ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2786 studies

2561–2580 of 2,786 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.

Sisto, S A, LaManca, J, Cordero, D L et al.·The American journal of medicine·1996

Researchers tested how well women with ME/CFS could exercise compared to healthy controls by having them walk on a treadmill until exhaustion. Women with ME/CFS had lower aerobic fitness levels than healthy controls, but their hearts and lungs appeared to work normally. Importantly, the maximal exercise test did not cause a major flare-up of fatigue or other ME/CFS symptoms.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Preliminary determination of a molecular basis of chronic fatigue syndrome.

McGregor, N R, Dunstan, R H, Zerbes, M et al.·Biochemical and molecular medicine·1996

Researchers tested the urine of 20 ME/CFS patients and 45 healthy controls to look for chemical differences. They found that ME/CFS patients had different levels of several substances in their urine, particularly one called CFSUM1 and beta-alanine, which were higher in patients with more severe symptoms. These findings suggest ME/CFS may have measurable biological markers that could help identify the condition.

BiomarkersEnergy Metabolism

E2 ModerateBehavioralPEM not requiredCase-Control

Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting.

Wessely, S, Chalder, T, Hirsch, S et al.·The American journal of psychiatry·1996

This study followed over 1,900 people in primary care and found that most individuals with ME/CFS also had a current mental health condition like depression or anxiety. The researchers discovered that people with chronic fatigue were much more likely to have psychiatric disorders (60-78%) compared to those without fatigue (19-31%). While the study suggests a strong link between psychiatric conditions and ME/CFS, it does not explain whether one causes the other.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

An examination of the working case definition of chronic fatigue syndrome.

Komaroff, A L, Fagioli, L R, Geiger, A M et al.·The American journal of medicine·1996

Researchers studied 281 patients with severe, long-lasting fatigue to see how well the official definition of ME/CFS worked. They compared these patients to healthy people and people with similar conditions like multiple sclerosis and depression. The study found that certain symptoms—like muscle pain, post-exertion exhaustion, headaches, and flu-like symptoms—were very common in ME/CFS patients but rare in the other groups.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.

Williams, G, Pirmohamed, J, Minors, D et al.·Clinical physiology (Oxford, England)·1996

This study looked at whether the internal body clocks of ME/CFS patients work normally. Researchers measured body temperature and melatonin (a sleep hormone) rhythms in 20 ME/CFS patients and 17 healthy people. They found that in healthy people, body temperature and melatonin rhythms are normally synchronized, but in ME/CFS patients, these two rhythms were disconnected from each other—like two clocks running at different times.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Assessing somatization disorder in the chronic fatigue syndrome.

Johnson, S K, DeLuca, J, Natelson, B H·Psychosomatic medicine·1996

This study compared how often doctors diagnosed somatization disorder (a condition where emotional distress causes physical symptoms) in ME/CFS patients versus people with multiple sclerosis, depression, or no illness. The researchers found that whether symptoms were labeled as 'psychiatric' or 'physical' dramatically changed the diagnosis rate, suggesting that labeling is somewhat arbitrary in ME/CFS. Very few patients in any group actually met strict diagnostic criteria for somatization disorder.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia.

Buchwald, D, Umali, J, Stene, M·The Journal of rheumatology·1996

Researchers tested whether people with ME/CFS have lower levels of a growth hormone called IGF-I, which had previously been found to be low in fibromyalgia patients. They measured IGF-I levels in 15 people with ME/CFS, 15 with both ME/CFS and fibromyalgia, 27 with fibromyalgia alone, and 15 healthy volunteers. The study found no significant differences in IGF-I levels between any of the patient groups and healthy controls, suggesting that low IGF-I may not be a key feature of ME/CFS.

Sleep

E2 ModerateBehavioralPEM unclearObservational

Does the stressed patient with chronic fatigue syndrome hyperventilate?

Lavietes, M H, Natelson, B H, Cordero, D L et al.·International journal of behavioral medicine·1996

This study investigated whether people with ME/CFS tend to breathe too quickly or shallowly when under stress, a condition called hyperventilation. Researchers observed patients with ME/CFS and measured their breathing patterns to see if stress triggered abnormal breathing that might contribute to their symptoms. The study helps clarify whether breathing problems are part of what causes ME/CFS symptoms.

E2 ModerateBehavioralPEM not requiredCase-Control

Chronic fatigue and minor psychiatric morbidity after viral meningitis: a controlled study.

Hotopf, M, Noah, N, Wessely, S·Journal of neurology, neurosurgery, and psychiatry·1996

Researchers followed 83 patients who had viral meningitis and compared them to 76 people who had other viral infections. They found that about 12.6% of all participants developed chronic fatigue after their illness—higher than expected. Interestingly, having meningitis specifically was not a stronger risk factor than other viral infections; instead, people who took longer to recover and those with a history of psychiatric illness were more likely to develop chronic fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

Conti, F, Magrini, L, Priori, R et al.·Allergy·1996

This study measured a protein called eosinophil cationic protein (ECP) in the blood of ME/CFS patients to see if their immune cells called eosinophils were overly active. Researchers found that ME/CFS patients had significantly higher ECP levels than healthy controls, and most ME/CFS patients also tested positive for allergies. However, ME/CFS patients with allergies did not have higher ECP levels than those without allergies, suggesting the connection may be more complex than initially expected.

Immune System

E2 ModerateCohortPEM not requiredLongitudinal

Changing epidemiology of Ross River virus disease in South Australia.

Selden, S M, Cameron, A S·The Medical journal of Australia·1996

This study followed people in South Australia who had Ross River virus (RRV) infections to see how long symptoms lasted. Researchers found that more than half of patients still had joint pain and tiredness 15 months after infection, with similar patterns continuing for 30 months. The symptoms were very disabling for many people and resembled chronic fatigue syndrome.

E2 ModerateCohortPEM unclearCross-Sectional

Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.

Grant, J E, Veldee, M S, Buchwald, D·Journal of the American Dietetic Association·1996

This study looked at what people with ME/CFS were eating and measured specific nutrients in their blood and body. Researchers compared the diets and nutrient levels of ME/CFS patients to see if there were any patterns or deficiencies that might be related to their illness. This was one of the first studies to systematically examine nutrition in ME/CFS patients.

E2 ModerateCohortPEM not requiredCross-Sectional

Descriptive epidemiology of chronic fatigue syndrome based on a nationwide survey in Japan.

Minowa, M, Jiamo, M·Journal of epidemiology·1996

Researchers surveyed hospitals across Japan in 1992 to understand how many people have ME/CFS and how it spreads. They found that about 0.85 cases per 100,000 people were diagnosed that year, with slightly more women affected than men. The number of cases appeared to be growing from 1992 to 1993, and a small percentage of cases started after an infection.

E2 ModerateCohortPEM not requiredCross-Sectional

Postinfectious chronic fatigue: a distinct syndrome?

Buchwald, D, Umali, J, Pearlman, T et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1996

Researchers studied 717 people with chronic fatigue to see if those whose illness started after a viral infection were different from those whose illness began differently. They found that people with post-viral onset reported more flu-like symptoms (fever, chills, sore throat, swollen lymph nodes) and had worse day-to-day functioning, but blood tests and other markers of inflammation or ongoing viral infection did not show clear differences between the two groups.

E2 ModerateCohortPEM not required

Interferon-alpha versus somatostatin or the combination of both in gastro-enteropancreatic tumours.

Oberg, K·Digestion·1996

This 1996 study tested two medications—interferon-alpha and somatostatin—for treating neuroendocrine tumors (hormone-producing cancers). Interferon-alpha was found to cause fatigue and flu-like symptoms in patients, and in some cases led to low-grade chronic fatigue syndrome. When the two drugs were combined, they worked better together, improved symptoms, and were better tolerated than interferon alone.

E2 ModerateCohortPEM not requiredCross-Sectional

Serum carnitine and disabling fatigue in multiple sclerosis.

Fukazawa, T, Sasaki, H, Kikuchi, S et al.·Psychiatry and clinical neurosciences·1996

This study tested whether a substance called carnitine, which helps muscles use fat for energy, might be low in people with multiple sclerosis (MS) and could explain their severe fatigue. Researchers compared carnitine levels in 25 MS patients and healthy people of similar age and sex, but found no differences between groups or between MS patients with and without severe fatigue.

Energy Metabolism

E2 ModerateCohortPEM not requiredCross-Sectional

Lymphocyte subsets, apoptosis, and cytokines in patients with chronic fatigue syndrome.

Swanink, C M, Vercoulen, J H, Galama, J M et al.·The Journal of infectious diseases·1996

This study compared immune system markers in blood samples from 76 ME/CFS patients and 69 healthy controls to see if immune abnormalities could explain fatigue severity. Researchers found one immune marker (CD11b on CD8 cells) was lower in ME/CFS patients, but most other immune measures were similar between groups, and none of these markers correlated with how severe a patient's fatigue or depression was.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

A national assessment of the service, support, and housing preferences by persons with chronic fatigue syndrome. Toward a comprehensive rehabilitation program.

Jason, L A, Ferrari, J R, Taylor, R R et al.·Evaluation & the health professions·1996

Nearly 1,000 people with ME/CFS across North America were surveyed about what services and support would help them most. The survey found that patients wanted better education about ME/CFS for doctors and the public, and preferred support groups and self-help resources over other types of treatment assistance. These results can help guide the development of programs specifically designed to support people with ME/CFS.

E2 ModerateBehavioralPEM not requiredCase-Control

Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study.

Cope, H, Mann, A, Pelosi, A et al.·Psychological medicine·1996

This study looked at 64 people who either developed lasting fatigue or didn't after a viral illness, examining their mental health, stress levels, and coping strategies. The researchers found that people who developed chronic fatigue were more likely to have had past mental health problems and used avoidance-based coping methods. Interestingly, those who met the full criteria for ME/CFS had severe fatigue but didn't necessarily have more psychiatric issues than others with chronic fatigue.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of 99m Tc HMPAO SPECT scan between chronic fatigue syndrome, major depression and healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow.

Fischler, B, D'Haenen, H, Cluydts, R et al.·Neuropsychobiology·1996

This study used a brain imaging technique called SPECT scans to compare blood flow in the brains of people with ME/CFS, people with depression, and healthy volunteers. Researchers found that in ME/CFS patients, blood flow in the front part of the brain was connected to cognitive problems and physical activity limitations. Unlike depression, ME/CFS did not show overall reduced blood flow in the brain, but did show a specific pattern of asymmetry (one side different from the other) in the side-back regions.

Cognitive Impairment

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Metabolic and cardiovascular effects of a progressive exercise test in patients with chronic fatigue syndrome.

Preliminary determination of a molecular basis of chronic fatigue syndrome.

Psychological symptoms, somatic symptoms, and psychiatric disorder in chronic fatigue and chronic fatigue syndrome: a prospective study in the primary care setting.

An examination of the working case definition of chronic fatigue syndrome.

Dissociation of body-temperature and melatonin secretion circadian rhythms in patients with chronic fatigue syndrome.

Assessing somatization disorder in the chronic fatigue syndrome.

Insulin-like growth factor-I (somatomedin C) levels in chronic fatigue syndrome and fibromyalgia.

Does the stressed patient with chronic fatigue syndrome hyperventilate?

Chronic fatigue and minor psychiatric morbidity after viral meningitis: a controlled study.

Eosinophil cationic protein serum levels and allergy in chronic fatigue syndrome.

Changing epidemiology of Ross River virus disease in South Australia.

Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome.

Descriptive epidemiology of chronic fatigue syndrome based on a nationwide survey in Japan.

Postinfectious chronic fatigue: a distinct syndrome?

Interferon-alpha versus somatostatin or the combination of both in gastro-enteropancreatic tumours.

Serum carnitine and disabling fatigue in multiple sclerosis.

Lymphocyte subsets, apoptosis, and cytokines in patients with chronic fatigue syndrome.

A national assessment of the service, support, and housing preferences by persons with chronic fatigue syndrome. Toward a comprehensive rehabilitation program.

Psychosocial risk factors for chronic fatigue and chronic fatigue syndrome following presumed viral illness: a case-control study.

Comparison of 99m Tc HMPAO SPECT scan between chronic fatigue syndrome, major depression and healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow.

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