ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

721–740 of 2,807 studies

E2 ModerateCohortPEM not requiredCross-Sectional

Virtual Consultations: Young People and Their Parents' Experience.

Proulx-Cabana, Stephanie, Segal, Terry Yvonne, Gregorowski, Anna et al.·Adolescent health, medicine and therapeutics·2021

This study asked 50 young people (ages 10-18) and their families in the UK about their experience with doctor visits done online instead of in person. Most felt prepared for the visits, found them helpful, and felt private. Many liked that they didn't have to travel and could continue seeing the same doctor, but only about one-third got to speak privately with their doctor without a parent present.

E2 ModerateCohortPEM unclearCross-Sectional

Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME).

Lupo, Giuseppe Francesco Damiano, Rocchetti, Gabriele, Lucini, Luigi et al.·Scientific reports·2021

This study looked at the bacteria living in the gut and mouth of people with ME/CFS compared to healthy people. Researchers found that people with ME/CFS have different types and amounts of bacteria in their intestines, including fewer beneficial bacteria and more of certain harmful ones. They also found differences in the chemical makeup of patients' stool samples. These differences suggest that gut bacteria imbalance may play a role in ME/CFS, though scientists don't yet know if this is a cause or a result of the illness.

E2 ModerateCohortPEM requiredObservational

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Boruch, Alexander E, Lindheimer, Jacob B, Klein-Adams, Jacquelyn C et al.·Life sciences·2021

This study looked at how Gulf War Veterans' bodies responded during exercise and whether those responses could predict post-exertional malaise (PEM)—the worsening of symptoms after physical activity. Veterans with Gulf War Illness had more severe symptom flare-ups after exercising compared to healthy veterans, but the researchers found that common exercise measurements like breathing patterns and muscle pain didn't reliably predict who would experience worse PEM.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredObservational

Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients.

Tirelli, U, Franzini, M, Valdenassi, L et al.·European review for medical and pharmacological sciences·2021

This study tested whether a treatment called oxygen-ozone autohemotherapy (a procedure where blood is mixed with ozone gas and returned to the body) could help reduce fatigue in 100 people with post-COVID symptoms. On average, the treatment reduced fatigue symptoms by 67%, and about 40% of patients reported nearly complete recovery from fatigue. The benefits appeared similar in men and women.

E2 ModerateCohortPEM not requiredCross-Sectional

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue.

Murga, Iñigo, Aranburu, Larraitz, Gargiulo, Pascual A et al.·Frontiers in psychiatry·2021

This study examined 84 ME/CFS patients and 22 healthy controls using questionnaires to measure fatigue, pain, sleep quality, heart rate problems, thinking difficulties, mood, and other symptoms. Researchers used statistical clustering to group patients into five distinct subtypes based on their symptom patterns. The findings suggest that ME/CFS is not one-size-fits-all—some patients have high anxiety and depression without fibromyalgia, while others have fibromyalgia combined with heart rate regulation problems, hormone imbalances, or immune issues.

Immune SystemPost-Exertional Malaise

E2 ModerateCohortPEM unclearObservational

Male vs. Female Differences in Responding to Oxygen-Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Chirumbolo, Salvatore, Valdenassi, Luigi, Franzini, Marianno et al.·Journal of clinical medicine·2021

This study looked at how well a treatment called oxygen-ozone autohemotherapy (O₂-O₃-AHT) worked for ME/CFS fatigue in men versus women. Two hundred patients received this treatment and filled out a fatigue questionnaire before and one month after. The results showed that women experienced more improvement in their fatigue than men did, especially among younger patients aged 14-29.

E2 ModerateCohortPEM unclearCross-Sectional

Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls.

Abou-Donia, Mohamed B, Krengel, Maxine H, Lapadula, Elizabeth S et al.·Brain sciences·2021

Researchers found that Gulf War veterans with Gulf War illness have abnormal immune proteins in their blood that attack brain cells, and these patterns differ between men and women. The study also found that these same immune markers can help distinguish Gulf War illness from other similar conditions like ME/CFS and IBS. This discovery is important because it offers a possible objective blood test that doctors could use to identify and diagnose these difficult-to-recognize illnesses.

BiomarkersImmune System

E2 ModerateCohortPEM not requiredCross-Sectional

A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines.

Schubert, Nick M A, Rosmalen, Judith G M, van Dijk, Pim et al.·Hearing research·2021

This study looked at how common tinnitus (ringing in the ears) is in a large group of Dutch adults and found that about one-third experience it at some point. The researchers discovered that tinnitus is linked to various conditions including hearing problems, heart issues, depression, and notably, chronic fatigue syndrome (ME/CFS). Understanding these connections may help doctors better treat tinnitus and related conditions.

E2 ModerateCohortPEM unclearCross-Sectional

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Wiedbusch, Elzbieta, Cotler, Joseph, Jason, Leonard A·Journal of preventive medicine & healthcare·2021

This study compared how ME/CFS affects people in the United States and Japan by surveying 124 Japanese patients and 210 U.S. patients. The research found that U.S. patients reported more severe brain fog, stomach problems, and exhaustion after activity compared to Japanese patients. Interestingly, Japanese women experienced similar levels of disability as American patients despite being less likely to receive official disability support.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments.

Almulla, Abbas F, Moustafa, Shatha R, Al-Dujaili, Arafat H et al.·Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)·2021

This study looked at a mineral called cesium in the blood of people with schizophrenia and compared it to healthy people. They found that people with schizophrenia had lower cesium levels, and this was connected to cognitive problems (like memory and thinking difficulties), fatigue symptoms, and signs of immune system activity. The researchers suggest that low cesium might contribute to some of the symptoms seen in schizophrenia.

Immune System

E2 ModerateBehavioralPEM not requiredCross-Sectional

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Sygit-Kowalkowska, Ewa·Psychiatria polska·2021

This study looked at fatigue in psychiatric nurses and found that most experienced moderate to high levels of chronic fatigue. The research suggests that workplace communication problems—like unclear instructions and poor teamwork—may contribute to this fatigue, and that some people's personality traits may make them more resilient to fatigue than others.

E2 ModerateCohortPEM not requiredCross-Sectional

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

Mckay, Pamela G, Walker, Helen, Martin, Colin R et al.·BMJ open·2021

This study compared people diagnosed with ME/CFS to people diagnosed with fibromyalgia to see if their symptoms were actually similar. The researchers found that both groups experienced pain, fatigue, sleep problems, and impacts on quality of life in very similar ways, suggesting these conditions may share common symptom patterns. The findings suggest that how these conditions are currently diagnosed and treated might need to be reconsidered since patients experience their symptoms so similarly.

Diagnostics

E2 ModerateCohortPEM unclearCross-Sectional

Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?

Mantovani, Elisa, Mariotto, Sara, Gabbiani, Daniele et al.·Journal of neurovirology·2021

Some people who recover from COVID-19 continue to experience symptoms that look very similar to ME/CFS, including severe tiredness, pain, and difficulty thinking clearly. This study found that about 27% of COVID-19 survivors had these ME/CFS-like symptoms, and they reported worse sleep, more fatigue, and more difficulty with basic activities compared to those who recovered normally. The researchers measured markers of nerve damage and inflammation to understand what might be causing these symptoms.

Long COVID OverlapPost-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology.

Capdevila, Lluis, Castro-Marrero, Jesús, Alegre, José et al.·Sensors (Basel, Switzerland)·2021

Researchers used a smartphone app connected to a heart monitor to measure heart rate variability (how much the time between heartbeats varies) in ME/CFS patients and healthy people. They found that women with ME/CFS showed different heart patterns than healthy women, but men with ME/CFS did not show the same clear difference. This suggests that ME/CFS may affect the heart's nervous system control differently in men versus women.

Biomarkers

E2 ModerateCohortPEM unclearObservational

Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Lutz, Lena, Rohrhofer, Johanna, Zehetmayer, Sonja et al.·Biomolecules·2021

This study looked at blood test results from 262 ME/CFS patients to understand problems with their immune systems. Researchers found that nearly two-thirds of patients had low levels of certain immune proteins or cells, while about one-quarter showed signs of inflammation. These findings suggest that immune system dysfunction is a common feature of ME/CFS and could potentially be used to help diagnose or treat the condition.

BiomarkersImmune System

E2 ModerateBehavioralPEM unclearObservational

Towards personalized assessment of fatigue perpetuating factors in patients with chronic fatigue syndrome using ecological momentary assessment: A pilot study.

Worm-Smeitink, Margreet, Monden, Rei, Groen, Robin Nikita et al.·Journal of psychosomatic research·2021

Researchers tracked what 50 ME/CFS patients experienced throughout their day—their thoughts, activities, and mood—five times daily using phones and activity monitors. They found that two main patterns seemed connected to fatigue: feeling psychologically uncomfortable and how much patients were moving around. However, these patterns looked different for each person, and knowing about them didn't clearly predict who would improve with cognitive behavioural therapy (CBT).

E2 ModerateCohortPEM not requiredLongitudinal

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period.

Ahn, So-Hyun, Kim, Jeong Lan, Kim, Jang Rae et al.·Journal of psychiatric research·2021

This study followed people who recovered from MERS (a serious respiratory illness) for 2 years to see if chronic fatigue increased their risk of suicidal thoughts. Researchers found that people who had chronic fatigue were about 7.5 times more likely to experience suicidal thoughts than those without fatigue. This connection remained strong even when accounting for other factors that might affect mental health.

E2 ModerateCohortPEM unclearCross-Sectional

Are Circulating Fibroblast Growth Factor 21 and N-Terminal Prohormone of Brain Natriuretic Peptide Promising Novel Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

Domingo, Joan Carles, Cordobilla, Begoña, Ferrer, Roser et al.·Antioxidants & redox signaling·2021

This study looked for new blood markers that could help identify ME/CFS by measuring two proteins called FGF21 and NT-proBNP in patients and healthy people. The researchers found that ME/CFS patients had significantly higher levels of both proteins and showed signs of increased inflammation and oxidative stress (cellular damage). These findings suggest these proteins might be useful tools for diagnosing ME/CFS or developing new treatments.

BiomarkersImmune System

E2 ModerateCohortPEM unclearLongitudinal

Salivary DNA Loads for Human Herpesviruses 6 and 7 Are Correlated With Disease Phenotype in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Lee, Ji-Sook, Lacerda, Eliana M, Nacul, Luis et al.·Frontiers in medicine·2021

This study tested saliva samples from people with ME/CFS and healthy people to measure levels of common viruses that stay dormant in the body. Researchers found that two viruses (HHV-6B and HHV-7) were present at higher levels in people with ME/CFS, especially in those whose viral levels went up and down over time. Importantly, when these viral levels were higher, patients reported worse symptoms like pain, brain fog, and heart/blood pressure problems.

Immune System

E2 ModerateCohortPEM unclearCase-Control

Saliva Fatigue Biomarker Index As a Marker for Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community Based Sample.

Jason, Leonard A, Kalns, John, Richarte, Alicia et al.·Fatigue : biomedicine, health & behavior·2021

Researchers tested whether a simple saliva test could help diagnose severe ME/CFS in children and teens. They measured two protein fragments in saliva from young people with ME/CFS and compared them to healthy controls. The study found that this 'Fatigue Biomarker Index' showed significant differences between those with severe ME/CFS and healthy youth, suggesting it might one day be a useful objective test to help doctors diagnose the condition.

Diagnostics

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Virtual Consultations: Young People and Their Parents' Experience.

Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME).

Predicting post-exertional malaise in Gulf War Illness based on acute exercise responses.

Fatigue in post-acute sequelae of SARS-CoV2 (PASC) treated with oxygen-ozone autohemotherapy - preliminary results on 100 patients.

Clinical Heterogeneity in ME/CFS. A Way to Understand Long-COVID19 Fatigue.

Male vs. Female Differences in Responding to Oxygen-Ozone Autohemotherapy (O2-O3-AHT) in Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Sex-Based Differences in Plasma Autoantibodies to Central Nervous System Proteins in Gulf War Veterans versus Healthy and Symptomatic Controls.

A retrospective cross-sectional study on tinnitus prevalence and disease associations in the Dutch population-based cohort Lifelines.

A Comparison of Patients with Chronic Fatigue Syndrome and Myalgic Encephalomyelitis from the United States and Japan.

Lowered serum cesium levels in schizophrenia: association with immune-inflammatory biomarkers and cognitive impairments.

Chronic fatigue of nurses in view of the challenges of contemporary psychiatric care. Do temperament and work environment matter?

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

Chronic fatigue syndrome: an emerging sequela in COVID-19 survivors?

Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology.

Evaluation of Immune Dysregulation in an Austrian Patient Cohort Suffering from Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Towards personalized assessment of fatigue perpetuating factors in patients with chronic fatigue syndrome using ecological momentary assessment: A pilot study.

Association between chronic fatigue syndrome and suicidality among survivors of Middle East respiratory syndrome over a 2-year follow-up period.

Are Circulating Fibroblast Growth Factor 21 and N-Terminal Prohormone of Brain Natriuretic Peptide Promising Novel Biomarkers in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome?

Salivary DNA Loads for Human Herpesviruses 6 and 7 Are Correlated With Disease Phenotype in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

Saliva Fatigue Biomarker Index As a Marker for Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in a Community Based Sample.

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