ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

281–300 of 2,807 studies

E2 ModerateCohortPEM unclearObservational

Low-dose Naltrexone Improves post-COVID-19 condition Symptoms.

Tamariz, Leonardo, Bast, Elizabeth, Klimas, Nancy et al.·Clinical therapeutics·2024

This study looked at whether treatments used for ME/CFS could help people with long COVID. Researchers reviewed records from 108 patients who tried different treatments including low-dose naltrexone, amitriptyline, duloxetine, and physical therapy. They found that patients taking low-dose naltrexone were about 5 times more likely to improve compared to those doing physical therapy alone, with improvements in both fatigue and pain.

Pain and SensitizationCognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Association of physical symptoms with accelerometer-measured movement behaviors and functional capacity in individuals with Long COVID.

Rosa-Souza, Francisco José, Freire, Yuri Alberto, Galliano, Leony Morgana et al.·Scientific reports·2024

This study looked at 102 people with Long COVID to understand how specific symptoms affect their ability to move and be physically active. Researchers used activity trackers to measure daily movement and tested how far people could walk and how quickly they could stand up from a chair. They found that fatigue and post-exertional malaise (feeling worse after activity) were linked to lower daily step counts, while shortness of breath was linked to poorer performance on physical tests.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Comparison of the symptom networks of long-COVID and chronic fatigue syndrome: From modularity to connectionism.

Hyland, Michael E, Antonacci, Yuri, Bacon, Alison M·Scandinavian journal of psychology·2024

This study compared how symptoms are connected to each other in long-COVID and ME/CFS patients, along with people who have other conditions like fibromyalgia and IBS. Researchers found that while long-COVID and ME/CFS are related conditions, their symptoms connect differently—ME/CFS symptoms form more separate clusters, whereas long-COVID symptoms are more tightly linked together. The study suggests that these conditions may work through a network-like system in the body rather than a single broken mechanism.

E2 ModerateCohortPEM unclearCross-Sectional

Psychometric evaluation of the DePaul Symptom Questionnaire-Short Form (DSQ-SF) among adults with Long COVID, ME/CFS, and healthy controls: A machine learning approach.

McGarrigle, William J, Furst, Jacob, Jason, Leonard A·Journal of health psychology·2024

Researchers tested whether a symptom questionnaire called the DSQ-SF can accurately identify and distinguish between Long COVID, ME/CFS, and healthy people. Using computer algorithms to analyze the results, they found the questionnaire works well at telling these groups apart and identified which specific symptoms are most helpful for telling Long COVID and ME/CFS apart from each other and from normal health.

Diagnostics

E2 ModerateCohortPEM unclearObservational

Management of severe ME/CFS in children and young people in the UK: a British Paediatric Surveillance Unit study.

Royston, Alexander Peter, Burge, Sarah, Idini, Ilaria et al.·BMJ paediatrics open·2024

This UK study looked at how children and young people with severe ME/CFS are diagnosed and treated. Researchers found that many young people with suspected severe ME/CFS were not getting complete medical investigations to rule out other conditions, and most were not being referred to specialist services. The care these young people received varied greatly, and some didn't receive any help at all.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Connecting the dots: Network structures of internalizing and functional symptoms in a population-based cohort.

Saini, Urvi, Rosmalen, Judith G M, Oldehinkel, Albertine J et al.·Journal of psychosomatic research·2024

This study looked at how symptoms of depression, anxiety, ME/CFS, fibromyalgia, and irritable bowel syndrome are connected in over 70,000 people. Researchers found that these conditions tend to cluster separately, but are linked together through specific 'bridge' symptoms like fatigue, difficulty concentrating, and sleep problems. This helps explain why people often experience multiple conditions at the same time.

Cognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

[What Medical Specialties do ME/CFS Sufferers Consult? A Public Health Study on the need for Better Medical Education and Training].

Habermann-Horstmeier, Lotte, Horstmeier, Lukas Maximilian·Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2024

This German study surveyed 674 ME/CFS patients to understand how they navigate the healthcare system and how long diagnosis takes. Patients saw an average of 6-15 different doctors from various specialties before getting diagnosed, with the diagnostic journey taking up to 10 years for most people. The study found that doctors often refer patients around based on individual symptoms rather than recognizing ME/CFS as a whole condition, highlighting the urgent need for better training about ME/CFS across all medical fields.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank.

Huang, Katherine, G C de Sá, Alex, Thomas, Natalie et al.·Communications medicine·2024

Researchers studied blood samples from nearly 1,200 people with ME/CFS and compared them to people with other common conditions like depression, asthma, and thyroid problems. They found nine specific markers in the blood that, combined with basic health information, could identify ME/CFS patients about 70% of the time. This blood test approach could eventually help doctors diagnose ME/CFS more easily, since there is currently no definitive test for the condition.

Biomarkers

E2 ModerateCohortPEM not requiredCross-Sectional

Functional and Morphological Differences of Muscle Mitochondria in Chronic Fatigue Syndrome and Post-COVID Syndrome.

Bizjak, Daniel Alexander, Ohmayer, Birgit, Buhl, Jasmine Leonike et al.·International journal of molecular sciences·2024

This study examined the energy-producing structures (mitochondria) inside muscle cells of people with ME/CFS and long COVID, comparing them to healthy people. Researchers found that mitochondria in both conditions work less efficiently and have structural damage, but the patterns differ: long COVID shows more damage to a specific energy-producing pathway, while ME/CFS shows more overall structural wear and tear in the mitochondria themselves.

Energy Metabolism

E2 ModerateBehavioralPEM not requiredCross-Sectional

Factors associated with having previously received a diagnosis of fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome: A cross sectional DanFunD study.

Tattan, Mais, Ørnbøl, Eva, Wellnitz, Kaare Bro et al.·Journal of psychosomatic research·2024

This study looked at 1,704 people with symptoms of functional somatic disorders (including ME/CFS, fibromyalgia, and irritable bowel syndrome) to understand who had received a diagnosis from a doctor. The researchers found that people—especially women—who had poor quality of life and negative beliefs about their illness were more likely to have received an official diagnosis. The study suggests that factors beyond just having symptoms affect whether people get diagnosed with these conditions.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome.

Saito, Suguru, Shahbaz, Shima, Osman, Mohammed et al.·Journal of autoimmunity·2024

This study compared blood samples from long COVID patients with ME/CFS to those who fully recovered from COVID-19. Researchers found that ME/CFS patients had unusual patterns in their immune cells and higher levels of inflammation-promoting substances in their blood. They also discovered specific immune markers that could reliably distinguish ME/CFS patients from those who recovered, suggesting these markers could potentially be used for diagnosis.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Insomnia and sleep characteristics in post COVID-19 fatigue: A cross-sectional case-controlled study.

Rauwerda, Nynke L, Kuut, Tanja A, Braamse, Annemarie M J et al.·Journal of psychosomatic research·2024

This study looked at sleep problems in people with long COVID fatigue and compared them to people with ME/CFS. Researchers found that 64% of long COVID patients had clinically significant insomnia, and their sleep problems were closely linked to depression and age. While long COVID patients slept slightly less than ME/CFS patients on average, both groups struggled significantly with sleep quality and nighttime insomnia.

Sleep

E2 ModerateBehavioralPEM not requiredLongitudinal

Longitudinal Course of Physical and Psychosocial Impairment in Patients With Borderline Personality Disorder and Personality-Disordered Comparison Subjects: Description and Prediction.

Glass, Isabel V, Frankenburg, Frances R, Fitzmaurice, Garrett M et al.·Journal of personality disorders·2024

This study followed 282 people with borderline personality disorder (BPD) and other personality disorders for 8 years to see how their physical and mental health changed over time. People with BPD reported significantly more physical and emotional difficulties than the comparison group, and those who didn't recover had worse outcomes. The study found that certain conditions—like chronic fatigue syndrome, osteoarthritis, obesity, depression, and PTSD—were strongly linked to physical health problems in BPD patients.

E2 ModerateCohortPEM unclearCross-Sectional

How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service.

Bodey, Rochelle, Grimaldi, Jennifer, Tait, Hannah et al.·Journal of clinical medicine·2024

This study followed people who had received specialist care for long COVID and were then discharged from the service. Nearly 3 years after their initial COVID infection, most patients (90%) still had long COVID symptoms and hadn't returned to their normal health. About 4 in 10 of these patients also met the criteria for ME/CFS, suggesting long COVID can develop into a lasting condition similar to ME/CFS.

E2 ModeratePEM unclearRegistry-Resource

Longterm course of neuropsychological symptoms and ME/CFS after SARS-CoV-2-infection: a prospective registry study.

Reuken, P A, Besteher, B, Finke, K et al.·European archives of psychiatry and clinical neuroscience·2024

This study followed over 1,000 people who had long-lasting symptoms after COVID-19 infection. Researchers found that about 31% of patients met the diagnostic criteria for ME/CFS at their first visit, but this dropped to 19% at a second visit months later. While patients reported feeling less fatigued and having fewer concentration problems over time, many continued to experience long-lasting symptoms that significantly affected their daily lives.

Cognitive ImpairmentLong COVID Overlap

E2 ModerateCohortPEM unclearObservational

The economic burden of long COVID in Australia: more noise than signal?

Angeles, Mary Rose, Dinh, Thi Thu Ngan, Zhao, Ting et al.·The Medical journal of Australia·2024

This Australian study looked at how many people have long COVID and how much it costs the economy. Researchers estimated that between 40,000 and 145,000 Australians were severely affected by long COVID in late 2022, costing the economy between $1.7 and $6.3 billion. The study found that tens of thousands of working-age Australians reported being unable to work due to long-term sickness, though Australia doesn't yet have good tracking systems to measure long COVID's true impact.

E2 ModerateCohortPEM requiredCross-Sectional

A pilot cross-sectional investigation of symptom clusters and associations with patient-reported outcomes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post COVID-19 Condition.

Weigel, Breanna, Eaton-Fitch, Natalie, Thapaliya, Kiran et al.·Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation·2024

This study compared people with ME/CFS and people with Long COVID to understand how their symptoms affect quality of life and daily functioning. Researchers found that both groups experience similar symptom patterns, particularly autonomic symptoms like breathing problems, which have the biggest impact on wellbeing. The findings suggest that Long COVID and ME/CFS may be closely related conditions, and that some people recovering from COVID-19 may develop ME/CFS-like illness over time.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredCross-Sectional

Heterogeneity in Measures of Illness among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Explained by Clinical Practice: A Study in Seven U.S. Specialty Clinics.

Unger, Elizabeth R, Lin, Jin-Mann S, Chen, Yang et al.·Journal of clinical medicine·2024

Researchers studied 465 ME/CFS patients across seven specialized clinics in the United States to see if doctors diagnosed and recognized the same disease. They found that while the clinics had similar patients, there was tremendous variation in how sick individual patients were—some had mild symptoms while others were severely affected. This suggests that ME/CFS may naturally come in many different forms, and understanding these differences could help improve research and treatment.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome.

Saito, Suguru, Shahbaz, Shima, Luo, Xian et al.·Frontiers in immunology·2024

This study looked at blood samples from people with long COVID who have ME/CFS-like symptoms and compared them to people who recovered from COVID, people with acute COVID, and people who never had COVID. Researchers found that long COVID patients had unusual chemical patterns in their blood, higher levels of inflammation-promoting substances, and lower energy molecules (ATP). They also discovered that two specific chemicals (sarcosine and serine) were reduced in long COVID patients and connected to depression, anxiety, and brain fog.

Energy MetabolismImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Comorbidity and sex differences in functional disorders and internalizing disorders.

Thomas, Nathaniel S, Gillespie, Nathan A, Kendler, Kenneth S et al.·General hospital psychiatry·2024

This study looked at how often ME/CFS, fibromyalgia, and irritable bowel syndrome occur together with depression and anxiety in over 107,000 people. The researchers found that people with one of these conditions are much more likely to also have depression or anxiety than would be expected by chance. Interestingly, these connections were even stronger in men than in women.

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Low-dose Naltrexone Improves post-COVID-19 condition Symptoms.

Association of physical symptoms with accelerometer-measured movement behaviors and functional capacity in individuals with Long COVID.

Comparison of the symptom networks of long-COVID and chronic fatigue syndrome: From modularity to connectionism.

Psychometric evaluation of the DePaul Symptom Questionnaire-Short Form (DSQ-SF) among adults with Long COVID, ME/CFS, and healthy controls: A machine learning approach.

Management of severe ME/CFS in children and young people in the UK: a British Paediatric Surveillance Unit study.

Connecting the dots: Network structures of internalizing and functional symptoms in a population-based cohort.

[What Medical Specialties do ME/CFS Sufferers Consult? A Public Health Study on the need for Better Medical Education and Training].

Discriminating Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and comorbid conditions using metabolomics in UK Biobank.

Functional and Morphological Differences of Muscle Mitochondria in Chronic Fatigue Syndrome and Post-COVID Syndrome.

Factors associated with having previously received a diagnosis of fibromyalgia, chronic fatigue syndrome and irritable bowel syndrome: A cross sectional DanFunD study.

Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome.

Insomnia and sleep characteristics in post COVID-19 fatigue: A cross-sectional case-controlled study.

Longitudinal Course of Physical and Psychosocial Impairment in Patients With Borderline Personality Disorder and Personality-Disordered Comparison Subjects: Description and Prediction.

How Long Is Long COVID? Evaluation of Long-Term Health Status in Individuals Discharged from a Specialist Community Long COVID Service.

Longterm course of neuropsychological symptoms and ME/CFS after SARS-CoV-2-infection: a prospective registry study.

The economic burden of long COVID in Australia: more noise than signal?

A pilot cross-sectional investigation of symptom clusters and associations with patient-reported outcomes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post COVID-19 Condition.

Heterogeneity in Measures of Illness among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Is Not Explained by Clinical Practice: A Study in Seven U.S. Specialty Clinics.

Metabolomic and immune alterations in long COVID patients with chronic fatigue syndrome.

Comorbidity and sex differences in functional disorders and internalizing disorders.

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