ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2782 studies

601–620 of 2,782 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany.

Sorg, Anna-Lisa, Becht, Selina, Jank, Marietta et al.·JAMA network open·2022

This study looked at whether children and teenagers who had been infected with the virus that causes COVID-19 were more likely to develop ME/CFS symptoms like severe fatigue and muscle pain. Researchers tested 634 young people in Germany and found that those who had been infected with COVID-19 showed only slightly higher rates of ME/CFS symptoms compared to those who hadn't been infected. The increase was small enough that other factors—like stress from lockdowns—might explain the symptoms just as well.

E2 ModerateCohortPEM not requiredCross-Sectional

Pathway Phenotypes Underpinning Depression, Anxiety, and Chronic Fatigue Symptoms Due to Acute Rheumatoid Arthritis: A Precision Nomothetic Psychiatry Analysis.

Smesam, Hasan Najah, Qazmooz, Hasan Abbas, Khayoon, Sinan Qayes et al.·Journal of personalized medicine·2022

This study looked at 118 people with rheumatoid arthritis (RA, an autoimmune disease affecting joints) and 50 healthy people to understand why RA patients often experience depression, anxiety, and fatigue. Researchers measured immune system markers and psychological symptoms, finding that about 70% of these mental and fatigue symptoms could be explained by the same immune system problems that cause RA itself.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Exposure-response relationship between K. brevis blooms and reporting of upper respiratory and neurotoxin-associated symptoms.

Abdullah, L, Ferguson, S, Niedospial, D et al.·Harmful algae·2022

Researchers studied whether harmful algal blooms caused by Karenia brevis (a type of seaweed) in Florida's Gulf waters trigger respiratory symptoms, headaches, and nerve-related illness symptoms in people living nearby. They surveyed 258 residents in five coastal counties and found a clear link: when blooms were stronger, more people reported these symptoms. People with previous diagnoses of migraines, chronic fatigue syndrome, or memory problems were more likely to report these symptoms during blooms.

E2 ModerateCohortPEM requiredCross-Sectional

ME/CFS and Post-Exertional Malaise among Patients with Long COVID.

Jason, Leonard A, Dorri, Joseph A·Neurology international·2022

Researchers studied 465 people with long-term COVID symptoms to see how many also had ME/CFS (a serious condition causing extreme fatigue and worsening after activity). They found that about 6 in 10 people with long COVID met the medical criteria for ME/CFS. Interestingly, some people thought they had ME/CFS when they didn't, while others had ME/CFS without realizing it—showing that self-diagnosis alone isn't reliable.

Long COVID OverlapPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCase-Control

High prevalence of fatigue in patients with Takayasu arteritis: a case-control study in a Brazilian centre.

Dos Santos, Alexandre Moura, Misse, Rafael Giovani, Borges, Isabela Bruna Pires et al.·Rheumatology advances in practice·2022

This study compared 53 patients with Takayasu arteritis (a rare blood vessel disease) to 100 healthy people and found that fatigue is much more common in patients with this condition. Patients with Takayasu arteritis also had more difficulty doing daily activities and were less physically active than healthy people. The researchers suggest that doctors should specifically treat fatigue as part of caring for these patients.

E2 ModerateCohortPEM unclearCross-Sectional

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Vehof, Jelle, Snieder, Harold, Jansonius, Nomdo et al.·The ocular surface·2021

This large study of nearly 80,000 Dutch adults found that about 9 out of 100 people experience dry eye symptoms. Interestingly, younger adults (ages 20-30) reported dry eye more often than expected. The researchers discovered that dry eye is connected to many different health conditions, including fibromyalgia, chronic fatigue syndrome, depression, and various autoimmune diseases.

E2 ModerateCohortPEM unclearCross-Sectional

Comparison of the finger plethysmography derived stroke volumes by Nexfin CO Trek and suprasternal aortic Doppler derived stroke volume measurements in adults with myalgic encephalomyelitis/chronic fatigue syndrome and in healthy controls.

van Campen, C Linda M C, Verheugt, Freek W A, Rowe, Peter C et al.·Technology and health care : official journal of the European Society for Engineering and Medicine·2021

This study compared two different ways of measuring how much blood the heart pumps with each beat during a tilt table test (where patients lie down then are tilted upright). Researchers tested 154 ME/CFS patients and 39 healthy people using finger cuff measurements and ultrasound of the heart. They found that the finger cuff method gave higher readings than ultrasound, but after adjusting the finger cuff numbers to match ultrasound values, the device became reliable enough to track changes during tilt testing.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

Josev, Elisha K, Cole, Rebecca C, Scheinberg, Adam et al.·Journal of clinical medicine·2021

This study followed Australian teenagers with ME/CFS for about two years after diagnosis to see how they were doing. While many young people improved in mood and some symptoms, fatigue, pain, and overall quality of life stayed significantly worse compared to healthy teenagers. About two-thirds of the teens still had ME/CFS at follow-up, suggesting the condition often persists in the early years after diagnosis.

Pain and Sensitization

E2 ModerateCohortPEM not requiredCross-Sectional

Associations between the gut microbiome and fatigue in cancer patients.

Hajjar, Joud, Mendoza, Tito, Zhang, Liangliang et al.·Scientific reports·2021

Researchers studied 88 cancer patients to see if the bacteria living in their gut were connected to cancer-related fatigue. They found that certain beneficial bacteria (Eubacterium hallii) were linked to lower fatigue levels, while other bacteria (Cosenzaea) were linked to higher fatigue. This suggests that the mix of gut bacteria might play a role in how tired cancer patients feel, opening the door to new treatments.

Gut Microbiome

E2 ModerateCohortPEM not requiredCross-Sectional

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

Mckay, Pamela G, Walker, Helen, Martin, Colin R et al.·BMJ open·2021

This study compared people diagnosed with ME/CFS to people diagnosed with fibromyalgia to see if their symptoms were actually similar. The researchers found that both groups experienced pain, fatigue, sleep problems, and impacts on quality of life in very similar ways, suggesting these conditions may share common symptom patterns. The findings suggest that how these conditions are currently diagnosed and treated might need to be reconsidered since patients experience their symptoms so similarly.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

A Comprehensive Examination of Severely Ill ME/CFS Patients.

Chang, Chia-Jung, Hung, Li-Yuan, Kogelnik, Andreas M et al.·Healthcare (Basel, Switzerland)·2021

This study examined severely ill ME/CFS patients who are mostly housebound or bedbound—a group that hasn't received much research attention. Researchers found that fatigue, pain, and thinking difficulties were the most common complaints, and patients showed distinct sleep problems and hormone imbalances. The study suggests that ME/CFS and long COVID may share similar mechanisms, meaning treatments discovered for one condition could potentially help the other.

Long COVID OverlapPost-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women.

Shafrir, Amy L, Palmor, Marissa C, Fourquet, Jessica et al.·American journal of reproductive immunology (New York, N.Y. : 1989)·2021

This study looked at whether young women and adolescents with endometriosis (a painful condition where tissue grows outside the uterus) are more likely to have immune system problems like allergies, asthma, or chronic fatigue. Researchers compared 551 women with surgically confirmed endometriosis to 652 women without it and found that those with endometriosis were significantly more likely to have chronic fatigue syndrome, fibromyalgia, or a history of mononucleosis. The more immune-related conditions a woman had, the higher her chances of also having endometriosis.

Immune System

E2 ModerateBehavioralPEM not requiredObservational

Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation.

Harenwall, Sari, Heywood-Everett, Suzanne, Henderson, Rebecca et al.·Journal of primary care & community health·2021

Researchers created a 7-week online rehabilitation program for people recovering from long COVID, led by psychologists and a team of other health professionals. The program covered topics like managing fatigue, improving sleep, nutrition, stress management, and activity pacing. Among 76 participants who completed the program and filled out quality-of-life surveys, people reported significant improvements in their ability to move around, care for themselves, do daily activities, and manage pain and mood.

Sleep

E2 ModerateCohortPEM unclearCross-Sectional

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Metselaar, Paula I, Mendoza-Maldonado, Lucero, Li Yim, Andrew Yung Fong et al.·Scientific reports·2021

Researchers found a set of 23 genes in blood cells that could reliably identify people with ME/CFS. By looking at both gene activity and chemical markers on genes, they developed a test that correctly identified ME/CFS patients about 92-97% of the time. This is important because there's currently no reliable blood test to diagnose ME/CFS.

BiomarkersImmune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Sygit-Kowalkowska, Ewa·Psychiatria polska·2021

This study looked at fatigue in psychiatric nurses and found that most experienced moderate to high levels of chronic fatigue. The research suggests that workplace communication problems—like unclear instructions and poor teamwork—may contribute to this fatigue, and that some people's personality traits may make them more resilient to fatigue than others.

E2 ModerateCohortPEM unclearCross-Sectional

Who should we ask about mental health symptoms in adolescents with CFS/ME? Parent-child agreement on the revised children's anxiety and depression scale.

Serafimova, Teona, Loades, Maria, Gaunt, Daisy et al.·Clinical child psychology and psychiatry·2021

This study looked at how well parents and teenagers with ME/CFS agreed when reporting on anxiety and depression symptoms. Researchers compared what 93 teenagers said about their mental health with what their parents said, using a standard questionnaire. Both teenagers and parents were reasonably accurate at spotting mental health problems, though teenagers more often reported reaching diagnostic thresholds. The findings suggest that doctors should listen to both the young person and their parent, since severe fatigue might make it harder for teenagers to fully report their symptoms on their own.

E2 ModerateCohortPEM not requiredLongitudinal

Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue.

Fevang, Børre, Wyller, Vegard Bruun Bratholm, Mollnes, Tom Eirik et al.·Frontiers in immunology·2021

This study tracked 200 teenagers with mononucleosis (caused by Epstein-Barr virus) for 6 months to understand why some developed chronic fatigue. Researchers found that teenagers who developed chronic fatigue showed persistent signs of immune system activation and inflammation, particularly elevated levels of RANTES (a signaling protein) and other inflammatory markers, both at the start of illness and 6 months later.

Immune System

E2 ModeratePEM unclearRegistry-Resource

Prevalence and characteristics of self-reported hypothyroidism and its association with nonorgan-specific manifestations in US sarcoidosis patients: a nationwide registry study.

Alzghoul, Bashar N, Amer, Farah N, Barb, Diana et al.·ERJ open research·2021

This study looked at how common thyroid problems are in sarcoidosis patients and how they relate to other symptoms. Researchers found that about 1 in 7 sarcoidosis patients reported having an underactive thyroid (hypothyroidism), and these patients were more likely to experience fatigue, depression, sleep problems, and difficulty with physical activities. The study suggests that checking for thyroid problems might help doctors better manage sarcoidosis symptoms.

E2 ModerateCohortPEM not requiredCross-Sectional

Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.

Laden, Bethany F, Bresee, Catherine, De Hoedt, Amanda et al.·Urology·2021

This study looked at how often people with bladder pain syndrome (IC/BPS) also have other health conditions, using data from a large group of veterans. Researchers found that people with IC/BPS are much more likely to have multiple overlapping conditions—including chronic fatigue syndrome, fibromyalgia, IBS, and migraines—as well as mental health challenges like depression and trauma. These patterns were especially strong in women.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19.

Simani, Leila, Ramezani, Mahtab, Darazam, Ilad Alavi et al.·Journal of neurovirology·2021

This study looked at whether people who survived COVID-19 developed chronic fatigue syndrome (ME/CFS) or PTSD within 6 months of infection. Among 120 COVID-19 survivors in Iran, about 2.5% met the criteria for ME/CFS and 5.8% showed signs of PTSD. Interestingly, the researchers found that having PTSD was not linked to developing ME/CFS in these patients.

Long COVID Overlap

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Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany.

Pathway Phenotypes Underpinning Depression, Anxiety, and Chronic Fatigue Symptoms Due to Acute Rheumatoid Arthritis: A Precision Nomothetic Psychiatry Analysis.

Exposure-response relationship between K. brevis blooms and reporting of upper respiratory and neurotoxin-associated symptoms.

ME/CFS and Post-Exertional Malaise among Patients with Long COVID.

High prevalence of fatigue in patients with Takayasu arteritis: a case-control study in a Brazilian centre.

Prevalence and risk factors of dry eye in 79,866 participants of the population-based Lifelines cohort study in the Netherlands.

Comparison of the finger plethysmography derived stroke volumes by Nexfin CO Trek and suprasternal aortic Doppler derived stroke volume measurements in adults with myalgic encephalomyelitis/chronic fatigue syndrome and in healthy controls.

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

Associations between the gut microbiome and fatigue in cancer patients.

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

A Comprehensive Examination of Severely Ill ME/CFS Patients.

Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women.

Post-Covid-19 Syndrome: Improvements in Health-Related Quality of Life Following Psychology-Led Interdisciplinary Virtual Rehabilitation.

Recursive ensemble feature selection provides a robust mRNA expression signature for myalgic encephalomyelitis/chronic fatigue syndrome.

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Who should we ask about mental health symptoms in adolescents with CFS/ME? Parent-child agreement on the revised children's anxiety and depression scale.

Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue.

Prevalence and characteristics of self-reported hypothyroidism and its association with nonorgan-specific manifestations in US sarcoidosis patients: a nationwide registry study.

Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome.

Prevalence and correlates of chronic fatigue syndrome and post-traumatic stress disorder after the outbreak of the COVID-19.

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