ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2768 studies

681–700 of 2,768 studies

E2 ModerateCohortPEM not requiredObservational

Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients.

Tirelli, U, Franzini, M, Valdenassi, L et al.·European review for medical and pharmacological sciences·2021

This study tested whether a treatment called oxygen-ozone autohemotherapy (a procedure where blood is mixed with ozone gas and returned to the body) could help reduce fatigue in 100 people with post-COVID symptoms. On average, the treatment reduced fatigue symptoms by 67%, and about 40% of patients reported nearly complete recovery from fatigue. The benefits appeared similar in men and women.

E2 ModerateCohortPEM requiredCross-Sectional

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

González-Hermosillo, J Antonio, Martínez-López, Jhanea Patricia, Carrillo-Lampón, Sofía Antonieta et al.·Brain sciences·2021

This study followed 130 people recovering from COVID-19 for 6 months to see how many developed symptoms similar to ME/CFS. Nearly half the patients experienced ongoing fatigue, and those with fatigue tended to be older and had spent more time in the hospital. Only 13% of the patients met the strict diagnostic criteria for ME/CFS, suggesting that while some people have overlapping symptoms, post-COVID fatigue and ME/CFS may be distinct conditions.

E2 ModerateCohortPEM unclearObservational

Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea.

Lim, Eun-Jin, Lee, Jin-Seok, Lee, Eun-Jung et al.·Journal of translational medicine·2021

This study looked at medical records from South Korea between 2010 and 2020 to understand how many people have ME/CFS and who gets diagnosed with it. Researchers found that about 45 out of every 100,000 people are newly diagnosed each year, and roughly 58 out of every 100,000 people have the condition overall. The number of diagnoses roughly doubled over the 10-year period, with women being about 1.5 times more likely to be diagnosed than men, and cases increasing with age.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Sygit-Kowalkowska, Ewa·Psychiatria polska·2021

This study looked at fatigue in psychiatric nurses and found that most experienced moderate to high levels of chronic fatigue. The research suggests that workplace communication problems—like unclear instructions and poor teamwork—may contribute to this fatigue, and that some people's personality traits may make them more resilient to fatigue than others.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue.

Murga, Iñigo, Aranburu, Larraitz, Gargiulo, Pascual A et al.·Frontiers in psychiatry·2021

This study examined 84 ME/CFS patients and 22 healthy controls using questionnaires to measure fatigue, pain, sleep quality, heart rate problems, thinking difficulties, mood, and other symptoms. Researchers used statistical clustering to group patients into five distinct subtypes based on their symptom patterns. The findings suggest that ME/CFS is not one-size-fits-all—some patients have high anxiety and depression without fibromyalgia, while others have fibromyalgia combined with heart rate regulation problems, hormone imbalances, or immune issues.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Male vs. Female Differences in Responding to Oxygen-Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Chirumbolo, Salvatore, Valdenassi, Luigi, Franzini, Marianno et al.·Journal of clinical medicine·2021

This study looked at how well a treatment called oxygen-ozone autohemotherapy (O₂-O₃-AHT) worked for ME/CFS fatigue in men versus women. Two hundred patients received this treatment and filled out a fatigue questionnaire before and one month after. The results showed that women experienced more improvement in their fatigue than men did, especially among younger patients aged 14-29.

E2 ModerateCohortPEM unclearCross-Sectional

Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls.

Abou-Donia, Mohamed B, Krengel, Maxine H, Lapadula, Elizabeth S et al.·Brain sciences·2021

Researchers found that Gulf War veterans with Gulf War illness have abnormal immune proteins in their blood that attack brain cells, and these patterns differ between men and women. The study also found that these same immune markers can help distinguish Gulf War illness from other similar conditions like ME/CFS and IBS. This discovery is important because it offers a possible objective blood test that doctors could use to identify and diagnose these difficult-to-recognize illnesses.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredObservational

Evolving phenotypes of non-hospitalized patients that indicate long COVID.

Estiri, Hossein, Strasser, Zachary H, Brat, Gabriel A et al.·BMC medicine·2021

This study looked at medical records from over 96,000 people to identify which health problems are more common in people who had COVID-19 compared to those who didn't. Researchers found that certain symptoms and conditions—including loss of taste and smell, hair loss, chest pain, extreme tiredness, shortness of breath, pneumonia, and new-onset diabetes—appear more frequently in COVID-19 survivors months after infection. Younger people under 65 developed more of these long-term problems than older adults.

Cognitive Impairment

E2 ModerateCohortPEM not requiredCross-Sectional

A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines.

Schubert, Nick M A, Rosmalen, Judith G M, van Dijk, Pim et al.·Hearing research·2021

This study looked at how common tinnitus (ringing in the ears) is in a large group of Dutch adults and found that about one-third experience it at some point. The researchers discovered that tinnitus is linked to various conditions including hearing problems, heart issues, depression, and notably, chronic fatigue syndrome (ME/CFS). Understanding these connections may help doctors better treat tinnitus and related conditions.

E2 ModerateCohortPEM requiredObservational

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Boruch, Alexander E, Lindheimer, Jacob B, Klein-Adams, Jacquelyn C et al.·Life sciences·2021

This study looked at how Gulf War Veterans' bodies responded during exercise and whether those responses could predict post-exertional malaise (PEM)—the worsening of symptoms after physical activity. Veterans with Gulf War Illness had more severe symptom flare-ups after exercising compared to healthy veterans, but the researchers found that common exercise measurements like breathing patterns and muscle pain didn't reliably predict who would experience worse PEM.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredLongitudinal

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period.

Ahn, So-Hyun, Kim, Jeong Lan, Kim, Jang Rae et al.·Journal of psychiatric research·2021

This study followed people who recovered from MERS (a serious respiratory illness) for 2 years to see if chronic fatigue increased their risk of suicidal thoughts. Researchers found that people who had chronic fatigue were about 7.5 times more likely to experience suicidal thoughts than those without fatigue. This connection remained strong even when accounting for other factors that might affect mental health.

E2 ModerateCohortPEM not requiredCross-Sectional

Chronotropic Incompetence in Non-Hospitalized Patients with Post-COVID-19 Syndrome.

Jimeno-Almazán, Amaya, Pallarés, Jesús G, Buendía-Romero, Ángel et al.·Journal of clinical medicine·2021

Some people who recover from COVID-19 experience persistent fatigue and difficulty exercising for months afterward. This study tested 32 people with long-lasting COVID symptoms and found that about 12% had a specific heart problem called chronotropic incompetence—their heart rate doesn't increase normally during exercise. This heart rhythm problem may explain why some patients struggle with exercise intolerance after COVID-19.

Autonomic Nervous System

E2 ModerateCohortPEM not requiredCross-Sectional

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments.

Almulla, Abbas F, Moustafa, Shatha R, Al-Dujaili, Arafat H et al.·Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2021

This study looked at a mineral called cesium in the blood of people with schizophrenia and compared it to healthy people. They found that people with schizophrenia had lower cesium levels, and this was connected to cognitive problems (like memory and thinking difficulties), fatigue symptoms, and signs of immune system activity. The researchers suggest that low cesium might contribute to some of the symptoms seen in schizophrenia.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?

Mantovani, Elisa, Mariotto, Sara, Gabbiani, Daniele et al.·Journal of neurovirology·2021

Some people who recover from COVID-19 continue to experience symptoms that look very similar to ME/CFS, including severe tiredness, pain, and difficulty thinking clearly. This study found that about 27% of COVID-19 survivors had these ME/CFS-like symptoms, and they reported worse sleep, more fatigue, and more difficulty with basic activities compared to those who recovered normally. The researchers measured markers of nerve damage and inflammation to understand what might be causing these symptoms.

Long COVID OverlapPost-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Wiedbusch, Elzbieta, Cotler, Joseph, Jason, Leonard A·Journal of preventive medicine & healthcare·2021

This study compared how ME/CFS affects people in the United States and Japan by surveying 124 Japanese patients and 210 U.S. patients. The research found that U.S. patients reported more severe brain fog, stomach problems, and exhaustion after activity compared to Japanese patients. Interestingly, Japanese women experienced similar levels of disability as American patients despite being less likely to receive official disability support.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology.

Capdevila, Lluis, Castro-Marrero, Jesús, Alegre, José et al.·Sensors (Basel, Switzerland)·2021

Researchers used a smartphone app connected to a heart monitor to measure heart rate variability (how much the time between heartbeats varies) in ME/CFS patients and healthy people. They found that women with ME/CFS showed different heart patterns than healthy women, but men with ME/CFS did not show the same clear difference. This suggests that ME/CFS may affect the heart's nervous system control differently in men versus women.

Biomarkers

E2 ModerateCohortPEM unclearObservational

Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Lutz, Lena, Rohrhofer, Johanna, Zehetmayer, Sonja et al.·Biomolecules·2021

This study looked at blood test results from 262 ME/CFS patients to understand problems with their immune systems. Researchers found that nearly two-thirds of patients had low levels of certain immune proteins or cells, while about one-quarter showed signs of inflammation. These findings suggest that immune system dysfunction is a common feature of ME/CFS and could potentially be used to help diagnose or treat the condition.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredLongitudinal

How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight.

Kuo, Chien-Feng, Shi, Leiyu, Lin, Cheng-Li et al.·Scientific reports·2021

This study looked at whether people who have had peptic ulcers (stomach ulcers often caused by H. pylori bacteria) are at higher risk of developing ME/CFS. Researchers compared hospital records from Taiwan for people with and without peptic ulcers over many years. They found that people with a history of peptic ulcers were about twice as likely to develop ME/CFS, with higher risk in women and older adults.

Immune System

E2 ModerateCohortPEM unclearCross-Sectional

Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.

Domingues, Tiago Dias, Grabowska, Anna D, Lee, Ji-Sook et al.·Frontiers in medicine·2021

This study looked at whether common herpes viruses (like the ones that cause cold sores and chickenpox) are connected to ME/CFS, and whether different groups of patients—based on what triggered their illness—have different patterns of virus exposure. Researchers tested blood samples from ME/CFS patients and healthy people to see if they had antibodies to these viruses. They found some differences between patient groups, but the results were weak and inconsistent depending on how they analyzed the data.

E2 ModerateCohortPEM unclearLongitudinal

Salivary DNA Loads for Human Herpesviruses 6 and 7 Are Correlated With Disease Phenotype in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Lee, Ji-Sook, Lacerda, Eliana M, Nacul, Luis et al.·Frontiers in medicine·2021

This study tested saliva samples from people with ME/CFS and healthy people to measure levels of common viruses that stay dormant in the body. Researchers found that two viruses (HHV-6B and HHV-7) were present at higher levels in people with ME/CFS, especially in those whose viral levels went up and down over time. Importantly, when these viral levels were higher, patients reported worse symptoms like pain, brain fog, and heart/blood pressure problems.

Immune System

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Evidence browser

Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients.

Post-Acute COVID-19 Symptoms, a Potential Link with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A 6-Month Survey in a Mexican Cohort.

Nationwide epidemiological characteristics of chronic fatigue syndrome in South Korea.

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue.

Male vs. Female Differences in Responding to Oxygen-Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls.

Evolving phenotypes of non-hospitalized patients that indicate long COVID.

A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines.

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period.

Chronotropic Incompetence in Non-Hospitalized Patients with Post-COVID-19 Syndrome.

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments.

Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology.

Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

How peptic ulcer disease could potentially lead to the lifelong, debilitating effects of chronic fatigue syndrome: an insight.

Herpesviruses Serology Distinguishes Different Subgroups of Patients From the United Kingdom Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Biobank.

Salivary DNA Loads for Human Herpesviruses 6 and 7 Are Correlated With Disease Phenotype in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

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