ME/CFS Evidence Browser — Classified Studies on Myalgic Encephalomyelitis

2807 studies

741–760 of 2,807 studies

E2 ModerateBehavioralPEM not requiredCross-Sectional

Exploring anhedonia in adolescents with Chronic Fatigue Syndrome (CFS): A mixed-methods study.

Smith, Lucie, Crawley, Esther, Riley, Madeleine et al.·Clinical child psychology and psychiatry·2021

This study looked at whether teenagers with ME/CFS lose the ability to enjoy activities they once loved. Researchers surveyed 164 young people and found that 42% experienced some loss of enjoyment, with 15% experiencing significant loss. Many of these teenagers said their condition either stopped them from doing activities or made it hard to enjoy them, even when they did participate.

E2 ModerateCohortPEM unclearCross-Sectional

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome.

Sato, Wakiro, Ono, Hirohiko, Matsutani, Takaji et al.·Brain, behavior, and immunity·2021

This study looked at immune cells called B cells in people with ME/CFS and compared them to healthy people. The researchers found that ME/CFS patients have an unusual pattern of B cells—certain types are overrepresented while others are underrepresented. These abnormal B cell patterns were especially strong in patients whose ME/CFS started after an infection, suggesting the immune system may be stuck responding to something from that earlier infection.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

Mckay, Pamela G, Walker, Helen, Martin, Colin R et al.·BMJ open·2021

This study compared people diagnosed with ME/CFS to people diagnosed with fibromyalgia to see if their symptoms were actually similar. The researchers found that both groups experienced pain, fatigue, sleep problems, and impacts on quality of life in very similar ways, suggesting these conditions may share common symptom patterns. The findings suggest that how these conditions are currently diagnosed and treated might need to be reconsidered since patients experience their symptoms so similarly.

Diagnostics

E2 ModerateCohortPEM not requiredObservational

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

Lechner, Johann, Schmidt, Marlene, von Baehr, Volker et al.·Journal of inflammation research·2021

This study examined jawbone abnormalities in 301 patients with various chronic illnesses, including ME/CFS. Researchers found that patients with bone loss in the jawbone had elevated levels of a chemical messenger called RANTES/CCL5, which promotes inflammation. These findings were consistent across all disease groups studied, suggesting that jawbone problems may contribute to systemic inflammation in multiple conditions.

Immune System

E2 ModerateBehavioralPEM unclearObservational

Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) for Adolescents With Chronic Fatigue Syndrome in Routine Clinical Care: Observational Study.

Albers, Eline, Nijhof, Linde N, Berkelbach van der Sprenkel, Emma E et al.·Journal of medical Internet research·2021

This study tested whether an internet-based therapy program called FITNET, delivered through routine clinical care, works as well as it did in earlier controlled research. The program helps teenagers with ME/CFS through structured cognitive behavioral therapy done online. Results showed that teenagers improved significantly with similar outcomes to the original research study, and very few got worse during treatment.

E2 ModerateCohortPEM requiredCross-Sectional

Network Analysis of Symptoms Co-Occurrence in Chronic Fatigue Syndrome.

Kujawski, Sławomir, Słomko, Joanna, Newton, Julia L et al.·International journal of environmental research and public health·2021

This study looked at how different ME/CFS symptoms appear together in patients. Researchers examined 110 Polish patients and used a network analysis method to see which symptoms tend to occur at the same time and which ones are most closely connected. They found that post-exertional malaise (feeling worse after activity), sleep problems, and memory/concentration difficulties were the most common symptoms, and that certain symptoms were strongly linked to each other.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCross-Sectional

Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME).

Lupo, Giuseppe Francesco Damiano, Rocchetti, Gabriele, Lucini, Luigi et al.·Scientific reports·2021

This study looked at the bacteria living in the gut and mouth of people with ME/CFS compared to healthy people. Researchers found that people with ME/CFS have different types and amounts of bacteria in their intestines, including fewer beneficial bacteria and more of certain harmful ones. They also found differences in the chemical makeup of patients' stool samples. These differences suggest that gut bacteria imbalance may play a role in ME/CFS, though scientists don't yet know if this is a cause or a result of the illness.

E2 ModerateCohortPEM not requiredObservational

Evolving phenotypes of non-hospitalized patients that indicate long COVID.

Estiri, Hossein, Strasser, Zachary H, Brat, Gabriel A et al.·BMC medicine·2021

This study looked at medical records from over 96,000 people to identify which health problems are more common in people who had COVID-19 compared to those who didn't. Researchers found that certain symptoms and conditions—including loss of taste and smell, hair loss, chest pain, extreme tiredness, shortness of breath, pneumonia, and new-onset diabetes—appear more frequently in COVID-19 survivors months after infection. Younger people under 65 developed more of these long-term problems than older adults.

Cognitive Impairment

E2 ModerateBehavioralPEM not requiredLongitudinal

The association between exposure to domestic abuse in women and the development of syndromes indicating central nervous system sensitization: A retrospective cohort study using UK primary care records.

Chandan, Joht Singh, Keerthy, Deepiksana, Gokhale, Krishna Margadhamane et al.·European journal of pain (London, England)·2021

This study looked at whether women who experienced domestic abuse were more likely to develop conditions involving chronic pain and nervous system sensitivity, such as fibromyalgia and ME/CFS. Researchers compared health records of over 22,000 women who had experienced abuse with nearly 45,000 women who had not. They found that abuse survivors had significantly higher rates of several pain-related conditions, suggesting that trauma may trigger or worsen these syndromes.

Pain and Sensitization

E2 ModerateCohortPEM unclearCross-Sectional

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients - A validation study in plasma and cerebrospinal fluid from two Swedish cohorts.

Bynke, Annie, Julin, Per, Gottfries, Carl-Gerhard et al.·Brain, behavior, & immunity - health·2020

Researchers tested blood and spinal fluid samples from ME/CFS patients and healthy people to look for certain antibodies (immune proteins) that mistakenly attack nerve receptors in the body. They found higher levels of some of these antibodies in ME/CFS patients compared to healthy controls, particularly antibodies targeting muscarinic receptors (involved in nerve signaling). However, the amount of these antibodies did not match how severe patients' symptoms were.

Immune System

E2 ModerateCohortPEM not requiredObservational

Breathing pattern disorders (dysfunctional breathing) characteristics and outcomes of children and young people attending a secondary care respiratory clinic.

Newson, Timothy P, Elias, Annie·Pediatric pulmonology·2020

This study looked at 18 young people (ages 11-16) who had breathing pattern disorders—abnormal ways of breathing that caused problems like chest tightness, difficulty breathing during exercise, or feeling like their throat was closing. Most of these young people also had asthma, anxiety, or other conditions. When properly diagnosed and treated by a speech therapist, most improved significantly and felt more confident managing their symptoms, though it often took months to get the right diagnosis.

Post-Exertional Malaise

E2 ModerateCohortPEM unclearCase-Control

Accurate and objective determination of myalgic encephalomyelitis/chronic fatigue syndrome disease severity with a wearable sensor.

Palombo, Turner, Campos, Andrea, Vernon, Suzanne D et al.·Journal of translational medicine·2020

Researchers developed a wearable sensor that measures how much time ME/CFS patients spend standing or walking each day (called UpTime). In a small study of 15 people, they found that severely ill ME/CFS patients spend less than 20% of their day upright, moderately ill patients spend 20-30%, while healthy people spend more than 30%. This sensor measurement was more accurate than asking patients to estimate their activity themselves, suggesting it could be a reliable way to track disease severity and test new treatments.

E2 ModerateBehavioralPEM not requiredCross-Sectional

Do adolescents with chronic fatigue syndrome (CFS/ME) and co-morbid anxiety and/or depressive symptoms think differently to those who do not have co-morbid psychopathology?

Loades, Maria E, Stallard, Paul, Morris, Richard et al.·Journal of affective disorders·2020

This study looked at how adolescents with ME/CFS think about their symptoms, comparing those who also have anxiety or depression with those who don't. Teenagers with both ME/CFS and anxiety/depression were more likely to have negative thoughts in general and worry more about their fatigue causing damage or embarrassment. The thinking patterns of both groups together explained about 43% of why some teens developed anxiety or depression alongside their ME/CFS.

Cognitive Impairment

E2 ModerateBehavioralPEM unclearLongitudinal

Longitudinal outcomes associated with significant other responses to chronic fatigue and pain.

Schmaling, Karen B, Fales, Jessica L, McPherson, Sterling·Journal of health psychology·2020

This study followed 68 people with chronic fatigue (some also with fibromyalgia) for 18 months to see how their loved ones' responses affected their health outcomes. The researchers found that when significant others responded negatively to fatigue and pain, patients experienced more pain, worse mental health, and worse fatigue symptoms over time. Interestingly, when loved ones were more helpful and comforting (solicitous), patients with more fibromyalgia tender points tended to have this response, and when loved ones helped distract patients, mental health was better.

Pain and Sensitization

E2 ModerateDiagnosticPEM not requiredMethods-Paper

Joint Assessment of Equilibrium and Neuromotor Function: A Validation Study in Patients with Fibromyalgia.

Lomas-Vega, Rafael, Rodríguez-Almagro, Daniel, Peinado-Rubia, Ana Belén et al.·Diagnostics (Basel, Switzerland)·2020

Researchers created and tested a new 20-question tool to measure balance problems and nerve-muscle coordination in people with fibromyalgia. The tool was tested on 62 fibromyalgia patients, 22 older adults, and 24 healthy people. The results show the tool works well at identifying balance issues in fibromyalgia patients, especially problems related to head movements.

E2 ModerateCohortPEM requiredCase-Control

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Lande, Asgeir, Fluge, Øystein, Strand, Elin B et al.·Scientific reports·2020

Researchers studied immune system markers called HLA alleles in 426 Norwegian ME/CFS patients and compared them to healthy controls. They found that two specific immune markers (HLA-C*07:04 and HLA-DQB1*03:03) were more common in ME/CFS patients than in healthy people, suggesting the immune system may play a role in developing ME/CFS. About 1 in 5 ME/CFS patients carried one or both of these markers, compared to 1 in 8 healthy people.

Immune System

E2 ModerateCohortPEM not requiredCross-Sectional

Chronic Pain Syndromes and Their Laryngeal Manifestations.

Piersiala, Krzysztof, Akst, Lee M, Hillel, Alexander T et al.·JAMA otolaryngology-- head & neck surgery·2020

This study looked at whether fibromyalgia, irritable bowel syndrome, and ME/CFS patients have similar voice and throat problems. Researchers reviewed medical records of over 4,000 patients at a voice center and found that patients with these three conditions were more likely to have functional voice disorders (problems with how the voice works rather than visible damage) compared to other patients.

E2 ModerateCohortPEM unclearObservational

Preliminary ICF core set for patients with myalgic encephalomyelitis/chronic fatigue syndrome in rehabilitation medicine.

Bileviciute-Ljungar, Indre, Schult, Marie-Louise, Borg, Kristian et al.·Journal of rehabilitation medicine·2020

Researchers studied 100 ME/CFS patients to identify which body functions, activities, and life areas are most affected by the illness. They found that nearly all patients experience severe fatigue, poor sleep, and pain, while most struggle with work, household tasks, and socializing. This study created a standardized checklist that doctors can use to understand and measure how ME/CFS impacts different aspects of patients' lives.

Post-Exertional Malaise

E2 ModerateCohortPEM not requiredCross-Sectional

Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome.

Tai, Foong Way David, Palsson, Olafur S, Lam, Ching Y et al.·Neurogastroenterology and motility·2020

This study looked at people with joint hypermobility disorders (including Ehlers-Danlos syndrome) to understand how often they experience stomach and digestive problems. The researchers found that those who also have POTS (a condition affecting heart rate and blood pressure when standing) had significantly more digestive issues than those without POTS. The digestive problems remained worse in the POTS group even after accounting for other conditions like chronic fatigue syndrome.

Autonomic Nervous System

E2 ModerateCohortPEM unclearCase-Control

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset.

Steiner, Sophie, Becker, Sonya C, Hartwig, Jelka et al.·Frontiers in immunology·2020

This study looked at specific genetic variations that are known to affect how the immune system works. Researchers compared DNA from ME/CFS patients and healthy controls, and found that certain genetic variations were more common in ME/CFS patients whose illness started with an infection. These genetic changes affect how immune cells are controlled, suggesting that autoimmunity may play a role specifically in ME/CFS cases that begin with an infection.

Immune System

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Exploring anhedonia in adolescents with Chronic Fatigue Syndrome (CFS): A mixed-methods study.

Skewing of the B cell receptor repertoire in myalgic encephalomyelitis/chronic fatigue syndrome.

Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design.

Undetected Jawbone Marrow Defects as Inflammatory and Degenerative Signaling Pathways: Chemokine RANTES/CCL5 as a Possible Link Between the Jawbone and Systemic Interactions?

Effectiveness of Internet-Based Cognitive Behavior Therapy (Fatigue in Teenagers on the Internet) for Adolescents With Chronic Fatigue Syndrome in Routine Clinical Care: Observational Study.

Network Analysis of Symptoms Co-Occurrence in Chronic Fatigue Syndrome.

Potential role of microbiome in Chronic Fatigue Syndrome/Myalgic Encephalomyelits (CFS/ME).

Evolving phenotypes of non-hospitalized patients that indicate long COVID.

The association between exposure to domestic abuse in women and the development of syndromes indicating central nervous system sensitization: A retrospective cohort study using UK primary care records.

Autoantibodies to beta-adrenergic and muscarinic cholinergic receptors in Myalgic Encephalomyelitis (ME) patients - A validation study in plasma and cerebrospinal fluid from two Swedish cohorts.

Breathing pattern disorders (dysfunctional breathing) characteristics and outcomes of children and young people attending a secondary care respiratory clinic.

Accurate and objective determination of myalgic encephalomyelitis/chronic fatigue syndrome disease severity with a wearable sensor.

Do adolescents with chronic fatigue syndrome (CFS/ME) and co-morbid anxiety and/or depressive symptoms think differently to those who do not have co-morbid psychopathology?

Longitudinal outcomes associated with significant other responses to chronic fatigue and pain.

Joint Assessment of Equilibrium and Neuromotor Function: A Validation Study in Patients with Fibromyalgia.

Human Leukocyte Antigen alleles associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

Chronic Pain Syndromes and Their Laryngeal Manifestations.

Preliminary ICF core set for patients with myalgic encephalomyelitis/chronic fatigue syndrome in rehabilitation medicine.

Functional gastrointestinal disorders are increased in joint hypermobility-related disorders with concomitant postural orthostatic tachycardia syndrome.

Autoimmunity-Related Risk Variants in PTPN22 and CTLA4 Are Associated With ME/CFS With Infectious Onset.

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