ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

621–640 of 2,768 studies

E2 ModerateCohortPEM requiredObservational

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Boruch, Alexander E, Lindheimer, Jacob B, Klein-Adams, Jacquelyn C et al.·Life sciences·2021

This study looked at how Gulf War Veterans' bodies responded during exercise and whether those responses could predict post-exertional malaise (PEM)—the worsening of symptoms after physical activity. Veterans with Gulf War Illness had more severe symptom flare-ups after exercising compared to healthy veterans, but the researchers found that common exercise measurements like breathing patterns and muscle pain didn't reliably predict who would experience worse PEM.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Aly, Menna A E G, Saber, Heba G·International journal of clinical practice·2021

This study looked at 115 elderly women in Egypt who had recovered from COVID-19 to see if their lingering symptoms might lead to chronic fatigue syndrome (ME/CFS). Most women reported problems like fatigue, muscle pain, and sleep trouble after COVID, and the study found that stress, sadness, and poor sleep were most strongly linked to developing CFS-like symptoms. Only one person in the study actually met full criteria for probable CFS, but the researchers suggest doctors should watch for these warning signs in long COVID patients.

SleepCognitive Impairment

E2 ModerateCohortPEM unclearCross-Sectional

Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Campen, C Linda M C van, Rowe, Peter C, Visser, Frans C·Medicina (Kaunas, Lithuania)·2021

This study compared people with long-haul COVID-19 to people with ME/CFS to see if they experience similar problems with dizziness and blood flow when standing up. Researchers found that long-haul COVID patients had very similar symptoms to ME/CFS patients and showed even greater reductions in blood flow to the brain during tilt testing. The findings suggest that COVID-19 infection may trigger ME/CFS-like illness in some people.

Autonomic Nervous System

E2 ModerateCohortPEM requiredCross-Sectional

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Freitag, Helma, Szklarski, Marvin, Lorenz, Sebastian et al.·Journal of clinical medicine·2021

This study examined whether certain antibodies in ME/CFS patients' blood relate to how severe their symptoms are. The researchers tested 116 ME/CFS patients for antibodies that target receptors controlling blood vessel function and other vital processes. They found that patients whose ME/CFS started after an infection had stronger connections between these antibodies and key symptoms like fatigue and muscle pain, suggesting these antibodies might play a role in how the disease develops.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredLongitudinal

Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients.

Kujawski, Sławomir, Cossington, Jo, Słomko, Joanna et al.·Journal of clinical medicine·2021

This study tested whether a personalized activity program could help ME/CFS patients feel less tired and function better. Thirty-four patients followed a 16-week program tailored to their individual abilities. After the program, patients reported significant improvements in fatigue, and blood tests showed improvements in mitochondrial markers (Mfn1 and Mfn2)—the energy-producing components of cells. However, about half of the patients found exercise difficult to tolerate.

Autonomic Nervous SystemPost-Exertional Malaise

E2 ModerateCohortPEM requiredCross-Sectional

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

González-Hermosillo, J Antonio, Martínez-López, Jhanea Patricia, Carrillo-Lampón, Sofía Antonieta et al.·Brain sciences·2021

This study followed 130 people recovering from COVID-19 for 6 months to see how many developed symptoms similar to ME/CFS. Nearly half the patients experienced ongoing fatigue, and those with fatigue tended to be older and had spent more time in the hospital. Only 13% of the patients met the strict diagnostic criteria for ME/CFS, suggesting that while some people have overlapping symptoms, post-COVID fatigue and ME/CFS may be distinct conditions.

E2 ModerateCohortPEM requiredCross-Sectional

Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS.

Jäkel, Bianka, Kedor, Claudia, Grabowski, Patricia et al.·Journal of translational medicine·2021

This study tested hand grip strength in ME/CFS patients compared to healthy people and cancer patients to see if it could help diagnose the condition. Researchers found that ME/CFS patients had weaker grip strength and their muscles got tired much faster during repeated squeezing tests. Importantly, their muscles also recovered more slowly after resting for an hour, suggesting that muscle fatigue is a real, measurable feature of ME/CFS.

Post-Exertional Malaise

E2 ModerateCohortPEM requiredCross-Sectional

A preliminary investigation of nutritional intake and supplement use in Australians with myalgic encephalomyelitis/chronic fatigue syndrome and the implications on health-related quality of life.

Weigel, Breanna, Eaton-Fitch, Natalie, Passmore, Rachel et al.·Food & nutrition research·2021

This study looked at what Australian ME/CFS patients eat and what supplements they take, and whether these choices affect their quality of life. Researchers surveyed 24 ME/CFS patients online and compared their diets to the general Australian population. They found that ME/CFS patients use supplements much more often than the general public, but couldn't find a clear link between specific nutrients or supplements and how patients felt.

E2 ModerateCohortPEM not requiredLongitudinal

Patient Reported Outcome Measures of Health-Related Quality of Life and Asthenia after Thyroidectomy.

Luddy, Mary Kate, Vetter, Rachel, Shank, Jessica et al.·The Journal of surgical research·2021

Some patients who have their entire thyroid removed experience lasting tiredness and fatigue after surgery, a condition called asthenia. This study followed 182 patients before and after thyroid surgery to measure their quality of life and fatigue levels over one year. Patients who had their entire thyroid removed were much more likely to develop asthenia (42%) compared to those who had only half removed (4%), especially if they had thyroid cancer.

E2 ModerateCohortPEM unclearObservational

Warning Signals of Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Retrospective Analysis of 197 Patients.

Ghali, Alaa, Lacout, Carole, Ghali, Maria et al.·Journal of clinical medicine·2021

This study looked at whether certain new or unusual symptoms might warn ME/CFS patients that a post-exertional malaise (PEM) flare is coming. Researchers reviewed medical records from 197 ME/CFS patients and found that about 14% experienced mood changes or other new symptoms before their baseline symptoms got worse. Interestingly, these patients had less intense PEM flares than those without warning symptoms, suggesting these early signals might help patients prepare or prevent more severe crashes.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

Josev, Elisha K, Cole, Rebecca C, Scheinberg, Adam et al.·Journal of clinical medicine·2021

This study followed Australian teenagers with ME/CFS for about two years after diagnosis to see how they were doing. While many young people improved in mood and some symptoms, fatigue, pain, and overall quality of life stayed significantly worse compared to healthy teenagers. About two-thirds of the teens still had ME/CFS at follow-up, suggesting the condition often persists in the early years after diagnosis.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Wiedbusch, Elzbieta, Cotler, Joseph, Jason, Leonard A·Journal of preventive medicine & healthcare·2021

This study compared how ME/CFS affects people in the United States and Japan by surveying 124 Japanese patients and 210 U.S. patients. The research found that U.S. patients reported more severe brain fog, stomach problems, and exhaustion after activity compared to Japanese patients. Interestingly, Japanese women experienced similar levels of disability as American patients despite being less likely to receive official disability support.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Van Oosterwijck, Jessica, Marusic, Uros, De Wandele, Inge et al.·Journal of clinical medicine·2021

This study examined how the nervous system controls heart rate and other body functions in ME/CFS patients compared to healthy people, both at rest and after exercise. Researchers found that while ME/CFS patients had normal nerve function at rest, their bodies had difficulty recovering after exercise—specifically, their parasympathetic nervous system (the 'rest and digest' system) didn't reactivate properly. This delayed recovery is concerning because similar patterns in other diseases are linked to worse health outcomes.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy.

Tirelli, Umberto, Franzini, Marianno, Valdenassi, Luigi et al.·Journal of clinical medicine·2021

This study tested whether a treatment called oxygen-ozone autohemotherapy (a procedure where blood is drawn, treated with ozone gas, and returned to the body) could help ME/CFS patients with fatigue. Among 200 patients treated, most experienced significant improvements in their fatigue levels within 30 days, with nearly half reporting the best possible improvement on a fatigue scale. No serious side effects were reported.

E2 ModerateCohortPEM unclearCross-Sectional

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Krumina, Angelika, Vecvagare, Katrine, Svirskis, Simons et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at 65 people with ME/CFS in Latvia to understand their main symptoms and how the condition differs from simple tiredness. Researchers found that people with ME/CFS commonly experience fatigue, muscle pain, joint pain, and sleep problems—more often than people without ME/CFS. When patients had other health conditions alongside ME/CFS, their symptoms tended to be more severe.

Pain and SensitizationSleepDiagnostics

E2 ModerateCohortPEM not requiredObservational

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

Lechner, Johann, Schmidt, Marlene, von Baehr, Volker et al.·Journal of inflammation research·2021

This study examined jawbone abnormalities in 301 patients with various chronic illnesses, including ME/CFS. Researchers found that patients with bone loss in the jawbone had elevated levels of a chemical messenger called RANTES/CCL5, which promotes inflammation. These findings were consistent across all disease groups studied, suggesting that jawbone problems may contribute to systemic inflammation in multiple conditions.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members.

Brittain, Esme, Muirhead, Nina, Finlay, Andrew Y et al.·Medicina (Kaunas, Lithuania)·2021

This study looked at how ME/CFS affects the quality of life of patients and their family members using two surveys. The researchers found that ME/CFS seriously damages patients' quality of life, particularly in physical health, and also significantly impacts the wellbeing of partners and family members who care for them. The study shows that family members experience worry, sadness, and difficulty maintaining normal family activities because of their loved one's illness.

E2 ModerateCohortPEM unclearCross-Sectional

Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Zinn, Mark A, Jason, Leonard A·International journal of psychophysiology : official journal of the International Organization of Psychophysiology·2021

This study looked at how the brain controls the autonomic nervous system (the part that manages heart rate, breathing, and other automatic functions) in people with ME/CFS. Researchers used special brain recordings to measure electrical activity in 34 ME/CFS patients and 34 healthy people at rest, then looked for differences in how different brain regions communicate with each other. They found that people with ME/CFS had different patterns of brain communication, and these differences were connected to specific symptoms like fatigue, thinking problems, and pain.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCross-Sectional

Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.

Domingues, Tiago Dias, Grabowska, Anna D, Lee, Ji-Sook et al.·Frontiers in medicine·2021

This study looked at whether common herpes viruses (like the ones that cause cold sores and chickenpox) are connected to ME/CFS, and whether different groups of patients—based on what triggered their illness—have different patterns of virus exposure. Researchers tested blood samples from ME/CFS patients and healthy people to see if they had antibodies to these viruses. They found some differences between patient groups, but the results were weak and inconsistent depending on how they analyzed the data.

E2 ModerateCohortPEM unclearCross-Sectional

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

Cullinan, John, Pheby, Derek F H, Araja, Diana et al.·Medicina (Kaunas, Lithuania)·2021

ME/CFS experts across Europe were asked what they think family doctors know about ME/CFS and how to help them understand it better. The experts reported serious concerns: about 60% of ME/CFS patients go undiagnosed because family doctors lack knowledge about the condition, don't believe it's real, or don't know how to manage it. Most experts agreed that better training for doctors at all levels would help.

Diagnostics

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Evidence browser

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Long COVID and chronic fatigue syndrome: A survey of elderly female survivors in Egypt.

Orthostatic Symptoms and Reductions in Cerebral Blood Flow in Long-Haul COVID-19 Patients: Similarities with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Relationship between Cardiopulmonary, Mitochondrial and Autonomic Nervous System Function Improvement after an Individualised Activity Programme upon Chronic Fatigue Syndrome Patients.

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

Hand grip strength and fatigability: correlation with clinical parameters and diagnostic suitability in ME/CFS.

A preliminary investigation of nutritional intake and supplement use in Australians with myalgic encephalomyelitis/chronic fatigue syndrome and the implications on health-related quality of life.

Patient Reported Outcome Measures of Health-Related Quality of Life and Asthenia after Thyroidectomy.

Warning Signals of Post-Exertional Malaise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Retrospective Analysis of 197 Patients.

Health, Wellbeing, and Prognosis of Australian Adolescents with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Case-Controlled Follow-Up Study.

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Reduced Parasympathetic Reactivation during Recovery from Exercise in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Greatly Improved Fatigue Symptoms When Treated with Oxygen-Ozone Autohemotherapy.

Clinical Profile and Aspects of Differential Diagnosis in Patients with ME/CFS from Latvia.

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Major Impact on Lives of Both Patients and Family Members.

Cortical autonomic network connectivity predicts symptoms in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).

Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE).

Curated Collections

Neuroinflammation Evidence

Metabolism & Mitochondria

Biomarkers

PEM-Specific Research