ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2785 studies

2241–2260 of 2,785 studies

E2 ModerateCohortPEM not requiredCase-Control

Chronic fatigue in a population-based study of Gulf War veterans.

McCauley, Linda A, Joos, Sandra K, Barkhuizen, Andre et al.·Archives of environmental health·2002

Researchers studied Gulf War veterans to see how many had chronic fatigue that couldn't be explained by standard medical tests. They found that about 2.2% of veterans met the official criteria for ME/CFS, and another 5.1% had unexplained fatigue. Women veterans were more likely to have these conditions than men. Unlike some other ME/CFS patients, most of these veterans developed their fatigue gradually rather than suddenly.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.

Sinaii, N, Cleary, S D, Ballweg, M L et al.·Human reproduction (Oxford, England)·2002

This study found that women with endometriosis—a painful condition where tissue grows outside the uterus—have much higher rates of ME/CFS, fibromyalgia, and autoimmune diseases compared to the general population. Researchers surveyed nearly 3,700 women with endometriosis and compared their health conditions to published data about women without endometriosis. Women with endometriosis were 150 times more likely to have ME/CFS and nearly twice as likely to have fibromyalgia.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Subclinical Sjögren's syndrome and anti-Ro/SSA-positive autoimmune fatigue syndrome in children.

Itoh, Y, Imai, T, Fujino, O et al.·Modern rheumatology·2002

This study looked at children with severe fatigue and found that some had a specific antibody (anti-Ro/SSA) in their blood that is also found in Sjögren's syndrome, an autoimmune condition affecting moisture-producing glands. Eight children with fatigue syndrome tested positive for this antibody, and two of them showed actual gland damage on biopsy similar to Sjögren's syndrome, suggesting that some fatigue cases may actually be caused by an autoimmune condition affecting the glands.

E2 ModerateCohortPEM not requiredCross-Sectional

Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome.

Timmers, H J L M, Wieling, W, Soetekouw, P M M B et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·2002

This study looked at whether ME/CFS patients have problems with blood pressure and heart rate control when standing up or tilting upright. Researchers tested 36 ME/CFS patients and 36 healthy people by tilting them upright for 40 minutes while measuring heart function and stress hormones. About 28% of ME/CFS patients had abnormal responses (like fainting symptoms or rapid heart rate), compared to 17% of healthy controls, though this difference was not statistically significant.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

Chronic fatigue and chronic fatigue syndrome: a co-twin control study of functional status.

Herrell, Richard, Goldberg, Jack, Hartman, Suzanne et al.·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2002

This study compared twins where one had chronic fatigue or ME/CFS and the other did not. Researchers found that fatigued twins had significantly worse quality of life and daily functioning than their healthy siblings, particularly in physical activities. The more severe the fatigue definition used, the greater the functional impairment observed.

E2 ModerateCohortPEM unclearCross-Sectional

Immunological variables mediate cognitive dysfunction in gulf war veterans but not civilians with chronic fatigue syndrome.

Brimacombe, Michael, Zhang, QuanWu, Lange, Gudrun et al.·Neuroimmunomodulation·2002

This study compared immune system markers and thinking/memory problems in Gulf War veterans with ME/CFS and civilians with ME/CFS. The researchers found that in Gulf War veterans, certain immune system patterns were connected to cognitive problems like slower reaction times, and these immune changes seemed to affect how well they could function. Interestingly, this same immune-cognition relationship was not found in civilians with ME/CFS, suggesting the two groups may have different underlying causes for their illness.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Patients' strategies for coping with psoriasis.

Fortune, D G, Richards, H L, Main, C J et al.·Clinical and experimental dermatology·2002

This study looked at how people with psoriasis (a skin condition) cope with their illness by comparing their coping strategies to healthy people and those with other diseases. Researchers found that psoriasis patients most often use acceptance and planning to manage their condition, while least often turning to alcohol, drugs, or denial. Interestingly, people with psoriasis used fewer active coping strategies than healthy controls, but used similar coping approaches to patients with other conditions like chronic fatigue syndrome and cancer.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Van Houdenhove, Boudewijn, Neerinckx, Eddy, Onghena, Patrick et al.·Psychotherapy and psychosomatics·2002

This study looked at the everyday frustrations and worries that ME/CFS and fibromyalgia patients experience compared to people with other chronic illnesses like multiple sclerosis and rheumatoid arthritis. Researchers found that ME/CFS and fibromyalgia patients reported more frequent daily hassles and felt more emotionally distressed by them. The main worries for ME/CFS and fibromyalgia patients centered on feeling bad about themselves, feeling uncertain, and not being recognized or understood by others.

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome.

McCue, P, Scholey, A B, Herman, C et al.·Journal of telemedicine and telecare·2002

This study tested whether a telephone-based brain function test could accurately detect thinking problems in people with ME/CFS. Researchers compared two versions of the same test—one on a computer and one done by telephone—in 30 people with ME/CFS and 30 healthy people. Both versions showed that people with ME/CFS were significantly slower at thinking tasks involving attention, memory, and focus, confirming that cognitive problems are real and measurable in this illness.

Cognitive Impairment

E2 ModerateDiagnosticPEM not requiredMethods-Paper

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale).

Zachrisson, Olof, Regland, Björn, Jahreskog, Marianne et al.·Journal of psychosomatic research·2002

Researchers created a simple checklist called the FibroFatigue scale to help doctors measure how severe fibromyalgia and ME/CFS symptoms are and track whether treatments are working. The scale includes 12 questions about common symptoms like pain, tiredness, sleep problems, and concentration difficulties. The new tool was tested on 100 women with both conditions and was found to be reliable and accurate.

E2 ModerateCohortPEM not requiredCross-Sectional

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Sargent, Charli, Scroop, Garry C, Nemeth, Peter M et al.·Medicine and science in sports and exercise·2002

This study tested whether people with ME/CFS have reduced oxygen processing ability compared to healthy people. Researchers had 33 ME/CFS patients and 33 matched healthy controls perform exercise tests on stationary bikes while measuring heart rate and oxygen use. The results showed that ME/CFS patients had normal oxygen uptake capacity similar to sedentary healthy people of the same age and gender, contrary to what some earlier studies had reported.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Servaes, Petra, Prins, Judith, Verhagen, Stans et al.·Journal of psychosomatic research·2002

This study compared 57 women with ME/CFS to 57 women who had breast cancer and were experiencing severe fatigue after treatment. Researchers measured fatigue, physical activity, mood, sleep, and concentration using questionnaires, tests, and activity monitors worn for 12 days. While both groups experienced significant fatigue, ME/CFS patients generally had more severe symptoms overall, though some breast cancer survivors reported similar problems with sleep and concentration.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.

Barron, Diana F, Cohen, Bernard A, Geraghty, Michael T et al.·The Journal of pediatrics·2002

This study compared how flexible the joints are in children with ME/CFS versus healthy children. Researchers found that children with ME/CFS had much more joint flexibility than healthy children—60% of children with ME/CFS had highly flexible joints compared to only 24% of healthy children. This suggests that joint hypermobility (unusually flexible joints) may be more common in ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome.

Cook, D B, Lange, G, DeLuca, J et al.·The International journal of neuroscience·2001

This study looked at brain MRI scans from 48 ME/CFS patients to see if visible abnormalities in the brain were related to how physically impaired they felt. Researchers found that patients whose brain scans showed abnormalities reported being significantly more physically limited than those with normal-looking scans. This suggests ME/CFS may involve real, measurable changes in the brain rather than being purely psychological.

E2 ModerateCohortPEM not requiredCross-Sectional

Patients' perceptions of medical care in chronic fatigue syndrome.

Deale, A, Wessely, S·Social science & medicine (1982)·2001

This study asked 68 ME/CFS patients about their experiences with medical care. Two-thirds of patients were unhappy with the care they received. Patients felt most satisfied when doctors listened, showed genuine interest, and communicated clearly—not necessarily when doctors could cure the illness. Patients were most frustrated when doctors were dismissive, confused about ME/CFS, or gave conflicting advice.

Diagnostics

E2 ModerateBehavioralPEM not requiredCross-Sectional

Defensive coping styles in chronic fatigue syndrome.

Creswell, C, Chalder, T·Journal of psychosomatic research·2001

This study looked at how people with ME/CFS cope with stress and worry compared to healthy people and those with other chronic illnesses. Researchers found that people with ME/CFS were more likely to use a coping style where they appear calm and in control on the surface while actually feeling anxious underneath. The study suggests this defensive coping pattern may be connected to how ME/CFS develops and affects the body.

E2 ModerateCohortPEM not requiredCross-Sectional

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Paul, L M, Wood, L, Maclaren, W·Gait & posture·2001

This study looked at whether people with ME/CFS have problems with walking and balance, and whether light exercise makes these problems worse. Researchers compared 11 ME/CFS patients with 11 healthy people and found that while ME/CFS patients did show different walking patterns, their balance was similar to healthy controls, and the exercise test did not worsen either group's balance or gait.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

Causal attributions for somatic sensations in patients with chronic fatigue syndrome and their partners.

Butler, J A, Chalder, T, Wessely, S·Psychological medicine·2001

This study looked at how people with ME/CFS explain their symptoms—whether they believe physical causes are responsible versus other factors. Researchers found that patients with ME/CFS tend to blame physical causes for their symptoms more often than healthy controls do. Interestingly, family members living with ME/CFS patients also blamed physical causes for the patients' symptoms, but not for their own symptoms. The researchers suggest that how partners view the illness might affect how well patients recover.

E2 ModerateCohortPEM not requiredCross-Sectional

A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue.

Jason, L A, Taylor, R R, Carrico, A W·Chronobiology international·2001

This study looked at when people developed ME/CFS and chronic fatigue symptoms to see if there was a pattern linked to seasons or viral infections. Researchers asked 31 people with CFS and 44 with similar fatigue symptoms what month their illness started. They found that more people than expected reported symptom onset in January, suggesting that seasonal factors—possibly increased viral infections in winter—might play a role in triggering these conditions.

E2 ModerateCohortPEM not requiredCase-Control

Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT.

Lewis, D H, Mayberg, H S, Fischer, M E et al.·Radiology·2001

Researchers used brain imaging scans to look for differences in blood flow to the brain in people with ME/CFS compared to their identical twins who don't have the disease. They found that the brain scans of people with ME/CFS looked very similar to those of their healthy twins, suggesting that ME/CFS may not cause detectable changes in how blood flows through the brain at rest.

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Chronic fatigue in a population-based study of Gulf War veterans.

High rates of autoimmune and endocrine disorders, fibromyalgia, chronic fatigue syndrome and atopic diseases among women with endometriosis: a survey analysis.

Subclinical Sjögren's syndrome and anti-Ro/SSA-positive autoimmune fatigue syndrome in children.

Hemodynamic and neurohumoral responses to head-up tilt in patients with chronic fatigue syndrome.

Chronic fatigue and chronic fatigue syndrome: a co-twin control study of functional status.

Immunological variables mediate cognitive dysfunction in gulf war veterans but not civilians with chronic fatigue syndrome.

Patients' strategies for coping with psoriasis.

Daily hassles reported by chronic fatigue syndrome and fibromyalgia patients in tertiary care: a controlled quantitative and qualitative study.

Validation of a telephone cognitive assessment test battery for use in chronic fatigue syndrome.

A rating scale for fibromyalgia and chronic fatigue syndrome (the FibroFatigue scale).

Maximal oxygen uptake and lactate metabolism are normal in chronic fatigue syndrome.

Fatigue after breast cancer and in chronic fatigue syndrome: similarities and differences.

Joint hypermobility is more common in children with chronic fatigue syndrome than in healthy controls.

Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome.

Patients' perceptions of medical care in chronic fatigue syndrome.

Defensive coping styles in chronic fatigue syndrome.

The effect of exercise on gait and balance in patients with chronic fatigue syndrome.

Causal attributions for somatic sensations in patients with chronic fatigue syndrome and their partners.

A community-based study of seasonal variation in the onset of chronic fatigue syndrome and idiopathic chronic fatigue.

Monozygotic twins discordant for chronic fatigue syndrome: regional cerebral blood flow SPECT.

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