ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2782 studies

281–300 of 2,782 studies

E2 ModerateCohortPEM unclearCross-Sectional

Longitudinal Progression of Patients with Long COVID Treated in a Post-COVID Clinic: A Cross-Sectional Survey.

Hurt, Ryan T, Yadav, Siddhant, Schroeder, Darrell R et al.·Journal of primary care & community health·2024

This study surveyed over 500 Long COVID patients who received care at a specialized clinic about 2 years after their initial infection. While most patients reported that their symptoms improved compared to their first visit, only 4.5% felt they had fully recovered. Some treatments like low-dose naltrexone, vagal nerve stimulation, and fisetin were rated as helpful by a majority of patients who tried them.

Interventions

E2 ModerateCohortPEM unclearCross-Sectional

The Cardiac Output-Cerebral Blood Flow Relationship Is Abnormal in Most Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with a Normal Heart Rate and Blood Pressure Response During a Tilt Test.

van Campen, C Linda M C, Verheugt, Freek W A, Rowe, Peter C et al.·Healthcare (Basel, Switzerland)·2024

This study looked at how blood flow to the brain changes when ME/CFS patients stand up or tilt on a table. Researchers found that in 91% of patients, the heart wasn't pumping enough blood and the brain wasn't getting enough blood flow—and these two problems were directly connected. This suggests that blood vessels in the brain may not be working properly to compensate when blood flow drops, which could explain why many ME/CFS patients feel dizzy or faint when standing.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Development and Validation of the Short Form (JAEN-10) of the Joint Assessment of Equilibrium and Neuromotor Status Scale (JAEN-20).

Peinado-Rubia, Ana Belén, Osuna-Pérez, María Catalina, Núñez-Fuentes, David et al.·Journal of functional morphology and kinesiology·2024

Researchers created a shorter version of a balance and movement test (JAEN-10) to measure physical problems in people with fibromyalgia. The new 10-question test works just as well as the original 20-question version but takes less time to complete, which is helpful for people who get tired easily. The test successfully identified people with fibromyalgia and those at risk of falling.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Sex and disease severity-based analysis of steroid hormones in ME/CFS.

Pipper, Cornelia, Bliem, Linda, León, Luis E et al.·Journal of endocrinological investigation·2024

Researchers measured hormone levels in the blood of ME/CFS patients and compared them to healthy people. They found that certain hormones—including cortisol-related compounds and progesterone—were different in people with ME/CFS, and the differences varied depending on whether patients had mild/moderate or severe disease and their sex. These hormone patterns might help doctors better identify and categorize ME/CFS in the future.

Biomarkers

E2 ModerateCohortPEM required

Identifying the mental health burden in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients in Switzerland: A pilot study.

König, Rahel Susanne, Paris, Daniel Henry, Sollberger, Marc et al.·Heliyon·2024

This Swiss study surveyed 169 ME/CFS patients to understand how the disease affects their mental health and well-being. The researchers found that most patients experience significant emotional challenges, including sadness, hopelessness, and concerning rates of suicidal thoughts, often because others don't believe or understand their illness. The study shows that ME/CFS creates serious mental health burdens beyond just physical symptoms, and patients urgently need better medical, psychological, and social support.

E2 ModerateCohortPEM unclearCross-Sectional

Association of physical symptoms with accelerometer-measured movement behaviors and functional capacity in individuals with Long COVID.

Rosa-Souza, Francisco José, Freire, Yuri Alberto, Galliano, Leony Morgana et al.·Scientific reports·2024

This study looked at 102 people with Long COVID to understand how specific symptoms affect their ability to move and be physically active. Researchers used activity trackers to measure daily movement and tested how far people could walk and how quickly they could stand up from a chair. They found that fatigue and post-exertional malaise (feeling worse after activity) were linked to lower daily step counts, while shortness of breath was linked to poorer performance on physical tests.

Post-Exertional Malaise

E2 ModeratePEM unclearRegistry-Resource

Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS).

Mundorf, Anna Katharina, Semmler, Amelie, Heidecke, Harald et al.·Vaccines·2024

This study looked at 191 people who developed long-term illness after receiving a COVID-19 vaccine, a rare condition affecting about 2 in 10,000 vaccinated people. The most common symptoms were extreme tiredness and overall malaise (affecting over 80%), along with problems like nerve pain, heart issues, and cognitive difficulties. The researchers found that many of these patients meet the criteria for ME/CFS, though some appear to have a different condition entirely.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Stroop task and practice effects demonstrate cognitive dysfunction in long COVID and myalgic encephalomyelitis / chronic fatigue syndrome.

Baraniuk, James N, Thapaliya, Kiran, Inderyas, Maira et al.·Scientific reports·2024

This study tested how quickly people with Long COVID and ME/CFS could complete a simple task involving reading color words displayed in different colored inks. Both patient groups were noticeably slower at this task than healthy people, and unlike healthy people, they didn't get faster with practice. This suggests that ME/CFS and Long COVID may involve a problem with how different parts of the brain communicate during problem-solving.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study.

Domingo, Joan Carles, Battistini, Federica, Cordobilla, Begoña et al.·Journal of translational medicine·2024

This study compared blood markers and body responses between people with ME/CFS, people with long COVID, and healthy controls. Researchers found that people with ME/CFS had distinct patterns of inflammation and blood vessel dysfunction compared to long COVID patients, suggesting these are different conditions with different underlying problems. By measuring specific proteins in the blood and testing how the body responds to positional changes, researchers could tell the two patient groups apart.

BiomarkersImmune System

E2 ModerateCohortPEM unclearCross-Sectional

How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service.

Bodey, Rochelle, Grimaldi, Jennifer, Tait, Hannah et al.·Journal of clinical medicine·2024

This study followed people who had received specialist care for long COVID and were then discharged from the service. Nearly 3 years after their initial COVID infection, most patients (90%) still had long COVID symptoms and hadn't returned to their normal health. About 4 in 10 of these patients also met the criteria for ME/CFS, suggesting long COVID can develop into a lasting condition similar to ME/CFS.

E2 ModerateCohortPEM unclearLongitudinal

Muscle abnormalities worsen after post-exertional malaise in long COVID.

Appelman, Brent, Charlton, Braeden T, Goulding, Richie P et al.·Nature communications·2024

This study looked at muscle tissue changes in long COVID patients, particularly focusing on post-exertional malaise (PEM)—the worsening of fatigue and pain after activity. Researchers found that muscles in long COVID patients showed structural damage, metabolic problems, and unusual deposits that got worse after activity triggered PEM. These findings help explain why exertion makes symptoms worse in some long COVID patients.

Energy MetabolismPost-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID.

Polizzi, Jessica, Tosto-Mancuso, Jenna, Tabacof, Laura et al.·Frontiers in rehabilitation sciences·2024

This study looked at whether slow, controlled breathing (called resonant breathing) could help people with Long COVID feel better. Ninety-nine people with Long COVID tried a resonant breathing program and reported their symptoms before and after. Most people said they felt better overall, especially in areas like stress control, focus, breathing ability, and sleep quality.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

The economic burden of long COVID in Australia: more noise than signal?

Angeles, Mary Rose, Dinh, Thi Thu Ngan, Zhao, Ting et al.·The Medical journal of Australia·2024

This Australian study looked at how many people have long COVID and how much it costs the economy. Researchers estimated that between 40,000 and 145,000 Australians were severely affected by long COVID in late 2022, costing the economy between $1.7 and $6.3 billion. The study found that tens of thousands of working-age Australians reported being unable to work due to long-term sickness, though Australia doesn't yet have good tracking systems to measure long COVID's true impact.

E2 ModerateCohortPEM requiredObservational

A Single-Center Pilot Study of Therapeutic Apheresis in Patients with Severe Post-COVID Syndrome.

Korth, Johannes, Steenblock, Charlotte, Walther, Romy et al.·Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2024

This small study looked at whether a blood-filtering treatment called apheresis could help 20 people with long COVID symptoms similar to ME/CFS. The researchers found that the treatment reduced harmful antibodies in patients' blood and many patients reported feeling better, with less fatigue, muscle pain, and post-exertional malaise. While these results are promising, the study was small and didn't use a control group, so we need larger tests to confirm whether the treatment truly works.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative data.

Bello-Chavolla, Omar Yaxmehen, Fermín-Martínez, Carlos A, Ramírez-García, Daniel et al.·Lancet regional health. Americas·2024

This study looked at how many adults in Mexico experienced long-lasting symptoms after COVID-19 infection in 2022. Researchers found that about 1 in 5 people who had COVID-19 reported ongoing problems like fatigue, muscle pain, brain fog, and loss of taste or smell. The study showed that people who caught COVID-19 multiple times, had depression, or lived in poorer areas were more likely to develop these long-term symptoms, while vaccination and infection with newer variants reduced risk.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Cognitive reserve as a protective factor against cognitive impairment in chronic fatigue syndrome.

Surendran, Gopika, Jose, Tony P·Applied neuropsychology. Adult·2024

This study examined whether people's life experiences and education—called 'cognitive reserve'—help protect them from the thinking and memory problems common in ME/CFS. Researchers tested 91 people with ME/CFS and found that those with more cognitive reserve had fewer cognitive problems. The severity of someone's ME/CFS was the main factor affecting both cognitive reserve and cognitive problems, rather than age or gender.

Cognitive Impairment

E2 ModerateCohortPEM requiredCross-Sectional

Heterogeneity in Measures of Illness among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Explained by Clinical Practice: A Study in Seven U.S. Specialty Clinics.

Unger, Elizabeth R, Lin, Jin-Mann S, Chen, Yang et al.·Journal of clinical medicine·2024

Researchers studied 465 ME/CFS patients across seven specialized clinics in the United States to see if doctors diagnosed and recognized the same disease. They found that while the clinics had similar patients, there was tremendous variation in how sick individual patients were—some had mild symptoms while others were severely affected. This suggests that ME/CFS may naturally come in many different forms, and understanding these differences could help improve research and treatment.

Post-Exertional Malaise

E2 ModerateBehavioralPEM not requiredCross-Sectional

[The Significance of Chronic Fatigue in the Post-Covid Consultation and its Consequences for Outpatient Rehabilitation in the Context of Statutory Accident Insurance].

Dalichau, Stefan, Kordy, Henrike, Klüver, Janna et al.·Psychotherapie, Psychosomatik, medizinische Psychologie·2024

This study looked at 454 people (mostly women aged 40–60) who developed long-term fatigue after COVID-19. Nearly all of them reported severe tiredness, and over 73% also experienced brain fog. The fatigue lasted about 14–15 months on average and significantly affected their ability to work and enjoy daily life. The researchers recommend that treatment should focus on managing chronic fatigue similar to ME/CFS, using education and practical coping strategies rather than trying to 'cure' the condition.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's disease and chronic fatigue syndrome.

Bourgonje, Arno R, Hörstke, Nicolai V, Fehringer, Michaela et al.·Microbiome·2024

This study looked at immune responses in ME/CFS and Crohn's disease patients by measuring antibodies against proteins from gut bacteria called flagellins. Researchers found that both patient groups had elevated antibodies against these bacterial proteins, but the pattern of where these antibodies attached differed between the two diseases. These antibody patterns could potentially help doctors diagnose ME/CFS and understand how the immune system may be responding abnormally to gut bacteria.

Gut MicrobiomeImmune System

E2 ModerateCohortPEM not requiredObservational

Naturally acquired adaptive immunity to Streptococcus pneumoniae is impaired in rheumatoid arthritis patients.

Ercoli, Giuseppe, Selway-Clarke, Hugh, Truijen, Dena et al.·Clinical & translational immunology·2024

This study compared how well people with rheumatoid arthritis (RA) and ME/CFS patients can fight off a common bacterial infection called Streptococcus pneumoniae. Researchers found that RA patients had weaker immune responses to this bacteria compared to ME/CFS patients, which may explain why RA patients get pneumonia more often. The study also looked at how a common RA treatment (rituximab, which depletes B cells) affected these immune responses.

Immune System

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Evidence Atlas

Evidence browser

Longitudinal Progression of Patients with Long COVID Treated in a Post-COVID Clinic: A Cross-Sectional Survey.

The Cardiac Output-Cerebral Blood Flow Relationship Is Abnormal in Most Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients with a Normal Heart Rate and Blood Pressure Response During a Tilt Test.

Development and Validation of the Short Form (JAEN-10) of the Joint Assessment of Equilibrium and Neuromotor Status Scale (JAEN-20).

Sex and disease severity-based analysis of steroid hormones in ME/CFS.

Identifying the mental health burden in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) patients in Switzerland: A pilot study.

Association of physical symptoms with accelerometer-measured movement behaviors and functional capacity in individuals with Long COVID.

Clinical and Diagnostic Features of Post-Acute COVID-19 Vaccination Syndrome (PACVS).

Stroop task and practice effects demonstrate cognitive dysfunction in long COVID and myalgic encephalomyelitis / chronic fatigue syndrome.

Association of circulating biomarkers with illness severity measures differentiates myalgic encephalomyelitis/chronic fatigue syndrome and post-COVID-19 condition: a prospective pilot cohort study.

How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service.

Muscle abnormalities worsen after post-exertional malaise in long COVID.

Resonant breathing improves self-reported symptoms and wellbeing in people with Long COVID.

The economic burden of long COVID in Australia: more noise than signal?

A Single-Center Pilot Study of Therapeutic Apheresis in Patients with Severe Post-COVID Syndrome.

Prevalence and determinants of post-acute sequelae after SARS-CoV-2 infection (Long COVID) among adults in Mexico during 2022: a retrospective analysis of nationally representative data.

Cognitive reserve as a protective factor against cognitive impairment in chronic fatigue syndrome.

Heterogeneity in Measures of Illness among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Explained by Clinical Practice: A Study in Seven U.S. Specialty Clinics.

[The Significance of Chronic Fatigue in the Post-Covid Consultation and its Consequences for Outpatient Rehabilitation in the Context of Statutory Accident Insurance].

Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn's disease and chronic fatigue syndrome.

Naturally acquired adaptive immunity to Streptococcus pneumoniae is impaired in rheumatoid arthritis patients.

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Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research