ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

2641–2660 of 2,768 studies

E2 ModerateCohortPEM not requiredCross-Sectional

[Chronic fatigue syndrome: immune dysfunction, role of pathogens and toxic agents and neurological and cardial changes].

Hilgers, A, Frank, J·Wiener medizinische Wochenschrift (1946)·1994

This study examined 375 patients with ME/CFS to understand what goes wrong with their immune systems and which infections might be involved. Researchers found that most patients had problems with immune cell function, signs of past viral infections (especially Epstein-Barr virus), and imbalances in immune chemicals. The study suggests ME/CFS may be connected to autoimmune problems and multiple infections.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Dimensional assessment of chronic fatigue syndrome.

Vercoulen, J H, Swanink, C M, Fennis, J F et al.·Journal of psychosomatic research·1994

This study asked 298 people with ME/CFS to fill out detailed questionnaires about how the illness affected them. Researchers found that ME/CFS affects people in nine different ways: mood and emotional health, ability to do daily activities, sleep quality, physical avoidance, thinking and memory problems, beliefs about what caused their illness, relationships and social life, confidence in their own abilities, and overall life satisfaction. Understanding these separate aspects could help doctors better assess and treat ME/CFS in individual patients.

SleepCognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome.

Wassif, W S, Sherman, D, Salisbury, J R et al.·Annals of clinical biochemistry·1994

Researchers tested muscle function and examined muscle samples from people with ME/CFS and people with chronic alcohol problems to see if their muscle problems were similar or different. They found that while some people initially thought to have ME/CFS actually had other conditions (like a rare enzyme deficiency or inflammation), the muscle changes in alcohol misuse were quite distinct and recognizable through muscle biopsies.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Sympathetic overactivity in subjects complaining of unexplained fatigue.

Pagani, M, Lucini, D, Mela, G S et al.·Clinical science (London, England : 1979)·1994

This study examined how the nervous system controls heart rate in people with unexplained fatigue compared to healthy people. Using heart rate recordings, researchers found that fatigue patients showed an imbalance in their autonomic nervous system—specifically, the part that triggers the "fight or flight" response was overactive while the calming part was underactive, even at rest.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCase-Control

Enteroviruses and the chronic fatigue syndrome.

Swanink, C M, Melchers, W J, van der Meer, J W et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

Researchers investigated whether a common virus called enterovirus might be causing ME/CFS by hiding in the body. They tested 76 ME/CFS patients and 76 healthy controls using multiple methods, including blood tests, stool samples, and genetic analysis. The study found no evidence that enterovirus plays a role in ME/CFS—only one patient showed traces of the virus in one test, which disappeared three months later.

E2 ModerateCohortPEM not requiredCross-Sectional

High titers of anti-Epstein-Barr virus DNA polymerase are found in patients with severe fatiguing illness.

Natelson, B H, Ye, N, Moul, D E et al.·Journal of medical virology·1994

This study looked for specific antibodies (proteins the immune system makes) against Epstein-Barr virus (EBV) in people with ME/CFS compared to healthy people. Researchers found that abnormal levels of these antibodies were twice as common in ME/CFS patients, and the effect was even stronger in sicker patients. This suggests these antibodies might help doctors identify which ME/CFS patients have more severe illness.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Fatigue secondary to chronic illness: postpolio syndrome, chronic fatigue syndrome, and multiple sclerosis.

Packer, T L, Sauriol, A, Brouwer, B·Archives of physical medicine and rehabilitation·1994

This study compared fatigue in people with three different chronic illnesses: postpolio syndrome, ME/CFS, and multiple sclerosis. Researchers found that people with all three conditions experienced much higher levels of fatigue than healthy people, and those with ME/CFS and MS also had greater difficulty doing everyday activities. The study highlights how serious and disabling fatigue can be across these different conditions.

E2 ModerateBehavioralPEM not requiredLongitudinal

Longitudinal study of outcome of chronic fatigue syndrome.

Wilson, A, Hickie, I, Lloyd, A et al.·BMJ (Clinical research ed.)·1994

This study followed 103 ME/CFS patients for about 3 years to see who got better and why. Most patients improved somewhat over time, but only a small number felt completely well. The researchers found that how patients thought about their illness and coped with it mattered more for recovery than immune system tests or how old they were when they got sick.

E2 ModerateCohortPEM not requiredCross-Sectional

SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression.

Schwartz, R B, Komaroff, A L, Garada, B M et al.·AJR. American journal of roentgenology·1994

Researchers used a type of brain imaging called SPECT scans to compare brain blood flow patterns in people with ME/CFS, AIDS-related dementia, depression, and healthy people. People with ME/CFS and AIDS dementia showed similar patterns of reduced blood flow in certain brain areas, while people with depression showed different patterns. These findings suggest ME/CFS may involve brain inflammation similar to a chronic viral infection rather than being purely psychological.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Population based study of fatigue and psychological distress.

Pawlikowska, T, Chalder, T, Hirsch, S R et al.·BMJ (Clinical research ed.)·1994

This study surveyed over 15,000 people in England to find out how common fatigue is and what causes it. About 18% reported severe tiredness lasting at least 6 months. The researchers found that fatigue and mood problems (like anxiety or depression) often occur together, and that very few people with severe fatigue actually identified it as ME/CFS.

E2 ModerateCohortPEM not requiredObservational

Concurrent sick building syndrome and chronic fatigue syndrome: epidemic neuromyasthenia revisited.

Chester, A C, Levine, P H·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at three groups of people in different buildings who reported feeling sick, and found that some developed symptoms beyond what's typically expected from poor indoor air quality. While many had the usual complaints like respiratory irritation and headaches from their building environments, others developed more serious symptoms like extreme fatigue and neurological problems that match ME/CFS. The researchers concluded that ME/CFS may often occur alongside or be connected to sick building syndrome.

E2 ModerateCohortPEM not requiredCase-Control

Simultaneous measurement of antibodies to Epstein-Barr virus, human herpesvirus 6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue syndrome: is there evidence of activation of a nonspecific polyclonal immune response?

Manian, F A·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at whether people with ME/CFS have higher levels of antibodies (immune proteins that fight viruses) to multiple different viruses compared to healthy people. Researchers tested blood samples from 20 ME/CFS patients and 20 healthy controls for antibodies to five different viruses. They found that most ME/CFS patients had elevated antibodies to at least one virus, but the pattern didn't suggest a generalized immune overreaction affecting all viruses equally.

Immune System

E2 ModerateCohortPEM not requiredObservational

Sleep disorders in patients with chronic fatigue.

Buchwald, D, Pascualy, R, Bombardier, C et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at sleep problems in 59 people with chronic fatigue, most of whom had ME/CFS. Researchers found that 81% had at least one sleep disorder—most commonly sleep apnea—that might be treatable. Importantly, these sleep problems occurred whether or not people met the full criteria for ME/CFS, suggesting they are a separate issue worth investigating and treating.

Sleep

E2 ModerateCohortPEM not requiredObservational

Low grade pyrexia: is it chronic fatigue syndrome?

Anand, A C, Kumar, R, Rao, M K et al.·The Journal of the Association of Physicians of India·1994

This study followed 87 patients who had a persistent low-grade fever (99-101°F) along with fatigue, muscle pain, and joint pain. Doctors ran many tests looking for infections, autoimmune diseases, or cancer, but found nothing abnormal. Most patients gradually improved over time, with about half becoming symptom-free within three years. The researchers suggest this condition might be related to ME/CFS.

E2 ModerateCohortPEM not requiredCross-Sectional

A comparison of case definitions of chronic fatigue syndrome.

Bates, D W, Buchwald, D, Lee, J et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study tested whether three different sets of diagnostic criteria for ME/CFS identified the same patients. Researchers looked at 805 patients at two clinics and found that about 55-61% met each of the three definitions, though different patients sometimes qualified under different criteria. The study suggests that using broader, more flexible definitions might better capture people with ME/CFS.

Diagnostics

E2 ModeratePEM not requiredRegistry-Resource

An approach to studies of cancer subsequent to clusters of chronic fatigue syndrome: use of data from the Nevada State Cancer Registry.

Levine, P H, Atherton, M, Fears, T et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at whether people in Nevada who developed a CFS-like illness in the mid-1980s had higher rates of cancer, particularly brain tumors and lymphoma, in the years that followed. Researchers checked cancer registry records to see if there was a connection. They found a slight increase in brain tumors but no clear pattern for lymphoma, though they noted the brain tumor trend might reflect a nationwide pattern rather than something specific to CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Neuropsychology and psychology of MCS.

Fiedler, N, Kipen, H, Deluca, J et al.·Toxicology and industrial health·1994

This study looked at whether people with multiple chemical sensitivities (MCS) and chronic fatigue syndrome (CFS) have psychiatric issues or thinking problems. Researchers found that both groups reported more psychiatric diagnoses than healthy people, and both groups tended to report physical symptoms rather than emotional ones. Surprisingly, the study did not find significant cognitive impairment in MCS patients, except for a small difference in visual memory.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredCross-Sectional

Cognitive functioning in chronic fatigue syndrome and depression: a preliminary comparison.

Schmaling, K B, DiClementi, J D, Cullum, C M et al.·Psychosomatic medicine·1994

Researchers tested thinking and memory skills in 16 people with ME/CFS and 23 people with depression using a brief set of mental tests. Both groups performed similarly to each other and scored in the normal range on most tests. Interestingly, people with ME/CFS reported more cognitive problems than their test scores showed, which the researchers suggest might be due to increased attention to physical sensations rather than actual cognitive damage.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Primary juvenile fibromyalgia syndrome and chronic fatigue syndrome in adolescents.

Bell, D S, Bell, K M, Cheney, P R·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1994

This study looked at whether children diagnosed with chronic fatigue syndrome (CFS) also had fibromyalgia, a condition involving widespread muscle pain and tender points. Researchers found that about 30% of children with CFS met the criteria for fibromyalgia, and these children experienced more muscle pain, sleep problems, and neurological symptoms than those without fibromyalgia. The study suggests that CFS and fibromyalgia in children may be closely related or even the same condition.

Pain and SensitizationSleep

E2 ModerateBehavioralPEM not requiredLongitudinal

Chronic fatigue syndrome: a follow up study.

Bonner, D, Ron, M, Chalder, T et al.·Journal of neurology, neurosurgery, and psychiatry·1994

Researchers followed up with 46 ME/CFS patients four years after their initial diagnosis to see how they were doing. Patients who had improved with treatment generally stayed better, while those who didn't benefit from treatment were unlikely to recover on their own. Patients who still had ME/CFS symptoms four years later tended to have had more physical health problems, greater fatigue levels, and a history of mental health conditions when first diagnosed.

Interventions

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[Chronic fatigue syndrome: immune dysfunction, role of pathogens and toxic agents and neurological and cardial changes].

Dimensional assessment of chronic fatigue syndrome.

Use of dynamic tests of muscle function and histomorphometry of quadriceps muscle biopsies in the investigation of patients with chronic alcohol misuse and chronic fatigue syndrome.

Sympathetic overactivity in subjects complaining of unexplained fatigue.

Enteroviruses and the chronic fatigue syndrome.

High titers of anti-Epstein-Barr virus DNA polymerase are found in patients with severe fatiguing illness.

Fatigue secondary to chronic illness: postpolio syndrome, chronic fatigue syndrome, and multiple sclerosis.

Longitudinal study of outcome of chronic fatigue syndrome.

SPECT imaging of the brain: comparison of findings in patients with chronic fatigue syndrome, AIDS dementia complex, and major unipolar depression.

Population based study of fatigue and psychological distress.

Concurrent sick building syndrome and chronic fatigue syndrome: epidemic neuromyasthenia revisited.

Simultaneous measurement of antibodies to Epstein-Barr virus, human herpesvirus 6, herpes simplex virus types 1 and 2, and 14 enteroviruses in chronic fatigue syndrome: is there evidence of activation of a nonspecific polyclonal immune response?

Sleep disorders in patients with chronic fatigue.

Low grade pyrexia: is it chronic fatigue syndrome?

A comparison of case definitions of chronic fatigue syndrome.

An approach to studies of cancer subsequent to clusters of chronic fatigue syndrome: use of data from the Nevada State Cancer Registry.

Neuropsychology and psychology of MCS.

Cognitive functioning in chronic fatigue syndrome and depression: a preliminary comparison.

Primary juvenile fibromyalgia syndrome and chronic fatigue syndrome in adolescents.

Chronic fatigue syndrome: a follow up study.

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