ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2541–2560 of 2,768 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive idiosyncrasies among children with the chronic fatigue syndrome: anomalies in self-reported activity levels.

Fry, A M, Martin, M·Journal of psychosomatic research·1996

This study looked at whether children with ME/CFS and their parents perceive their activity levels differently than healthy children do. Researchers used activity monitors (objective measurement) and asked children and parents to estimate activity (subjective measurement) over 3 days. They found that children with ME/CFS and their parents underestimated how much activity was actually happening, and there was a bigger gap between what they expected to do in the future versus what they wanted to do.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCase-Control

Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study.

Cope, H, Mann, A, Pelosi, A et al.·Psychological medicine·1996

This study looked at 64 people who either developed lasting fatigue or didn't after a viral illness, examining their mental health, stress levels, and coping strategies. The researchers found that people who developed chronic fatigue were more likely to have had past mental health problems and used avoidance-based coping methods. Interestingly, those who met the full criteria for ME/CFS had severe fatigue but didn't necessarily have more psychiatric issues than others with chronic fatigue.

E2 ModerateBehavioralPEM not requiredLongitudinal

Chronic fatigue in the community: 'a question of attribution'.

Chalder, T, Power, M J, Wessely, S·Psychological medicine·1996

This study looked at 38 people with chronic fatigue who believed they had ME, comparing them to two similar groups who attributed their tiredness to psychological or social causes. After 18 months, people who believed they had ME were more disabled in daily activities like work and socializing, even though they were less emotionally distressed. Interestingly, people who attributed their fatigue to social reasons seemed to do better overall.

E2 ModerateCohortPEM requiredCross-Sectional

Decreased vagal power during treadmill walking in patients with chronic fatigue syndrome.

Cordero, D L, Sisto, S A, Tapp, W N et al.·Clinical autonomic research : official journal of the Clinical Autonomic Research Society·1996

This study compared how the nervous system controls heart rate in people with ME/CFS versus healthy volunteers during and after treadmill walking. Researchers found that people with ME/CFS had weaker parasympathetic (rest-and-recover) nervous system activity during walking, and this activity dropped even further after exercise stopped. This abnormality might help explain why ME/CFS patients feel worse after physical activity.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Functional status in patients with chronic fatigue syndrome, other fatiguing illnesses, and healthy individuals.

Buchwald, D, Pearlman, T, Umali, J et al.·The American journal of medicine·1996

This study used a health survey (SF-36) to measure how much ME/CFS affects daily activities in 185 patients, comparing them to people with other illnesses and healthy controls. ME/CFS patients had the lowest scores, meaning the most disability, especially in physical activities, work, and pain. The survey was useful for showing that ME/CFS causes more functional impairment than other conditions like depression or infectious mononucleosis.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.

Williams, G, Pirmohamed, J, Minors, D et al.·Clinical physiology (Oxford, England)·1996

This study looked at whether the internal body clocks of ME/CFS patients work normally. Researchers measured body temperature and melatonin (a sleep hormone) rhythms in 20 ME/CFS patients and 17 healthy people. They found that in healthy people, body temperature and melatonin rhythms are normally synchronized, but in ME/CFS patients, these two rhythms were disconnected from each other—like two clocks running at different times.

E2 ModerateCohortPEM not requiredCross-Sectional

Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.

Sisto, S A, LaManca, J, Cordero, D L et al.·The American journal of medicine·1996

Researchers tested how well women with ME/CFS could exercise compared to healthy controls by having them walk on a treadmill until exhaustion. Women with ME/CFS had lower aerobic fitness levels than healthy controls, but their hearts and lungs appeared to work normally. Importantly, the maximal exercise test did not cause a major flare-up of fatigue or other ME/CFS symptoms.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue and minor psychiatric morbidity after viral meningitis: a controlled study.

Hotopf, M, Noah, N, Wessely, S·Journal of neurology, neurosurgery, and psychiatry·1996

Researchers followed 83 patients who had viral meningitis and compared them to 76 people who had other viral infections. They found that about 12.6% of all participants developed chronic fatigue after their illness—higher than expected. Interestingly, having meningitis specifically was not a stronger risk factor than other viral infections; instead, people who took longer to recover and those with a history of psychiatric illness were more likely to develop chronic fatigue.

E2 ModerateCohortPEM not requiredObservational

No findings of enteroviruses in Swedish patients with chronic fatigue syndrome.

Lindh, G, Samuelson, A, Hedlund, K O et al.·Scandinavian journal of infectious diseases·1996

Researchers tested 34 Swedish patients with ME/CFS to see if a virus called enterovirus might be causing their illness. They looked for the virus in stool samples, blood, spinal fluid, and muscle tissue using several different detection methods. The study found no evidence of enterovirus infection in any of the patients tested.

Immune System

E2 ModerateCohortPEM not requiredObservational

Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome.

Kitani, T, Kuratsune, H, Fuke, I et al.·Microbiology and immunology·1996

This 1996 study investigated whether a virus called Borna disease virus (BDV) might be connected to chronic fatigue syndrome (ME/CFS). Borna disease virus naturally infects animals like horses and sheep, and researchers found evidence of this virus or antibodies to it in some ME/CFS patients. The study suggests there may be a link between BDV infection and ME/CFS symptoms, though more research is needed to understand if and how this virus contributes to the condition.

Immune System

E2 ModerateCohortPEM not requiredCase-Control

A case-control study to assess possible triggers and cofactors in chronic fatigue syndrome.

MacDonald, K L, Osterholm, M T, LeDell, K H et al.·The American journal of medicine·1996

This study compared 47 people with ME/CFS to 47 matched healthy controls to identify what might trigger or contribute to the illness. Researchers found that people with ME/CFS were more likely to have exercised regularly before getting sick, and women with ME/CFS were more likely to have never had children. Depression was more common after ME/CFS developed, though it wasn't more common before illness onset.

Post-Exertional Malaise

E2 ModerateCohortPEM not required

Interferon-alpha versus somatostatin or the combination of both in gastro-enteropancreatic tumours.

Oberg, K·Digestion·1996

This 1996 study tested two medications—interferon-alpha and somatostatin—for treating neuroendocrine tumors (hormone-producing cancers). Interferon-alpha was found to cause fatigue and flu-like symptoms in patients, and in some cases led to low-grade chronic fatigue syndrome. When the two drugs were combined, they worked better together, improved symptoms, and were better tolerated than interferon alone.

E2 ModerateCohortPEM unclearCross-Sectional

Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.

Grant, J E, Veldee, M S, Buchwald, D·Journal of the American Dietetic Association·1996

This study looked at what people with ME/CFS were eating and measured specific nutrients in their blood and body. Researchers compared the diets and nutrient levels of ME/CFS patients to see if there were any patterns or deficiencies that might be related to their illness. This was one of the first studies to systematically examine nutrition in ME/CFS patients.

E2 ModerateBehavioralPEM not requiredCross-Sectional

A controlled comparison of multiple chemical sensitivities and chronic fatigue syndrome.

Fiedler, N, Kipen, H M, DeLuca, J et al.·Psychosomatic medicine·1996

This study compared people with multiple chemical sensitivities (MCS), chemical sensitivities without a clear trigger (CS), and chronic fatigue syndrome (CFS) to healthy controls. Researchers found that chemically sensitive patients reported more lifestyle disruption and avoided more substances than CFS patients, but all three patient groups had higher rates of psychiatric conditions and unexplained physical symptoms compared to healthy people. Interestingly, standard memory and thinking tests did not show significant differences between groups, suggesting that cognitive problems in these conditions may not show up on typical office-based tests.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Personality dimensions in the chronic fatigue syndrome: a comparison with multiple sclerosis and depression.

Johnson, S K, DeLuca, J, Natelson, B H·Journal of psychiatric research·1996

This study looked at personality traits in people with ME/CFS and compared them to people with multiple sclerosis, depression, and healthy controls. The researchers found that people with ME/CFS had some personality differences, but these were mostly explained by those who also had depression. Overall, the ME/CFS group fell between the healthy controls and the depression group in terms of personality traits.

E2 ModerateCohortPEM not requiredCross-Sectional

Preliminary determination of the association between symptom expression and urinary metabolites in subjects with chronic fatigue syndrome.

McGregor, N R, Dunstan, R H, Zerbes, M et al.·Biochemical and molecular medicine·1996

Researchers found that ME/CFS patients have a distinctive substance in their urine called CFSUM1 that is rarely found in healthy people. This study examined whether certain chemicals in urine could be linked to the different symptoms ME/CFS patients experience, such as fatigue, cognitive problems, muscle pain, and digestive issues. They discovered that two specific urine metabolites—CFSUM1 and beta-alanine—were strongly associated with symptom severity, suggesting these could eventually be used as biological markers for diagnosing ME/CFS.

E2 ModerateBehavioralPEM unclearObservational

Does the stressed patient with chronic fatigue syndrome hyperventilate?

Lavietes, M H, Natelson, B H, Cordero, D L et al.·International journal of behavioral medicine·1996

This study investigated whether people with ME/CFS tend to breathe too quickly or shallowly when under stress, a condition called hyperventilation. Researchers observed patients with ME/CFS and measured their breathing patterns to see if stress triggered abnormal breathing that might contribute to their symptoms. The study helps clarify whether breathing problems are part of what causes ME/CFS symptoms.

E2 ModerateBehavioralPEM not requiredCross-Sectional

MMPI profiles of patients with chronic fatigue syndrome.

Schmaling, K B, Jones, J F·Journal of psychosomatic research·1996

This study examined personality and psychological profiles in 53 ME/CFS patients compared to 43 healthy people using a standard psychological test called the MMPI. Researchers also measured levels of Epstein-Barr virus (a virus often linked to ME/CFS) in all participants. They found that ME/CFS patients showed higher virus levels and distinctive patterns on the psychological test, particularly in areas related to physical symptoms, mood, and anxiety.

E2 ModerateCohortPEM not requiredObservational

The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections.

Hana, I, Vrubel, J, Pekarek, J et al.·Biotherapy (Dordrecht, Netherlands)·1996

This study looked at 222 patients with weak immune systems, many of whom also had ME/CFS and/or chronic viral infections (EBV or CMV). They were treated with transfer factor, a type of immune-boosting therapy, given as injections over 8 weeks. The researchers found that younger patients improved more often than older patients, with failure rates rising significantly in those over 54 years old.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

The measurement of fatigue in patients with multiple sclerosis. A multidimensional comparison with patients with chronic fatigue syndrome and healthy subjects.

Vercoulen, J H, Hommes, O R, Swanink, C M et al.·Archives of neurology·1996

This study compared fatigue in three groups: people with MS, people with ME/CFS, and healthy people. The researchers found that both MS and ME/CFS patients experienced severe fatigue that affected their daily life. Interestingly, psychological factors like how much someone focuses on their body sensations and whether they feel in control of their symptoms seemed to influence fatigue severity in both diseases.

← Previous Next 20 studies →

Or browse by topic

PEM Immune Neuro Metabolic Biomarkers Severe ME Long COVID Cognitive

Evidence Atlas

Evidence browser

Cognitive idiosyncrasies among children with the chronic fatigue syndrome: anomalies in self-reported activity levels.

Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study.

Chronic fatigue in the community: 'a question of attribution'.

Decreased vagal power during treadmill walking in patients with chronic fatigue syndrome.

Functional status in patients with chronic fatigue syndrome, other fatiguing illnesses, and healthy individuals.

Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.

Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.

Chronic fatigue and minor psychiatric morbidity after viral meningitis: a controlled study.

No findings of enteroviruses in Swedish patients with chronic fatigue syndrome.

Possible correlation between Borna disease virus infection and Japanese patients with chronic fatigue syndrome.

A case-control study to assess possible triggers and cofactors in chronic fatigue syndrome.

Interferon-alpha versus somatostatin or the combination of both in gastro-enteropancreatic tumours.

Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.

A controlled comparison of multiple chemical sensitivities and chronic fatigue syndrome.

Personality dimensions in the chronic fatigue syndrome: a comparison with multiple sclerosis and depression.

Preliminary determination of the association between symptom expression and urinary metabolites in subjects with chronic fatigue syndrome.

Does the stressed patient with chronic fatigue syndrome hyperventilate?

MMPI profiles of patients with chronic fatigue syndrome.

The influence of age on transfer factor treatment of cellular immunodeficiency, chronic fatigue syndrome and/or chronic viral infections.

The measurement of fatigue in patients with multiple sclerosis. A multidimensional comparison with patients with chronic fatigue syndrome and healthy subjects.

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research