ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2786 studies

2461–2480 of 2,786 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

The relationship between temporomandibular disorders and stress-associated syndromes.

Korszun, A, Papadopoulos, E, Demitrack, M et al.·Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics·1998

This study looked at how often jaw joint problems (temporomandibular disorder) occur together with ME/CFS and fibromyalgia. Researchers found that 42% of patients with these conditions also had jaw problems, and most of these patients had developed their general symptoms before their jaw pain started. Interestingly, most were treated only for the jaw problem with bite splints, even though they had multiple related conditions.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers.

Scott, L V, Dinan, T G·Journal of affective disorders·1998

This study measured a stress hormone called cortisol in urine samples from people with ME/CFS, people with depression, and healthy individuals. The researchers found that people with ME/CFS had lower cortisol levels than healthy people, while people with depression had higher levels. This suggests that ME/CFS and depression affect the body's stress response system in opposite ways.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Evaluating neuropsychological impairment in chronic fatigue syndrome.

Vercoulen, J H, Bazelmans, E, Swanink, C M et al.·Journal of clinical and experimental neuropsychology·1998

This study looked at whether people with ME/CFS have problems with thinking, memory, and concentration. Researchers tested patients using standard cognitive tests and also asked them to report their own memory and concentration difficulties. Surprisingly, most patients performed normally on the tests, and there was no clear connection between test results and what patients reported experiencing in daily life.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model.

Vercoulen, J H, Swanink, C M, Galama, J M et al.·Journal of psychosomatic research·1998

This study tested whether thoughts, behaviors, and emotions affect how severe fatigue becomes and stays in ME/CFS patients. Researchers found that when patients believe their symptoms are purely physical, they tend to be less active, which makes fatigue worse. They also found that how much control patients felt they had over symptoms and how much they focused on body sensations directly affected fatigue levels. Importantly, the patterns that explained fatigue in ME/CFS were different from those in MS patients.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCase-Control

Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Scott, L V, Burnett, F, Medbak, S et al.·Psychological medicine·1998

This study looked at whether an opioid-blocking drug called naloxone could trigger the body's stress hormone system in ME/CFS patients versus healthy people. The researchers found that when given naloxone, ME/CFS patients had a blunted response in one stress hormone (ACTH) compared to healthy controls, suggesting that excess opioids are not the primary cause of the stress hormone problems seen in ME/CFS.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of SPET brain perfusion and 18F-FDG brain metabolism in patients with chronic fatigue syndrome.

Abu-Judeh, H H, Levine, S, Kumar, M et al.·Nuclear medicine communications·1998

Researchers used two different types of brain scans to look at blood flow and energy use in patients with ME/CFS. They found that these two scans gave different results: many patients had abnormal blood flow patterns, but most had normal energy metabolism. This suggests that ME/CFS may affect how blood moves through the brain differently than how the brain uses glucose for energy.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Adaptive tasks, coping and quality of life of chronically ill patients: the cases of Parkinson's disease and chronic fatigue syndrome.

De Ridder, D T, Schreurs, K M, Bensing, J M·Journal of health psychology·1998

This study compared how people with Parkinson's disease and ME/CFS cope with the challenges their illnesses create and how this affects their quality of life. Researchers found that while both groups face similar types of challenges (like managing symptoms and adjusting daily life), the way these challenges affect quality of life differs between the two diseases. For people with ME/CFS, how patients think about and evaluate their illness challenges was more important in predicting their quality of life than the actual severity of their symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.

Kuratsune, H, Yamaguti, K, Lindh, G et al.·International journal of molecular medicine·1998

Researchers measured a substance called acylcarnitine in the blood of people with ME/CFS and compared it to healthy people and those with other diseases. They found that people with ME/CFS had significantly lower levels of this substance, and this same pattern appeared in both Japanese and Swedish patients. Importantly, this low level was only seen in ME/CFS and one other condition (chronic hepatitis C), not in other common diseases like diabetes or high blood pressure.

BiomarkersEnergy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

The role of delayed orthostatic hypotension in the pathogenesis of chronic fatigue.

Streeten, D H, Anderson, G H·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1998

This study looked at whether problems with blood pressure regulation—specifically a delayed drop in blood pressure when standing up—might explain why some people with chronic fatigue syndrome feel so exhausted. Researchers surveyed 431 patients with various neurological and hormonal disorders and found that fatigue was very common in people with delayed blood pressure drops and low cortisol levels (70-83%), but much less common in people with other conditions like multiple system atrophy (7-33%). This suggests a possible connection between blood pressure regulation problems and severe fatigue.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome.

Heijmans, M, De Ridder, D·Journal of health psychology·1998

This study looked at how people with ME/CFS and Addison's disease think about their illnesses—what they believe causes it, how long it will last, whether they can control it, and how it affects their lives. Researchers interviewed 98 ME/CFS patients and 63 Addison's disease patients and found that the two groups had quite different views about their conditions. However, the way these different beliefs connected to each other followed similar patterns in both groups.

E2 ModerateCohortPEM not requiredLongitudinal

Clinical and serologic follow-up in patients with neuroborreliosis.

Treib, J, Fernandez, A, Haass, A et al.·Neurology·1998

Researchers followed 44 patients who had been treated for a tick-borne brain infection caused by Borrelia bacteria. Even though the patients' neurological symptoms improved after antibiotics, more than half continued to experience ongoing fatigue and other non-specific symptoms similar to chronic fatigue syndrome years later. Some patients also continued to show signs of Borrelia infection in their blood tests.

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

Borish, L, Schmaling, K, DiClementi, J D et al.·The Journal of allergy and clinical immunology·1998

This study looked at whether allergies and psychological factors play a role in ME/CFS. Researchers compared 18 people with ME/CFS to healthy controls, people with allergies, and people with depression. They found that people with ME/CFS had different immune molecules (called cytokines) in their blood compared to healthy people, similar to those with allergies. Interestingly, people with ME/CFS who also had certain psychological profiles showed different immune patterns, suggesting that both allergies and how the mind responds to them may contribute to ME/CFS in some patients.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Saltzstein, B J, Wyshak, G, Hubbuch, J T et al.·General hospital psychiatry·1998

This study interviewed 15 women with ME/CFS about their experiences and what helped them cope with the illness. Researchers found that 60% of the women reported improvement or recovery. Having strong support from family and friends, a supportive doctor who believed in the diagnosis, and lower depression symptoms were associated with better outcomes.

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of chronic fatigue syndrome in a community population in Japan.

Kawakami, N, Iwata, N, Fujihara, S et al.·The Tohoku journal of experimental medicine·1998

This Japanese study looked at how common ME/CFS is in everyday communities by interviewing 137 people. Researchers found that about 1 in 67 people had severe, persistent fatigue that met ME/CFS criteria and significantly disrupted their daily life. The findings suggested ME/CFS might be more common in Japan than in Western countries studied previously.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Post-infection fatigue syndrome following Q fever.

Ayres, J G, Flint, N, Smith, E G et al.·QJM : monthly journal of the Association of Physicians·1998

This study followed 71 people in the UK who were infected with Q fever (a bacterial infection) in 1989 and compared them to 142 similar people who were not infected. Five years later, the infected group reported significantly more fatigue, sweating, breathlessness, and blurred vision than the control group. About 42% of the infected patients met the diagnostic criteria for chronic fatigue syndrome, suggesting that a single Q fever infection can lead to long-lasting tiredness and related symptoms in some people.

E2 ModerateCohortPEM not requiredObservational

Amplified amplitudes of circadian rhythms and nighttime hypotension in patients with chronic fatigue syndrome: improvement by inopamil but not by melatonin.

van de Luit, L, van der Meulen, J, Cleophas, T J et al.·Angiology·1998

This study found that people with ME/CFS have unusually large swings in heart rate and blood pressure throughout the day and night, even though the overall pattern matches healthy controls. Importantly, their nighttime blood pressure drops too low (below 100 mm Hg systolic), which may contribute to fatigue and other symptoms. When treated with a heart-strengthening medication called inopamil, nighttime blood pressure improved, but melatonin actually made it worse.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredObservational

Cancer and a fatiguing illness in Northern Nevada--a causal hypothesis.

Levine, P H, Fears, T R, Cummings, P et al.·Annals of epidemiology·1998

Researchers compared cancer rates in two areas of Nevada where an unexplained fatiguing illness (including ME/CFS cases) occurred in the 1980s against an area with no reported illness. They found higher rates of non-Hodgkin lymphoma and brain tumors in the affected areas, but similar rates of breast and lung cancer. The authors suggest this could mean ME/CFS might increase cancer risk, but they emphasize it's too early to draw firm conclusions.

E2 ModerateCohortPEM not requiredCase-Control

[Risk factors for ischemic heart disease in patients with chronic fatigue syndrome].

Vilikus, Z, Marecková, H, Janatková, I et al.·Sbornik lekarsky·1998

This study compared heart disease risk factors between people with ME/CFS and healthy controls. Researchers found that despite ME/CFS patients exercising less overall, they had no higher risk for heart disease than the control group. This suggests that reduced exercise activity in ME/CFS does not appear to increase cardiovascular risk in the way it might in other conditions.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Secretion of growth hormone in patients with chronic fatigue syndrome.

Berwaerts, J, Moorkens, G, Abs, R·Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society·1998

This study looked at growth hormone levels in people with ME/CFS, because low growth hormone has been seen in related conditions like fibromyalgia. Researchers tested 20 ME/CFS patients and compared them to healthy controls, measuring growth hormone in different ways. They found that ME/CFS patients had lower levels of a growth hormone marker (IGF-I) and tended to produce less growth hormone at night, though other growth hormone tests were similar between groups.

Endocrine Disruption

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome and seasonal affective disorder: comorbidity, diagnostic overlap, and implications for treatment.

Terman, M, Levine, S M, Terman, J S et al.·The American journal of medicine·1998

This study looked at whether ME/CFS symptoms get worse during winter months, similar to seasonal depression. Researchers asked 110 ME/CFS patients about their symptoms in summer and winter, and found that about one-third showed a seasonal pattern with winter worsening. This suggests that some ME/CFS patients might benefit from light therapy, a treatment commonly used for seasonal depression.

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The relationship between temporomandibular disorders and stress-associated syndromes.

Urinary free cortisol excretion in chronic fatigue syndrome, major depression and in healthy volunteers.

Evaluating neuropsychological impairment in chronic fatigue syndrome.

The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: development of a model.

Naloxone-mediated activation of the hypothalamic-pituitary-adrenal axis in chronic fatigue syndrome.

Comparison of SPET brain perfusion and 18F-FDG brain metabolism in patients with chronic fatigue syndrome.

Adaptive tasks, coping and quality of life of chronically ill patients: the cases of Parkinson's disease and chronic fatigue syndrome.

Low levels of serum acylcarnitine in chronic fatigue syndrome and chronic hepatitis type C, but not seen in other diseases.

The role of delayed orthostatic hypotension in the pathogenesis of chronic fatigue.

Structure and Determinants of Illness Representations in Chronic Disease: A Comparison of Addison's Disease and Chronic Fatigue Syndrome.

Clinical and serologic follow-up in patients with neuroborreliosis.

Chronic fatigue syndrome: identification of distinct subgroups on the basis of allergy and psychologic variables.

A naturalistic study of the chronic fatigue syndrome among women in primary care.

Prevalence of chronic fatigue syndrome in a community population in Japan.

Post-infection fatigue syndrome following Q fever.

Amplified amplitudes of circadian rhythms and nighttime hypotension in patients with chronic fatigue syndrome: improvement by inopamil but not by melatonin.

Cancer and a fatiguing illness in Northern Nevada--a causal hypothesis.

[Risk factors for ischemic heart disease in patients with chronic fatigue syndrome].

Secretion of growth hormone in patients with chronic fatigue syndrome.

Chronic fatigue syndrome and seasonal affective disorder: comorbidity, diagnostic overlap, and implications for treatment.

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