ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2808 studies

2641–2660 of 2,808 studies

E2 ModerateBehavioralPEM not requiredLongitudinal

Chronic fatigue: risk factors for symptom persistence in a 2 1/2-year follow-up study.

Clark, M R, Katon, W, Russo, J et al.·The American journal of medicine·1995

This study followed 78 patients with chronic fatigue for about 2.5 years to understand why some people recover while others continue to struggle. Researchers found that people were more likely to have ongoing symptoms if they had multiple unexplained physical symptoms, a history of depression-like mood disorder, longer-lasting fatigue, less formal education, and were older than 38. Importantly, standard blood tests and immune system measurements did not predict who would improve.

E2 ModerateCohortPEM not requiredCross-Sectional

Silicone breast implant--associated musculoskeletal manifestations.

Cuellar, M L, Gluck, O, Molina, J F et al.·Clinical rheumatology·1995

This study looked at 300 women with silicone breast implants who came to a rheumatology clinic with muscle and joint pain. The researchers found that over 80% of these women had signs of connective tissue disease, and more than half met criteria for fibromyalgia or chronic fatigue syndrome. When some women had their implants removed, over 70% reported improvement in their overall symptoms.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

General practitioners' attitudes to patients with a self diagnosis of myalgic encephalomyelitis.

Scott, S, Deary, I, Pelosi, A J·BMJ (Clinical research ed.)·1995

This study looked at what general practitioners (GPs) think about patients who diagnose themselves with ME/CFS. Researchers surveyed GPs in Scotland to understand their attitudes toward self-diagnosed ME/CFS patients. The findings revealed important gaps between patient experiences and how some doctors view the condition.

Diagnostics

E2 ModerateCohortPEM not requiredCase-Control

Seroepidemiology of chronic fatigue syndrome: a case-control study.

Mawle, A C, Nisenbaum, R, Dobbins, J G et al.·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·1995

Researchers tested people with ME/CFS and healthy control groups for antibodies to many common viruses, including herpesviruses and enteroviruses. They found no differences between the two groups—patients with ME/CFS did not have higher levels of antibodies to any of the viruses tested. This suggests that recent or past infection with these particular viruses is not a distinguishing feature of ME/CFS.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

The impact of catastrophic beliefs on functioning in chronic fatigue syndrome.

Petrie, K, Moss-Morris, R, Weinman, J·Journal of psychosomatic research·1995

This study looked at whether how people think about ME/CFS affects how disabled they become. Researchers asked 282 people with ME/CFS what they thought would happen if they pushed themselves too hard, and sorted their answers into catastrophic (very negative) or non-catastrophic thinking. People who had catastrophic thoughts about pushing themselves were significantly more fatigued and more disabled in work, household tasks, sleep, socializing, and hobbies—even though they had been sick for similar lengths of time as others.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Estimating rates of chronic fatigue syndrome from a community-based sample: a pilot study.

Jason, L A, Taylor, R, Wagner, L et al.·American journal of community psychology·1995

This study looked at how many people in the general community have ME/CFS by calling over 1,000 randomly selected households by telephone. Instead of relying on patients referred by doctors (which may miss people who can't afford care or distrust doctors), the researchers directly asked community members about their symptoms. They found that ME/CFS may be more common than previously thought, affecting about 0.2% of the population.

Diagnostics

E2 ModerateCohortPEM not requiredCross-Sectional

P300 assessment of chronic fatigue syndrome.

Polich, J, Moore, A P, Wiederhold, M D·Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society·1995

This study measured electrical activity in the brains of people with ME/CFS and healthy controls using a simple listening task where they had to identify specific sounds. Researchers found no differences in brain wave patterns (called P300) between the two groups, even though many ME/CFS patients report problems with memory and attention. This suggests that brain electrical activity measured this way may not be a reliable marker for ME/CFS.

Cognitive Impairment

E2 ModerateBehavioralPEM unclearObservational

Exercise responses and psychiatric disorder in chronic fatigue syndrome.

Lane, R J, Burgess, A P, Flint, J et al.·BMJ (Clinical research ed.)·1995

This study looked at how people with ME/CFS respond to exercise and whether they experience psychiatric problems like depression or anxiety. Researchers examined whether exercise responses and psychiatric symptoms are connected in ME/CFS patients. The study helps clarify the relationship between physical symptoms and mental health in this condition.

E2 ModerateCohortPEM not requiredCross-Sectional

Frequency of deviant immunological test values in chronic fatigue syndrome patients.

Natelson, B H, Ellis, S P, Braonáin, P J et al.·Clinical and diagnostic laboratory immunology·1995

Researchers tested 11 different immune system markers in ME/CFS patients and compared them to fatigued people without ME/CFS. They found that three immune tests (protein A binding, Raji cell test, and complement proteins C3 or C4) showed different results between the groups. However, most other immune tests they looked at, including antibody levels and other complement markers, did not reliably distinguish ME/CFS patients from those with other causes of fatigue.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome.

Patnaik, M, Komaroff, A L, Conley, E et al.·The Journal of infectious diseases·1995

Researchers tested whether people with ME/CFS have more signs of a virus called human herpesvirus 6 (HHV-6) compared to healthy people. They found that 77% of ME/CFS patients had antibodies suggesting exposure to or active HHV-6 infection, compared to only 12% of healthy controls. This suggests HHV-6 may be more common in people with ME/CFS, though it's unclear whether the virus causes the illness or is simply more active in these patients.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Quality of life in chronic fatigue syndrome.

Schweitzer, R, Kelly, B, Foran, A et al.·Social science & medicine (1982)·1995

This 1995 study compared 47 people with ME/CFS to 30 healthy controls to understand how the condition affects daily life and well-being. Using surveys and interviews, researchers found that ME/CFS patients experienced significantly worse quality of life, particularly in social activities and relationships. The findings showed that isolation and loss of ability to work or participate in hobbies were major impacts that deserved more clinical attention.

E2 ModerateCohortPEM not requiredCross-Sectional

Comparison of coxsackie B neutralisation and enteroviral PCR in chronic fatigue patients.

Nairn, C, Galbraith, D N, Clements, G B·Journal of medical virology·1995

Researchers tested whether two different methods of detecting enterovirus (a type of virus) could identify it in ME/CFS patients. One method looked for antibodies (immune proteins) the body makes against Coxsackie B virus, while the other used PCR to directly detect viral genetic material. They found that the PCR test was better at distinguishing ME/CFS patients from healthy people, but the antibody test could not tell the two groups apart.

E2 ModerateCohortPEM not requiredLongitudinal

[The Epstein-Barr virus and chronic fatigue syndrome].

Jovanović, J, Cvjetković, D, Brkić, S et al.·Medicinski pregled·1995

This small study looked at whether ME/CFS symptoms develop after people recover from infectious mononucleosis caused by Epstein-Barr virus (EBV). Researchers followed 31 patients who had recovered from mono and found that several developed ongoing fatigue, sore throats, and sleep problems in the months and years after their acute illness. The results suggest a possible connection between EBV infection and ME/CFS symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Sleep disturbances and fatigue in women with fibromyalgia and chronic fatigue syndrome.

Schaefer, K M·Journal of obstetric, gynecologic, and neonatal nursing : JOGNN·1995

This study looked at sleep problems in women with fibromyalgia and chronic fatigue syndrome (CFS). Researchers found that both groups had significant sleep difficulties, and that trouble staying asleep was the most common sleep problem reported. There was a clear link between poor sleep and fatigue—women who slept poorly felt more tired.

Sleep

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue syndrome in the community. Prevalence and associations.

Lawrie, S M, Pelosi, A J·The British journal of psychiatry : the journal of mental science·1995

This study surveyed over 1,000 people in a community to understand how common ME/CFS is and what it's associated with. Researchers found that about 0.56% of people met the criteria for ME/CFS, and they discovered a strong connection between fatigue and psychological distress. However, the authors concluded that ME/CFS should not be dismissed as purely a psychiatric disorder.

E2 ModerateBehavioralPEM not requiredObservational

Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew.

Lutgendorf, S K, Antoni, M H, Ironson, G et al.·Psychosomatic medicine·1995

This study looked at how a major natural disaster (Hurricane Andrew in 1992) affected people with ME/CFS living in Florida. Patients who experienced the most hurricane damage had worse ME/CFS symptoms and greater difficulty with daily activities compared to those in less-affected areas. Interestingly, how stressed people felt about the hurricane and whether they had social support mattered more than the actual damage itself.

E2 ModerateCohortPEM unclearCross-Sectional

Neuropsychological impairments in chronic fatigue syndrome, multiple sclerosis, and depression.

DeLuca, J, Johnson, S K, Beldowicz, D et al.·Journal of neurology, neurosurgery, and psychiatry·1995

This study tested thinking and memory skills in people with ME/CFS, comparing them to people with multiple sclerosis, depression, and healthy individuals. Researchers found that people with ME/CFS had significant trouble processing information quickly, similar to those with depression. The cognitive problems in ME/CFS were not explained by depression or anxiety alone.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

Secchiero, P, Carrigan, D R, Asano, Y et al.·The Journal of infectious diseases·1995

Researchers developed a sensitive test to detect human herpesvirus 6 (HHV-6) DNA in blood. They tested blood samples from children with a specific rash illness, bone marrow transplant patients, HIV-infected patients, people with chronic fatigue syndrome (ME/CFS), and healthy adults. The test found HHV-6 DNA most often in children with the rash illness, less commonly in transplant and HIV patients, rarely in ME/CFS patients, and not at all in healthy people.

E2 ModerateCohortPEM not requiredCase-Control

A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome.

Dunstan, R H, Donohoe, M, Taylor, W et al.·The Medical journal of Australia·1995

Researchers measured levels of chlorinated hydrocarbons—chemicals that persist in the environment and accumulate in the body—in the blood of people with ME/CFS and compared them to healthy controls. People with ME/CFS had significantly higher levels of these chemicals, particularly a pesticide byproduct called HCB, suggesting that long-term exposure to these substances might play a role in developing the illness.

E2 ModerateBehavioralPEM not requiredCross-Sectional

[Epidemiologic study of chronic fatigue in primary care (general practice)].

Mann, A H, Mc Donald, E, Cope, H et al.·L'Encephale·1994

Researchers studied fatigue in patients visiting regular doctors' offices to understand how common it is and what causes it. They found that some patients had long-lasting, disabling fatigue, but these patients were very different from each other in why they thought they were tired. Most of these patients also had depression or other mental health conditions alongside their fatigue.

Diagnostics

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Evidence browser

Chronic fatigue: risk factors for symptom persistence in a 2 1/2-year follow-up study.

Silicone breast implant--associated musculoskeletal manifestations.

General practitioners' attitudes to patients with a self diagnosis of myalgic encephalomyelitis.

Seroepidemiology of chronic fatigue syndrome: a case-control study.

The impact of catastrophic beliefs on functioning in chronic fatigue syndrome.

Estimating rates of chronic fatigue syndrome from a community-based sample: a pilot study.

P300 assessment of chronic fatigue syndrome.

Exercise responses and psychiatric disorder in chronic fatigue syndrome.

Frequency of deviant immunological test values in chronic fatigue syndrome patients.

Prevalence of IgM antibodies to human herpesvirus 6 early antigen (p41/38) in patients with chronic fatigue syndrome.

Quality of life in chronic fatigue syndrome.

Comparison of coxsackie B neutralisation and enteroviral PCR in chronic fatigue patients.

[The Epstein-Barr virus and chronic fatigue syndrome].

Sleep disturbances and fatigue in women with fibromyalgia and chronic fatigue syndrome.

Chronic fatigue syndrome in the community. Prevalence and associations.

Physical symptoms of chronic fatigue syndrome are exacerbated by the stress of Hurricane Andrew.

Neuropsychological impairments in chronic fatigue syndrome, multiple sclerosis, and depression.

Detection of human herpesvirus 6 in plasma of children with primary infection and immunosuppressed patients by polymerase chain reaction.

A preliminary investigation of chlorinated hydrocarbons and chronic fatigue syndrome.

[Epidemiologic study of chronic fatigue in primary care (general practice)].

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