ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2581–2600 of 2,768 studies

E2 ModerateCohortPEM not requiredCase-Control

Contrasting neuroendocrine responses in depression and chronic fatigue syndrome.

Cleare, A J, Bearn, J, Allain, T et al.·Journal of affective disorders·1995

This study compared hormone levels and brain chemistry in people with ME/CFS, people with depression, and healthy controls. The researchers found that people with ME/CFS had lower cortisol (a stress hormone) and higher responses to a serotonin-related chemical, which is the opposite pattern seen in depression. This suggests ME/CFS and depression are biologically different conditions despite sometimes sharing similar symptoms like fatigue.

Endocrine Disruption

E2 ModerateCohortPEM not requiredCross-Sectional

Gait abnormalities in chronic fatigue syndrome.

Boda, W L, Natelson, B H, Sisto, S A et al.·Journal of the neurological sciences·1995

Researchers filmed how people with ME/CFS walked at different speeds and compared them to sedentary (non-exercising) healthy people. They found that people with ME/CFS walked differently—they moved their hips differently, bent their knees less, and took shorter steps relative to their leg length. People with ME/CFS also ran much more slowly than the comparison group.

E2 ModerateCohortPEM not requiredCross-Sectional

Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome.

Di Luca, D, Zorzenon, M, Mirandola, P et al.·Journal of clinical microbiology·1995

Researchers looked for two common viruses (HHV-6 and HHV-7) in immune cells of ME/CFS patients and compared them to healthy people. They found that HHV-7 was equally common in both groups, but a specific type of HHV-6 called variant A was found more often in ME/CFS patients. This suggests that HHV-6 variant A may be connected to ME/CFS, though the study does not prove it causes the illness.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.

Plioplys, A V, Plioplys, S·Neuropsychobiology·1995

This study looked at carnitine, a substance that helps cells produce energy. Researchers found that people with ME/CFS have lower levels of carnitine in their blood compared to what would be expected. They also discovered that patients with higher carnitine levels reported better ability to function in daily life, suggesting a link between this energy-related chemical and symptom severity.

Energy Metabolism

E2 ModerateCohortPEM not requiredCase-Control

The relationship between neurally mediated hypotension and the chronic fatigue syndrome.

Bou-Holaigah, I, Rowe, P C, Kan, J et al.·JAMA·1995

Researchers tested whether ME/CFS patients have an abnormal blood pressure response when standing upright. They tilted 23 ME/CFS patients and 14 healthy controls on a special table and monitored their vital signs. Nearly all ME/CFS patients showed an abnormal response, and about 9 patients felt much better after taking medications to treat low blood pressure.

Autonomic Nervous System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome in the community. Prevalence and associations.

Lawrie, S M, Pelosi, A J·The British journal of psychiatry : the journal of mental science·1995

This study surveyed over 1,000 people in a community to understand how common ME/CFS is and what it's associated with. Researchers found that about 0.56% of people met the criteria for ME/CFS, and they discovered a strong connection between fatigue and psychological distress. However, the authors concluded that ME/CFS should not be dismissed as purely a psychiatric disorder.

E2 ModerateCohortPEM not requiredCross-Sectional

Abnormalities of carnitine metabolism in chronic fatigue syndrome.

Majeed, T, de Simone, C, Famularo, G et al.·European journal of neurology·1995

This study examined carnitine, a substance that helps cells produce energy, in people with ME/CFS. Researchers found that while carnitine levels in the blood were normal, the levels inside immune cells were significantly lower in ME/CFS patients compared to healthy people. This finding suggests that ME/CFS patients might benefit from taking carnitine supplements to restore normal energy production.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Quality of life in chronic fatigue syndrome.

Schweitzer, R, Kelly, B, Foran, A et al.·Social science & medicine (1982)·1995

This 1995 study compared 47 people with ME/CFS to 30 healthy controls to understand how the condition affects daily life and well-being. Using surveys and interviews, researchers found that ME/CFS patients experienced significantly worse quality of life, particularly in social activities and relationships. The findings showed that isolation and loss of ability to work or participate in hobbies were major impacts that deserved more clinical attention.

E2 ModerateBehavioralPEM not requiredCross-Sectional

The impact of catastrophic beliefs on functioning in chronic fatigue syndrome.

Petrie, K, Moss-Morris, R, Weinman, J·Journal of psychosomatic research·1995

This study looked at whether how people think about ME/CFS affects how disabled they become. Researchers asked 282 people with ME/CFS what they thought would happen if they pushed themselves too hard, and sorted their answers into catastrophic (very negative) or non-catastrophic thinking. People who had catastrophic thoughts about pushing themselves were significantly more fatigued and more disabled in work, household tasks, sleep, socializing, and hobbies—even though they had been sick for similar lengths of time as others.

Post-Exertional Malaise

E2 ModerateBehavioralPEM unclearObservational

Can the chronic fatigue syndrome be defined by distinct clinical features?

Hickie, I, Lloyd, A, Hadzi-Pavlovic, D et al.·Psychological medicine·1995

This study examined whether all people diagnosed with ME/CFS have the same illness or whether they actually have different types. Researchers analyzed symptoms from 565 patients and found that ME/CFS is not one uniform condition—instead, they identified two distinct patient groups with different symptom patterns, illness duration, and recovery rates.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of coxsackie B neutralisation and enteroviral PCR in chronic fatigue patients.

Nairn, C, Galbraith, D N, Clements, G B·Journal of medical virology·1995

Researchers tested whether two different methods of detecting enterovirus (a type of virus) could identify it in ME/CFS patients. One method looked for antibodies (immune proteins) the body makes against Coxsackie B virus, while the other used PCR to directly detect viral genetic material. They found that the PCR test was better at distinguishing ME/CFS patients from healthy people, but the antibody test could not tell the two groups apart.

E2 ModerateCohortPEM not requiredCase-Control

A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome.

Dunstan, R H, Donohoe, M, Taylor, W et al.·The Medical journal of Australia·1995

Researchers measured levels of chlorinated hydrocarbons—chemicals that persist in the environment and accumulate in the body—in the blood of people with ME/CFS and compared them to healthy controls. People with ME/CFS had significantly higher levels of these chemicals, particularly a pesticide byproduct called HCB, suggesting that long-term exposure to these substances might play a role in developing the illness.

E2 ModerateCohortPEM not requiredCross-Sectional

Silicone breast implant--associated musculoskeletal manifestations.

Cuellar, M L, Gluck, O, Molina, J F et al.·Clinical rheumatology·1995

This study looked at 300 women with silicone breast implants who came to a rheumatology clinic with muscle and joint pain. The researchers found that over 80% of these women had signs of connective tissue disease, and more than half met criteria for fibromyalgia or chronic fatigue syndrome. When some women had their implants removed, over 70% reported improvement in their overall symptoms.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive functioning and magnetic resonance imaging in chronic fatigue.

Cope, H, Pernet, A, Kendall, B et al.·The British journal of psychiatry : the journal of mental science·1995

This study tested whether people with chronic fatigue have real problems with thinking and memory, or whether these complaints are mainly due to depression and anxiety. Researchers gave cognitive tests and brain scans (MRI) to people with chronic fatigue, people with depression, and healthy controls. They found that people with chronic fatigue performed similarly to controls on objective tests, and brain scans showed no consistent abnormalities. The researchers concluded that complaints of cognitive problems were likely related to mood symptoms rather than physical brain changes.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredObservational

A clinical study of chronic fatigue syndrome.

Shanks, M F, Ho-Yen, D O·The British journal of psychiatry : the journal of mental science·1995

This study looked at 64 ME/CFS patients to understand whether psychiatric conditions (like depression or anxiety) are part of ME/CFS itself or develop separately. Researchers found that patients without pre-existing psychiatric disorders had milder illness overall, suggesting that ME/CFS can occur on its own. Most patients improved with counseling and by staying within their energy limits.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Coping with chronic fatigue syndrome: illness responses and their relationship with fatigue, functional impairment and emotional status.

Ray, C, Jefferies, S, Weir, W R·Psychological medicine·1995

This study looked at how different ways of coping with ME/CFS affected patients' symptoms and daily functioning. Researchers found that trying to stay active was linked to better functioning, while accepting the illness as permanent was linked to more disability. Giving up or withdrawing from activities was connected to both worse disability and emotional problems like depression or anxiety.

E2 ModerateBehavioralPEM not requiredLongitudinal

Chronic fatigue: risk factors for symptom persistence in a 2 1/2-year follow-up study.

Clark, M R, Katon, W, Russo, J et al.·The American journal of medicine·1995

This study followed 78 patients with chronic fatigue for about 2.5 years to understand why some people recover while others continue to struggle. Researchers found that people were more likely to have ongoing symptoms if they had multiple unexplained physical symptoms, a history of depression-like mood disorder, longer-lasting fatigue, less formal education, and were older than 38. Importantly, standard blood tests and immune system measurements did not predict who would improve.

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Secchiero, P, Carrigan, D R, Asano, Y et al.·The Journal of infectious diseases·1995

Researchers developed a sensitive test to detect human herpesvirus 6 (HHV-6) DNA in blood. They tested blood samples from children with a specific rash illness, bone marrow transplant patients, HIV-infected patients, people with chronic fatigue syndrome (ME/CFS), and healthy adults. The test found HHV-6 DNA most often in children with the rash illness, less commonly in transplant and HIV patients, rarely in ME/CFS patients, and not at all in healthy people.

E2 ModerateBehavioralPEM not requiredObservational

Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew.

Lutgendorf, S K, Antoni, M H, Ironson, G et al.·Psychosomatic medicine·1995

This study looked at how a major natural disaster (Hurricane Andrew in 1992) affected people with ME/CFS living in Florida. Patients who experienced the most hurricane damage had worse ME/CFS symptoms and greater difficulty with daily activities compared to those in less-affected areas. Interestingly, how stressed people felt about the hurricane and whether they had social support mattered more than the actual damage itself.

E2 ModerateCohortPEM not requiredLongitudinal

[The Epstein-Barr virus and chronic fatigue syndrome].

Jovanović, J, Cvjetković, D, Brkić, S et al.·Medicinski pregled·1995

This small study looked at whether ME/CFS symptoms develop after people recover from infectious mononucleosis caused by Epstein-Barr virus (EBV). Researchers followed 31 patients who had recovered from mono and found that several developed ongoing fatigue, sore throats, and sleep problems in the months and years after their acute illness. The results suggest a possible connection between EBV infection and ME/CFS symptoms.

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Contrasting neuroendocrine responses in depression and chronic fatigue syndrome.

Gait abnormalities in chronic fatigue syndrome.

Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome.

Serum levels of carnitine in chronic fatigue syndrome: clinical correlates.

The relationship between neurally mediated hypotension and the chronic fatigue syndrome.

Chronic fatigue syndrome in the community. Prevalence and associations.

Abnormalities of carnitine metabolism in chronic fatigue syndrome.

Quality of life in chronic fatigue syndrome.

The impact of catastrophic beliefs on functioning in chronic fatigue syndrome.

Can the chronic fatigue syndrome be defined by distinct clinical features?

Comparison of coxsackie B neutralisation and enteroviral PCR in chronic fatigue patients.

A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome.

Silicone breast implant--associated musculoskeletal manifestations.

Cognitive functioning and magnetic resonance imaging in chronic fatigue.

A clinical study of chronic fatigue syndrome.

Coping with chronic fatigue syndrome: illness responses and their relationship with fatigue, functional impairment and emotional status.

Chronic fatigue: risk factors for symptom persistence in a 2 1/2-year follow-up study.

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew.

[The Epstein-Barr virus and chronic fatigue syndrome].

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