal of psychosomatic research·2001

This study looked at how ME/CFS patients' beliefs about their illness—such as what they think caused it, whether they can control it, and how long they expect it to last—relate to their mood and fatigue levels. Researchers surveyed 126 ME/CFS patients from a clinic and found that these beliefs were connected to both how tired patients felt and their levels of anxiety and depression, suggesting that what patients think about their illness may influence how much it affects them.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Thoroughly modern worries: the relationship of worries about modernity to reported symptoms, health and medical care utilization.

Petrie, K J, Sivertsen, B, Hysing, M et al.·Journal of psychosomatic research·2001

This study looked at whether worries about modern health threats (like pollution, food safety, and radiation) are linked to symptom reporting and chronic fatigue syndrome (CFS). Researchers surveyed over 8,000 people and found that those with higher worries about modernity reported more physical symptoms, food intolerances, and CFS diagnoses. The study suggests that health anxiety about modern threats may influence how people interpret body signals and perceive their health.

E2 ModerateCohortPEM not requiredCase-Control

Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome.

Hamilos, D L, Nutter, D, Gershtenson, J et al.·Clinical physiology (Oxford, England)·2001

Researchers wanted to know if ME/CFS might be caused by broken internal body clocks, similar to jet lag. They measured core body temperature continuously in 10 ME/CFS patients and 10 healthy controls over 48 hours and analyzed the patterns. The body temperature rhythms in ME/CFS patients looked almost identical to healthy people, suggesting a disrupted body clock is unlikely to be the main cause of ME/CFS symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Assessment of pentachlorophenol-exposed timber workers using a test-of-poisoning model.

Gorman, D, Monigatti, J, Glass, B et al.·International journal of occupational and environmental health·2001

This study looked at 62 former timber workers in New Zealand who were exposed to a toxic chemical called pentachlorophenol (PCP) during their jobs. Researchers found that some workers developed a cluster of symptoms including fever, headaches, breathing problems, and skin issues, while others developed a long-lasting fatigue that started while they were still working. However, the researchers concluded that these fatigue syndromes didn't clearly match what doctors expect from PCP poisoning, and many other factors could have caused the symptoms.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Psychological adjustment of adolescent girls with chronic fatigue syndrome.

van Middendorp, H, Geenen, R, Kuis, W et al.·Pediatrics·2001

This study looked at how 36 teenage girls with ME/CFS were coping emotionally and psychologically. The researchers found that most girls had experienced problems before getting sick, but they generally maintained healthy self-esteem and social skills despite their illness. However, the girls struggled with activities typical for teenagers, like sports and dating, and many kept their emotions bottled up rather than expressing them openly.

E2 ModerateCohortPEM not requiredLongitudinal

Thirteen-year follow-up of children and adolescents with chronic fatigue syndrome.

Bell, D S, Jordan, K, Robinson, M·Pediatrics·2001

This study followed 35 children and teenagers who developed ME/CFS, checking in with them about 13 years after they first got sick. Most participants (80%) felt they had recovered or were doing reasonably well by the follow-up, though many still had some lingering symptoms. However, about 20% remained significantly ill with ongoing fatigue and activity limitations a decade and a half later.

E2 ModerateCohortPEM unclearCross-Sectional

Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders.

Nishikai, M, Tomomatsu, S, Hankins, R W et al.·Rheumatology (Oxford, England)·2001

Researchers tested blood samples from ME/CFS and fibromyalgia patients to look for specific antibodies (immune proteins) that might be unique to these conditions. They found that about 13% of ME/CFS patients and 16% of fibromyalgia patients had antibodies against a protein called 68/48 kDa. Importantly, patients with these antibodies were more likely to experience severe sleep problems, memory issues, and trouble concentrating.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Cardiovascular response to upright tilt in fibromyalgia differs from that in chronic fatigue syndrome.

Naschitz, J E, Rozenbaum, M, Rosner, I et al.·The Journal of rheumatology·2001

This study compared how the bodies of people with fibromyalgia and ME/CFS respond to standing up from lying down. Researchers measured blood pressure and heart rate while patients lay down and then tilted upright for 30 minutes. They found that fibromyalgia and ME/CFS patients had very different cardiovascular responses to this position change, suggesting these are two distinct conditions rather than the same illness.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredLongitudinal

Natural course of symptoms in Cambodia veterans: a follow-up study.

De Vries, M, Soetekouw, P M, Van Der Meer, J W et al.·Psychological medicine·2001

Researchers followed Dutch military veterans who served in Cambodia in 1992-1993 and reported fatigue and memory problems after returning home. At 18 months later, about 39% of veterans reported feeling much better or completely recovered, while 57% still had the same symptoms and 4% felt worse. The study found that veterans who started with less severe fatigue and felt they had more control over their symptoms were more likely to improve.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome.

Cook, D B, Lange, G, DeLuca, J et al.·The International journal of neuroscience·2001

This study looked at brain MRI scans from 48 ME/CFS patients to see if visible abnormalities in the brain were related to how physically impaired they felt. Researchers found that patients whose brain scans showed abnormalities reported being significantly more physically limited than those with normal-looking scans. This suggests ME/CFS may involve real, measurable changes in the brain rather than being purely psychological.

E2 ModerateCohortPEM unclearCase-Control

Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness.

Bourdette, D N, McCauley, L A, Barkhuizen, A et al.·Journal of occupational and environmental medicine·2001

Researchers surveyed over 2,000 Gulf War veterans and conducted detailed medical exams on 443 of them to look for unexplained health symptoms. They found that many veterans experienced overlapping symptoms—including cognitive problems, fatigue, and muscle pain—that resembled conditions like fibromyalgia and chronic fatigue syndrome, but they found few clear physical differences between sick and healthy veterans.

Pain and SensitizationCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Paul, L M, Wood, L, Maclaren, W·Gait & posture·2001

This study looked at whether people with ME/CFS have problems with walking and balance, and whether light exercise makes these problems worse. Researchers compared 11 ME/CFS patients with 11 healthy people and found that while ME/CFS patients did show different walking patterns, their balance was similar to healthy controls, and the exercise test did not worsen either group's balance or gait.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Patients' perceptions of medical care in chronic fatigue syndrome.

Deale, A, Wessely, S·Social science & medicine (1982)·2001

This study asked 68 ME/CFS patients about their experiences with medical care. Two-thirds of patients were unhappy with the care they received. Patients felt most satisfied when doctors listened, showed genuine interest, and communicated clearly—not necessarily when doctors could cure the illness. Patients were most frustrated when doctors were dismissive, confused about ME/CFS, or gave conflicting advice.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Defensive coping styles in chronic fatigue syndrome.

Creswell, C, Chalder, T·Journal of psychosomatic research·2001

This study looked at how people with ME/CFS cope with stress and worry compared to healthy people and those with other chronic illnesses. Researchers found that people with ME/CFS were more likely to use a coping style where they appear calm and in control on the surface while actually feeling anxious underneath. The study suggests this defensive coping pattern may be connected to how ME/CFS develops and affects the body.

E2 ModerateCohortPEM not requiredCross-Sectional

A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue.

Jason, L A, Taylor, R R, Carrico, A W·Chronobiology international·2001

This study looked at when people developed ME/CFS and chronic fatigue symptoms to see if there was a pattern linked to seasons or viral infections. Researchers asked 31 people with CFS and 44 with similar fatigue symptoms what month their illness started. They found that more people than expected reported symptom onset in January, suggesting that seasonal factors—possibly increased viral infections in winter—might play a role in triggering these conditions.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinicopathological findings consistent with primary Sjögren's syndrome in a subset of patients diagnosed with chronic fatigue syndrome: preliminary observations.

Sirois, D A, Natelson, B·The Journal of rheumatology·2001

Some people with ME/CFS experience dry eyes and dry mouth, which are also common symptoms of Sjögren's syndrome, an autoimmune disorder. This study tested 25 ME/CFS patients and 18 healthy volunteers for signs of Sjögren's syndrome using eye tests, saliva gland biopsies, and blood tests. The researchers found that about one-third of the ME/CFS patients had findings consistent with primary Sjögren's syndrome, while none of the healthy volunteers did.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Cardiovascular responses of women with chronic fatigue syndrome to stressful cognitive testing before and after strenuous exercise.

LaManca, J J, Peckerman, A, Sisto, S A et al.·Psychosomatic medicine·2001

This study compared how the hearts and blood pressure of women with ME/CFS respond to stressful mental tasks compared to healthy women. Researchers found that women with ME/CFS had a weaker cardiovascular response to cognitive stress than healthy controls, and this pattern held true even after exercise. The study also found that women with more severe ME/CFS symptoms had the lowest cardiovascular responses to stress.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Health-related quality of life in patients with chronic fatigue syndrome: an international study.

Hardt, J, Buchwald, D, Wilks, D et al.·Journal of psychosomatic research·2001

This study measured how ME/CFS affects daily life and well-being in patients from the United States, United Kingdom, and Germany. Researchers found that patients in all three countries experienced very similar impacts on their quality of life—significantly worse than healthy people across most areas measured, including physical function, emotional health, and energy levels. The findings suggest that ME/CFS affects people similarly regardless of where they live.

E2 ModerateCohortPEM not requiredCase-Control

Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT.

Lewis, D H, Mayberg, H S, Fischer, M E et al.·Radiology·2001

Researchers used brain imaging scans to look for differences in blood flow to the brain in people with ME/CFS compared to their identical twins who don't have the disease. They found that the brain scans of people with ME/CFS looked very similar to those of their healthy twins, suggesting that ME/CFS may not cause detectable changes in how blood flows through the brain at rest.

E2 ModerateCohortPEM not requiredCross-Sectional

IgE levels are the same in chronic fatigue syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types.

Repka-Ramirez, M S, Naranch, K, Park, Y J et al.·Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology·2001

Researchers tested whether people with ME/CFS have higher levels of IgE, a protein the immune system makes during allergic reactions. They compared IgE levels in 95 ME/CFS patients and 109 healthy people, including those with and without allergies. They found IgE levels were the same in both groups, suggesting that allergies are probably not a major cause of ME/CFS.

Immune System

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Illness perceptions and mood in chronic fatigue syndrome.

Thoroughly modern worries: the relationship of worries about modernity to reported symptoms, health and medical care utilization.

Circadian rhythm of core body temperature in subjects with chronic fatigue syndrome.

Assessment of pentachlorophenol-exposed timber workers using a test-of-poisoning model.

Psychological adjustment of adolescent girls with chronic fatigue syndrome.

Thirteen-year follow-up of children and adolescents with chronic fatigue syndrome.

Autoantibodies to a 68/48 kDa protein in chronic fatigue syndrome and primary fibromyalgia: a possible marker for hypersomnia and cognitive disorders.

Cardiovascular response to upright tilt in fibromyalgia differs from that in chronic fatigue syndrome.

Natural course of symptoms in Cambodia veterans: a follow-up study.

Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome.

Symptom factor analysis, clinical findings, and functional status in a population-based case control study of Gulf War unexplained illness.

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Patients' perceptions of medical care in chronic fatigue syndrome.

Defensive coping styles in chronic fatigue syndrome.

A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue.

Clinicopathological findings consistent with primary Sjögren's syndrome in a subset of patients diagnosed with chronic fatigue syndrome: preliminary observations.

Cardiovascular responses of women with chronic fatigue syndrome to stressful cognitive testing before and after strenuous exercise.

Health-related quality of life in patients with chronic fatigue syndrome: an international study.

Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT.

IgE levels are the same in chronic fatigue syndrome (CFS) and control subjects when stratified by allergy skin test results and rhinitis types.

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